Metoprolol (Intravenous)

Metoprolol is beta blocker which decreases the heart’s workload, helping it beat more normally.


Metoprolol injection helps to decrease the chances of death due to a serious heart attack. It's administered to people who've already suffered a heart attack.

This medication is a beta blocker, which works by altering the response of the nerves to impulses in certain areas of the body, including the heart. Therefore, the heart beat is slowed down and blood pressure is decreased. When blood pressure is decreased, the amount of oxygen and blood to the heart is increased.

This medication is only available with your physician's prescription.

Metoprolol injection comes in the form of a solution and is marketed under the brand name Lopressor.

Metoprolol injection may be taken for other reasons; be sure to ask your pharmacist or healthcare professional if you've got any questions.

Conditions Treated

Type Of Medicine

  • Beta blocker

Side Effects

Apart from its helpful effects, Metoprolol injection may cause some negative effects. While not all of the side effects below will occur, if they do they may require medical care.

Check with your nurse or doctor promptly if you develop any of these effects:

More common:

  • Confusion
  • Chest discomfort or pain
  • Blurred vision
  • Shortness of breath
  • Lightheadedness, dizziness, or faintness when suddenly standing from a sitting/lying position
  • Unusual tiredness/weakness
  • Sweating
  • Irregular or slow heartbeat

Less common:

  • Cough
  • Dilated neck veins
  • Labored or difficult breathing
  • Bloating/swelling of the feet, lower legs, hands, arms, or face
  • Loss of vision
  • Irregular breathing
  • Halos around lights
  • Extreme fatigue
  • Double vision
  • Disturbed color perception
  • Racing, fast, or pounding pulse or heartbeat
  • Noisy breathing
  • Mental confusion
  • Extremely bright look of lights
  • Cold feeling or paleness in the toes and fingertips
  • Tension, weakness, and pain on walking that eases during rest periods
  • Tunnel vision
  • Troubled breathing
  • Rapid weight gain
  • Short-term memory loss
  • Feeling, hearing, or seeing things that aren't there
  • Swelling of the feet, lower legs, fingers, or face
  • Tingling of the feet or hands
  • Tightness in chest
  • Pain or tingling in the toes or fingers upon exposure to cold
  • Unusual weight loss or gain


  • Difficulty with moving
  • Dark urine
  • Persistent or severe stomach/abdominal pain
  • Persistent or severe vomiting and nausea
  • Persistent loss of appetite
  • Chills
  • Clay-colored stools
  • Bluish color of skin on the toes or fingers
  • General weakness or tiredness
  • Hoarseness
  • Itching skin
  • Increased urge to urinate
  • Rash
  • Difficult or painful urination
  • Redness, pain, or swelling in the joints
  • Light-colored stools
  • Muscle stiffness or pain
  • Numbness of the toes or fingers
  • Unpleasant breath odor
  • White spots, ulcers, or sores in the mouth or on the lips
  • Unusual bruising or bleeding
  • Vomiting of blood
  • Stomach or upper right abdominal pain
  • Weakness
  • Yellow skin and eyes

Seek emergency assistance if any of these overdose symptoms occur after taking a Metoprolol injection:

Overdose symptoms:

  • Severe drowsiness or sleepiness
  • Unconsciousness
  • Stopping of heart
  • No pulse or blood pressure
  • Loss of consciousness
  • Change in consciousness
  • Bluish color of nail beds, palms, skin, lips, or fingernails

Some Metoprolol injection side effects that normally don't require medical attention may occur. These effects may clear during treatment as you get used to the drug. In addition, your healthcare provider may recommend ways to relieve or prevent some of the effects below. Please see your healthcare provider if you have any queries about any of the effects below, if any of them persist, or if any of them bother you.

Less common:

  • Bloating
  • Belching
  • Decreased desire for sexual intercourse
  • Dry mouth
  • Discouragement
  • Difficulty with passing stools (having bowel movements)
  • Irritability
  • Inability to keep or have an erection
  • Full feeling
  • Feeling of sadness or emptiness
  • Excess gas or air in the intestines or stomach
  • Feeling of endless movement of surroundings or self
  • Loss of desire, drive, performance, or ability to have sex
  • Loss of pleasure or interest
  • Tiredness
  • Nightmares
  • Passing gas
  • Sensation of spinning
  • Redness or other skin discoloration
  • Pain in chest just below the breastbone
  • Difficulty with sleeping
  • Difficulty with concentration


  • Bone pain
  • Hearing loss
  • Continuing buzzing or ringing or other unusual noise in ears
  • Pain on the penis upon erection
  • Increased skin sensitivity to sunlight

Other Metoprolol injection side effects not mentioned above may also affect some people. If you experience any other effects, please go and see your healthcare provider immediately.

If you need medical advice about the above side effects, call up your doctor. You can let the FDA know about these side effects at 1-800-FDA-1088.


A nurse or any other qualified healthcare provider will give you Metoprolol injection. This medication is given via a needle positioned in your vein.

Your healthcare professional will give you only a few Metoprolol injection doses until your condition gets better, and then you'll be changed to an oral medication that works in the same manner. If you've got any questions or concerns about this, please consult your doctor.

If you've missed a dose of this medicine, call up your healthcare provider to know what to do.


When you take the Metoprolol injection with other medications, it may alter the way the following or other medications work. Nonprescription medications, natural remedies, vitamins, and some foods can also interact with Metoprolol. Taking any of these products together with Metoprolol injection may cause serious side effects. Be sure to tell your healthcare professional if you're using:

  • ACE inhibitors like Ramipril (Altace), Quinapril (Accupril), Lisinopril (Zestril, Prinivil), Fosinopril, Enalapril (Vasotec), Captopril, and Benazepril (Lotensin)
  • Alpha blockers like Tamsulosin (Flomax), Silodosin (Rapaflo), Doxazosin (Cardura), and Alfuzosin (Uroxatral)
  • Anesthetics like Mepivacaine, Lidocaine, and Bupivacaine
  • Angiotensin receptor 2 blockers like Valsartan (Diovan), Telmisartan (Micardis), Olmesartan (Benicar), Losartan (Cozaar), Ibesartan (Avapro), Eprosartan (Teveten), Candesartan (Atacand), and Azilsartan (Edardbi)
  • Anticancer medicines like Rituximab (Rituxan), Abiraterone (Zytiga), Nilotinib (Tasigna), and Ceritinib (Zykadia)
  • Antibiotics like Rifampin (Rifadin) and Isoniazid

Antidepressants like Trazodone (Oleptro), Sertraline (Zoloft), Paroxetine (Paxil), Nortriptyline (Pamelor), Imipramine (Tofranil), Fluvoxamine (Luvox CR), Fluoxetine (Prozac, Sarafem), Duloxetine (Cymbalta), Doxepin, Despiramine (Norpramin), Clomipramine), Bupropion (Wellbutrin, Zyban), and Amitriptyline

Antifungal medications like Terbinafine (Lamisil) and Ketoconazole

Anti-HIV medications like Tipranavir (Aptivus), Saquinavir (Invirase), Ritonavir (Norvir), Nevirapine (Viramune), Nelfinavir (Viracept), Ritonavir/Lopinavir (Kaletra), Indinavir (Crixivan), Fosamprenavir (Lexiva), Elvitegravir/Cobicistat/Emtricitabine/Tenovir (Stribild), Efavirenz (Sustiva), Delavirdine (Rescriptor), Darunavir (Prezista), and Atazanavir (Reyataz)

Breathing or asthma medicines such as Zileuton (Zyflo), Theophylline, Metaproterenol, Indaceterol (Arcapta), Formoterol (Foradil), Epinephrine (Adrenalin), Arformoterol (Brovana), and Albuterol (Ventolin, Proventil)

Antimalarial medications such as Primaquine, Chloroquine (Aralen), Lumefantrine/Artemether (Coartem), and Hydoxychloroquine (Plaquenil)

Antipsychotic medications such as Trifluoperazine, Thioridazine, Perphenazine, Prochlorperazine, Haloperidol (Haldol), Clozapine (Clozaril), and Chlorpromazine

  • Clobazam (Onfi)
  • Cinacalcet (Sensipar)
  • Cimetidine (Tagamet)
  • Dipyridamole (Persantine)
  • Epinephrine (EpiPen)
  • Barbiturates such as Phenobarbital, Pentobarbital (Nembutal), and Butabarbital (Butisol)

Cold medicines including antihistamines and decongestants like Pseudoephedrine (Sudafed), Phenylephrine (Neo-Synephrine), and Diphenhydramine (Benadryl)

  • Lorcaserin (Belviq)
  • Levothyroxine (Unithroid, Synthroid, Levoxyl)
  • Water pills or diuretics such as Torsemide (Demadex), Spironolactone, Hydrochlorothiazide, Furosemide (Lasix), Ethacrynic (Edecrin), Chlorthalidone, Bumetanide, and Amiloride
  • Mirabegron (Myrbetriq)
  • Methadone (Methadose)
  • Ergot medicines like Methylergonovine (Methergine), Ergonovine, Ergotamine (Migergot, Cafergot, Ergomar), and Dihydroergotamine (D.H.E.45)
  • MAO inhibitors like Tranylcypromine (Parnate), Selegiline (Emsam, Eldepryl), Phenelzine (Nardil), and Isocarboxazid (Marplan). Please don't take a Metoprolol injection and an MAO inhibitor within two weeks of each other.
  • Oral diabetes and insulin medicines such as Tolbutamide, Rosiglitazone (Avandia), Repaglinide (Prandin), Pioglitazone (Actos), Metformin (Glucophage), Glyburide (DiaBeta), and Glipizide (Glucotrol)

Blood pressure or heart medications such as Verapamil (Calan, Isoptin), Terazosin (Hytrin), Reserpine, Quinidine, Prazosin (Minipress), Propafenone (Rythmol), Procainamide, Nifedipine (Procardia, Adalat), Nicardipine (Cardene), Isradipine (DynaCirc), Hydralazine , Flecainide, Felodipine, Dronedarone (Multaq), Disopyramide (Norpace), Dofetilide (Tikosyn), Diltiazem (Cardizem), Digoxin (Lanoxin), Clonidine (Catapres), and Am iodarone (Cordarone)

Medications to treat ED or erectile dysfunction like Tadalafil (Cialis), Sildenafil (Viagra), Avanafil (Stendra), and Vardenafil (Staxyn, Levitra)

Natural remedies like Yohimbe, St John's Wort, Shepherd's Purse, Periwinkle, Mistletoe, Ma Huang, Licorice, Kola, Hawthorn, Goldenseal, Ginseng, Ginger, Garlic, Ephedra, Dog Quai, Coleus, Cayenne, California Poppy, Blue Cohosh, Black Cohosh, and Bayberry

NSAIDs (nonsteroidal anti-inflammatory medications) such as Sulindac (Clinoril), Piroxicam (Feldene), Oxaprozin (Daypro), Naproxen (Naprelan, Aleve, Anaprox, Naprosyn), Nabumetone (Relafen), Ketoprofen, Ketorolac, Indomethacin (Indocin), Ibuprofen (Advil, Motrin IB, Motrin), Diclofenac (Cataflam, Voltaren), and Celecoxib (Celebrex)

  • Quinine (Qualaquin)
  • Dextromethorphan/Quinidine (Nuedexta)
  • Stimulant medication such as Methamphetamine (Desoxyn), Amphetamine/Dextroamphetamine (Adderall XR, Adderall), and Dextroamphetamine (Dexedrine)

Don't take alcohol while you're taking Metoprolol injection unless your healthcare professional tells you to.

If you aren't sure if your medications can interact, consult your healthcare provider or pharmacist. Have a list of all medications you take, such as prescription medicines, over-the-counter or nonprescription medicines, natural remedies, supplements, as well as vitamins. Be sure to let all your healthcare professionals know about all the medicinal products you are using.


It is vitally important to be checked by your doctor closely to ensure that Metoprolol injection is working well and to find out any side effects.

Before you take Metoprolol injection, make sure to let your healthcare professional know if you've ever suffered:

  • An allergy to any other medication
  • Diabetes
  • Low blood pressure
  • A heart attack, heart failure, or any other conditions of the heart
  • A lung disease like COPD or asthma that causes wheezing, coughing, shortness of breath, or other breathing difficulties. Metoprolol injection may worsen these problems.
  • Thyroid problems

If you're a woman of childbearing age, please let your healthcare professional know if you plan to get pregnant or are pregnant. It's not yet known whether Metoprolol injection will harm the fetus. Don't breastfeed while using this medication without informing your healthcare professional.

Metoprolol injection may make heart failure symptoms worse in some people. Make sure to alert your doctor promptly if you're having chest discomfort or pain, extreme fatigue, dilated neck veins, an irregular heartbeat, irregular breathing, swelling of the feet, lower legs, fingers, or face, shortness of breath, wheezing, or weight gain.

Metoprolol injection may change your levels of blood sugar. In addition, this medication can cover up low blood sugar symptoms like a fast pulse rate. Consult your healthcare provider if you've got these issues or if you have a change in your urine or blood sugar tests.

Ensure any dentist or doctor that treats you knows you're taking Metoprolol injection. You may have to stop taking this medication several days before you have an operation.

Metoprolol injection may make some patients less alert or attentive than they normally are. If this effect occurs, please don't use machines, drive, or carry out any task or activity that might be hazardous if you're not attentive while taking this medicine.

Lightheadedness, dizziness, or even fainting can happen when you suddenly get up from a sitting/lying position. You can ease this problem by getting up slowly. In addition, lying down for some time may ease your lightheadedness or dizziness.

Don't take other drugs unless you have discussed them with your healthcare professional. This includes over-the-counter or nonprescription medicines, prescription medicines, as well as vitamin supplements and herbal products.


You will be given Metoprolol injection in a doctor's office or hospital. Therefore, you'll not store this medication at home.


As a beta blocker, intravenous Metoprolol (brand name Lopressor) is an injection which helps to prevent chest pain and can be used to treat hypertension (high blood pressure).

It can also be used in the prevention of suffering a follow-up heart attack after one has already occurred. It decreases the heart's workload and enables it to beat more naturally.

You should tell all your healthcare professionals that you use Metoprolol injection. This includes your doctor, nurse, dentist, and pharmacist.

Avoid driving and carrying out other activities or tasks that require you to stay alert until you know for sure how this medication affects you.

To lower your chances of passing out or feeling dizzy, rise slowly if you've been lying or sitting down. Be careful when using the stairs.

Check your heart rate and pressure as instructed by your doctor. For more information, consult your doctor.

Have your blood work examined as recommended by your doctor. Consult your doctor for more information.

This medication may alter some lab tests. Let all your healthcare professionals and lab personnel know that you use Metoprolol injection.

Speak to your healthcare professional before you take alcohol while using Metoprolol injection.

This medication may hide low blood sugar symptoms. For more information, consult your doctor.

If you suffer from diabetes (high blood sugar), you'll need to closely check your blood sugar.

If you have hypertension (high blood pressure) and are using Metoprolol injection, talk to your healthcare professional before taking over-the-counter products that may elevate blood pressure. These products include cold or cough medicines, stimulants, diet pills, ibuprofen or similar products, as well as some natural aids or products.

This medication may make it more difficult to know if you've got signs of an overactive thyroid. If you suddenly stop using Metoprolol injection and you've got an overactive thyroid, it may worsen the condition and potentially cause death. Consult your doctor about this.

Tell your healthcare provider if you're pregnant or nursing a baby. You'll need to discuss the risks of this medicine to your baby.

If you've had a very serious allergy, consult your physician. You may suffer an even worse allergy if you use what caused your allergic reaction. If you take Epinephrine to treat extremely serious allergic reactions, speak to your doctor. While you're using Metoprolol injection, Epinephrine may be less effective.