Meclizine (Oral)

Meclizine is an antihistamine that blocks signals in the brain for the treatment and control of nausea, vomiting and dizziness.


Meclizine is predominantly a treatment for motion sickness but it is also used in the treatment of vertigo that is cause by ear problems.

Meclizine is used in the prevention and control of vomiting, nausea and dizziness. It works by blocking signals in the brain that cause these symptoms.

Meclizine is an antihistamine and is only available when prescribed by a doctor. The medication comes in a wide range of forms and can be administered orally as a tablet, capsule or chewable tablet. It is available in the following brands:

  • Travel Sickness
  • Simply Motion
  • Motion Sickness Relief
  • Meni-D
  • Meclicot
  • Dramamine II
  • Antivert50
  • Antivert25
  • Antivert

Patients should use only the brand of medication prescribed for their condition as the different brands work differently and can have different effects.

Condition treated

  • Motion sickness
  • Vertigo

Type Of Medicine

  • Antihistamine

Side Effects

In addition to blocking the symptoms of nausea, dizziness and vomiting, Meclizine can also have other unwanted side effects in the patient. While not all of these side effects may occur, in some cases the patient may need to seek urgent medical help.

If you experience the following side effects from the use of Meclizine then you should seek immediate medical attention:

Frequency of occurrence not known:

  • Unusual tiredness or weakness
  • Tightness in the chest
  • Skin rash
  • Shortness of breath
  • Puffy or swollen:
  • tongue
  • lips
  • face
  • eyes
  • eyelids
  • Itching
  • Hives
  • Fast heartbeat
  • Drowsiness
  • Dizziness
  • Difficulty swallowing
  • Coughing

Certain other side effects can also occur from the use of this medication that are milder and do not necessitate that you seek medical attention. Usually these side effects will abate over time as the body gets used to the treatment and they do not normally indicate any wider medical problems occurring. If these side effects are bothersome or ongoing, however, then you should check with your healthcare professional:

Occurring only rarely:

  • Blurring of vision

Frequency of occurrence not known:

Other side effects from the use of Meclizine can also occur that have not been listed here. If you experience any other side effects from use then you should inform your doctor and seek advice on how to react. If you believe that your health is in immediate danger, however, then you should always contact the emergency services straight away.


Meclizine should only ever be taken as prescribed by your doctor. You should never take more of it than prescribed, take it more frequently than ordered nor take it for longer than you have been instructed. To do so will increase your risk of side effects occurring.

The dose of this medication will differ depending on different patients and their own personal conditions. The doctor will prescribe a particular brand of this medication and you should only ever use this treatment as you have been directed. The information on dosing provided herein is based on averages only and does not take into account any relevant factors in your personal dosing. This information is intended as a guide only and should not be used to make changes to your dose:

When treating motion sickness with Meclizine:

  • Initially adults should take 25-50mg. This dose should be taken 1 hour before you travel. Patients may repeat the dose once every 24 hours while traveling.
  • The use of this medication for motion sickness in children will need to be determined in each case by the prescribing doctor.

When treating vertigo with Meclizine:

  • Adults should be treated with 25-100mg of Meclizine taken in divided doses throughout the day.
  • The use of Meclizine in children must be determined in each case by the prescribing doctor.

If a dose of this medication is missed then you should take it as soon as you are able to. If it is nearly time for your next dose, however, then you should skip the dose you have missed and return to your normal schedule. Never take a double dose of this medication nor use it more frequently than directed.


Meclizine can interact with a range of different medication in the body. You should always inform your doctor of all medications and substances you are taking before you begin any treatment because drug interactions can be very dangerous. In the most serious cases they may be life-threatening. In other cases medications may prevent one another from working or may increase the risk of side effects occurring. Interactions can occur with prescribed medications and also with over the counter treatments, dietary supplements and herbal remedies. For Meclizine it is essential that you tell the doctor if you are taking any of the following. These medications are not normally recommended for use with Meclizine. In some cases, however, your doctor may prescribe both with adjustments made to the frequency of use and the dose taken:

  • Zopiclone
  • Zolpidem
  • Zaleplon
  • Triazolam
  • Tramadol
  • Tiotropium
  • Tilidine
  • Thioridazine
  • Temazepam
  • Tapentadol
  • Sufentanil
  • Sodium Oxybate
  • Secobarbital
  • Remifentanil
  • Ramelteon
  • Quazepam
  • Propoxyphene
  • Propofol
  • Promethazine
  • Prazepam
  • Piritramide
  • Phenobarbital
  • Periciazine
  • Pentobarbital
  • Pentazocine
  • Paregoric
  • Papaveretum
  • Oxymorphone
  • Oxycodone
  • Oxazepam
  • Opium Alkaloids
  • Opium
  • Nitrazepam
  • Nicomorphine
  • Nalbuphine
  • Morphine Sulfate Liposome
  • Morphine
  • Midazolam
  • Methotrimeprazine
  • Methadone
  • Meprobamate
  • Meperidine
  • Lorazepam
  • Levorphanol
  • Ketobemidone
  • Ketazolam
  • Hydroxyzine
  • Hydromorphone
  • Hydrocodone
  • Halazepam
  • Fospropofol
  • Flurazepam
  • Flibanserin
  • Fentanyl
  • Ethylmorphine
  • Ethchlorvynol
  • Eszopiclone
  • Estazolam
  • Doxylamine
  • Donepezil
  • Diphenoxylate
  • Diphenhydramine
  • Dihydrocodeine
  • Difenoxin
  • Diazepam
  • Diacetylmorphine
  • Dexmedetomidine
  • Codeine
  • Clorazepate
  • Clonazepam
  • Chlorpromazine
  • Chlordiazepoxide
  • Chloral Hydrate
  • Butorphanol
  • Butabarbital
  • Buspirone
  • Bupropion
  • Buprenorphine
  • Bromazepam
  • Anileridine
  • Amobarbital
  • Alprazolam
  • Alfentanil

Meclizine can also interact with other medications not listed here. This list has been compiled for severity of interaction and may not be all-inclusive. Ensure your doctor is aware of all medications you take before you begin treatment.

Certain medical problems can also impact on the use of Meclizine. This is because some conditions may be worsened by the use and other conditions may increase the potency of the treatment. You must inform your doctor of all conditions from which you suffer, especially the following:

These conditions may be worsened by use:

The following conditions may increase the effect and side effects of Meclizine due to slower release from the body:

Other medical problems can also impact on the use of Meclizine. Ensure your doctor has access to your full medical history before you begin use of this treatment.


Before you begin use of this medication it is essential to weigh the benefits of use against the potential harm that use can cause. You should make the decision to use this medication with your doctor having ensured that all of the following factors have been considered:

Allergies' You must inform your doctor of any allergies from which you suffer. It is especially important to inform your doctor if you have ever reacted badly to any antihistamine treatments in the past. Certain allergies may prohibit the use of Meclizine.

Pediatric' This medication has not been tested for safety and efficiency in children below the age of 12. You should not give this to a child below this age unless expressly directed to by your doctor.

Geriatric' There is no known limitation to the use of this medication in elderly patients. Elderly patients are, however, more likely to have problems of the liver and kidney that may limit the use of Meclizine.

Pregnancy' There is only a limited risk to the use of this medication when pregnant. Ensure that your doctor is aware if you are pregnant and inform your doctor before use if you think you have become pregnant.

Breastfeeding' There is a minimal risk to the use of this medication when breastfeeding. You should inform your doctor if you are breastfeeding and should weigh the benefits against the risks of use.

This medication may cause you to become drowsy or less alert than you normally are. You should learn how this medication effects you before you carry out any tasks that may put you or others at risk. You should not drive or operate machinery unless you are fit to do so and must remember that it is your legal responsibility to ensure that this is the case.

As this medication affects the central nervous system in the patient it may also increase the effects of other medications and substances that act upon the central nervous system. Some CNS depressants that are commonly used should not be used in conjunction with this medication. These include but are not limited to the following:

  • Alcohol
  • Antihistamines
  • Hay fever tablets
  • Sedatives
  • Cold medication
  • Tranquilizers
  • Antidepressants
  • Sleeping medication
  • Pain medication
  • Narcotics
  • Barbiturates
  • Medication for seizures
  • Relaxants

You should not take any other medication in conjunction with this treatment unless it has been expressly approved by the prescribing doctor. You must also tell any medical professionals treating you that you use this medication before any tests, treatments or procedures.


This medication can be kept at room temperature. It should be kept away from heat, direct light and moisture.

You should not store this medication in a car where it will be exposed to extreme temperatures and potentially freezing conditions.


Meclizine is an antihistamine that acts as a central nervous system depressant to block signals in the brain. The blocked signals cause nausea, vomiting and dizziness. The treatment is commonly used to control and prevent motion sickness but it is also used in the treatment of vertigo.

Meclizine is available with a prescription only and is provided in a range of different brands to be taken orally.

Patients using Meclizine should not take any other substances that act as central nervous system depressants including alcohol and many common over the counter treatments. Meclizine can interact with a wide range of other medications so patients should not take anything with Meclizine that has not been previously discussed with and approved by the prescribing doctor.

When treating motion sickness Meclizine should be taken 1 hour before travel and can be used once every 24 hours.

Patients being treated for vertigo will be given a daily dose divided into smaller doses to take for the duration of the condition.