Metaxalone (Oral)

Also known in the US under Skelaxin, this drug is a muscle relaxant that is used to relieve discomfort or pain caused by bone or muscle conditions.


Metaxalone is a drug used in the relaxing of certain muscle in the body and to relieve any discomfort caused by acquiring painful bone or muscle conditions. However, this medication doesn't take the place of exercise, rest, physical therapy, or other forms of treatment that your healthcare team has recommended for your medical condition.

Metaxalone is what is known as a skeletal muscle relaxant. It works by acting on the central nervous system to help the muscles to relax. You can only obtain this medication from a doctor via a prescription and it is available in the dosage form of tablet for oral consumption.

Conditions treated

  • Muscle Spasm

Type of medication

  • Oral tablet

Side effects

Alongside the intended effects of this medication, it's consumption could produce some unwanted side effects. Not all of these may be present at the one time, but if they do occur, you may need to seek medical attention.

Seek advice from a healthcare professional if you suffer from any of the following side effects whilst taking this drug:

More common


  • Tightness in the chest

Some of the side effects that occur with this drug, don't usually require any medical attention. You typically find these side effects begin to reduce as your body starts adjusting to the medication. Your doctor may be able to give you advice on how to reduce these side effects if they are problematic. You should seek advice from your healthcare professional if any of the following side effects listed below linger or become bothersome.

More common

You may suffer from other side effects that are not listed above. You should seek medical attention if you feel unwell after taking this drug. Other side effects not listed may also occur in some patients. If you wish you can report side effects to the FDA. You can find them on 1-800-FDA-1088.


The final dose of this medication will depend on individual factors such as your age, weight and height, any other medical conditions you suffer from and any other medications you are currently taking. Your doctor will also consider the strength of the medication, the duration of your treatment plan and your reaction to the first dose. You should not alter your dose unless you have been advised to do so by your doctor. If you take too much of this drug it could increase your risk of side effects, whereas if you take too little, it could reduce your effectiveness in treatment.

Oral tablet for relaxing muscles:

  • Adults and teenagers older than twelve years old: 800 milligrams 3-4 times daily.
  • Children twelve years of age and younger: The final dose and use will be determined by a doctor.

Missed Dose

If you miss a dose of Metaxalone, you need to take it as soon as you have remembered. This is unless its close to the time of your next dose. In this case, you should skip the dose you have missed and return to the original dosing schedule that was set by your doctor. Don't double your doses.

It's best to take these tablets on an empty stomach or without the consumption of food.


Drug interactions can occur with Metaxalone. These interactions could reduce the effect of this treatment or even produce serious side effects. You can help limit these interactions by letting your doctor know about any other medications you are taking. Your list should include all prescription and nonprescription drugs, all herbal products or remedies and all vitamin supplements. It's also a smart idea to make your doctor aware of any other medical conditions you suffer from as your dose may need to be adjusted. In most cases, your doctor will avoid treating you with any drugs which increase your risk of interactions. However, in some circumstances, the use of the drug may still be needed, despite the interaction.

The use of this medication alongside any of the following is not typically recommended, but in some cases, it may be necessary. If you are prescribed both medications at the same time, your doctor may alter your dose or the frequency in which you use either medication.

  • Tapentadol

Let your doctor know if you are taking any of the following drugs:

  • Levocetirizine

Other medical conditions

If you suffer from other medical conditions, these could affect the use of this drug. Therefore it's important to make your doctor aware of any other medical issues you suffer from including:

  • Kidney disease, severe


Before you decide to take a medication, there are a number of different elements to consider. Below are some things to consider alongside the advice of your doctor to help you determine whether this is the best treatment plan for you.


Let your doctor know if you have ever suffered from an allergic reaction to this medication or other medications. Also let them know about any other allergies such as to preservatives, dyes, animals or foods.

Pediatric population

Appropriate studies have not been conducted on the relationship of age to the effects of this drug in children aged twelve and under. Therefore efficacy and safety haven't been established.

Geriatric population

Appropriate studies conducted to date have not indicated a geriatric-specific problem that could limit the effectiveness of this drug in the elderly. However, older patients are more likely to have age-related liver or kidney problems, which may require a degree of caution to be exercised in those patients who are receiving metaxalone.

Use in pregnancy and breastfeeding

This drug has not been assigned an FDA pregnancy category, therefore safety has not been established. It's important to make your doctor aware if you are currently pregnant to discuss the next steps.

The safety of this drug during breastfeeding has also not been established. You should let your doctor know if you are currently breastfeeding, but it is usually best to avoid breastfeeding while using this medication.

It's extreme;y important that your doctor monitors your progress at regular appointments to ensure this medication is working correctly and to test for unwanted effects.

This medication could cause some people to become drowsy, dizzy, or less alert than they normal. These effects could be increased if you take this medication whilst consuming food. Ensure you know how you react to this medication before you use machinery, drive, or do any other activities that could be dangerous if you aren't alert.

This medication will add to the effects of CNS depressants and alcohol. Some examples of CNS depressants are medication for allergies, hay fever, or colds, antihistamines sedatives, medication to aid sleeping, tranquilizers, narcotics or prescription pain medication, medication for seizures, barbiturates, or anesthetics, including some dental anesthetics. You should seek advice from your dentist or doctor before you take any of the following drugs listed above whilst you are using Metaxalone.


You should store Metaxalone at room temperature in a closed container that is kept away from moisture, heat and direct light. Do not let this medication freeze. Ensure you keep this medication out of the reach of children.

Dispose of any medication that has passed its expiry date or you no longer need. A doctor or pharmacist can give you specific advice on the best method of disposal of these medications.


When used as directed, Metaxalone is successful in relaxing muscles. However, due to the vast number of drugs that can interact with this medication, it is important that you give your doctor a full list of all medications you are taking. The safety and efficacy of this drug have not been established for use in children. It is unknown whether this drug can harm an unborn child or harm a breastfeeding child. You should let your doctor know if you are breastfeeding or pregnant. It's important that your doctor monitors your progress on this medication. Do not share your drug with anyone else and try to remember to take medication at the same time every day. It's best to avoid food whilst taking this medication. If you require any further information about the practical uses of this drug or you have more questions, you can contact your doctor or healthcare team for more advice.