Moexipril and Hydrochlorothiazide (Oral)

Moexipril and hydrochlorothiazide is a combination drug that is used in the treatment of patients with high blood pressure (hypertension).

Overview

In the US, moexipril and hydrochlorothiazide is sold under the brand name, Uniretic. It is a prescription only drug and comes in tablet form.

Moexipril and hydrochlorothiazide is a combination drug that is used to treat patients who have hypertension (high blood pressure). High blood pressure causes the arteries and the heart to work harder, placing stress on these structures and potentially leading to further medical complications. Patients whose high blood pressure is left uncontrolled can develop damage to the blood vessels that supply the kidneys, heart, and brain, ultimately leading to stroke, heart attack, or kidney disease.

Moexipril is one of a family of drugs called angiotensin converting enzyme inhibitors. It works by relaxing the blood vessels, causing the blood pressure to become lower and the supply of oxygenated blood to be increased to the heart. Hydrochlorothiazide is a water pill, or thiazide diuretic. It works by increasing urine production, thereby reducing the amount of water in the body and lowering the blood pressure.

Moexipril and hydrochlorothiazide combination will not provide a cure for your high blood pressure, but it can be very effective in treating the condition, especially when used together with a low sodium diet and weight loss program.

Female patients who are prescribed this drug must note that it can be extremely dangerous to the unborn baby. Do not take moexipril and hydrochlorothiazide if you think you may be pregnant.

Conditions treated

  • High blood pressure (hypertension)

Type of medicine

  • Angiotensin converting enzyme inhibitors
  • Thiazide diuretic

Side effects

In addition the effects it is designed to have, a drug can cause unwanted side effects. Not every patient using moexipril and hydrochlorothiazide will experience these effects, but if they do occur you may need further medical attention.

If you notice any of the following effects, check with your treating physician right away:

  • Wrinkled skin
  • Weakness and heaviness of the legs
  • Unusual tiredness or weakness
  • Trembling
  • Thirst
  • Sweating
  • Sunken eyes
  • Seizures
  • Rapid breathing
  • Tingling, numbness, pain, or weakness in the feet or hands
  • Muscle cramps or pain
  • Rapid, slow, or irregular heartbeat
  • Dry mouth
  • Feeling dizzy, faint, or lightheaded when rising suddenly from a prone or seated position
  • Decreased urination
  • Confusion
  • Blurred vision

Moexipril and hydrochlorothiazide can cause a dry cough. This side effect usually resolves itself once your body becomes acclimatized to the medication. Your health care professional may also be able to suggest ways of preventing or managing this effect. However, if the dry cough is persistent or especially bothersome, check with your doctor.

There may be other side effects caused by moexipril and hydrochlorothiazide that are not mentioned here. If you notice anything else untoward while you are using this drug, check with your doctor.

Dosage

Moexipril and hydrochlorothiazide should not be the first medication that is used to treat your hypertension. This drug is designed to be used if all other medications have failed to control your condition or have caused too many side effects.

Your treatment may also include changes to your diet, including reducing the amount of salt that you consume. Your doctor may also suggest a weight control regimen in addition to your drug therapy. Before changing your diet, always check with your treating physician.

Many people who have hypertension do not notice any symptoms and many feel completely normal. For this reason, it is very important that you continue to take this medication as directed and keep all your doctor's appointments, even if you feel fine.

This drug will not provide a cure for your high blood pressure, but it will help to control it. You must therefore continue to take the drug as directed if you want to lower your blood pressure and keep it at a healthy level. You may need to take hypertension medication for the remainder of your life.

If possible, take moexipril and hydrochlorothiazide a minimum of one hour before consuming any food.

The dose of this drug that you take will vary between patients. You must follow your treating physician's advice or the directions on the product label. The information that follows includes the average dose of this drug. If your dose is not the same as this, do not alter it unless your treating physician tells you to.

The size of your dose of moexipril and hydrochlorothiazide will depend on the strength of the preparation. The number of daily doses and their frequency will depend on your condition and the way in which your body responds to the drug.

Tablets for the treatment of hypertension

  • Adults: Take one or two tablets daily.
  • Children: The use and dose of this medicine will be determined by your child's GP.

If you omit a dose of moexipril and hydrochlorothiazide, you should try to take it right away. If it is nearly time for your next dose, leave out the one you missed and revert to your usual schedule. Do not take double doses.

Interactions

Drug interactions

Some drugs should never be taken at the same time as this can cause a serious interaction. However, in some cases your treating physician may decide to treat you with both medicines, even though there may be an interaction. Your dose or frequency of use may be changed in these circumstances. While you are using moexipril and hydrochlorothiazide, you must tell your doctor if you are using any of the medicines in the following list.

It is not recommended that you use moexipril and hydrochlorothiazide with any of the following drugs, but this may be necessary in some circumstances. If you are prescribed both drugs together, your GP may adjust the dose or frequency of use of one or both of them:

  • Valsartan
  • Valdecoxib
  • Trimethoprim
  • Triamterene
  • Tolmetin
  • Tolfenamic acid
  • Tiaprofenic acid
  • Tenoxicam
  • Telmisartan
  • Sulindac
  • Spironolactone
  • Sotalol
  • Sodium salicylate
  • Sirolimus
  • Salsalate
  • Salicylic acid
  • Sacubitril
  • Rofecoxib
  • Proscillaridin
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Potassium
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Ouabain
  • Olmesartan medoxomil
  • Nimesulide beta cyclodextrin
  • Nimesulide
  • Niflumic acid
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Metildigoxin
  • Methotrexate
  • Mercaptopurine
  • Meloxicam
  • Mefenamic acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Losartan
  • Lornoxicam
  • Lithium
  • Levomethadyl
  • Ketorolac
  • Ketoprofen
  • Ketanserin
  • Irbesartan
  • Indomethacin
  • Ibuprofen
  • Flurbiprofen
  • Flufenamic acid
  • Floctafenine
  • Flecainide
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Everolimus
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Eprosartan
  • Eplerenone
  • Droxicam
  • Droperidol
  • Dofetilide
  • Dipyrone
  • Digoxin
  • Digitoxin
  • Digitalis
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Deslanoside
  • Cyclophosphamide
  • Clonixin
  • Choline salicylate
  • Celecoxib
  • Canrenoate
  • Candesartan cilexetil
  • Bufexamac
  • Bromfenac
  • Azilsartan medoxomil
  • Azilsartan
  • Azathioprine
  • Aspirin
  • Arsenic trioxide
  • Amtolmetin guacil
  • Amphetamine
  • Amiloride
  • Alteplase, recombinant
  • Aliskiren
  • Acetyldigoxin
  • Acemetacin
  • Aceclofenac

Taking moexipril and hydrochlorothiazide with any of the following drugs can cause side effects to be increased. If you are told to use both drugs, your doctor may change the frequency of use or the dose of one or both of them:

  • Valdecoxib
  • Torsemide
  • Topiramate
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Propionic Acid
  • Proglumetacin
  • Piroxicam
  • Piretanide
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nesiritide
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Licorice
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Gossypol
  • Gold Sodium Thiomalate
  • Ginkgo
  • Furosemide
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Clonixin
  • Choline Salicylate
  • Cholestyramine
  • Celecoxib
  • Carbamazepine
  • Capsaicin
  • Bupivacaine Liposome
  • Bupivacaine
  • Bumetanide
  • Bufexamac
  • Bromfenac
  • Bepridil
  • Azosemide
  • Amtolmetin Guacil
  • Acemetacin
  • Aceclofenac

Other interactions

Some drugs must not be taken when you are eating food or certain food groups, as this can cause an interaction. Using tobacco or alcohol with some drugs is not recommended as this can cause interactions. You should discuss this aspect of your treatment with your health care professional.

Medical interactions

Some historical or existing health problems can affect how moexipril and hydrochlorothiazide works. Be sure to tell your health care professional if you have any other health conditions, especially the following:

Patients with a history of angioedema should not use moexipril and hydrochlorothiazide, as this can increase the chances of this condition recurring.

Moexipril and hydrochlorothiazide should not be used in patients with the following conditions:

  • Sulfa drug allergy
  • Diabetic patients who are also taking Aliskiren
  • Anuria (not able to pass urine)

Patients who have a history or asthma should not use moexipril and hydrochlorothiazide, as this could increase the likelihood of an allergic reaction.

Moexipril and hydrochlorothiazide can present an increased danger of blood problems in patients who have collagen vascular disease and kidney disease.

Moexipril and hydrochlorothiazide must not be used by patients with any of the conditions listed below, as the drug can cause the blood pressure to fall too low:

  • Kidney disease
  • Hyponatremia (low sodium in the blood)
  • Heart or blood vessel disease
  • Diarrhea
  • Dehydration
  • Congestive heart failure

Patients with kidney problems or diabetes should not use moexipril and hydrochlorothiazide, as the drug could cause an increased risk of excessively high potassium levels in the body.

People with any of the following conditions should use moexipril and hydrochlorothiazide with caution, as this drug can make these problems worse:

  • Systemic lupus erythematosus
  • Acute myopia
  • Liver disease
  • Hypercholesterolemia
  • Hypercalcemia
  • Heart disease
  • Gout
  • Glaucoma, secondary angle closure
  • Fluid imbalance (due to excessive perspiration, diarrhea, or vomiting)
  • Electrolyte imbalance (low levels of potassium, magnesium, or sodium in the body)
  • Edema

Warnings

Before deciding to use any drug, including moexipril and hydrochlorothiazide, you must weigh the advantages of doing so against the risks. This decision should be arrived at following discussions with your health care professional. In the case of moexipril and hydrochlorothiazide, consider the points below:

You should mention to your health care professional if you have ever noticed any odd reactions to moexipril and hydrochlorothiazide or to any other drugs. Also mention any allergies that you have to certain food groups, food colors, preservatives, or animal derivatives.

Note that safety and efficacy of moexipril and hydrochlorothiazide in children has not been established through research. Discuss any concerns that you have in this regard with your child's health care professional.

Note that safety and efficacy of moexipril and hydrochlorothiazide in elderly patients has not been established through research. However, you should note that geriatric patients are more likely to have age-related kidney disease so the dose of this drug may need adjusting. Discuss any concerns that you have in this regard with your child's health care professional.

Pregnant women should be aware that moexipril and hydrochlorothiazide can present severe risk of death to the unborn baby. Do not use this drug if you are pregnant. Tell your health care professional immediately if you think you have become pregnant while you are using this drug. Use a reliable form of contraception while you are using this medicine.

Although there is nothing to suggest that moexipril and hydrochlorothiazide can be ingested by a breastfeeding infant, you may wish to discuss this with your treating physician or midwife before you begin using this drug. To err on the side of caution, it may be best to use an alternative feeding solution while you are using this medicine.

You must see your health care professional for regular progress checks to make sure that moexipril and hydrochlorothiazide is working as desired and to discuss any side effects that the drug may be causing. You may also need to have urine and blood tests.

In some patients moexipril and hydrochlorothiazide can cause very serious allergic reactions, including anaphylaxis. If you notice any of the following signs, you must summon emergency medical assistance right away:

  • Itching
  • Rash
  • Breathing problems
  • Hoarseness
  • Swelling of the throat, tongue, tips, face, legs, arms, or eyes

If you experience sudden severe stomach pain, even if you do not feel nauseous or vomit, you must check with your health care professional immediately. This could indicate a condition called intestinal angioedema.

Some patients experience feelings of lightheadedness, dizziness or fainting while taking moexipril and hydrochlorothiazide, especially when getting up from a sitting or lying position. If you suffer this side effect, do not drive, operate machinery or take part in any other potentially hazardous activity. Getting up more slowly or lying down for a few minutes if you feel dizzy can prevent fainting. If you do faint, stop taking the drug and speak to your treating physician right away.

Dehydration can result if you suffer from vomiting and diarrhea while you are using moexipril and hydrochlorothiazide. Dehydration can cause low blood pressure, so be sure to drink plenty of water during hot weather or after exercise. Check with your doctor if you suffer these symptoms.

If you develop a fever, sore throat, or chills, you must speak with your health care professional right away. These can all be symptoms of an infection due to low levels of white blood cells in the body.

Moexipril and hydrochlorothiazide can affect your blood sugar levels. If your urine or blood sugar test results change, you should check with your health care professional.

The following symptoms can be indicative of liver problems. Check with your treating physician if you notice any of these signs:

  • Pale stools
  • Dark-colored urine
  • Vomiting
  • Nausea
  • Poor appetite
  • Pain in the upper stomach area
  • Yellow eyes or skin

If you have blurred vision, eye pain, difficulty in reading, or any other visual problems, you must speak to your doctor right away. You may be referred for an eye test with a specialist.

High potassium levels in the blood (hyperkalemia) may occur while you are using moexipril and hydrochlorothiazide. Alert your health care professional right away if you notice any of the symptoms listed below:

  • Stomach or abdominal pain
  • Confusion
  • Breathing problems
  • Irregular heartbeat
  • Vomiting or nausea
  • Nervousness
  • Tingling or numbness in the lips, feet, or hands
  • Shortness of breath
  • Heaviness or weakness of the legs

You must not use supplements or salt substitutes that contain potassium without first consulting your health care professional.

Be sure to tell your health care professional or dentist that you are using moexipril and hydrochlorothiazide. It may be necessary to stop using this drug a few days prior to medical tests or surgery.

Patients should be aware that black people can be less sensitive to the blood pressure lowering effect of moexipril and hydrochlorothiazide. They may also be especially susceptible to a serious allergic reaction that causes swelling of the mouth, face, feet or hands.

While you are taking moexipril and hydrochlorothiazide, you must not take any other prescription or over the counter medications, including cough and cold medicines, hay fever treatments, appetite control medicines, and products that treat sinus problems or asthma. All these products can cause your blood pressure to increase.

Storage

You must keep moexipril and hydrochlorothiazide at room temperature and in a sealed container. Keep the medicine well away from heat sources, direct sunlight and moisture. Do not freeze the medication.

Make sure that you keep your drugs somewhere they cannot be accessed by children or pets. If a pet should eat any of your moexipril and hydrochlorothiazide, seek veterinary advice right away.

Do not retain any moexipril and hydrochlorothiazide tablets that have passed their use-by date or that are no longer required. For instructions on how to dispose of unwanted medication safely, speak to your health care professional or pharmacist.

Summary

Moexipril and hydrochlorothiazide in combination is a drug that is used in the treatment of people who suffer from chronic high blood pressure (hypertension). Left untreated for a long time, high blood pressure places undue strain on the arteries and on the heart, potentially leading to complications such as heart disease, kidney failure, stroke, and blood vessel damage. This medicine is used when other blood pressure medications have failed to bring the condition under control or have caused side effects.

The medicine is a combination drug. The moexipril component is an angiotensin converting enzyme inhibitor. It relaxes the blood vessel walls, which has the effect of increasing blood flow and lowering the blood pressure. Hydrochlorothiazide is a water pill, or thiazide diuretic. This drug works by increasing urine volume, thereby reducing the amount of water in the body and consequently lowering blood pressure.

Moexipril and hydrochlorothiazide cannot cure your high blood pressure, but is very effective at controlling it, especially when taken as part of a low sodium diet and weight control program. You may need to take this medicine for what is left of your life, in order to control your condition.

This drug can interact adversely with a great many other medicines. It can also cause complications and side effects in patients with a variety of other health conditions. For these reasons, you must be sure to discuss your medical history fully with your health care professional before you begin using moexipril and hydrochlorothiazide. Throughout the course of your treatment with this drug you will be required to attend your health care professional for regular check-ups to make sure that the drug is working properly and to discuss any side effects that it may be causing.

Moexipril and hydrochlorothiazide is extremely dangerous to the unborn baby. Pregnant women must not use this drug. If you think you may be pregnant, tell your health care professional immediately and stop using the medication right away.