Mepenzolate (Oral)


Mepenzolate is used in the treatment of peptic ulcers. This drug works by decreasing bowel contractions and stomach acid production. This drug is an anticholinergic agent.

You cannot obtain this medication on your own, it can only be given via a prescription from your doctor. It is available in the dosage form of tablet for oral consumption.

Conditions treated

  • Irritable Colon

Type of medication

  • Oral tablet

Side effects

Alongside the intended effects of this drug, it can produce some unwanted side effects. Whilst not all of these may be present, if they do occur, you may need to seek medical attention.

Seek medical attention if you suffer from any of the following side effects whilst taking this drug.

Incidence not known

  • Tightness in the chest

Some of the side effects that occur with this drug, don't typically require medical attention. You usually find that these side effects begin to disappear as your body start adjusting to the medication. Your healthcare professional may be able to suggest ways in which to reduce these side effects. You should contact your doctor if any of the following side effects listed below cause you bother or begin to linger.

Incidence not known

  • Loss of taste

It is possible you could suffer from other side effects that are not listed above. If you notice anything unusual or strange, you should seek advice. If you wish, you can report side effects to the FDA on 1-800-FDA-1088.


The final dose of this medication will depend on different factors determined by your doctor. These could include your weight, age and height, other medical conditions you suffer from and any other medications you are taking. Your doctor will also consider the strength of the medication, your reaction to the first dose and the duration of your treatment. You should never change your dose without speaking with your doctor beforehand. If you take too much of a drug you could put yourself at risk of side effects, whereas if you take too little you, you could reduce your treatment. The following doses are guidelines.

For oral dosage form of tablets for the treatment of peptic ulcer.

Adults: 25 or 50 milligrams four times daily. Your healthcare team can adjust your dose as necessary.

Children: The final dose and use will be determined by your healthcare team.

Missed Dose

If you miss a dose of Mepenzolate, you should take it as soon as possible. Although, if it is close to the time of your next dose, you should skip the dose you have missed and returned to the original dosing schedule that was set by your healthcare team. Don't double your doses to make up for missing a dose.

Proper Use

Take this medication only as it has been directed by your doctor. Don't take more of it, or take it more frequently or for a longer period of time than you have been told to do so. You could increase your risk of side effects.

You should take this medication with meals and at bedtime.


Drug interactions can occur with Mepenzolate which could result in serious side effects or a decrease in your treatment. To avoid these interactions occurring, you should give your healthcare team a full list of all medications you are currently taking including any prescription and nonprescription drugs, vitamins or herbal products. It's also worth telling your doctor about any other medical conditions you may suffer from as these too could increase your risk of interactions

The use of this medication alongside any of the following is not typically recommended, but in some cases, it may be necessary. If you are given both medications at the same time, your doctor may change your final dose or the frequency in which you take either medication.

  • Donepezil

Let your healthcare team know if you are taking any of the following medications as these can cause interactions with this drug.

  • Triflupromazine

Other medical conditions

The presence of other medical conditions could potentially affect the use of Mepenzolate. Make sure you let your doctor know if you have any other medical conditions, especially:

  • Tachycardia (fast heart rate): Caution should be exercised as this drug could make this condition worse.



Make your healthcare team aware if you have ever suffered from an allergic reaction to this medication or any medication. You should also inform them of any other allergies to preservatives, dyes, foods or animals.

Pediatric population

Appropriate studies have not been conducted on the relationship of age to the effects of this drug in the pediatric population. Therefore efficacy and safety have not yet been established.

Geriatric population

Appropriate studies conducted to date have not indicated a geriatric-specific problem that could limit the effectiveness of this drug in the elderly population. However, elderly patients are more likely to have age-related liver, kidney, or heart issues, which could require a degree of caution and an adjustment in the dose for those who are grieving this drug.

Use in pregnancy and breastfeeding

This drug is under FDA pregnancy category B. This drug is not expected to harm to an unborn child. Let your doctor know if you are currently pregnant or intend on becoming pregnant whilst using this medication.

It's unknown whether mepenzolate can pass into breast milk or if it could cause potential harm to a nursing child. Don't take this drug without informing your doctor if you are breastfeeding a child.

It's extremely important that your doctor monitors your progress at regular appointments. This will allow them to see if the medication is working correctly and to decide if you should continue taking it.

This medication can make you sweat less often, which can cause your body temperature to rise. You should use extra care to avoid becoming overheated in hot weather, or during exercising since overheating could result in com/health/heat-stroke/">heat stroke.

This medication could cause drowsiness, dizziness, or blurred vision. You should avoid using machinery, driving or taking part in any other activities that require you to be alert until you know how the medication will affect you.

Check with your doctor immediately if you suffer from confusion, agitation, difficulty with speaking, unusual changes in behavior or mood, trouble sleeping, or if you hear, see, or feel things that aren't there. These could be nervous system side effects of the medication.


Ensure that you store this medication in a closed container at room temperature and keep it away from moisture, light, and heat. Do not let this medication freeze. Make sure it is kept out of the reach of children. Don't keep any medication that is no longer needed or has passed its expiry date. You should seek advice from a local pharmacist for the best method of disposal for this medication.


When used as directed, this drug is successful in treating peptic ulcers. Since there is a large number of interactions possible with this drug, it's important your healthcare team are aware of all medications you are currently taking, including other medical conditions. The safety and efficacy of this drug have not been established for use in children. Older patients may suffer more from the effects of this medication than younger patients. You should let your doctor know if you are pregnant or intend on becoming pregnant whilst using this medication. You should also let them know if you are currently breastfeeding. This drug isn't expected to harm an unborn child or cause harm whilst breastfeeding. You should only take the amount of medication that has been prescribed to you, otherwise, you increase your risk of harmful side effects. To obtain the most benefit from this drug, you need to use it regularly at a similar time each day. It's important you let your doctor know if your condition persists or worsens as you may need a different dose or different medication. Do not share this medication with anyone else. If you require any further information about the practical uses of this drug, or you have more questions or queries, you should contact your local healthcare professional or a qualified doctor for further advice and information.