Moexipril (Oral)

Moexipril treats high blood pressure, as well as congestive heart failure, diabetes, and certain types of renal dysfunction.

Overview

High blood pressure is a commonly diagnosed cardiovascular condition that occurs when the amount of pressure against artery walls when blood goes through them is too high. Moexipril is an angiotensin converting enzyme (ACE) inhibitor often prescribed by doctors to treat patients with this condition. This medication is designed to widen blood vessels by relaxing them so blood flows more easily throughout the body, which in turn lowers a person's blood pressure. Lowering a patient's blood pressure lessens the risk of them having heart attacks, stroke, kidney issues, or other medical conditions later on.

Less commonly, moexipril is prescribed for patients with diabetes to protect their kidneys from damage due to their condition. It is often combined with diuretics to treat patients diagnosed with congestive heart failure.

While this medication is most commonly prescribed to treat high blood pressure, it is not a cure for the condition. An overall treatment plan for the condition includes patients making changes in their dietary and exercise habits in combination with this and other medications.

Conditions Treated

  • Congestive heart failure

Type Of Medicine

  • CE inhibitor

Brand Names or Other Names:

  • Univasc

Side Effects

Although this medication is meant to treat hypertension (high blood pressure), there are times when some of the effects it can have on a patient's body are not what the manufacturers intended when they created it. Some of these effects can be more serious than others, but none of these effects are common amongst patients taking this medication. Talk to your doctor if you have questions about any effects that may occur outside of the ones intended.

Some of the side effects that may occur with use of this medication are milder and typically do require medical attention. Generally, they will lessen and eventually disappear as your body adjusts to the drug. A list of these effects includes:

  • Aches and pains in your body

If these effects last for longer than the few weeks your body needs to adjust to the medication, if they worsen, if they are bothersome, or if you have questions, check with your doctor. They may have some recommendations for reducing or preventing some of these effects.

Other side effects may be more serious and require medical attention. These effects include:

  • Aches and pains in your muscles

If you experience any of these side effects, contact your doctor immediately.

It is possible for side effects that are not listed above to occur while taking this medication. Let your doctor know about any other effects you notice while you are taking this medication.

This drug can cause higher potassium blood levels to occur. Let your doctor know right away if you experience any symptoms of this condition. Symptoms include:

  • Fainting

Sometimes this medication is prescribed to treat or prevent certain kidney problems. It is rare, but it can sometimes be the cause of kidney issues or worsen kidney problems that are already occurring. While your doctor will be checking your kidney function while you use this medication, you should tell them immediately if you experience any symptoms, like a change in the amount of urine you are producing.

Liver disease is another condition that is rare, but can occur with use of this medication. Seek medical attention immediately if you notice any symptoms of this condition. Symptoms of this condition include:

  • Abdominal / stomach pain

Rarely, serious allergic reactions can occur while using this medication. Get medical attention immediately if you see the symptoms of a serious allergic reaction. Symptoms include:

  • Extreme dizziness

Dosage

The following dosages are general recommendations from the manufacturers who created this medication. Your doctor will determine the exact amount you should take and how often you should take it based on information they have about your medical history and other medications you are already taking as well as other factors.

Dosage for Adult Patients to Treat Hypertension:

Initially, take 7.5 mg once a day on an empty stomach. This amount may be increased by your doctor to as much as 30 mg per day, to be taken as either a single dose or to be divided into two separate doses.

Dosage For Pediatric Patients

There are no general recommendations for patients in this age group. Your doctor will determine if this medication is necessary and the exact dosage for your child.

Dosage For Geriatric Patients

Initially, take 7.5 mg once a day on an empty stomach. This amount may be increased by your doctor to as much as 30 mg per day, to be taken as either a single dose or to be divided into two separate doses.

Other Dosage Information:

Should you miss a dose, take that dose as soon as you realize you missed it unless it is almost time to take the next one. In that case, skip the dose you have missed and take the next dose at its regular time.

Always follow your doctor's instructions for taking this medication. Do not take more of it or less of it than you have been instructed. Do not take it more often than you have been instructed. Do not double the number of doses you take at one time. Do not share this medication with anyone else. Once you have finished treatment with this medication, dispose of it according to your doctor's instructions. Do not save extra doses for later use. Even if your doctor decides to start treatment again, these doses may have expired by the time that decision is made.

Types of Interactions:

While this medication was created to lower blood pressure in patients with hypertension, its effectiveness may be affected by other drugs, substances, or medical conditions that are already present. Before starting treatment, talk to your doctor about your medical history, as well as any medications or vitamins and supplements you are taking and your dietary habits.

Drug Interactions:

There are many drugs that either cause this medication to work less effectively than intended or whose intended effects are lessened by use of this medication. A list of the medications this most commonly occurs with includes:

  • Angiotensin II receptor antagonists like candesartan, irbesartan, losartan, and valsartan

This is not an exhaustive list of drugs, medications, vitamins or supplements that can have negative interactions with moexipril. Provide your doctor with a list of prescribed medications, over-the-counter drugs, and vitamins and supplements you take regularly so they can decide whether they need to adjust your dosage or place you on a different medication.

Food and Drink Interactions:

Moexipril can raise the level of potassium in your body, so you should adjust your diet and eat foods with lower levels of potassium while taking this medication.

Disease Interactions:

There are several medical conditions and treatments that this medication can either cause or negatively impact if the patient already has the condition or is undergoing treatment. A list of these medical conditions and treatments includes:

  • Angioedema

This is not a complete list. Talk to your doctor about any and all medical conditions you have already been diagnosed with to make sure that use of this medication will not affect it.

Warnings

Before you start taking moexipril, inform your doctor or pharmacist of any allergies you have to it or other ACE inhibitors (like captopril, lisinopril, or memantine), or if there are any other allergies you have. This medication could contain inactive ingredients that can cause either allergic reactions or other medical problems.

Before you begin using this medication, talk to your doctor about your medical history, especially if that medical history includes allergic reactions like angioedema (swelling in the throat, tongue, lips, or face), blood filtering procedures like dialysis or LDL apheresis, high potassium levels in your blood, or liver disease.

Before you undergo any surgery, tell the doctor or dentist performing it about everything you are taking, including this medicine, other prescription medications, nonprescription drugs, and vitamins and supplements.

Because this medicine can make you dizzy, you should not drive, use machinery, or perform any other activity that requires you to be alert until you can do so safely.

While taking this medication, report any prolonged periods of diarrhea or vomiting to your doctor. Too much diarrhea, vomiting or sweating can result in dehydration (loss of body water). They can also increase the risk of becoming lightheaded. Make sure you are drinking enough fluids to stay hydrated unless otherwise directed by your doctor.

If you start having a fever, chills, or sore throat, check in with your doctor. These could be signs that you have an infection due to a low white blood cell count.

Talk to your doctor as soon as possible if you see any signs or symptoms of liver problems. Symptoms include appetite loss, nausea or vomiting, pale stools or dark-colored urine, stomach pain, and yellow eyes or skin.

It is possible for high potassium levels (hyperkalemia) to occur while using this medication. Let your doctor know as quickly as possible if you experience any of the symptoms of this condition. Symptoms include confusion, having trouble breathing, having an irregular heartbeat, feelings of heaviness or weakness in your legs, nervousness, nausea or vomiting, shortness of breath, stomach or abdominal pain, or tingling or numbness in your lips, feet, or hands.

Consult with your doctor before using salt substitutes or supplements with potassium. Also discuss your use of certain over-the-counter medicines for asthma, coughs and colds, sinus problems, hay fever, or controlling your appetite. These medicines have been known to raise your blood pressure.

Some groups of people, especially older adults, could be more sensitive to certain side effects of this medication, such as high levels of potassium and dizziness. Other groups may be less sensitive to this medication's intended effects. Talk to your doctor for more information.

If you have severe stomach pains (whether or not you are nauseous or vomiting), contact your doctor immediately. You may be experiencing intestinal angioedema.

If you are a woman of child-bearing age, make sure to use an effective form of birth control in order to prevent pregnancy from occurring. If you are pregnant or trying to become pregnant, do not use this medication. It may have harmful effects on an unborn child. Talk to your doctor immediately if you think you might have become pregnant while taking this medication.

If you are nursing, talk to your doctor before using this medication, as it is not known at this time if this medication is excreted into breast milk.

Storage Instructions

This medication should be stored at room temperature (between 59-70 degrees Fahrenheit) in a tightly sealed container.

Keep this and other medicines away from sources of heat, like the stove or oven in the kitchen. Also keep it away from sources of moisture, like near the shower or next to the sink in the bathroom.

This medication should not be frozen, so do not store it in a freezer.

Store this medication in a place where children and pets are not able to reach it.

Disposal Instructions:

Talk to your doctor or pharmacist about how to properly dispose of this medication. While it may seem like a wise idea, you should not hold onto extra doses of this medication once it has expired or after your doctor has taken you off of it.

Do not dispose of this medication by flushing it down the toilet or pouring it down the sink unless instructed to do so by your doctor or pharmacist.

Summary

Hypertension, or high blood pressure, is a serious condition that affects many people. If it is not treated, properly, it can lead to medical conditions that are much more severe - like heart disease, a heart attack, or a stroke, to name a few. Moexipril, when used properly for this specific condition, relaxes blood vessel walls and lowers a patient's blood pressure so the damage that leads to more serious medical conditions lessens or is completely stopped.

While this medication can be an effective part of an overall treatment plan for high blood pressure, there are many risks associated with its use, especially if a patient is already taking medications for other medical conditions. Doctors know what the potential benefits and risks are, but it can be difficult for them to correctly determine what benefit this medication could be for their patient without a more complete picture of their patient's overall medical condition.

For this reason, and many others, patients need to be willing to have open and honest conversations with the medical professionals working with them about their medical history and everything they know about their family's medical history, as well as any medications, vitamins, supplements, and herbal products they are using and their dietary habits. With this information available, it is easier for doctors to determine the risks involved in treating their patient with moexipril and if the benefits outweigh them. Without this information, however, it will take a doctor much longer to come to the same conclusion, and it is possible for more damage to occur in the meantime.

When this medication is administered correctly, it is an effective part of an overall treatment plan for high blood pressure. Combined with changes in diet and exercise habits, patients are less likely to experience more severe medical conditions and can expect to enjoy living a much longer life in much better health overall.

Resource Links:

  • Drugs.com. "moexipril". Link https://www.drugs.com/mtm/moexipril.html

Moexipril is an ACE inhibitor commonly used to treat hypertension, and less commonly to prevent kidney damage that could happen as the result of other issues.

  • Diabetes
  • Renal dysfunction
  • High blood pressure (hypertension)
  • Changes in your voice
  • Cramping or stiffness in your muscles
  • Congestion
  • Dizziness
  • Dry cough
  • Feelings of warmth
  • Having difficulty moving around
  • Having trouble swallowing
  • Hoarseness
  • Joints that are swollen
  • Rash
  • Redness in your upper chest, arms, neck and face areas
  • Swollen, tender glands in your neck
  • Appetite loss
  • Blurry vision
  • Chills or fever
  • Confusion
  • Coughing, runny nose, sore throat, or other cold-like symptoms
  • Diarrhea
  • Feeling unusually tired or weak
  • Faintness, lightheadedness or dizziness upon getting up too suddenly from a sitting or lying down position
  • Having trouble sleeping
  • Headache
  • Nausea or vomiting
  • Pain in your joints
  • Sweating
  • Muscle weakness; and
  • A slow or irregular heartbeat
  • Appetite loss
  • Dark urine
  • Nausea or vomiting that will not stop
  • Yellowing of your skin or eyes
  • Rash
  • Swelling / itching (especially of the throat, tongue, or face)
  • Trouble breathing
  • Antibiotics like trimethoprim
  • Anti-epileptic drugs like pregabalin
  • Antigout medications like allopurinol
  • Antihyperlipidemic combinations like ezetimibe / simvastatin
  • Antihypertensive drugs like aliskiren and azilsartan medoxomil
  • Calcium channel blockers like amlodipine
  • Cardioselective beta blockers like metoprolol
  • Cholesterol-lowering medications like mipomersen
  • Cholinesterase inhibitors like donepezil
  • Nonsteroidal anti-inflammatory drugs like acetaminophen and celecoxib
  • Oral diabetes medicines like glimepiride
  • Other ACE inhibitors like captopril, lisinoprol and memantine
  • Potassium-sparing diuretics like spironolactone and triamterene
  • Skeletal muscle relaxants like tizanidine
  • Statin medications like atorvastatin and rosuvastatin
  • Thiazide diuretics like hydrochlorothiazide
  • Vitamins, minerals, and supplements like Calcium 600 D, Fish Oil, iron dextran, and Vitamins B6 (pyridoxine), B12 (cyanocobalamin), D2 (ergocalciferol) and D3 (cholecalciferol)
  • Congestive heart failure
  • Hemodialysis
  • High potassium
  • Hypotension (low blood pressure)
  • Liver disease
  • Renal impairment or dysfunction
  • Suppression of bone marrow