Meloxicam (Oral)

Meloxicam is used to relieve symptoms such as inflammation, swelling, joint pain and stiffness that are experienced with arthritis.

Overview

Meloxicam is an anti-inflammatory medication that is nonsteroidal. It can be used in the treatment of arthritis to relieve the symptoms that are experienced by the patient. Symptoms of arthritis such as swelling, stiffness, inflammation and joint pain will be relieved by this medication on a temporary basis. This medicine will not, however, serve to cure arthritis. It will only continue to work for as long as the medication is used.

Meloxicam is available only with a prescription and is administered as capsules, tablets or suspension. Meloxicam is available as Mobic of Vivlodex.

Condition treated

Arthritis, symptoms of

Type Of Medicine

Nonsteroidal anti-inflammatory

Side Effects

In addition to relieving the symptoms of arthritis, the use of Meloxicam can also cause other unwanted side effects to occur in the patient. Some side effects may be mild and do not need treating while others may require that you seek medical attention. Not all side effects may occur in any patient.

If you experience the following side effects then you should contact your doctor immediately:

Occurring less commonly:

  • Yellow eyes or skin
  • Weight gain or loss
  • Watery or bloody diarrhea
  • Upper right abdominal or stomach pain
  • Unusual bleeding or bruising
  • Trouble breathing
  • Trembling or shaking of the hands or feet
  • Swollen glands
  • Swelling or puffiness of the face
  • Sweating
  • Stomach bloating, burning, cramping, tenderness, or pain
  • Sores, welting, or blisters
  • Sores or ulcers
  • Sore throat
  • Skin blisters
  • Shakiness in the legs, arms, feet or hands
  • Severe sunburn
  • Severe and continuing nausea
  • Seizures
  • White spots on the lips or tongue or inside the mouth
  • Redness, soreness, or itching skin
  • Pounding in the ears
  • Pinpoint red or purple spots on the skin
  • Pains in the stomach, side, or abdomen
  • Painful or difficult urination
  • Pain or discomfort in the arms, back, jaw, or neck
  • Noisy breathing
  • Lower side or back pain
  • Loss of appetite
  • Light-colored stools
  • Large swelling with a hive-like appearance on the:
  • Face
  • Eyelids
  • Lips
  • Tongue
  • Throat
  • Hands
  • Legs
  • Feet
  • Sex organs
  • Itching, redness, or other discoloration of the skin
  • Irregular breathing
  • Increased thirst
  • Increased sensitivity of the skin to sunlight
  • Increased blood pressure
  • Hives or welts
  • Headache
  • General tiredness and weakness
  • Dizziness or faintness when rising suddenly from sitting or lying
  • Dizziness
  • Dilated neck veins
  • Difficult or labored breathing
  • Decreased frequency or amount of urine
  • Dark urine
  • Cramping
  • Cough
  • Cloudy urine
  • Chills
  • Chest tightness or heaviness
  • Canker sores
  • Burning upper abdominal or stomach pain
  • Blurred vision
  • Blood in the urine
  • Bloating
  • Bleeding gums
  • Arm, back, or jaw pain

Occurring only rarely:

  • Vomiting of blood or material with the appearance of coffee grounds
  • Unusual tiredness or weakness
  • Unpleasant breath odor
  • Tightness in the chest
  • Severe stomach pain
  • Scaly skin
  • Red, swollen skin
  • Red, irritated eyes
  • Red skin lesions that may have a purple center
  • Puffy or swollen around the eyelids or the eyes, face, lips or tongue
  • Loss of heat from the body
  • Lightheadedness
  • Joint or muscle pain
  • Greatly decreased frequency of urination or volume of urine
  • Fever with or without chills
  • Fast, weak pulse
  • Difficulty with swallowing
  • Cracks in the skin
  • Cough or hoarseness
  • Continuing vomiting
  • Cold, clammy skin
  • Clay-colored stools
  • Bloody or black, tarry stools
  • Blistering, peeling, or loosening of the skin
  • Area rash

Frequency of incidence not known:

  • Sudden vision changes
  • Sudden onset of slurred speech
  • Sudden onset of shortness of breath with no cause
  • Sudden loss of coordination
  • Slow speech
  • Severe headaches of sudden onset
  • Pains in the chest, groin or legs, especially the calves
  • Inability to speak
  • Inability to normally move the arms, legs or facial muscles
  • Double vision
  • Difficulty with speaking

It is also possible to suffer from an overdose of this medication. If you believe that you or anyone else is suffering from an overdose of Meloxicam then you must contact the emergency services straight away. The symptoms of overdose can include all of the following:

  • Weight gain (rapid)
  • Swelling of the eyes, face, tongue or lips
  • Slow or fast heartbeat
  • Skin rash
  • Severe stomach pain
  • Pain in the chest
  • Pain in the upper stomach
  • Pain in the throat
  • Convulsions (seizures)
  • Blue lips, fingernails, or skin

Certain other side effects can occur that would not normally require any medical attention. These side effects may be milder and will often abate over time as the body gets used to the medication. If these side effects do become bothersome or are ongoing, however, then you can seek advice from your healthcare professional on how to alleviate them:

Occurring more commonly:

  • Indigestion
  • Heartburn
  • Gas
  • Diarrhea

Occurring less common or rarely:

  • Wrinkled skin
  • Trouble sleeping
  • Trouble concentrating
  • Tiredness
  • Tingling feelings
  • Thirst
  • Thinning of the hair
  • Tenderness in the stomach area
  • Sunken eyes
  • Stomach upset
  • Sleepiness
  • Sensation of spinning
  • Redness, pain, or swelling of the:

O eye

O eyelid

O inner lining of the eyelid

  • Rapid breathing
  • Prickling
  • Pain or burning in the throat
  • Numbness
  • Nervousness
  • Nausea or vomiting
  • Loss of interest or pleasure
  • Irritability
  • Hot flushes
  • Itching
  • Hearing loss
  • Hair loss
  • General feeling of discomfort or illness
  • Feeling sad or empty
  • Feeling of constant movement of self or surroundings
  • Excessive tearing
  • Excess air or gas in the stomach
  • Dry mouth
  • Discouragement
  • Discharge
  • Decreased urination
  • Crawling
  • Continuing ringing or buzzing or other unexplained noise in the ears
  • Constipation
  • Confusion
  • Changes in vision
  • Change in taste
  • Burning, dry, or itching eyes
  • Burning feeling in the chest or stomach
  • Burning
  • Bloated or full feeling
  • Belching
  • Bad, unusual, or unpleasant after taste
  • Appetite increased
  • Anxiety
  • Abnormal dreaming
  • Abdominal or stomach pain
  • "pins and needles"

Other side effects could also occur that have not been listed herein. If you experience any other side effects then you should consult your doctor for advice. If you believe your health to be at immediate risk, however, then you should always contact the emergency services to get treatment.

Dosage

For safe and effective use of Meloxicam you should not ever use it otherwise than directed by the doctor. Do not take more of it, take it more often nor take it for longer than your doctor has ordered. By taking an increased dose of this medication you will face an increased likelihood of side effects and increased severity of side effects.

This medication will always be issued with a guide about the use of Meloxicam and the risks and benefits of use. It is important that you read this medication guide thoroughly and ensure that you understand everything within. If there is anything that you do not understand then you should consult your doctor for advice.

When using the oral liquid you should shake it vigorously before use each time. You must use only the provided measurement device to measure the medication to ensure that the dose taken is correct. Teaspoons and other household items may not be correct.

Always swallow capsules or tablets whole and avoid breaking, crushing or chewing them. You should not take broken medication.

This medication can be taken with or without food. Taking it with food, particularly in the first few weeks of use, can help you to cope with stomach discomfort that may occur.

You should only ever use the brand of medication that your doctor has prescribed for you. Different brands of medications may have different strengths and may act differently on the body. If your refill medication appears to be different then you should consult your pharmacist for advice.

The dose of this medication prescribed will be individual to you and will be tailored to your condition, wider health and other factors too. You should never make changes to your dosing yourself and should only ever change your dose or use if instructed to by your doctor. Remember that this medication can take some time to take effect and be patient in use. The following information is to be used as a guideline only and should not be used to make adjustments to your medication:

When taking Meloxicam as capsules:

  • Adults should be treated with 5mg once daily. This may be increased to a maximum of 10mg taken daily.
  • The use of the Meloxicam capsules must be determined in each case for children.

When taking Meloxicam as suspension or tablets:

  • Adults should be started on a dose of 7.5mg taken once daily. The doctor may increase the dose but it should not normally be greater than 15mg taken once daily.
  • Children aged 2+ should be treated with a dose based on body weight that is calculated by the doctor. The average dose is 0.125mg/kg taken once daily. The dose should not exceed 7.5mg taken daily, however.
  • Children below this age should only be treated with this medication at the discretion of the doctor.

This medication needs to be taken regularly to have the best effect. You should not miss doses of this treatment but if you do miss a dose then you should take it as soon as possible. If you are close to your next dose being due, however, then you should return to your normal schedule. You should not ever take double doses of this medication.

Interactions

Certain medications should never be used in conjunction with one another while others are not recommended for use but can be used in certain combinations. This is because medications can interact in the body and can cause severe complications. In the worst cases these may be life-threatening and in other cases the side effects may be increased. Certain treatments may even prevent other medications from working completely.

To avoid medication interactions occurring with Meloxicam it is important that you inform your doctor of all other medications that you are taking. This includes any prescribed treatments, herbal remedies, over the counter medications and even nutritional supplements. It is especially important that you inform your doctor if you are taking any of these medications:

The following medication should not be used with Meloxicam and your doctor may decide not to prescribe one or the other:

  • Ketorolac

These medications should not normally be used with Meloxicam. In some cases treatment with both may be required, however, and your doctor may prescribe both with adjustments made to the dose or frequency of use:

  • Xipamide
  • Warfarin
  • Vortioxetine
  • Vorapaxar
  • Vilazodone
  • Venlafaxine
  • Valdecoxib
  • Trolamine Salicylate
  • Trimipramine
  • Trichlormethiazide
  • Triamterene
  • Treprostinil
  • Torsemide
  • Tolmetin
  • Tolfenamic Acid
  • Tirofiban
  • Tinzaparin
  • Ticlopidine
  • Ticagrelor
  • Tiaprofenic Acid
  • Tianeptine
  • Tenoxicam
  • Tacrolimus
  • Sulindac
  • Sulfasalazine
  • Spironolactone
  • Sodium Salicylate
  • Sodium Polystyrene Sulfonate
  • Sibutramine
  • Sertraline
  • Salsalate
  • Salicylic Acid
  • Salicylamide
  • Rofecoxib
  • Rivaroxaban
  • Reviparin
  • Reboxetine
  • Protriptyline
  • Protein C
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Prednisone
  • Prednisolone
  • Prasugrel
  • Pralatrexate
  • Polythiazide
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Phenyl Salicylate
  • Phenprocoumon
  • Phenindione
  • Pentoxifylline
  • Pentosan Polysulfate Sodium
  • Pemetrexed
  • Paroxetine
  • Parnaparin
  • Parecoxib
  • Paramethasone
  • Oxyphenbutazone
  • Oxaprozin
  • Opipramol
  • Olsalazine
  • Nortriptyline
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Nefazodone
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Milnacipran
  • Metolazone
  • Methylprednisolone
  • Methyclothiazide
  • Methotrexate
  • Mesalamine
  • Meloxicam
  • Melitracen
  • Mefenamic Acid
  • Meclofenamate
  • Meadowsweet
  • Magnesium Salicylate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lofepramine
  • Lithium
  • Levomilnacipran
  • Lepirudin
  • Ketoprofen
  • Indomethacin
  • Indapamide
  • Imipramine
  • Iloprost
  • Ibuprofen
  • Hydroflumethiazide
  • Hydrocortisone
  • Hydrochlorothiazide
  • Heparin
  • Gossypol
  • Ginkgo
  • Furosemide
  • Fondaparinux
  • Fluvoxamine
  • Flurbiprofen
  • Fluoxetine
  • Fluocortolone
  • Flufenamic Acid
  • Floctafenine
  • Feverfew
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Escitalopram
  • Eptifibatide
  • Epoprostenol
  • Eplerenone
  • Enoxaparin
  • Edoxaban
  • Duloxetine
  • Droxicam
  • Doxepin
  • Dothiepin
  • Dipyrone
  • Dipyridamole
  • Digoxin
  • Diflunisal
  • Diclofenac
  • Dibenzepin
  • Diazoxide
  • Dexketoprofen
  • Dexibuprofen
  • Dexamethasone
  • Desvenlafaxine
  • Desirudin
  • Desipramine
  • Deflazacort
  • Danaparoid
  • Dalteparin
  • Dabigatran Etexilate
  • Cyclosporine
  • Cyclopenthiazide
  • Cortisone
  • Clopidogrel
  • Clopamide
  • Clonixin
  • Clomipramine
  • Citalopram
  • Cilostazol
  • Choline Salicylate
  • Choline Magnesium Trisalicylate
  • Chlorthalidone
  • Chlorothiazide
  • Certoparin
  • Ceritinib
  • Celecoxib
  • Cangrelor
  • Bumetanide
  • Bufexamac
  • Budesonide
  • Bromfenac
  • Bivalirudin
  • Bismuth Subsalicylate
  • Betamethasone
  • Beta Glucan
  • Benzthiazide
  • Bendroflumethiazide
  • Bemiparin
  • Balsalazide
  • Aspirin
  • Argatroban
  • Ardeparin
  • Apixaban
  • Anagrelide
  • Amtolmetin Guacil
  • Amoxapine
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine
  • Amiloride
  • Acenocoumarol
  • Acemetacin
  • Aceclofenac
  • Abciximab

Use of Meloxicam with the following treatments may increase the risk of certain side effects occurring. In some cases you may be treated with both but the dose or dosing schedule may be adjusted for one or more of the treatments to minimise interaction:

  • Zofenopril
  • Voriconazole
  • Valsartan
  • Trandolapril
  • Timolol
  • Temocapril
  • Telmisartan
  • Spirapril
  • Sotalol
  • Ramipril
  • Quinapril
  • Propranolol
  • Practolol
  • Pindolol
  • Perindopril
  • Pentopril
  • Penbutolol
  • Oxprenolol
  • Olmesartan
  • Nebivolol
  • Nadolol
  • Moexipril
  • Metoprolol
  • Metipranolol
  • Losartan
  • Lisinopril
  • Levobunolol
  • Labetalol
  • Itraconazole
  • Irbesartan
  • Imidapril
  • Fosinopril
  • Esmolol
  • Eprosartan
  • Enalaprilat
  • Enalapril
  • Delapril
  • Cilazapril
  • Cholestyramine
  • Celiprolol
  • Carvedilol
  • Carteolol
  • Captopril
  • Candesartan
  • Bisoprolol
  • Betaxolol
  • Benazepril
  • Azilsartan Medoxomil
  • Azilsartan
  • Atenolol
  • Alacepril
  • Acebutolol

Meloxicam could also interact with other medications. These medications have been listed because of severity only and the list is not necessarily all-inclusive. Ensure that your doctor is informed of all other medications that you are taking before starting treatment.

Your use of and suitability for treatment with Meloxicam may also be affected by your wider health. Other medical problems from which you suffer may also impact on the suitability of this treatment for you. This is because certain medical conditions can be worsened by treatment and can also impact on the severity of side effects. You must inform your doctor of all conditions from which you suffer and this is especially important with the following conditions:

These conditions may be worsened by use of Meloxicam:

  • Anemia
  • Asthma
  • Bleeding problems
  • Congestive heart failure
  • Dehydration
  • Edema
  • Heart attack or history of heart attack
  • Heart disease
  • Blood vessel disease
  • Hyperkalemia
  • Hypertension
  • Kidney disease
  • Liver disease
  • History of stomach ulcers or bleeding
  • History of stroke

Patients with these conditions should not be treated with Meloxicam:

  • Aspirin sensitive asthma
  • History a aspirin sensitivity

Meloxicam should not be used for the treatment of pain around heart surgery.

Other medical problems could also impact on the use of Meloxicam. Patients must ensure that the doctor is aware of their full medical history before any treatment begins.

Warnings

Before beginning use of Meloxicam it is important to consider the risks of use in relation to the benefits of use. You should make this consideration with your doctor and should ensure that you have both taken the following factors into account:

Allergies 'You must inform your doctor if you have ever suffered any unusual reactions to any medications in the past. If you have reacted badly to aspirin previously this medication may not be suitable for you. Inform your doctor of all other allergies from which you believe that you suffer.

Pediatric' Capsules of Meloxicam have not been approved for use in children and should not be prescribed. Tablets and oral liquids have been tested for safety and efficiency and approved for use in children aged 2+ for the treatment of juvenile rheumatoid arthritis only. Discuss child use with your doctor and consider the wider risks involved.

Geriatric' The studies performed to date have not identified any limitations to the use of Meloxicam in elderly patients. Elderly patients will, however, be more likely to be suffering from the range of medical conditions that can limit or prohibit use of this medication. Where such conditions are present caution should be exercised.

Pregnancy' The risk of use during pregnancy varies depending on the stage of gestation. Use I the later stages of pregnancy can harm the unborn baby. You must tell your doctor before use if you believe you may be pregnant or are pregnant. You must also inform your doctor right away if you believe that you have become pregnant during your use of Meloxicam.

Meloxicam can also delay ovulation in women and can affect the ability to have children. If you are planning to have children in the future then you should discuss this with your doctor before you begin the treatment.

Breastfeeding' The risks of use while breastfeeding are unknown. Patients should consider the benefits and potential risks with their doctor before beginning treatment and breastfeeding.

Patients will need to have regular examinations during the use of this treatment to ensure that the medication is working properly and is not causing any unwanted side effects to occur. You may need to give blood samples as a part of this examination each time you visit the doctor.

When you are taking this medication you will have an increased risk of suffering from a heart attack or stroke. This condition is more likely to occur in people who have existing conditions of the heart or blood vessel or in those who have previously suffered such problems. It also becomes more likely with the ongoing use of this medication. You should be alert to the following symptoms and must inform your doctor if you begin to experience them:

  • Weakness
  • Vomiting
  • Slurring of speech
  • Shortness of breath
  • Pain in the neck
  • Pain in the jaw
  • Pain in the arms
  • Nausea
  • Chest pain

Meloxicam can cause stomach bleeding to occur and may cause bleeding of the intestines. These side effects may occur suddenly without an prior warning. They are more likely to occur in people who have previously suffered a stomach ulcer, in people who smoke, in those who drink heavily and in those aged 60+ or in poor health. Certain other medications that you may be taking, such as blood thinners or steroids, can also increase the risk of this occurrence.

Liver problems can develop when you are using this medication. Such problems can be very serious and you will need to see a doctor immediately. Be alert for the following symptoms of liver problems:

  • Yellowing of the eyes or skin
  • Vomiting
  • Unusual weakness
  • Unusual tiredness
  • Swelling of feet or legs
  • Stomach pain
  • Skin rash
  • Nausea
  • Lost appetite
  • Itching
  • Headache
  • Fever
  • Decreased appetite
  • Darkened urine
  • Clay-colored stools
  • Abdominal pain

Serious side effects can occur without warning, but warning signs may occur that should alert you to take action before the problem develops. You should be alert to any of the following symptoms of other problems that are developing when you are taking Meloxicam and in doing so you may be able to prevent them from developing. These symptoms to look out for include:

  • Warmth of the skin
  • Vomiting of material that appears like coffee grounds
  • Vomiting of blood
  • Tightness across the chest
  • Swelling of and around the face
  • Skin rash
  • Severe stomach pain
  • Increased heartrate
  • Heart problem
  • Flushing of the skin
  • Chest pains
  • Black or tarry stools

Check with your doctor immediately if you notice any of these warning signs.

Meloxicam can cause a serious allergic reaction called anaphylaxis to occur. This can occur at any time when you are using this treatment and you should always be alert to it. Common symptoms include swelling of the face, mouth and throat as well as difficulties with breathing and a loss of consciousness. You must seek emergency medical care if these symptoms begin to occur.

Serious skin conditions may develop from the use of this medication. You should report any changes to your skin composition or coloration to your doctor straight away.

If you experience any unexplained weight gain then you will need to visit your doctor. This may be a sign of water retention or edema that will need to be treated.

Do not take any other form of medication in conjunction with Meloxicam unless it has been expressly approved for use by your doctor. To do so will risk serious interactions and side effects of a severe nature.

Storage

You should store this medication at room temperature well out of the reach of children.

Keep it out of direct light and away from both heat and moisture.

Dispose of any unwanted medication safely and promptly as directed to by your doctor.

Summary

Meloxicam is used in the treatment of arthritis in both adults and children. It is a non-steroidal anti-inflammatory that works to relieve the symptoms of arthritis. Meloxicam can reduce swelling, joint soreness, inflammation and stiffness to allow for normal movement to occur.

Meloxicam is not a cure for arthritis, instead it is used to relieve the symptoms. Once patients have begun use of Meloxicam they will need to continue to take it to continue to benefit from it.

There are potentially severe side effects that may occur from the use of Meloxicam. Patients should be aware of these risks before use and should weigh them against the benefits of use. This medication will be prescribed with a medication guide that you should read ad understand before you begin treatment.