Monoctanoin (Injection)

This injected medicine is used to dissolve cholesterol gallstones in the gall bladder or bile duct, often after other medications have failed to provide relief.


Monoctanoin is an injectable drug used to remove cholesterol gallstones residing in the bile duct or in the gall bladder. In about one third of all patients treated, the gallstones are dissolved completely, and in another one third of patients the gallstones are reduced in size enough that they can be passed naturally by the body.
To accomplish the dissolution or reduction, a tube or catheter is positioned into the bile duct, so that the monoctanoin solution can come in direct contact with the gallstones, and act on them. It is generally necessary to repeat this treatment for a period lasting between two and ten days, before the gallstones have been sufficiently reduced that they can then be normally passed out by the body. This approach is only used when the gallstones are of such size that the body cannot pass them out through normal processes.

Condition Treated

  • Dissolution of gallstones

Type Of Medicine

  • Solubilizer for gallstones

Side Effects

Along with its beneficial effects of reducing gallstones or dissolving completely, monoctanoin may also may carry some undesirable side effects which it imparts to patients. For the most part however, there are relatively few side effects which are associated with this drug, and they are also relatively mild in severity. While most patients will experience either no side effects at all or very few of them, it is possible that an allergic reaction could cause a very serious problem for anyone being treated with this drug. If you suspect that you are having an allergic reaction to monoctanoin, you should immediately seek emergency medical attention, because there is a possibility that the symptoms may become life-threatening.
The symptoms to look for in an allergic reaction are the following:

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    • Tightness in the chest, often accompanied by extreme difficulty breathing
    • Itchiness all over the body
    • The appearance of hives and/or rashes on skin surfaces
    • Dizziness or lightheadedness, to the point where you feel like you might pass out
    • Swelling or puffiness prominently observed on the eyelids, lips, throat, or tongue.

Some of the most commonly reported side effects experienced by patients being treated with monoctanoin are those listed below:

  • Abdominal pains or cramping
  • Stomach pains or cramping
  • Severe back pain
  • Shortness of breath, even without exertion
  • Persistent nausea and/or vomiting
  • Extreme drowsiness or sensation of weakness
  • Diarrhea
  • Flushing or redness through the facial area
  • Metallic aftertaste left in the mouth
  • Loss of appetite on a temporary basis.


The precise dosage given to any specific patient will vary, based on a number of different factors, including the strength of the medicine itself, the body's tolerance to the medicine, the degree of success achieved by the medication, the frequency of dosage, and the total duration of the program of treatment. While the dosage listed below is not to be considered appropriate dosage for everyone seeking to have gallstones dissolved, it is a fairly standard dosage, and is one that is often recommended by doctors for the purpose of dissolution of gallstones.
When treating both adults and teenagers, a typical dosage of monoctanoin is between three and 5 mL per hour given through a catheter or tube, with a total dosage period extending between two days and 10 days. If this medication is administered to pediatric patients, the precise dosage would have to be calculated by a family doctor, since the application is far less prevalent than in patients of older ages.


When a patient is being administered a dosage of monoctanoin, there is potential for this medication to interact with other medicines that are being taken. It's also possible for this drug to interact with medical conditions that you may already have, and in that case, it could worsen the effects of the condition. In order to avoid these kinds of adverse impacts, patients are advised to prepare a list of all medications currently being used, including over-the-counter drugs, prescription medications, herbal supplements, and vitamins, as well as the dosage levels of each of these.
Your doctor will review this medication list as part of a routine for determining whether or not there is a potential for monoctanoin to interact with any of the other drugs you are taking. If this is deemed likely or even possible, it may be that your doctor will recommend a temporary discontinuance of some other medications, or at least a reduction in the dosage levels, for the duration of your program treatment with monoctanoin.
If you should happen to need to visit some other healthcare clinic or an emergency room for special treatment during the 10-day period that you are being administered monoctanoin, it will be important to have this list with you, so that any doctor at these facilities can make the same determination about potential drug interactions.
For the period that you are being administered monoctanoin, it is advisable that you discontinue any usage of alcohol or tobacco, since these two may have an impact on your body's processing of monoctanoin.
In addition, you should have a review of your complete medical history with your doctor prior to being given monoctanoin, since it may interact with a medical condition you already have. Those medical conditions which are primarily impacted by this medication are as follows:

  • Intestinal problems these can be worsened, and any bleeding associated with them can be exacerbated
  • Duodenal ulcers
  • Pancreatitis' inflammation can be worsened
  • Jaundice or biliary tract problems
  • Bile duct blockage' a potential exists for fairly serious side effects related to an existing blockage
  • Liver disease' if your liver is not functioning properly or is working at a subpar level, some undesirable side effects may occur.


There are a few precautions which should be observed by patients who are being treated with monoctanoin. While these precautions are far fewer than they would be for most medications, there are still some things to be aware of for patients being administered this medication.
First of all, since this is an injectable drug, the injection site may be subject to some kind of reaction to the medication, so this should be carefully monitored during the period of treatment, which generally lasts for several days.
If you have any allergies at all, you should inform your doctor about these, since there is a potential for some of the inactive ingredients in this medicine to trigger your allergies. For instance, you may be allergic to pets, fabrics, food, or preservatives, and any of these should be related to your doctor.
There are no specific precautions which are necessary for pediatric patients, or for geriatric patients, since this medicine carries very few side effects, which means they will not be worsened by the age factor.
Although there are no studies which have been conducted on the impact of monoctanoin with pregnant women, the advisability of being treated with this drug while pregnant is an issue that should be thoroughly discussed with family doctor. The same is true about breast-feeding a nursing infant'no harmful impacts have been reported by patients being treated with monoctanoin, so it is likely that there is no real impact. However, it is still worth discussing with your doctor the rewards versus the risks of breast-feeding while being treated with this medicine.


This medicine will always be delivered to a patient in a clinical or hospital setting, so storage at home will not be an issue that the patient need take into account. Medical personnel will be responsible for proper storage at the healthcare facility, so that it should always be in a usable state and at maximum effectiveness. However, there is a chance that the solution may become discolored, or that it may be observed to have particles suspended in the solution, and in either of these cases, it should not be administered to a patient, but should instead be discarded.


Monactanoin is an injectable drug which is exclusively used for the dissolution of cholesterol gallstones, and it is most commonly recommended as a treatment option after other medications have failed to produce the desired results. In many cases, monoctanoin will completely dissolve the gallstones, and in other cases, it will at least reduce the size of the gallstones so that they can then be naturally passed out by the body.
It is administered to a patient through a tube or catheter, directly into the bile duct where the gallstones commonly reside, and this puts the medicine in direct contact with the gallstones so that they can be operated on. A period of treatment lasting between two and ten days is generally indicated for the medicine to be effective. At the end of this period, there will probably not be any further progress made on the reduction of the gallstones, so there will be no justification for continuance of further treatment.