Meprobamate and Aspirin (Oral)

When prescribed as a combination medicine, Meprobamate and Aspirin can be used to treat short-term and it associated symptoms, such as anxiety and tension.

Overview

Appropriate for relieving short-term pain Meprobamate and aspirin also reduces tension and anxiety. There are many musculoskeletal conditions which can cause increased tension and/or anxiety, as well as mild-to-moderate pain. Similarly, migraine headaches are often worsened by tension. By using Meprobamate and Aspirin as a combination medicine, patients can benefit from pain relief but can also reduce the anxiety and tension associated with their condition.

Derived from carbamic acid, Meprobamate has sedative and hypnotic properties. Although Meprobamate is also thought to induce muscle relaxation, it is believed that this a by-product of anxiety reduction, as opposed to a direct effect on the musculature.

Although Meprobamate is an effective anxiolytic, it is still not known exactly how the medication works. However, Meprobamate is known to impact various parts of the central nervous system. In addition to this, the medication binds to gamma-aminobutyric acid (GABA) receptors in the spinal cord and reticular formation, which causes the patient to have an altered sensation of pain and induces mild sedation.

Acetylsalicylic acid, also known as Aspirin, is an analgesic which is effective in reducing mild-to-moderate pain. Furthermore, Aspirin has antipyretic and anti-inflammatory properties and can, therefore, be used to reduce fevers and treat swelling or inflammation. Although Aspirin is an anti-inflammatory drug, it differs from other nonsteroidal anti-inflammatory drugs (NSAIDs) due to its irreversible inhibition of cyclooxygenase enzymes. When these enzymes are inhibited, the production of prostaglandins are reduced. As prostaglandins are mediators of inflammation and pain, reducing the amount of prostaglandins in the patient's symptoms can also relieve their symptoms.

Although Meprobamate and Aspirin can be used separately, the patient may gain greater symptom relief if they are used as a combination medicine. Due to this use of benzodiazepines and other anti-anxiety medications, Meprobamate is no longer a first-line treatment. However, it can still be prescribed to patients for various reasons. If patients are suffering from pain, accompanied by anxiety or tension, Meprobamate and Aspirin may still be considered an effective form of treatment.

Conditions Treated

  • Mild-to-moderate pain, with associated anxiety or tension

Type Of Medicine

  • Anxiolytic (Meprobamate)
  • Analgesic (Aspirin)
  • Antipyretic (Aspirin)
  • Anti-inflammatory (Aspirin)

Side Effects

Although any type of medication can cause adverse effects, there are some side-effects which require immediate medical attention and others which may not. When patients first start taking Meprobamate and Aspirin, for example, they may develop the following side-effects:

  • Drowsiness
  • Indigestion or heartburn
  • Nausea, may be with or without vomiting
  • Blurred vision or a change in distant or near vision
  • Stomach pain (mild)
  • Lightheadedness or dizziness
  • Headache

However, if they are relatively mild and short-lived, further medical treatment may not be required. If the above side-effects are severe or continuing, patients should seek medical help.

Furthermore, patients should inform their doctor if they experience any of the following side-effects when using Meprobamate and Aspirin:

  • Tarry, black or bloody stools
  • Rash on the skin
  • Confusion
  • Vomiting of blood
  • Hives, or itching
  • Unusual weakness or tiredness
  • Fever
  • Unusual bruising or bleeding
  • Sore throat
  • Vomiting of material which looks like coffee grounds
  • Unusual excitement

In addition to this, patients should obtain immediate medical help if they exhibit the following symptoms when taking Meprobamate and Aspirin:

  • Wheezing
  • Chest tightness
  • Difficulty breathing
  • Shortness of breath

If patients experience any other adverse effects when taking Meprobamate and Aspirin, they should also obtain medical advice.

When using Meprobamate and Aspirin, patients should be aware of the symptoms of an overdose. If too much Meprobamate and Aspirin is taken or if the medication is used too often, patients may display the following symptoms:

  • Any loss of hearing
  • Vision problems
  • Stomach pain (continuing or severe)
  • Bloody urine
  • Confusion (severe)
  • Slurred speech
  • Convulsions (seizures)
  • Slow heartbeat
  • Diarrhea (continuing or severe)
  • Lightheadedness or dizziness (continuing)
  • Buzzing or ringing in the ears (continuing)
  • Drowsiness (severe)
  • Deep or fast breathing
  • Excitement or nervousness (severe)
  • Hallucinations (feeling, hearing or seeing things that are not there)
  • Unexplained fever
  • Headache (continuing or severe)
  • Weakness (severe)
  • Increased sweating
  • Unusual thirst
  • Nausea or vomiting (continuing)
  • Uncontrolled or unusual flapping movements of the hands, particularly in elderly patients

If Meprobamate and Aspirin has been used to treat pediatric patients, they may exhibit different symptoms if an overdose occurs. These could include:

  • Deep or fast breathing
  • Changes in behavior
  • Tiredness or drowsiness (severe)

An overdose of Meprobamate and Aspirin is a life-threatening emergency and urgent medical assistance must be sought if patients display the above symptoms. Patients or their caregivers should access help from their nearest Emergency Room, call 911 and/or contact a Poison Control Center in the event of an overdose.

If patients or caregivers are aware that too much Meprobamate and Aspirin has been taken, they should seek help straight away and should not wait for the symptoms of an overdose to develop.

Dosage

When patients use Meprobamate and Aspirin, they should only take the medication in accordance with their doctor's instructions. If patients take too much Meprobamate and Aspirin or use the medication too often, they could suffer serious side-effects and/or an overdose.

Typically, adult patients are advised to take one or two Meprobamate and Aspirin tablets, three to four times per day. However, if the patient's symptoms subside, additional doses may not be required.

Although Meprobamate and Aspirin may be prescribed to patients over the age of twelve years, teenage patients may be prescribed as smaller dose of Meprobamate and Aspirin.

Taking Meprobamate and Aspirin with an eight ounce glass of water or food may help to lessen stomach upsets and irritation.

Before taking Meprobamate and Aspirin, patients should ensure that the medication does not have a vinegar-like odor. If it does, it may indicate that the medication has expired and that the Aspirin in the medication is starting to break down. If so, patients should not use the medication and should request another prescription of Meprobamate and Aspirin.

Potential Drug Interactions

Before patients start taking Meprobamate and Aspirin, they should tell their doctor if they are using any other medicines, including over-the-counter remedies, supplements or vitamins. As some medicines can interact with each other, it may not be safe to take Meprobamate and Aspirin alongside some other medications.

For example, Meprobamate and Aspirin should not be used alongside any of the following:

  • Defibrotide
  • Influenza Virus Vaccine, Live
  • Dichlorphenamide
  • Ketorolac

Similarly, patients are not usually advised to take Meprobamate and Aspirin in conjunction with any of the following substances:

  • Acarbose
  • Fepradinol
  • Aceclofenac
  • Floctafenine
  • Acemetacin
  • Feverfew
  • Alfentanil
  • Flibanserin
  • Alipogene Tiparvovec
  • Feprazone
  • Alprazolam
  • Fluconazole
  • Alteplase, Recombinant
  • Hydromorphone
  • Amiloride
  • Levorphanol
  • Amineptine
  • Indomethacin
  • Amitriptyline
  • Ketazolam
  • Amitriptylinoxide
  • Levomilnacipran
  • Amobarbital
  • Ketoprofen
  • Amoxapine
  • Lepirudin
  • Amtolmetin Guacil
  • Lofepramine
  • Anagrelide
  • Lithium
  • Anileridine
  • Imipramine
  • Anisindione
  • Indapamide
  • Apixaban
  • Ibuprofen
  • Aprobarbital
  • Propofol
  • Argatroban
  • Propyphenazone
  • Bendroflumethiazide
  • Proglumetacin
  • Benzthiazide
  • Prazepam
  • Beta Glucan
  • Prasugrel
  • Bivalirudin
  • Pranoprofen
  • Bromazepam
  • Propoxyphene
  • Bromfenac
  • Pralatrexate
  • Bromopride
  • Proquazone
  • Bufexamac
  • Polythiazide
  • Bumetanide
  • Primidone
  • Buprenorphine
  • Metformin
  • Butabarbital
  • Methotrexate
  • Butalbital
  • Midazolam
  • Butorphanol
  • Methadone
  • Carbinoxamine
  • Methohexital
  • Carisoprodol
  • Methocarbamol
  • Celecoxib
  • Methyclothiazide
  • Chloral Hydrate
  • Metolazone
  • Chlordiazepoxide
  • Meperidine
  • Chlorothiazide
  • Meloxicam
  • Chlorpropamide
  • Melitracen
  • Chlorthalidone
  • Milnacipran
  • Chlorzoxazone
  • Meprobamate
  • Choline Salicylate
  • Mephenesin
  • Cilostazol
  • Mephobarbital
  • Citalopram
  • Metaxalone
  • Clobazam
  • Nabumetone
  • Clomipramine
  • Morniflumate
  • Clonazepam
  • Naproxen
  • Clonixin
  • Niflumic Acid
  • Clopamide
  • Nepafenac
  • Clopidogrel
  • Nefazodone
  • Clorazepate
  • Nimesulide
  • Codeine
  • Nateglinide
  • Cyclopenthiazide
  • Nitrazepam
  • Cyclosporine
  • Pemetrexed
  • Dabigatran Etexilate
  • Oxaprozin
  • Danaparoid
  • Oxyphenbutazone
  • Dantrolene
  • Oxycodone
  • Desipramine
  • Oxazepam
  • Desirudin
  • Parecoxib
  • Desvenlafaxine
  • Opipramol
  • Dexibuprofen
  • Nortriptyline
  • Dexketoprofen
  • Pentazocine
  • Diazepam
  • Pentobarbital
  • Diazoxide
  • Paroxetine
  • Dibenzepin
  • Spironolactone
  • Temazepam
  • Diclofenac
  • Tenoxicam
  • Dicumarol
  • Tapentadol
  • Diflunisal
  • Sulindac
  • Digoxin
  • Tacrolimus
  • Dihydrocodeine
  • Sufentanil
  • Dipyrone
  • Tianeptine
  • Dothiepin
  • Thiopental
  • Doxepin
  • Periciazine
  • Doxylamine
  • Phenprocoumon
  • Venlafaxine
  • Droxicam
  • Phenylbutazone
  • Duloxetine
  • Vilazodone
  • Piketoprofen
  • Edoxaban
  • Phenobarbital
  • Eplerenone
  • Piroxicam
  • Eptifibatide
  • Piracetam
  • Escitalopram
  • Phenindione
  • Eslicarbazepine Acetate
  • Protriptyline
  • Estazolam
  • Rofecoxib
  • Ethacrynic Acid
  • Ethchlorvynol
  • Salicylic Acid
  • Etodolac
  • Reteplase, Recombinant
  • Etofenamate
  • Quazepam
  • Etoricoxib
  • Repaglinide
  • Felbinac
  • Remifentanil
  • Fenoprofen
  • Rivaroxaban
  • Fentanyl
  • Tiaprofenic Acid
  • Flufenamic Acid
  • Tolazamide
  • Flunitrazepam
  • Ticlopidine
  • Fluoxetine
  • Tolbutamide
  • Flurazepam
  • Ticagrelor
  • Flurbiprofen
  • Tirofiban
  • Fluvoxamine
  • Secobarbital
  • Fondaparinux
  • Sodium Oxybate
  • Fospropofol
  • Sertraline
  • Furosemide
  • Sodium Salicylate
  • Ginkgo
  • Tolfenamic Acid
  • Glimepiride
  • Torsemide
  • Glipizide
  • Salsalate
  • Glyburide
  • Pentoxifylline
  • Gossypol
  • Protein C
  • Halazepam
  • Meclofenamate
  • Heparin
  • Hydrochlorothiazide
  • Nimesulide Beta Cyclodextrin
  • Hydrocodone
  • Pentosan Polysulfate Sodium
  • Hydroflumethiazide
  • Tramadol
  • Lorazepam
  • Treprostinil
  • Lormetazepam
  • Tolmetin
  • Lornoxicam
  • Varicella Virus Vaccine
  • Triamterene
  • Loxoprofen
  • Valdecoxib
  • Lumiracoxib
  • Warfarin
  • Trimipramine
  • Meclizine
  • Xipamide
  • Trichlormethiazide
  • Medazepam
  • Vortioxetine
  • Mefenamic Acid
  • Zolpidem
  • Triazolam

However, in some cases, doctors may feel it is in the patient's best interests for them to take Meprobamate and Aspirin in conjunction with one of the medications listed above. If so, the patient may be advised to take certain medications at a specific time and that patient's dose may be modified in order to try and prevent and interaction occurring.

In addition to this, patients may have an increased risk of developing side-effects if they take Meprobamate and Aspirin alongside any of the following:

  • Acebutolol
  • Penbutolol
  • Atenolol
  • Paramethasone
  • Betamethasone
  • Oxprenolol
  • Betaxolol
  • Nebivolol
  • Bisoprolol
  • Pindolol
  • Captopril
  • Practolol
  • Carteolol
  • Prednisone
  • Carvedilol
  • Prednisolone
  • Celiprolol
  • Sotalol
  • Cortisone
  • Propranolol
  • Delapril
  • Probenecid
  • Dexamethasone
  • Streptokinase
  • Enalaprilat
  • Nitroglycerin
  • Enalapril Maleate
  • Esmolol
  • Nadolol
  • Imidapril
  • Tamarind
  • Labetalol
  • Tenecteplase
  • Levobunolol
  • Temocapril
  • Lisinopril
  • Methylprednisolone
  • Timolol
  • Metipranolol
  • Triamcinolone
  • Metoprolol
  • Valproic Acid

If patients do experience side-effects whilst taking Meprobamate and Aspirin alongside one of the medications listed above, they should contact their physician for advice.

As Meprobamate and Aspirin can interact with other substances as well, patients should avoid the following whilst taking this medication:

  • Ethanol (Alcohol)

If patients consume alcohol whilst taking Meprobamate and Aspirin, they are likely to experience increased side-effects.

Once patients have started taking Meprobamate and Aspirin, they should obtain medical advice before taking any other medicines, supplements or vitamins.

Warnings

If patients have any other health conditions, they should notify their physician before they begin taking Meprobamate and Aspirin. Similarly, patients should disclose their medical history to the relevant healthcare practitioners before they take this medications. There are some conditions which can affect the use of Meprobamate and Aspirin and these may include:

Although pediatric patients may be prescribed Meprobamate and Aspirin, it is not normally used to treat young children or infants. When taking this medication, pediatric patients may be more sensitive to the effects of Aspirin and may, therefore, experience increased side-effects.

Children and teenagers should not be treated with Meprobamate and Aspirin if they have a viral infection, such as chickenpox or flu. If the patient has a fever caused by a virus, Meprobamate and Aspirin should only be used if their doctor has instructed them to take this medication. If children or teenagers are treated with Meprobamate and Aspirin whilst they have a viral infection, they could develop a serious illness, known as a Reye's syndrome.

Whilst geriatric patients can be treated with Meprobamate and Aspirin, they may be more sensitive to the impact of Meprobamate and Aspirin and may, therefore, increase the risk of developing side-effects.

If patients are instructed to take Meprobamate and Aspirin for a long period of time, they should have regular consultations with their physician. Patients should not go longer than four months without consulting their doctor if they are taking Meprobamate and Aspirin.

If patients have used Meprobamate and Aspirin for a long period of time or if they have been instructed to take this medicine in high doses, they should not stop taking the medication suddenly, unless they are advised to do so by a healthcare practitioner. In order to prevent withdrawal symptoms occurring, doctors may advise the patient to reduce their dose of Meprobamate and Aspirin gradually, rather than stopping the medication suddenly.

Patients should seek medical help before taking any other medications whilst they are using Meprobamate and Aspirin. Many over-the-counter medicines contain Aspirin and taking them in conjunction with Meprobamate and Aspirin could cause an overdose.

If Meprobamate and Aspirin is taken alongside any other central nervous system (CNS) depressants, it will increase the effects of these substances. Examples of CNS depressants include:

  • Alcohol
  • Cold and flu medications
  • Asthma medication
  • Seizure medication
  • Cough syrups
  • Antihistamines and allergy medicines
  • Sinus medications
  • Barbiturates
  • Narcotic or prescription pain medication
  • Sedatives
  • Anesthetics, including dental anesthetics
  • Muscle relaxants
  • Sleeping medications

If patients consult with any healthcare professionals or are due to have any medical tests or procedures, they must tell the relevant practitioner that they are taking Meprobamate and Aspirin. This medication can interfere with the effects of anesthetic, including dental anesthesia so it is essential that patients inform their physician or dentist that they are using Meprobamate and Aspirin before any procedures are carried out.

As Aspirin has blood-thinning properties, it should not normally be used for the five days preceding any medical treatments, such as surgery. Patients should seek medical advice so that they know when and if they will need to stop taking Meprobamate and Aspirin.

Patients should not consume alcohol whilst taking Meprobamate and Aspirin as it may lead to stomach problems. This is more likely to occur if patients are taking high doses of Meprobamate and Aspirin or if they are taking the medicine over a long period of time.

Taking Meprobamate and Aspirin alongside the following medications increases the risk of stomach problems and patients should not, therefore, take any of the following unless they are advised to do so by a healthcare professional:

  • Acetaminophen (e.g., Tylenol)
  • Tiaprofenic acid (e.g., Surgam)
  • Diclofenac (e.g., Voltaren)
  • Naproxen (e.g., Naprosyn)
  • Ketorolac (e.g., Toradol)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Piroxicam (e.g., Feldene)
  • Fenoprofen (e.g., Nalfon)
  • Phenylbutazone (e.g., Butazolidin)
  • Floctafenine (e.g., Idarac)
  • Mefenamic acid (e.g., Ponstel)
  • Flurbiprofen (oral) (e.g., Ansaid)
  • Meclofenamate (e.g., Meclomen)
  • Ibuprofen (e.g., Motrin)
  • Sulindac (e.g., Clinoril)
  • Indomethacin (e.g., Indocin)
  • Tolmetin (e.g., Tolectin)
  • Ketoprofen (e.g., Orudis)

If patients are also using a laxative which contains a substance called cellulose, they should not take the laxative within two hours of taking Meprobamate and Aspirin. If laxatives are taken at a similar time to Meprobamate and Aspirin, it could prevent the Aspirin from being absorbed and the medication is likely to be less effective.

Meprobamate and Aspirin can affect the results of urine sugar tests, particularly if the medication has been used consecutively over a number of days. Patients should consult their physician if they are concerned that their blood sugar is not well controlled and should notify the relevant healthcare professionals that they are taking Meprobamate and Aspirin before sugar tests are carried out.

When taking Meprobamate and Aspirin, patients may feel drowsy, dizzy or less alert than they usually do. If patients are affected by these side-effects, they should not operate machinery, drive or perform potentially dangerous tasks until the side-effects have passed.

Patients may develop a dry mouth when taking Meprobamate and may want to suck sugarless candy, chew gum or use a saliva substitute. However, if this side-effect continues, patients should notify their dentist or doctor. A persistent dry mouth can increase the risk of developing fungal infections, tooth decay and/or dental disease.

An overdose of Meprobamate and Aspirin can result in the patient losing consciousness and may lead to death. It is essential that emergency medical help if obtain if an overdose is suspected. Common symptoms associated with an overdose of Meprobamate and Aspirin may include:

  • Continuing buzzing or ringing in the ears
  • Slow heartbeat
  • Hearing loss
  • Shortness of breath
  • Drowsiness
  • Troubled or slow breathing
  • Severe confusion
  • Weakness
  • Staggering

Aspirin can thin the blood and may not be suitable for patients who have existing bleeding problems or who are already taking anti-coagulant (blood thinning) medication.

Patients should not take Meprobamate and Aspirin if they are pregnant. Using this medication during pregnancy can cause harm to the unborn fetus. Due to this, Meprobamate and Aspirin should only be used under a doctor's supervision, in a life-threatening emergency, if there is no alternative drug available, when patients are pregnant.

If patients become pregnant when taking Meprobamate and Aspirin, they should inform their physician straight away.

Both Meprobamate and Aspirin can be excreted in breast milk and Meprobamate, in particular, could be harmful to infants if it is transferred via breastfeeding. Due to this, patients should not breastfeed whilst using this medication. As the medicine may remain in the patient's system for some time after their last dose of Meprobamate and Aspirin, patients should obtain medical advice before breastfeeding if they have taken Meprobamate and Aspirin relatively recently, even if they are no longer using the medicine.

Before patients take Meprobamate and Aspirin, they should tell their doctor if they have any known allergies. If patients exhibit an allergic reaction when taking Meprobamate and Aspirin, they will require emergency medical treatment. During an allergic reaction, patients may exhibit the following symptoms:

  • Hoarseness
  • Shortness of breath
  • Itching
  • Rash on the skin
  • Wheezing
  • Hives
  • Difficulty swallowing
  • Trouble breathing
  • Swelling, affecting the lips, tongue, mouth, throat, face or hands

Storage

When storing Meprobamate and Aspirin at home, patients should follow the medication guidelines and should ensure that the medication is kept in a safe location. It is important that children and/or pets cannot gain access to Meprobamate and Aspirin.

Typically, Meprobamate and Aspirin can be kept at room temperature but should be stored away from sources of light, moisture or heat.

If patients stop using Meprobamate and Aspirin or if they medication reaches its use-by date, it should be disposed of. Patients should not throw medication out with household waste and should contact their physician's office or pharmacist in order to access a safe medicine disposal service.

Summary

As Meprobamate and Aspirin has anxiolytic properties, as well as an analgesic effect, it can be used for more than just pain relief. Whilst Meprobamate and Aspirin is effective in reducing mild-to-moderate pain, it is particularly beneficial for patients who are experiencing pain-related tension and/or anxiety.