Methyldopa and Hydrochlorothiazide (Oral)

Methyldopa and Hydrochlorothiazide work in combination to relax the blood vessels in the body to allow easier flow and to reduce blood pressure.


Methyldopa and Hydrochlorothiazide are used in combination for the treatment of high blood pressure, which is also known as hypertension.

High blood pressure can often have no noticeable symptoms but can be very dangerous when it lasts for a long time. High blood pressure increases the load that is placed on both the heart and the arteries and if it continues for a long time then they may cease to function properly. The heart, brain and kidneys may all be affected by this health problem and the result, if left untreated, will be a stroke, heart attack or kidney failure. The chance of these serious complications occurring is dramatically reduced if the patient is treated to lower the blood pressure.

Methyldopa works by controlling impulses along nerve pathways and in doing so relaxes the blood vessels to reduce the blood pressure. Hydrochlorothiazide is a diuretic that increases the flow of urine and in doing so reduces the amount of water in the body. This also helps to relieve the blood pressure and the strain placed on the heart and arteries. In combination, the use of Methyldopa and Hydrochlorothiazide can help to control the blood pressure of the patient.

Methyldopa and Hydrochlorothiazide do not, however, offer a cure for hypertension. The medications offer only a temporary solution in helping to control the blood pressure. Patients should always seek to lower their blood pressure naturally or they will have to use treatment for the rest of their lives and the side effects may increase in severity over time. To aid with this, the doctor will always also provide instruction on diet control and exercise with this medication to enable the patient to lower their blood pressure. It is vital that you follow this advice closely as well as taking the medication properly.

Methyldopa and Hydrochlorothiazide are available only with a prescription from a doctor. The medication is taken orally as an Aldoril tablet.

Condition treated

  • Hypertension

Type Of Medicine

  • Methyldopa - Inhibitor
  • Hydrochlorothiazide' Diuretic (water pill)

Side Effects

In addition to the required effects of taking Methyldopa and Hydrochlorothiazide, certain other unwanted side effects can also occur from use. While not all side effects may occur, in some cases the patient may be required to seek urgent medical attention. In other cases, the side effects may be milder and may abate over time.

If you experience the following side effects from the use of Methyldopa and Hydrochlorothiazide then you should contact your doctor immediately:

Occurring only rarely:

  • Unexplained fever shortly after starting to take this medicine

Signs and symptoms of too much potassium loss:

  • Weak pulse
  • Unusual tiredness or weakness
  • Nausea or vomiting
  • Muscle cramps or pain
  • Irregular heartbeats
  • Increased thirst
  • Dry mouth

Occurring less commonly:

  • Unusually vivid dreams
  • Nightmares
  • Mental depression
  • Anxiety

Occurring only rarely:

  • Yellow eyes or skin
  • Tiredness or weakness after having taken this medicine for several weeks (continuing)
  • Stomach pain (severe) with nausea and vomiting
  • Skin rash, hives, or itching
  • Pale stools
  • Painful or difficult urination
  • Lower back or side pain
  • Joint pain
  • General feeling of discomfort or illness or weakness
  • Fever, chills, troubled breathing, and fast heartbeat
  • Diarrhea or stomach cramps (severe or continuing)
  • Dark or amber urine
  • Cough or hoarseness

The following side effects will not normally necessitate that you seek attention from a doctor. These side effects are usually mild, abate over time and do not normally indicate any wider medical conditions occurring as a result of the medication. If these side effects do become bothersome or are ongoing, however, then you can consult your doctor for advice on how to alleviate them:

Occurring more commonly:

  • Headache
  • Dryness of mouth
  • Drowsiness
  • Dizziness or light-headedness when rising from sitting or lying down

Occurring less commonly:

  • Swelling of breasts or unusual milk production
  • Stuffy nose
  • Slow heartbeat
  • Numbness, tingling, pain, or weakness in hands or feet
  • Loss of appetite
  • Increase in the sensitivity of skin to sunlight and UV light. This may result in the folioing: rash, itchiness, redness, discoloration of the skin or severe sunburn
  • Diarrhea
  • Decreased sexual ability or interest in sex

Other side effects that have not been listed could also occur from the use of this medication. If you experience any other side effects then you should consult your doctor for advice on how best to react. If you believe that your health is in immediate danger, however, then you should always seek emergency attention.


This medication will always be prescribed along with orders for dietary changes, exercise and healthier living. It is essential that you follow this instruction in order so you may be able to lower your blood pressure naturally. Failure to do so will mean that you have to keep using this medication for the rest of your life and the side effects may become more severe over time. You will need to control the foods that you eat, take this medication regularly and exercise regularly to lower your blood pressure and be able to stop using this treatment.

You may not notice any symptoms of a high blood pressure and you will likely feel healthy when taking the medication. You should not, however, stop taking this treatment because doing so will cause your blood pressure to increase rapidly. You must take the medication as directed until your doctor says otherwise. Stopping use suddenly can be very risky. This medication will not cure your high blood pressure, it will only help you to control it. Stopping use can expose you to risk of heart attack, stroke and kidney disease very quickly.

You may become more tired with the use of this medication and your frequency of urination will increase. These side effects should reduce over time but you can lessen the impact of them by doing the following:

  • Take your dose earlier in the day where possible. If you are taking a single dose then take it after breakfast in the morning.
  • If you are taking more than one dose a day then take your final dose before 6pm unless your doctor orders you to do otherwise.
  • Plan your dosing schedule so that it will have the least impact on your personal life and sleep.

You must form a habit and take this medication at the same time each day so that you do not forget to take it.

The dose of this medication that you are prescribed with will differ for each patient depending on personal conditions. You should not change the dose you have been prescribed and should always follow your doctor's orders. The following information is a guideline only and should not be used to adjust dosing:

  • Adults should take 2-4 tablets each day in either 1-2 doses.
  • Use of this medication in children should be determined individually in each case by the doctor.

If you miss a dose of this medication then you should take it as soon as possible. You should not, however, take the dose if you are then close to your next dose being due. Do not ever take a double dose of Methyldopa and Hydrochlorothiazide.


Certain medications should never be used together because they can cause severe medical problems to occur. In the most serious cases, these interactions can be life-threatening. In other cases, medications may counteract each other or may increase the incidence of side effects. To avoid drug interactions it is important to inform your doctor of all medications that you are taking before you begin use of this treatment. This is particularly important in the following cases:

The use of Methyldopa and Hydrochlorothiazide with the following medications is not recommended and your doctor may decide not to proceed with this treatment or may cease your use of the other treatments:

  • Tranylcypromine
  • Toloxatone
  • Selegiline
  • Rasagiline
  • Procarbazine
  • Phenelzine
  • Pargyline
  • Nialamide
  • Moclobemide
  • Linezolid
  • Lazabemide
  • Isocarboxazid
  • Iproniazid
  • Furazolidone
  • Dofetilide
  • Clorgyline
  • Brofaromine

Use of Methyldopa and Hydrochlorothiazide with the following medications is not normally recommended. You may be prescribed both in some cases, however, with dosing changes or changes in the frequency of use:

  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sotalol
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Pseudoephedrine
  • Proscillaridin
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Ouabain
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Metildigoxin
  • Methotrexate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lithium
  • Levomethadyl
  • Ketorolac
  • Ketoprofen
  • Ketanserin
  • Indomethacin
  • Ibuprofen
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Flecainide
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Entacapone
  • Droxicam
  • Droperidol
  • Dipyrone
  • Digoxin
  • Digitoxin
  • Digitalis
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Deslanoside
  • Cyclophosphamide
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Bufexamac
  • Bromfenac
  • Aspirin
  • Arsenic Trioxide
  • Amtolmetin Guacil
  • Amphetamine
  • Acetyldigoxin
  • Acemetacin
  • Aceclofenac

Use of the following treatments in conjunction with Methyldopa and Hydrochlorothiazide can lead to an increased incidence of side effects. For this reason, the use of these together is not normally recommended. In some cases, you may be treated with both but adjustments may be made to reduce this risk:

  • Topiramate
  • Timolol
  • Sotalol
  • Phenylpropanolamine
  • Licorice
  • Iron
  • Haloperidol
  • Gossypol
  • Ginkgo
  • Ferric Ammonium Citrate
  • Cholestyramine
  • Carbamazepine
  • Bisoprolol
  • Bepridil
  • Alprenolol

Methyldopa and Hydrochlorothiazide may also interact with other medications that have not been listed herein. These medications have been selected only for severity of interaction and the list is not all-inclusive. Patients must inform their doctor of all treatments they are taking in order so they may be able to avoid any interactions occurring. This includes any prescribed medications, over-the-counter treatments, herbal remedies and any other substances you are taking.

Certain foods and drinks and tobacco can also affect the use of this medication. Tobacco increases the blood pressure and must not be used with this treatment as it will counteract the effects. As this medication is used to control blood pressure it needs to be used on a regular schedule with a regular diet as a basis for treatment too. Significant changes in diet, excessive consumption of alcohol and reductions in exercise can all make the medication ineffective and can put you at risk. You should discuss all of this with your doctor and follow the advice they give.

Other medical problems can also have an impact on the use of Methyldopa and Hydrochlorothiazide. This is because some medications may make other conditions worse or may be made ineffective by certain conditions. You must inform your doctor of all conditions from which you suffer before use. This is especially important in the following cases

Other medical conditions not listed herein may also impact the use of Methyldopa and Hydrochlorothiazide. Ensure that you tell your doctor about your full medical history before use.


Before you begin taking Methyldopa and Hydrochlorothiazide it is important that you understand the risks in relation to the benefits. It is also important that you understand that this is not a cure for high blood pressure. You should make the decision to take this medication with your doctor having ensured that all of the following factors have been considered:

Allergies ' You must inform your doctor of all allergies from which you suffer. Allergies to medications may affect the use of Methyldopa and Hydrochlorothiazide. Any other allergies to foods, dyes, preservatives and other substances should also be shared as these may also impact on use.

Pediatric ' This medication is not expected to work differently in children. The use of this medication in children should be determined in each case by the doctor and should discuss all risks of use with the parents bc ' Elderly patients can be treated with this medication but they are more likely to become drowsy or suffer effects from the loss of too much potassium. Care should be used in treatment.

efore use.


Pregnancy' There is a minimal risk to the use of Methyldopa and Hydrochlorothiazide when pregnant. You should inform your doctor before use if you may be pregnant and should inform your doctor straight away if you become pregnant during use of this medication.

Breastfeeding' There is only a minimal risk to the use of Methyldopa and Hydrochlorothiazide when breastfeeding. You should inform your doctor before use if you are breastfeeding and should discuss the risks in relation to the benefits of continuing.

Your doctor will need to monitor your progress regularly when you are taking this medication to check that your blood pressure is being controlled, adjust dosage and check for unwanted side effects.

You should not take any other medications with this medication unless they have been approved by the doctor. This especially prohibits over-the-counter treatments for appetite control, colds, coughs, hay fever, asthma and some other conditions. These medications will increase your blood pressure and make the treatment ineffectual.

This medication can reduce the amount of potassium in the body so you will need to eat particular potassium-rich foods, take potassium supplements and/or take another medication.

You should not ever make changes to your diet without first discussing them with your doctor. If you become sick or are vomiting or have diarrhea then you will need to consult your doctor. These conditions may cause you to lose too much water and you may be placed at risk from continued use.

You must inform all health professionals that you are taking this medication before you undergo any other treatment or receive any other kind of medication. You may need to stop use before certain procedures and tests are carried out.

If you are suffering from an unexplained fever in the first few weeks of use then you should consult your doctor. This may be a sign that you are reacting badly to the medication.

This medication can cause you to be less alert and sleepy. You should not do anything that could put you or others at risk while you are experiencing these side effects. This includes driving and operating machinery. Remember that you have a legal responsibility to protect yourself and others from injury during such operation.

If you are dizzy or lightheaded after use then you should try to relieve this by rising slowly. Rising suddenly may cause you to become faint when you get up. These side effects will also be more likely to occur if you drink alcohol or if you do increased amounts of exercise in hot weather without drinking enough liquids. You should always ensure that you are remaining hydrated properly when you are taking this medication.

This medication can cause a feeling of dryness in the mouth. Chewing sugar-free gum and melting ice chips in the mouth can help to lessen this effect. If this side effect continues for longer than the first few weeks of treatment then you should consult your doctor or dentist. Prolonged dryness can cause dental or gum diseases to occur and infections may also result.

This medication can make you more sensitive to light, making it easier for you to get burned. You should avoid exposure to direct sunlight where possible and should cover up when you are outside. Any exposed skin should be covered in suncream and you should take the following precautions:

  • Stay out of direct light during the hottest parts of the day (10am-3pm).
  • Wear protective clothing to prevent exposure to the sun.
  • Wear a hat and sunglasses.
  • Apply a minimum of SPF30 when you are outside. Increase this SPF if you have fair skin and are naturally likely to burn.
  • Apply sunblocking lipstick to protect the lips from burning.
  • Do not ever use sunbeds or sunlamps.
  • Contact your doctor if you do become sunburned as it may not heal as effectively and normal.

Do not take any other medications with Methyldopa and Hydrochlorothiazide unless directed to by a doctor. You should always inform any medical professional that you are taking Methyldopa and Hydrochlorothiazide before tests or treatment.


This medication must always be stored out of the reach of children. Methyldopa and Hydrochlorothiazide can be stored at room temperature as long as it is kept out of direct light and away from both heat and moisture.

Dispose of any unwanted medication promptly as directed by your doctor. Do not keep medication for longer than needed.


Methyldopa and Hydrochlorothiazide is used in the treatment of hypertension, which is also known as high blood pressure. Hypertension is a very serious medical condition that puts increased strain on the heart and arteries. If left untreated this conditions can result in a stroke, heart attack or kidney failure.

Methyldopa and Hydrochlorothiazide is not a cure for hypertension, rather it helps the patient to control their blood pressure. This medication will need to be taken indefinitely to control the blood pressure unless the patient is able to lower their blood pressure naturally.

To help with this the doctor will always provide dietary advice and an exercise regime for the patient to follow when prescribing this medication. These are to aid the patient in controlling their blood pressure and also in losing weight where necessary. It is very important that this advice is followed in order that the patient is able to reduce their blood pressure naturally and improve their health. Only by doing so will the patient be able to cease use of Methyldopa and Hydrochlorothiazide.

Once a patient has started using Methyldopa and Hydrochlorothiazide they will need to take it indefinitely and should not cease use unless directed to by the doctor. It is common for people taking this medication to feel fit and healthy because their blood pressure is controlled, but stopping use will immediately put a strain on the blood vessels once again and make the heart beat harder to get oxygen around the body. This will rapidly expose the patient to a risk of heart attack, stroke and kidney failure once again.

This medication should not ever be used in conjunction with any other treatment that has not been approved by the doctor. Using this medication with over the counter treatments that may increase the blood pressure can be very dangerous and must be avoided.