Miconazole (Buccal mucosa)

Miconazole tablets are prescribed for the treatment of infections to the throat and mouth that are caused by strains of yeasts, making this an antifungal classification of medication.

Overview

Oral thrush is an infection that occurs in the throat or mouth as the result of a fungus named Candida albicans. This fungus is present in everyone in small amounts and found in the skin and digestive tract. Normally its growth is kept in check by the body's natural microorganisms and bacterium, but occasionally something stresses out the delicate balance of the body, causing these organisms to spontaneously grow. The result is oral thrush, a yeast infection that is typically harmless but may become chronic if not treated right away. Symptoms include raised white lesions on the tongue or inner cheeks, sometimes on the roof of the mouth. These lesions resemble cottage cheese and may cause pain and bleeding. Without treatment, the infection could spread to the gut and cause wider spread pain and infection symptoms.

Miconazole buccal tablets, approved for use in 2010 by the US FDA, are a once-daily treatment for the safe, effective removal of oral thrush infections. This is the only medication of its kind approved for this use in the US.

Miconazole is an anti-fungal medication that works by interfering with certain enzymes that yeast strains use to feed and grow. By interfering with the necessary elements of this activity, Miconazole effectively kills the infection at the cellular level, preventing new occurrences of the infection.

Conditions Treated

Type Of Medicine

  • Anti-fungal
  • Enzyme inhibitor

Side Effects

As Miconazole inhibits the growth of fungal infections, it may also affect your healthy cells and cause unwanted symptoms. If you should experience any of the following symptoms after taking this medication, let your doctor know immediately:

  • Body pain or aches
  • Coughing
  • Difficulty breathing
  • Congestion in ears
  • Elevated body temperature
  • Chills
  • Headache
  • Losing voice
  • Side or lower back pain
  • Nasal runniness, sneezing or congestion
  • Difficulty urinating, possibly painful
  • Skin paleness
  • Throat soreness
  • Difficulty breathing when exerting oneself
  • Bruising or bleeding unexpectedly
  • Fatigue
  • Weak Muscles
  • Stools are black and tar-like
  • Skin paleness
  • Gasping for breath
  • Ulcerated white spots on tongue or mouth

Other symptoms may occur that don't require urgent attention and usually disappear over time with use of the medication. It is best, however, to alert your physician if you are experiencing these symptoms, as there may be a way for you to ease them:

  • Everything tastes strange or of nothing
  • Diarrhea
  • Mouth dryness
  • Headache
  • Skin itches
  • Nausea
  • Swollen, painful, red gums
  • Tongue sores
  • Toothache
  • Pain in stomach or upper abdomen
  • Little to no appetite
  • Pain
  • Weak muscles

Some patients may experience symptoms other than those listed here. If you have any changes to your overall health or mood while taking Miconazole, report them to your doctor immediately.

Dosage

Follow your doctor's prescribed instructions for the amount of Miconazole you should take and do not change how much or when you are to take it. Take this medication for the full duration prescribed to you, even if your symptoms get better. You may experience a recurrence of your infection if you don't take the full prescribed amount.

Read and understand the patient information leaflet and ask any questions of your physician or pharmacist that are necessary for your full comprehension of how to take your prescribed amount of Miconazole.

Miconazole prescription medication comes in tablet form. Adult patients and teenagers who are older than 16 years of age will be prescribed a single tablet dosage to be placed on the upper gum and allowed to dissolve once per day. Children younger than 16 years old will be prescribed Miconazole if appropriate and their amount will vary depending on many factors. The 50 milligram size tablets should be dissolved between cheek and gum near an incisor and taken once daily for two weeks.

To use the buccal tablet safely, the following process is recommended:

  • Brush your teeth first thing in the morning.
  • Using dry hands, place the round side of the tablet on your outside upper gum near to an incisor, which are the teeth adjacent to your front teeth on either side.
  • Place your finger over your upper lip to hold the tablet in place for 30 seconds to make it adhere to your gum or cheek.
  • Leave the tablet to dissolve on its own without chewing, crushing or swallowing it.
  • If the tablet falls off within the first few hours, reapply it. Replace it with a new tablet if you cannot get it to stick.
  • If it has been longer than six hours since you applied the tablet and it falls off, discard it safely and do not apply a new tablet until your next dose.
  • Drinking and eating are permitted as normal with the tablet in place but avoid chewing gum.

If you miss a dose of Miconazole, do not double dose, as this does more harm than good. If you are far enough out from your next dose, you can take it when you remember. If you are close to your next dose, skip it in favor of double dosing.

Interactions

Report any past sensitivity you have experienced to this medication or any others. Include any sensitivity to animals, foods, perfumes, dyes or preservatives as well when you are communicating with your health care provider. Reactions to these substances sometimes indicate a pending sensitivity to Miconazole. Avoid any adverse symptoms by listing your allergens for your physician.

Children younger than 16 have not been studied to provide data that proves they are safe to be treated with Miconazole or that it will be effective on their condition. Avoid use in this age group unless prescribed with caution and monitored carefully.

Miconazole has not been studied with regard to use in geriatric patients. It is believed that this age group can benefit from this treatment much like the adult age group.

This medication may harm fetal growth and development if taken while pregnant. If you discover that you are pregnant during your Miconazole treatment, alert your physician immediately. Prevent pregnancy during your treatment by using reliable forms of birth control.

Nursing mothers should only take this medication when there is a clear need to do so, as safety has not been established in this group with regard to transmission of the drug through breast milk.

Avoid taking any other medications during your Miconazole treatment unless they are specifically approved by your physician for your use. This includes any vitamins or herbal supplements that you take as well as prescription and non-prescription medications. Allow your doctor to determine what you should be taking until your infection clears up.

Some medications should be avoided completely during your treatment and one of those is Pimozide. If you have been taking this medication, before your doctor prescribes Miconazole, discuss the use of these drugs together.

The following medicines, while not specifically recommended for use with Miconazole, can be taken if your physician allows it and adjusts your dosage. Let your doctor know if you are taking:

  • Cilostazol
  • Amiodarone
  • Domperidone
  • Clozapine
  • Doxorubicin Hydrochloride Liposome
  • Doxorubicin
  • Escitalopram
  • Eliglustat
  • Ifosfamide
  • Fosphenytoin
  • Olaparib
  • Naloxegol
  • Piperaquine
  • Phenytoin
  • Warfarin
  • Simeprevir

Certain adverse effects on your health can be at a greater risk if you are taking the following medications. Be sure to let your doctor know if you are taking these medications:

  • Dicumarol
  • Anisindione
  • Phenprocoumon
  • Oxycodone
  • Trimetrexate
  • Tolterodine

Discuss the consumption of alcoholic beverages and the use of tobacco products with your physician as well as any foods or beverages you should avoid. While the Miconazole buccal treatment is dissolving near the front of your mouth, you may eat and drink as normal.

The following diseases should be made known to your doctor if you have them, as they could have an effect on how this medication works on your symptoms. They could also become worse themselves due to the drug interactions. For your safety, report your full medical history to your doctor, especially with regard to:

Warnings

Your physician will want to see you for regular office visits while you are being treated with Miconazole so that your progress can be monitored. You will be observed for the effectiveness of the drug on your infection as well as checked for any unwanted health effects.

Anaphylaxis, a serious, life-threatening sensitivity to Miconazole, has occurred in some patients. Report symptoms such as skin rash, itchy skin, and hoarse voice, difficulty swallowing or breathing or swelling in face, mouth or hands while you're taking this medication as they could be signs of anaphylaxis.

Report any worsening of your symptoms or if you don't experience any improvement after taking Miconazole for a few days to your physician in case another medication needs to be prescribed for you.

Avoid taking any other medications during your drug treatment therapy with Miconazole unless they have been specifically approved by your physician. This includes any over-the-counter medications as well as vitamin and herbal therapies and holistic treatments.

Children younger than 16 years old and women who are pregnant should not take Miconazole, as it will harm their health or the health of their developing child. Avoid taking this medication if you are a nursing mother unless it is clearly needed.

Be sure to use dry hands when placing the tablet between your cheek and gum in the upper part of your mouth, just to the side of your front teeth. Avoid swallowing the tablet or chewing it and replace it immediately if it falls off within six hours of placement. Discard if it falls off after six hours and wait to take your next scheduled dose.

Alert your physician if you have any problems with your liver or any other medical conditions prior to taking Miconazole. Tell your doctor if you're pregnant, if you suspect you may be pregnant or if you are planning to become pregnant in the near future. Also alert your doctor if you are breastfeeding, as you may be advised to stop during your treatment.

Miconazole may alter how diabetes medicines and blood thinners affect you, so make sure your physician knows all medications you are taking by keeping a list to educate your physician or your pharmacist when getting a new prescription.

Storage

Miconazole buccal tablets should be stored at room temperature in the original packaging and kept dry. Do not expose the tablets to excessive heat, cold or light and do not keep them in moisture-heavy environments such as the bathroom. Keep this and all medications out of sight and reach of children and pets, this includes disposing of used tablets. Unused or expired doses of Miconazole should be disposed of safely, according to instructions available from your physician or pharmacist.

Summary

Oral thrush is a yeast infection caused by a normally occurring fungus that begins to grow out of control. Settling in the mouth and showing up as white, cottage-cheese-like patches on the back of the tongue or in the throat, oral thrush can spread to the gut causing pain, bleeding and other symptoms if left untreated.

Miconazole buccal tablets are prescribed to patients with oral thrush infections, as it kills the infection and prevents it from coming back. Miconazole works by interfering with yeast cellular functions that use enzymes to grow and spread. Without these enzymes, the cells of the infection die and do not reproduce and the infection clears up with the body's own natural healing.

Patients older than 16 are typically safe to take Miconazole for their oral thrush treatment and are given 50-milligram tablets to place between the upper cheek and gum near their front teeth and allowed to dissolve. This once-daily dose typically continues for 14 days. Pregnant women, nursing mothers and children younger than 16 should not take Miconazole, as it has not been proven safe for their treatment. Patients with liver disease may need to have their dosage adjusted by their doctor to be safe in taking this medication.

Patients have reported unwanted health symptoms as the result of Miconazole treatment, including a bad taste in the mouth or loss of taste, sores on tongue, nausea, headache and dry mouth. Severe or prolonged symptoms should be reported to your doctor immediately.

Signs of sensitive reactions to this medication should be reported immediately to your health care provider. These symptoms include itchy skin, hoarse voice, and difficulty swallowing or breathing and swelling in the face, mouth or hands.