Methylprednisolone (Injection)

Methylprednisolone is a corticosteroid used to treat many different conditions that require relief from inflammation in the body.


Methylprednisolone acetate injectable suspension (pronounced METH il pred NIS oh lone) is a medication that provides relief for the areas of the body that may become inflamed. A wide range of serious medical conditions are treated with this medication and is known to be highly effective. Methylprednisolone is a corticosteroid (a medicine or steroid that is cortisone-like) that is administered by injection. This medication acts upon the immune system to relieve symptoms of itching, redness of the skin, swelling, or allergic reactions.

This medication is administered by injection by trained medical personnel, and side effects may occur that may need medical treatment. Severe interactions with certain medications may occur, your physician should be made aware of all medications taken by the patient. This medication should not be discontinued unless ordered by a physician. This medication can only be prescribed by a physician, and should only be used under the direct supervision of a physician or medical personnel.

Conditions Treated

Type Of Medicine

  • Corticosteroid

Side Effects

When your physician has prescribed this medication, it has been determined that the risk of potential side effects is less important than the perceived benefits you may receive. When taking this medication, your physician must be aware of your medical condition and you and your families medical history. Your physician must be made aware of any side effects that are encountered immediately. Do not delay informing physician or medical personnel of the experiencing of any of these side effects and do not leave untreated or unreported.

The following is a list of side effects that can occur in many patients. Some are not generally known to occur, some are relatively common, and some are rare. Check with your physician and let them inform you of all the side effects or potential side effects and how to handle them before you begin taking this medication.

Some side effects sometimes occur that are undocumented, if one suspects side effects that are unknown these effects should be reported immediately to a physician or other medical personnel.
These side effects are quite common and may require medical treatment and should be reported to your physician at once if experienced:

  • Gaining weight
  • Changes in mood
  • Depressed thinking
  • Dizziness or lightheadedness
  • Blurriness of vision
  • Rattling, noisy breathing
  • Pounding in the ears
  • Troubled breathing when body at rest
  • Swelling of the hands, fingers, feet, or lower legs
  • Headaches
  • Agitation
  • Aggression
  • Decrease in urine amounts
  • Tingling or numbness in the legs or arms
  • Pounding, slow, fast, or irregular pulse or heartbeat
  • Difficulty speaking, thinking, or walking

The rate of incidence is unknown in these side effects, but they have either been known to occur some of the time or suspected of occurring an unknown amount of the time. Inform your physician if you suspect any of these side effects may be a result of your use of this medication.

  • Acne
  • Redness of the face
  • Purplish, reddish lines appearing on the face, legs, arms, trunk of body, or genital areas
  • Dryness of the scalp
  • Swelling in the area of the stomach
  • Thinning of the hair on scalp
  • Abnormal deposits of fat on the trunk, neck, or face
  • Lightening of your normal color of your skin
  • Redness, pain, or hardness at the site of injection
  • Depression of skin or pitting at the site of injection

The following side effects are experienced rarely but may cause discomfort and may require medical treatment. In the case of medical emergency, contact a 911 center immediately and inform emergency personnel of the use of this medication promptly.

  • Difficulty breathing
  • Tightness in the chest area
  • Decrease in vision
  • Decrease in body height
  • Decrease or loss of appetite
  • Irregularities in menstruation
  • Difficulty in sleeping
  • Unexplainable loss of weight
  • Lack of sexual desire or inability to perform sexually
  • Increase in hunger
  • Increase in thirst
  • Fruit-like odor in breath
  • Dryness or flushing of the skin
  • Growth of facial hair in females
  • Backaches
  • Fractures
  • Roundness or fullness of the face, trunk, or neck
  • Wasting or weakness of the muscles
  • Tenderness or pain of the muscles
  • Difficulty in sleeping
  • Difficulty in healing
  • Soreness in the throat
  • Unusual weakness or tiredness of the body
  • Difficulty or painful urination
  • Light-colored, tarry, bloody, or black stools
  • Severe and continuous heartburn or indigestion
  • Fainting
  • Chills or fevers
  • Hoarseness
  • General feeling of illness in the body
  • Diarrhea
  • Eye pain
  • Tearing of the eyes
  • Stomach or abdominal pain
  • Sweating
  • Changes in vision
  • Vomiting or nausea
  • Vomiting of material with appearance of coffee grounds
  • Abdominal or stomach pain on the upper right side
  • Yellowing of the skin or eyes
  • Pain in the back, ribs, legs, or arms
  • Darkening of skin color
  • Darkness of urine
  • Increase in urination
  • Loss of appetite
  • Side or lower back pain

Potential side effects of this medication are extensive, understanding each of them by consulting with your physician or medical personnel is recommended before using. If you have any questions about side effects, ask your physician or medical personnel for information either before you use this medication or when experiencing side effects. Make your physician or medical personnel aware of any side effects that have been discussed as they occur.

Remember to report any side effects to your physician or health care professionals immediately. Consult with your physician and find out how to reduce or prevent side effects prior to beginning using this medication. In the event you do find yourself experiencing side effects, whether mild or severe, you may report the side effects to the FDA at 1-800-FDA-1088 or at their website at


This medication and its dosage must be administered by a physician or medical personnel. The physician prescribes the correct dose and dosing schedule and will adjust any dosing or schedule changes. The following information relates to the average dosing amounts and scheduling and is not intended to be a substitute for a physician's care.

When therapy requiring high dosing is desirable, the recommended dose of this medication in a solution, prepared from powder form, is 30 milligrams/kg administered by intravenous injection for a period of 30 minutes in duration. This dose may be repeated at intervals of 4 to 6 hours apart.

High doses of corticosteroid should only be administered for brief periods of time, usually from about 48 to 72 hours. Adverse reactions to short-term corticosteroid therapy are not considered common. Occasionally, peptic ulceration may develop which will require prophylactic antacid therapy until this condition becomes stabilized.

Other indications will call for an initial dosage of 10 to 40 milligrams/kg which will depend on the medical condition that is under treatment. Acute, severe conditions may require short-term management with the use of higher dosing. Initial doses should be administered by intravenous route for short periods of time. All subsequent doses can be administered intravenously or intramuscularly in timeframes relating to the condition and response to this medication.

Corticoid therapy is not a replacement for conventional therapy and only plays an adjunct role. Dosage for children and infants should be made relative to the nature and severity of the condition as well as patient response rather than patient size or age. Doses should not be smaller than 0.5 milligrams/kg in any 24 hours period.

Dosing must be reduced or discontinued gradually when administered over a period exceeding several days. In chronic conditions, if spontaneous remission occurs in the patient, then this medication must be discontinued at once.


When using this medication, in certain cases you should not use certain other medicines whatsoever. In other instances, you can use other certain medicines, but only under the supervision of a physician. The physician may decide upon adjusting the use and dosage of this medication and/or other medications to an optimum level and frequency to avoid complications from interactions. Your physician may also want to take additional precautions.

You should always follow your physician's instructions and if you have been advised to discontinue or avoid using certain medications, you must follow your physician's advice or dire consequences, some life-threatening can result. Always make your physician aware of any medications you take while using this medication. Never take more of this medication than has been prescribed or use with other medicines without the approval of your physician.

The following medications can be used with this medication, but only under the supervision of a doctor so that steps can be taken for the prevention of interactions. Do not take these medications without your physician's approval and oversight.

  • Aceclofenac
  • Nepafenac
  • Sulindac
  • Aldesleukin
  • Oxyphenbutazone
  • Feprazone
  • Tolmetin
  • Floctafenine
  • Tiaprofenic Acid
  • Flufenamic Acid
  • Flurbiprofen
  • Amtolmetin Guacil
  • Bemiparin
  • Bromfenac
  • Acemetacin
  • Bufexamac
  • Bupropion
  • Celecoxib
  • Etoricoxib
  • Felbinac
  • Choline Salicylate
  • Clonixin
  • Dexibuprofen
  • Dipyrone
  • Droxicam
  • Fepradinol
  • Feprazone
  • Flufenamic Acid
  • Flurbiprofen
  • Etodolac
  • Etofenamate
  • Floctafenine
  • Fenoprofen
  • Morniflumate
  • Ibuprofen
  • Indomethacin
  • Mefenamic Acid
  • Meloxicam
  • Ketoprofen
  • Ketorolac
  • Proquazone
  • Nimesulide
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Piroxicam
  • Oxyphenbutazone
  • Pixantrone
  • Beta Cyclodextrin
  • Valdecoxib
  • Salicylic Acid
  • Nabumetone
  • Niflumic Acid
  • Phenylbutazone
  • Oxaprozin
  • Tolfenamic Acid
  • Nadroparin
  • Lornoxicam
  • Pranoprofen
  • Tenoxicam
  • Salsalate
  • Loxoprofen
  • Telaprevir
  • Lumiracoxib
  • Parecoxib
  • Meclofenamate
  • Naproxen
  • Rofecoxib
  • Proglumetacin
  • Parecoxib
  • Propyphenazone
  • Proquazone

The following list of medications have a high risk of potential side effects while using this medication. Consult a physician to adjust dosing to prevent or manage the occurrence of any potential side effects. Never use these medications while using this medication without the knowledge and supervision of your physician.

  • Acenocoumarol
  • Besifloxacin
  • Alcuronium
  • Carbamazepine
  • Aprepitant
  • Ciprofloxacin
  • Aspirin
  • Clarithromycin
  • Atracurium
  • Cyclosporine
  • Balofloxacin
  • Dalfopristin
  • Flumequine
  • Diltiazem
  • Gallamine
  • Enoxacin
  • Gatifloxacin
  • Erythromycin
  • Gemifloxacin
  • Fleroxacin
  • Hexafluorenium
  • Fluindione
  • Ketoconazole
  • Levofloxacin
  • Nadifloxacin
  • Licorice
  • Nefazodone
  • Lomefloxacin
  • Norfloxacin
  • Metocurine
  • Ofloxacin
  • Mibefradil
  • Pazufloxacin
  • Moxifloxacin
  • Pefloxacin
  • Warfarin
  • Phenobarbital
  • Saiboku-To
  • Primidone
  • Sparfloxacin
  • Prulifloxacin
  • Tosufloxacin
  • Quinupristin
  • Rifampin
  • Troleandomycin
  • Rufloxacin

In some cases, this medication should be avoided for patients who have certain medical problems. The following is a partial list of these conditions, but some unknown conditions may also not be appropriate for concurrent use this medication.


The epidermal injection of this medication has been known to produce and cause serious neurologic events, with some reported fatalities. Some of these events include stroke, corticol blindness, paraplegia, quadriplegia, and spinal cord infarction, but this is not a complete list. Serious neurological events such as these have been reported with and without the performance of a fluoroscopy. The effectiveness and safety of corticosteroids administered by epidural means have not been established. Corticosteroids are not approved for epidermal use.

Corticosteroids contain benzyl alcohol, and when administered locally to neural tissue, is potentially toxic. High amounts of benzyl alcohol have been found to display toxicity (hypotension and/or metabolic acidosis) particularly in neonates and a condition known as kernicterus forms in small preterm infants.
Rare deaths have occurred in preterm infants who have been exposed to high amounts of benzyl alcohol. The amount of benzyl alcohol found in this medication is considered negligible, but physicians need to be aware of level of exposure to benzyl alcohol in infants.

Multi-dose use of this medication in acetate injectable suspension form dispensed from single vials will require special handling to prevent contamination from occurring. Strict aseptic techniques must be used, even though initially the single vial will be completely sterile. The use of disposable sterile syringes and needles are vital to prevent contamination.

Dermal or subdermal changes may result from the injection of this medication, which may result in the visible appearance of depressions of the skin at the site of injection. Extreme care must be made to avoid excessive dosing of injections to contain the incidence of dermal and subdermal atrophy.

Whenever possible, multiple small injections should be administered to the area of the lesion. When performing intramuscular or intraarticular injections, techniques should include precautions of leakage into the dermis. A high incidence of subcutaneous atrophy requires avoiding injection of this medication into the deltoid muscle.

During injection of this medication, it is critical that techniques be used to assure proper placement of this medication. In certain rare cases, anaphylactoid reactions have occurred in a small number of patients receiving corticosteroid therapy. In patients subjected to unusual stress before, during, or after an emergency situation, an increased dosage of this medication is indicated. High doses of this medication should not be used for the treatment of traumatic brain injury.


Protect from direct light at controlled room temperature. For unreconstituted product keep stored at 68 to 77 (F) degrees or 20 to 25 (C) degrees. For a solution, keep stored at 68 to 77 (F) degrees or 20 to 25 (C) degrees. If solution is mixed, use within 48 hours of time of mixing.


Methylprednisolone acetate injectable suspension is a corticosteroid medication that is meant to reduce the inflammation in the body due to a wide variety of serious medical conditions. This is a medication that works with the immune system with a patient to reduce symptoms including allergic reactions, itching, swelling, or the redness of the skin.

Many different serious medical conditions are treated with this medication, and it is deemed to have a relatively low risk. This is a highly effective medication that is given in high or low doses over usually short periods of time. This medication is administered by injection by physician or medical personnel only. This medication is only available with a physician's prescription.

Serious side effects have been known to occur in many patients, either commonly, rarely, or unknown but suspected. It is critical for patients to consult with their physician before using this medication and informing them of all medical conditions and medications they currently take. Interactions with other medications can be quite severe, and the physician can adjust the medications to proper levels to compensate for different contraindications if needed.

Corticosteroid therapy is not a replacement or substitute for conventional therapy and serves only an adjunct therapeutic role. High doses of this medication are not appropriate for patients with severe traumatic brain injuries or for a small preterm infant. Epidermal use of this medication has been linked to serious neurological events, including death.

The role of benzyl alcohol is deemed to be negligible, but this product contains benzyl alcohol and precautions for its use must be taken. In some cases, rare deaths have been associated with exposure to benzyl alcohol in preterm infants, so additional steps may be needed to ensure the safety of these patients.

When injecting this medication, use of the proper techniques for the proper placement of the medication is necessary. In certain rare cases, anaphylactoid reactions have been reported when using this medication. Using disposable syringes and needles are vital in preserving the sterility of this medication and preventing contamination.

When storing this medication, the solution must be kept out of direct sunlight in a controlled room temperature of 68 to 77 (F) degrees or 20 to 25 (C) degrees. If the medication solution is already mixed, it must be used within 48 hours of the time of mixing.