Methoxy Polyethylene Glycol-epoetin Beta (Injection)

Methoxy polyethylene glycol-epoetin beta is a medication that is given as an injection. This treatment is used as a form of treatment for anemia in patients that have CKD or chronic kidney disease.

Overview

Methoxy polyethylene glycol-epoetin beta is available as an injectable solution, that can be given both in a medical environment or at home under the correct circumstances.

Methoxy polyethylene glycol-epoetin beta is a synthetic type of protein created to replace functions in the body that are not working correctly. The protein this medicine replaces is normally created in the body by the kidneys and aids the body in producing red blood cells. In patients with chronic kidney disease, this body function does not work correctly, resulting in a lack of red blood cells. This condition is called anemia.

The injected medication stimulates the bone marrow to produce red blood cells, increasing the amount in the blood. This reduces the risk of severe anemia, which often occurs in patients with chronic kidney failure. Methoxy polyethylene glycol-epoetin beta injection is a prescribed medication and is only available through a doctor or medical professional.

Conditions Treated

  •  Anemia

Type Of Medicine

  •  Solution
  • Side Effects

There are several required effects of Methoxy polyethylene glycol-epoetin beta that allow this medication to reduce anemia. In addition to these effects, there is the potential that taking this medication may result in other, unwanted side effects. It is highly unlikely that all of these side effects will occur, but should you experience any of the below-listed symptoms you may require medical treatment or attention.

It's important that you check with your medical team or a trained professional as soon as possible if you find yourself experiencing any of the following effects:

  •  Welts
  •  Weight gain
  •  Vomiting
  •  Vision changes
  •  Unusual tiredness or weakness
  •  Tightness in the chest
  •  Swelling of the face, hands, feet, or lower legs
  •  Sweating
  •  Sweating
  •  Sudden, unexplained shortness of breath
  •  Sudden, severe weakness or numbness in the arms or legs
    Sudden vision changes
  •  Sudden onset of slurred speech
  •  Sudden onset of shortness of breath for no reason
  •  Sudden loss of coordination
  •  Sore throat
  •  Sneezing
  •  Slow or slurred speech
  •  Slow or fast heartbeat
  •  Severe, sudden headache
  •  Severe headaches of sudden onset
  •  Seizures
  •  Runny nose
  •  Redness of the skin
  •  Puffiness or swelling of the eyelids or around the face
  •  Pounding in the ears
  •  Pains in the chest, legs, or groin, especially calves of the legs
  •  Pain or discomfort in the arms, back, jaw, or neck
  •  Nervousness
  •  Nasal congestion
  •  Lower back or side pain
  •  Loss of voice
  •  Lightheadedness when standing up
  •  Large, hive-like swelling on the face, throat, legs, hands, feet, or sex organs
  •  Irregular breathing
  •  Inability to speak
  •  Inability to move the arms, legs, or facial muscles
  •  Hives, itching, or skin rash
  •  Headache
  •  Frequent urge to urinate
  •  Fever
  •  Fast, pounding, or irregular heartbeat or pulse
  •  Extreme fatigue
  •  Ear congestion
  •  Double vision
  •  Dizziness
  •  Dilated neck veins
  •  Difficulty with swallowing
  •  Difficulty with speaking
  •  Difficulty with breathing
  •  Difficult, burning, or painful urination
  •  Decreased urine output
  •  Cough
  •  Confusion
  •  Confusion
  •  Chills
  •  Body aches or pain
  •  Blurred vision
  •  Bloody or cloudy urine
  •  Bladder pain

Other side effects that may result from taking Methoxy polyethylene glycol-epoetin beta are less likely to require medical support, as these conditions are unlikely to cause further complications. These effects may reduce or disappear completely over the course of treatment. However, you may wish to contact your doctor should any of the below effects increase, or become uncomfortable, in order to discuss ways to prevent these conditions:

  • Muscle spasms
  • Difficulty in bowel movements (stool)
  • Diarrhea
  • Back pain

The side effects of Methoxy polyethylene glycol-epoetin beta that are listed above are chosen because of their relevance and number of occurrences in relation to this medication, and the listing of the effects depend on the likelihood of their occurrence. However, this does not mean that other side effects will not happen to you during the time you take this drug.

Should you notice any unusual or unexpected side effects, first and foremost you should contact your medical doctor for support and advice. Following this, you can report any side effects directly to the FDA at 1-800-FDA-1088.

Dosage

It is important when you are prescribed this medication, that you follow the exact instructions and prescription dosage that you are given by your doctor. The below dosage is based on an average, you should never change the dosage of medication you are given unless otherwise advised to by your doctor.

The following is the average dose for adults to combat anemia in patients with chronic renal failure, in which the patient is not being treated with an erythropoiesis-stimulating agent (ESA).

Initial dosage:

0.6 mcg per kg of body weight given as a single IV or subcutaneous injection every two weeks.
The following is the average dose for adults to combat anemia in patients with chronic renal failure, in which the patient is currently being treated with an erythropoiesis-stimulating agent (ESA).

The amount of Epoetin beta-methoxy polyethylene glycol to be administered should be given in direct relation to the weekly dosage of ESA at the time. Your doctor will be able to calculate and decide the exact requirements for each of your dosages and adjust accordingly. If you have any queries about taking both Epoetin beta-methoxy polyethylene glycol and ESA, a trained medical professional should be able to help you understand the levels of each medication required for this treatment.

Should you miss an appointment for Epoetin beta-methoxy polyethylene glycol or are otherwise unable to take a dose of this medicine, contact your doctor as soon as possible for directions on how to move forward with your treatment plan.

Interaction:

Due to the nature of Epoetin beta-methoxy polyethylene glycol as part of a treatment plan, it's essential that your doctor has a complete understanding of every type of medication that you take, from prescribed drugs to over the counter medicines and herbal and vitamin supplements. Though no known drug interactions apply to this medication, as Epoetin beta-methoxy polyethylene glycol is used alongside other medications, it's important to be aware of all possible interactions with all of your drugs.

As well as interactions with other medications, it's vital that both you and your medical team are aware of any direct interactions your treatment may have with foods, tobacco and alcohol. Epoetin beta-methoxy polyethylene glycol has no specific interactions with any substances, but it's important to discuss your use of alcohol, food and tobacco with all your medications.

When taking Epoetin beta-methoxy polyethylene glycol, the existence of other medical conditions in the body may result in this treatment being fewer effects, or even causing harm. Ensure that your doctor is aware if you are suffering from any of the following conditions:

  •  Vitamin deficiency
  •  Stroke
  •  Seizures
  •  Pure red cell aplasia (PRCA, bone marrow disease)
  •  Inflammatory or metabolic conditions
  •  Hypertension
  •  Hypertension
  •  Heart or blood vessel disease
  •  Heart bypass surgery
  •  Heart attack
  •  Congestive heart failure
  •  Cancer
  •  Blood clots
  •  Bleeding problems

Warnings

It is essential that you should not use Epoetin beta-methoxy polyethylene glycol if you have issues with high blood pressure that is not controlled, or if you have had or currently have pure red cell aplasia (PRCA), as this can affect your treatment.

Taking this medication carries specific risks if certain factors are not taken into considerations. Illnesses that can result from this can include stroke, heart attack or increased risk of blood clots.

Should you experience any of the following effects during the time you are prescribed Epoetin beta-methoxy polyethylene glycol, speak to your doctor or request emergency medical support immediately:

  •  Sweating
  •  Sudden numbness/weakness
  •  Problems with speech or balance
  •  Nausea
  •  Confusion
  •  Cold or pale arm/leg
  •  Chest pain

In addition to the above risks associated with Epoetin beta-methoxy polyethylene glycol, this medication may also shorten remission or survival times in patients with certain types of cancer; it's important to discuss these risks with a doctor prior to starting this treatment.

It is unknown whether this drug will directly cause harm to an unborn baby. You should inform your doctor as soon as possible if you are pregnant or you are planning to become pregnant. It is also unknown if this medication can be passed through breast milk.

This medication is usually injected under the skin or can be administered into a vein through an IV. Depending on suitability, some patients are prescribed this medication to administer themselves at home. It's crucial that you are entirely aware of how to use this medicine before you administer it to yourself.

When you are prescribed this medication, you will be shown the best places to inject this medication, and how to do so. Never inject Epoetin beta-methoxy polyethylene glycol into the same area twice, always inject into a different location or alternate.

Epoetin beta-methoxy polyethylene glycol for home administration is supplied in prefilled syringes. Do not shake the syringe, or the medicine may be ruined. Only prepare your dose when you are preparing to inject your medication, and never use medicine that has changed color or that has visible particles. Each pre-filled syringe is for a single use, never reuse syringes.

Should you experience signs that your anemia is not improving when you are taking this medication, such as feeling tired, lacking energy or having pale skin, contact your doctor as soon as possible to discuss how to move forward with your treatment plan.

Epoetin beta-methoxy polyethylene glycol will come with a complete Medication Guide on prescription. It is essential that you read and follow the instructions provided carefully. Speak with your doctor should you have any further questions.

If you are taking Epoetin beta-methoxy polyethylene glycol at home, follow the below instructions for use:

  •  Always use an unopened syringe and new needle for each injection
  •  Never use more medication than prescribed by your doctor
  •  Inject into the areas discussed with your medical team, and never inject the same place twice in a row
  •  Check the solution in the syringe to ensure the medicine has not changed color or contains particles
  •  Any leftover solution within an open syringe should not be saved, use a syringe only once before you dispose of it.
  •  Dispose of used needles in an appropriate container, away from pets and children at all times
  • For many patients with kidney-related illness, a special diet will also be required to maintain the best level of health possible. This may include medication or diet to keep their blood pressure at the right level. Following taking Epoetin beta-methoxy polyethylene glycol, the correction of anemia in the body may increase appetite or feeling, but it's important to follow all medication and diet requirements even if you feel better.

In addition to Epoetin beta-methoxy polyethylene glycol, your doctor may suggest that you take iron or vitamin supplements to improve the iron in the blood. Your doctor will advise you on additional supplements to take if required.

When you are taking Epoetin beta-methoxy polyethylene glycol, your blood will need to be tested regularly. It is likely that blood pressure will also need to be often checked to ensure your treatment is working as it should. If you are unable to make an appointment for blood testing, your prescription may be postponed until this has happened.

If you have ever had any unusual or allergic reaction to Epoetin beta-methoxy polyethylene glycol or to any other drugs, inform your doctor before taking this medication. It's also important to tell your doctor if you have had any other types of allergies, such as to dyes, foods, animals, or preservatives.

Storage

This medication should always be kept out of the reach of pets and children.It is important not to keep any outdated medicine or drugs that you no longer need. If you have medication that you do not require or that is not fit to be used, a doctor or pharmacist will be able to advise you on the correct way to dispose of this medication.

Store this medicine in the refrigerator. Never freeze it. If you are prescribed this medication to store at home, ensure that you keep Epoetin beta-methoxy polyethylene glycol in its original provided packaging. Keep this medication away from direct light. You can store the syringes for this medication at room temperature for us to thirty days.

Summary

Methoxy polyethylene glycol-epoetin beta is an injectable medication that is used to treat anemia for patients who have chronic kidney disease (CKD).

Methoxy polyethylene glycol-epoetin beta is a man-made form of protein created to replicate actions in the body that are not working properly as a result of illness. The protein this drug replaces is normally created by the kidneys and helps the body in producing red blood cells. In patients suffering from chronic kidney disease, this production does not work correctly, resulting in a reduction of red blood cells. This condition is called anemia.

The injected medication stimulates the bone marrow to produce red blood cells, increasing the amount of the blood. This reduces the chance of the patients suffering from severe anemia, which can occur commonly in patients with chronic kidney failure. Methoxy polyethylene glycol-epoetin beta injection is solely a prescribed medication.

It's important when taking this medication to have a complete understanding of how to correctly administer this drug. If you are unsure of the correct process for this medicine, speak with a medical professional or doctor for further advice and support.