Misoprostol (Oral)

Misoprostol helps the stomach to protect itself against acid in the stomach and is used to prevent ulceration of the stomach from occurring.


Misoprostol is an oral tablet that is usually taken in conjunction with other medication. Commonly it is used by patients who are taking anti-inflammatory medications or aspirin. The medication is used to help the stomach to protect itself against irritation from stomach acid that may be increased when taking these medications. It does so by reducing the amount of acid produced and this can help to prevent ulceration of the stomach lining from occurring.

Misoprostol is prescribed as Cytotec and is available only with a prescription.

Condition treated

  • Stomach ulceration, protection against.

Type Of Medicine

  • Prostaglandin

Side Effects

In addition to the desired effects of using Misoprostol, other unwanted side effects can also occur from use. In some cases, you may need to seek medical attention for treatment of these.

You should seek emergency help if any of the following symptoms of allergic reaction occur:

  • Difficulty breathing
  • Swelling of the throat
  • Swelling of lips, mouth or face
  • Hives

The following side effects may also occur that may become bothersome over time, but which should usually abate with use as your body gets used to Misoprostol. If these side effects are ongoing, consult your doctor. You would not normally need treatment for the following:

  • Moderate diarrhea
  • Stomach cramps
  • Nausea
  • Sickness

These side effects may often be minimised by taking Misoprostol at the same time as food.


Misoprostol should be taken with, or shortly after, meals. You should also take it before bed unless you have been otherwise directed. This medication should be taken with milk. This will help to prevent the loosening of stools, diarrhea and cramping in the abdomen.

You should only ever take this medication as directed by your doctor. Never take more of the medication, nor take it for longer than prescribed or more frequently than prescribed. The following dosing information contains only the average doses and your dose may be higher or lower, depending on your condition. The number of doses you take and the time between doses can also differ. The following dosing information is intended as a guideline only and should not be used to make changes to the medication you take.

Adults should be treated with a dose of 200mcg taken four times daily. These should be taken after each meal and then before bed. This dose can be taken instead as 400mcg taken twice daily with the last dose before bed. In patients who are sensitive to the treatment, the dose may be lowered to 100mcg.

The use of this medication in children should be determined in each case by the prescribing doctor.

If you miss a dose of this medication then you should take the missed dose as soon as possible with a snack. If you are close to your next dose being due, however, then you should instead skip the missed dose and return to the usual schedule. Never take two doses to make up for a missed dose.


Certain medications can never be used together because they can interact with one another in the body. In the most serious cases, serious medical complications can occur from the use of these treatments together. In other cases, medications may prevent one another from working or may increase the side effects that are experienced.

To avoid interactions occurring, you must inform your doctor of all other treatments that you are taking or receiving. This includes all prescribed medications, over the counter treatments and even vitamin supplements and herbal remedies.

The use of Misoprostol with the following medication can cause an increased risk of certain side effects occurring. In some cases, your doctor may prescribe both treatments but may change the dose or frequency of use of one or both medications.

  • Phenylbutazone

Other medications not listed herein can also interact with Misoprostol. Ensure your doctor is fully aware of all other medications you are taking.

Misoprostol can also interact with certain foods and drinks in the body. Before beginning use, you should discuss eating and drinking habits with your doctor and discuss your use of tobacco.

Other medical problems from which you suffer can also affect the use of Misoprostol. You must inform your doctor of all medical conditions, past and present, from which you suffer. This is especially important if you suffer from any of the following conditions

  • Blood vessel disease
  • Epilepsy
  • Inflammatory bowel disease

Other medical conditions could also affect the use of Misoprostol. Ensure that your doctor is fully aware of all conditions from which you suffer.


Before beginning the use of any medication, it is important that you understand the risks of use and have weighed these against the benefits of using the treatment. The decision to take any medication is one that should be made with your doctor having considered all of the following:

Allergies ' You must inform your doctor of any allergies you suffer. This includes all allergies to foods, dyes, preservatives and other substances. It is also especially important that you inform your doctor if you have ever reacted unusually to any other medications in the past. Severe allergic reactions called anaphylaxis can occur from the use of this medication. If this occurs, emergency medical care will be required. Common symptoms of this include having difficulty breathing and swelling of the face, mouth, throat and lips. Contact emergency services immediately if you believe you are having an anaphylactic shock, which can occur at any time.

Pediatric' Studies have only be carried out for use in adults and there is no information on safety and efficiency in children available. Ensure that you have discussed this with your doctor.

Geriatric This medication is not known to cause any problems in elderly patients. Elderly patients may, however, be more likely to be suffering from other medical problems that may limit the use.

Pregnancy This medication should not ever be used when pregnant. If you are pregnant then you must inform your doctor before use. Studies have demonstrated a positive trend of fetal abnormalities with use and should be avoided at all times. Misoprostol can also cause a com/health/miscarriage/">miscarriage to occur if taken during pregnancy. Alternative treatments must be found for pregnant women. If you believe that you have become pregnant during use then you must stop use immediately and contact your doctor.

Breastfeeding There are no adequate studies to determine the risk of use in infants during breastfeeding. You should discuss this with your doctor to consider the potential risks in relation to the benefits. You may be advised not to breastfeed.

This medication can cause patients to suffer from diarrhea, cramping of the stomach and nausea. Usually, these side effects abate after a few days as the body becomes used to the presence of Misoprostol. If these are ongoing or very severe, however, then you should stop taking it after a week of use and consult your doctor. You may need to dose to be reduced if you are sensitive to the treatment.


Misoprostol can be stored at room temperature. It must be stored away from heat, moisture and direct light.

Keep this medication away from children at all times.

Dispose of all medication that is unneeded, unwanted our out of date safely as directed to by your healthcare professional.


Misoprostol is a prostaglandin that works in the body to reduce the amount of stomach acid that is produced. The treatment is mainly used in conjunction with anti-inflammatory medications that can cause stomach ulceration to occur. Misoprostol helps to prevent the ulceration of the stomach lining in these cases.

Misoprostol is a prescribed medication that is usually taken four times daily. It should always be taken with milk to prevent cramping and nausea and should be taken after meals and before bed.

Misoprostol is not suitable for the treatment of pregnant women. Misoprostol can cause miscarriage to occur and can cause fetal abnormalities too. If you are pregnant then you must inform your doctor and must not take this medication. If you believe that you may have become pregnant during use then you must stop taking the medication and should contact your doctor for advice.

If you suffer severe side effects from use then these will usually abate over a few days as the body adjusts to the treatment. If the side effects do not abate, however, then you may need to have your dose lowered and should stop use and contact your doctor for advice.