Moclobemide (Oral)

Moclobemide is a monoamine oxidase inhibitor used to treat patients with depression.

Overview

Moclobemide is a medication used to treat patients with depression. It is usually prescribed to patients with depression that have not responded well to treatment by other medications.

Moclobemide is a type of medication known as a monoamine oxidase inhibitor. It helps to treat depression by blocking the substance monoamine oxidase in the nervous system. Monoamine oxidase is a type of neurotransmitter, which can cause depression or anxiety when it is out of balance in the brain.

Moclobemide is only available to patients whose doctors have prescribed it to them.

Moclobemide can be very effective in treating depression, but it must be taken according to certain instructions. Your doctor will tell you how to take moclobemide and which foods, beverages, and other products you need to avoid to make sure moclobemide will not cause adverse reactions. Follow your doctor's or pharmacist's instructions carefully. If you have any questions about how to take moclobemide, or what you need to avoid while taking it, ask your doctor or pharmacist right away.

You may not begin to notice the effects of moclobemide for the first several weeks that you are taking it. Your doctor should check in with you regularly to make sure that moclobemide is working the way it should to treat your depression.

Do not take moclobemide in any way other than how your doctor has instructed you to take it. If you do not understand the instructions you have gotten, ask your doctor or pharmacist before taking moclobemide. Do not change your dosage unless you talk to your doctor about it first. Your dosage has been designed specifically for you for your own safety and the effectiveness of the medication.

Do not share your prescription with others. Make sure you keep all medications stored safely where they cannot be reached by children or animals.

If you experience any of the symptoms of an allergic reaction or overdose, stop taking moclobemide and get medical attention right away.

Condition Treated

  • Mental Depression

Type Of Medicine

  • Monoamine oxidase inhibitor
  • Antidepressant

Side Effects

All medications come with the risk of causing negative side effects as well as the effects that they are intended to produce. If you are uncomfortable with any of the side effects that you are experiencing or have any questions about them, talk to your doctor or medical professional. Your doctor may be able to help you prevent or lessen some of the side effects that you are experiencing.

If you experience any of the following side effects, tell your doctor about them immediately:

  • Bleeding gums
  • Changes in mood or mentality
  • Difficulty breathing
  • Difficulty or pain with urination or bowel movements
  • Difficulty speaking
  • Eyes are more sensitive to light
  • Faintness, dizziness, or lightheadedness when rising
  • Feelings of anxiousness
  • Feeling confused
  • Feelings of irritability
  • Feelings of nervousness
  • Feelings of restlessness
  • Feeling like you have something in your eye
  • General ill feeling
  • Headache or a feeling of head pressure
  • Hearing ringing in the ears
  • Hearing, seeing, or experiencing things that do not exist
  • High blood pressure (hypertension)
  • Hives, rash, or itchy skin
  • Increased symptoms of depression
  • Lack of interest in yourself or your environment
  • Longer or irregular menstruation
  • Losing balance
  • Pain in the chest
  • Pain or burning in the stomach
  • Problems remembering things
  • Rapid, irregular, slowing, or pounding heartbeat
  • Soreness or irritation in the mouth
  • Swelling, irritation, or redness of the eye
  • Tingling, prickling, or burning feelings
  • Unusually aggressive behavior
  • Unusual fatigue
  • Unusual twisting motions of the body or other uncontrollable movements
  • Urinating more frequently
  • Vision changes or blurring

Some side effects can be dangerous and require immediate medical attention. If you have any of the side effects listed below, stop taking moclobemide and get medical help right away.

  • Heartbeat that is: pounding, racing, slow, or irregular
  • Stiffness in the neck
  • Severe headache that starts at the back of your head and moves forward, throbbing

The side effects listed below are not normal side effects and may be symptoms of overdose. If you experience any of these side effects, get emergency medical help right away:

  • Agitation
  • Confusion
  • High blood pressure
  • Lowered reflexes
  • Memory loss
  • Nausea
  • Seizures or convulsions
  • Severe sleepiness
  • Slurring of your speech
  • Vomiting

You may also experience some of the side effects, listed below, that are considered normal and do not require medical attention. Side effects should lessen as your body gets used to the new medications. If your side effects continue after taking moclobemide consistently, or if they get worse, talk to your doctor.

  • Arms or legs that are shaky or trembling
  • Bad dreams
  • Change in appetite
  • Constipation or diarrhea
  • Difficulty sleeping
  • Dizziness
  • Dry mouth
  • Heartburn
  • Indigestion
  • Pain in the muscles or joints
  • Sleepiness
  • Unusual amount of sweating
  • Warm feeling in the chest, neck, arms or face

It is also possible that you may experience other side effects that have not been listed here. If you are experiencing any other side effects, check in with your doctor to make sure they are not indications of any issues with your treatment or medical condition. You should also talk to your doctor if you have any concerns or problems with any of the side effects that you are experiencing.

You may also report any side effects that you experience to the FDA at 800-FDA-1080.

Dosage

Your doctor will prescribe you an individual dosage based upon factors like your weight, your medical history, and the severity of your depression. Do not alter the dosage that your doctor has prescribed without talking to him or her about it first. Increasing your dose will not increase the positive effects of the medication.

A typical dose is: 150 mg tablet taken twice a day, after a meal.

You should take your dose at roughly the same time(s) each day. If you miss a dose, take it as soon as you remember. If you are close to the time you take your next dose, skip the forgotten dose and resume your usual dosing schedule. Do not take a double dose.

If you think you might be having an overdose, seek emergency medical help or call your local poison control center immediately.

Interactions

Many medications can interact with other medications in ways that can reduce their effectiveness or increase the risk of side effects. Make sure you talk to your doctor or pharmacist about any medications you are taking to make sure they won't have negative interactions. Do not start taking any new medications while you are taking indinavir without talking to your doctor about it first.

Moclobemide and other monoamine oxidase inhibitors can have dangerous interactions with certain medications or beverages. Failing to avoid these products can cause sudden increases in your blood pressure, which can be very dangerous.

While you are taking moclobemide:

  • Do not drink alcohol excessively
  • Do not take medications that your doctor has not instructed you to take. This includes all over the counter medicines and treatments

Taking moclobemide with any of the following medications is not recommended. Your doctor may take you off one of these medications, or find a different medication for you to take instead.

  • Isometheptene
  • Methadone
  • Atomoxetine
  • Fluoxetine
  • Pseudoephedrine
  • Cyproheptadine
  • Fluvoxamine
  • Dexfenfluramine
  • Vilazodone
  • Milnacipran
  • Diethylpropion
  • Sumatriptan
  • Protriptyline
  • Tetrabenazine
  • Dothiepin
  • Trimipramine
  • Methamphetamine
  • Escitalopram
  • Levomethadyl
  • Desipramine
  • Doxepin
  • Opicapone
  • Imipramine
  • Guanadrel
  • Guanethidine
  • Meperidine
  • Selegiline
  • Paroxetine
  • Methylphenidate
  • Cyclobenzaprine
  • Citalopram
  • Sertraline
  • Phendimetrazine
  • Amitriptyline
  • Brimonidine
  • Carbinoxamine
  • Amphetamine
  • Bupropion
  • Safinamide
  • Mirtazapine
  • Trazodone
  • Phentermine
  • Phenylalanine
  • Tapentadol
  • Clomipramine
  • Levodopa
  • Carbidopa
  • Tryptophan
  • Nortriptyline
  • Dextromethorphan
  • Venlafaxine
  • Opipramol
  • Benzphetamine
  • Vortioxetine
  • Methotrimeprazine
  • Doxylamine
  • Maprotiline
  • Lofepramine
  • Lisdexamfetamine
  • Hydroxytryptophan
  • Desvenlafaxine
  • Carbamazepine
  • Reserpine
  • Nefopam
  • Sibutramine
  • Fenfluramine
  • Dexmethylphenidate
  • Amoxapine
  • Dextroamphetamine
  • Phenmetrazine
  • Levomilnacipran
  • Apraclonidine
  • Methyldopa
  • Mazindol

Taking moclobemide with any of the following medications is usually not recommended. Your doctor may decide that you need to take both medications. He or she may change the way you take one of the medications in order to minimize the risk of an interaction.

  • Mate
  • Morphine
  • Hydromorphone
  • Morphine Sulfate Liposome
  • Fentanyl
  • Droperidol
  • Difenoxin
  • Guarana
  • Oxycodone
  • Ethchlorvynol
  • Nefazodone
  • Diphenoxylate
  • Methylene Blue
  • Clovoxamine
  • Palonosetron
  • Femoxetine
  • Buspirone
  • Hydrocodone
  • Cilostazol
  • Ma Huang
  • Buprenorphine
  • Kava
  • Tramadol
  • St John's Wort
  • Granisetron
  • Licorice
  • Naratriptan
  • Ziprasidone
  • Iobenguane I 123
  • Oxymetazoline
  • Dolasetron
  • Atropine
  • Tyrosine
  • Altretamine
  • Frovatriptan
  • Reboxetine
  • Nebivolol

Taking moclobemide with any of the following medications may increase the risk or severity of some side effects. However, your doctor might determine that it is still best for you to take both medications. He or she may alter the way you take one of the medications or change your dosage.

  • Insulin Glargine, Recombinant
  • Tolbutamide
  • Insulin
  • Nateglinide
  • Repaglinide
  • Insulin Degludec
  • Tolazamide
  • Acarbose
  • Insulin Detemir
  • Glimepiride
  • Ginseng
  • Metformin
  • Insulin Lispro, Recombinant
  • Insulin Bovine
  • Insulin Glulisine
  • Chlorpropamide
  • Insulin Aspart, Recombinant
  • Glyburide
  • Glipizide

Some foods may interact with certain medications. Your doctor or pharmacist will tell you if there are certain foods that you should avoid, or if you need to maintain a special diet of any kind while taking moclobemide. Eating avocado or bitter orange should be avoided while you are taking moclobemide. If you have any questions about this or if you accidentally ate avocado or bitter orange, talk to your doctor or pharmacist.

Tobacco or alcohol may cause interactions with some medications. Make sure you talk to your doctor or pharmacist about your use of tobacco or alcohol. Your doctor or pharmacist will tell you if you need to alter your use of tobacco or alcohol in order to ensure the optimal functioning of moclobemide. You should not drink excessive quantities of alcohol while you are taking moclobemide.

Warnings

Do not stop taking moclobemide unless your doctor has instructed you to do so. Your doctor will likely prescribe a plan that will enable you to wean off of moclobemide, so your body can adjust to the change.

Moclobemide and other monoamine oxidase inhibitors can have dangerous interactions with certain medications or beverages. Failing to avoid these products can cause sudden increases in your blood pressure, which can be very dangerous.

While you are taking moclobemide, do not drink alcohol excessively. This can be dangerous.

Do not take medications that your doctor has not instructed you to take. This includes all over the counter medicines and treatments.

Make sure that you tell your doctor about your complete medical history. Tell your doctor about any medical conditions that you have or have had. Other medical conditions may affect the way your body reacts to moclobemide. Taking moclobemide if you have certain conditions may exacerbate them and endanger your health. If you have high blood pressure, it may be exacerbated by taking moclobemide. If you have liver disease, the effects of moclobemide may be amplified because your body will be slower at removing it from your system.

Do not take moclobemide in any way except the way your doctor or pharmacist has instructed you to take it. If you do not understand how you are supposed to be taking moclobemide, talk to your doctor or medical professional before taking it. Do not share your prescription with others.

Before you take moclobemide, make sure you have told your doctor about all of your allergies. It is possible that moclobemide may contain inactive ingredients that you are allergic to.

Moclobemide has not established to be safe for use by children. Children should not use moclobemide without serious consideration of the possible risks it may pose.

Geriatric patients may be more sensitive to moclobemide than younger adults. This may mean that you have a higher risk of side effects, especially dizziness and lightheadedness.

Moclobemide can give you feelings of dizziness, sleepiness, or lightheadedness, or cause blurred vision. Do not drive, operate heavy machinery, or do tasks that require your full attention until you have learned how your body will react to moclobemide.

Even after you have stopped taking moclobemide, you may still experience interactions with food, drinks, or medications. For at least two weeks after you have stopped taking moclobemide, continue to avoid the food, beverages, and medications that you were not able to ingest while you were taking moclobemide.

Storage

Moclobemide should always be stored in a tightly sealed container, and kept at room temperature. Do not expose moclobemide to direct light, heat, or moisture, and do not allow it to freeze.

Keep all medications out of the reach of children and animals.

Do not used expired medications. Do not dispose of medications by flushing them down the toilet, pouring them in the sink, or putting them in the garbage. Ask your pharmacist how you should safely and appropriately dispose of unused medications.

Summary

Moclobemide is a monoamine oxidase inhibitor used as an antidepressant. By blocking monoamine oxidase, it helps to restore the balance of neurotransmitters in the brain and reduce the symptoms and severity of depression.

Because moclobemide can have serious interactions with certain foods, beverages, and other medications, it is often prescribed in patients whose conditions have not responded positively to other antidepressants. This also means that it is extremely important to talk to your doctor about all of the medications you take, as well as your diet and your medical history, before taking moclobemide. Some medical conditions may make moclobemide dangerous for you to take, or may exacerbate some side effects.

If you have liver disease or high blood pressure, you should talk to your doctor about this before taking moclobemide, as it may cause complications in one of your conditions.

Make sure you understand all of the instructions from your doctor about how to take moclobemide. If you do not understand these instructions, talk to your doctor or pharmacist before taking moclobemide.

Do not stop taking moclobemide on your own. Talk to your doctor before you stop taking moclobemide. Your doctor will likely want to give you a schedule to slowly reduce your dosage so as to let your body adjust to the change.

It is possible to overdose on moclobemide. If you notice any signs that you may be overdosing, seek medical help immediately and do not take any more moclobemide until your doctor tells you it is safe to do so.

Do not change your dosage or the way you are taking moclobemide unless you have talked to your doctor about it first. Take moclobemide exactly as your doctor has instructed.