Moxifloxacin (Ophthalmic)

Moxifloxacin is a topical eye solution used to treat ocular infections caused by bacterial conjunctivitis (pink eye).

Moxifloxacin belongs to the family of medicines called fluoroquinolone antibiotics used for treating ophthalmic (eye) infections.

Overview

Moxifloxacin ophthalmic solution treats eye bacterial infections, helping to stop the growth. The eye drops are administered directly into the eye. Patients taking this medicine need to be careful when administering the drops – the infection is contagious. Be sure to wash your hands and do not allow the dropper to touch your eye during treatment.

This medicine does have side effects and in some cases it should not be used:

  • If you have allergies to fluoroquinolone antibiotics.
  • If you are allergic to any of the ingredients or chemical compounds used in this eye solution.
  • If you have a history of hypersensitivity.
  • Safety and effectiveness of this medicine is not established for infants younger than 4 months.

It may be rare, but quinolone antibiotics like moxifloxacin ophthalmic solution have reportedly caused serious health conditions:

  • Serious to permanent tendon damage
  • Nerve problems
  • Complications affecting the nervous system

Conditions Treated

  • Bacterial Conjunctivitis

Type Of Medicine

  • Antibiotic

Side Effects

All medicines have some level of side effects. The levels vary from person to person depending on age, health and the severity of the condition treated. Your own tolerance to the medicine influences the response and the outcome of treatment. Sometimes, unfortunately, the side effects cause unwanted consequences.

If you have existing disorders treated with other medicines, the effects or the condition itself could worsen. Sometimes our own genetics can prompt the side effects. Before you start treatment with this medicine, talk to the doctor. Share as much information about your family's medical history, current health ailments and daily routines. Each of these life phases has valuable information to help your doctor decide what works best for you.

The following lists are effects known to happen and are categorized as most common, least common, and rare. If you experience any of these effects and they worsen or persist beyond a week, tell your doctor at once. There may be other effects not listed or unknown, be sure to tell the doctor if you experience them.

Most Common

  • Change in vision
  • Dry itching eye
  • Eye discharge
  • Pain in the eye
  • Red eyes
  • Swelling
  • Tearing

Least Common

  • Body pain
  • Congestion
  • Cough
  • Diarrhea
  • Fever
  • Rash
  • Runny nose
  • Trouble with swallowing
  • Vomiting

Rare

  • Fainting
  • Irregular breathing
  • Skin rash

Not all situations need medical attention. When starting a new medicine side effects can occur. If you detect a change, DO NOT stop taking any of your medicines without talking to the doctor first. Your doctor will help to prevent or ease an uncomfortable effect.

Bacterial Attribution

Moxifloxacin ophthalmic solution treats several strains of bacterial conjunctivitis. Your location (geography) and age are responsible for the exact species. These are the most common species treated with this medicine.

  • Acinetobacter
  • Chlamydia trachomatis
  • Corynebacterium
  • Haemophilus
  • Micrococcus
  • Moraxella
  • Pseudomonas
  • Staphylococcus
  • Streptococcus

Health Precautions

Moxifloxacin may increase your sensitivity to natural or artificial sunlight. Depending on the dose and your own intolerance, you may need to avoid exposure to tanning beds or ultraviolet sunrays during treatment. If you are involved in outside activities, make an effort to cover any exposed skin. Consider using a sun protection factor (SFP) of 15 or higher. Talk to the doctor about methods to avoid being sunburned. It can cause serious skin infections. Symptoms could include blistering, peeling of the skin accompanied by a fever.

This medicine can also trigger allergic reactions causing problems with breathing or swallowing. If you experience swelling of your hands, face or mouth – contact your doctor.

Antibiotics are known to cause dizziness in some individuals. For your own safety and others, you should not operate a vehicle, machinery or take part in activities requiring full mental concentration, alertness and coordination skills.

Managing Health Conditions

There are times when the side effects include secondary infections with the presence of existing health conditions. Be sure to tell the doctor about all of the medicines you are taking now. There are medicines that should not be taken at the same time with moxifloxacin. Doing so can alter the effects of this medicine.

Moxifloxacin can cause diarrhea, which may be a sign of a new infection, call your doctor. Do not use anti-diarrhea medicine without instructions from the doctor.

Adverse Effects

There are several ocular incidents associated with conjunctivitis. Less than 10 percent of patients experience these effects. Although these events may not occur with everyone – it's best to talk to the doctor about your own health condition. As a precaution and an attempt to avoid these reactions, do not wear contact lenses during treatment.

  • Decreased visual acuity
  • Discomfort
  • Dry eye
  • Excessive tearing
  • Hyperemia – inflammation or irritation
  • Keratitis – cornea inflammation
  • Pruritus – itching
  • Subconjunctival hemorrhage – red patches on the white areas of the eye

Dosage

Doses of this medicine may differ for each person. The doctor will prescribe the strength and schedule for your condition. Do not use more than instructed by the doctor. Do not share this medicine with someone else, even if they have similar symptoms. It may cause serious effects to their health and vision.

Continue using this medicine for the duration prescribed by the doctor. If you do have unused medicine at the end of the treatment, be sure to discard it. Keeping medicines beyond their purpose or expired dates will change its effectiveness for treating an ocular disorder. This medicine is not prescribed for long-term use.

How to Use Moxifloxacin Eye Drops

Before you begin using this medicine, read the product and label information. The doctor's office will also have the Medication Guide available. Your pharmacist may also have the patient information brochure – it's important that you understand the risk of medicines you take and the benefits.

Always wash your hands before administering the medicine. Tilt your head back, gently pull the lower eyelid away from the eye and insert one drop – DO NOT blink. Do not allow the applicator tip to touch your eye. Close your eye for a couple of minutes, allowing the medicine to make contact with the infection. Cover the applicator with the cap and store the medicine as instructed. Wash your hands to remove any residue from the medicine.

For Bacterial Conjunctivitis

For Moxeza – over 17 strain species

Adult

  • 1 drop in the affected eye, 2 times a day (every 12 hours) for 7 days

Pediatric – 4 months or older

  • 1 drop in the affected eye, 2 times a day (every 12 hours ) for 7 days
  • Doctor may change the solution dose and duration for children
  • Doctor will decide dose for infants younger than 4 months of age

For Vigamox – over 12 strain species

Adult

  • 1 drop in the affected eye, 3 times (every 8 hours) a day for 7 days

Pediatric – 1 year or older

  • 1 drop in the affected, 3 times (3 every 8 hours) a day for 7 days
  • Doctor may change the solution dose and duration for children
  • Doctor will decide dose for children younger than 1 year of age

Missed Dose

If you miss a dose, take it as soon as possible – the only exception – if it is almost time to take the next dose, skip the missed dose and continue with your normal schedule. Contact your doctor about the missed dose. DO NOT double the dose; you could trigger a serious side effect.

Overdose

In any situation when an accidental or unintended overdose occurs or an individual shows signs of breathing difficulties, fainting or collapsing – contact the emergency health center for help at once. If a child is involved in this overdose, contact the pediatric poison information center in your neighborhood for instructions.

Interactions

Most health conditions improve when using multiple medications. In some cases, there are certain medicines that interact with each other causing serious or unpleasant reactions. The interaction can prompt unexpected side effects to existing health conditions. The doctor may adjust the dosage of the medicines to avoid the effects.

Let the doctor know about the medications you are taking, they may share ingredients or chemical compounds known to interact with each other. If you have been taking several drugs for a long time, tell the doctor. It could change how you respond to this medication.

As an antibiotic, moxifloxacin is known to interact with several medications. Some may not be listed here.

  • Acetohexamide
  • Amifampridine
  • Amiodarone
  • Amitriptyline
  • Apomorphine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Benfluorex
  • Bepridil
  • Canagliflozin
  • Chloroquine
  • Chlorpromazine
  • Chlorpropamide
  • Ciprofloxacin
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dapagliflozin
  • Desipramine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Dronedarone
  • Droperidol
  • Ebastine
  • Eribulin
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Gatifloxacin
  • Gliquidone
  • Glyburide
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Insulin
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Levofloxacin
  • Linagliptin
  • Mefloquine
  • Mesoridazine
  • Metformin
  • Methadone
  • Mifepristone
  • Nelfinavir
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Posaconazole
  • Pramlintide
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Risperidone
  • Ritonavir
  • Rosiglitazone
  • Sertindole
  • Sevoflurane
  • Sitagliptin
  • Sodium Phosphate
  • Solifenacin
  • Sparfloxacin
  • Tacrolimus
  • Tamoxifen
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Thioridazine
  • Tizanidine
  • Tolazamide
  • Tolterodine
  • Toremifene
  • Trazodone
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Venlafaxine
  • Vildagliptin
  • Vinflunine
  • Voriconazole
  • Vorinostat
  • Ziprasidone

Other Interactions

Lifestyle choices about alcohol, tobacco, exercise routines and specific foods affect your body's response to medications. You need to learn how to recognize the side effects or changes associated with these conditions when introducing a new medicine.

Warnings

The U.S. Food Drug and Administration routinely post notices on medications and studies. The updated postings are intended to provide information to consumers and medical professionals about the risks and the benefits associated with medicines.

There are varying side effects when taking moxifloxacin that may outweigh the benefits of this medication for some individuals with existing health conditions or severe allergies. If you have questions about the risks and the benefits – talk to your doctor.

Health Warnings

  • Topical ophthalmic use only.
  • Hypersensitivity and anaphylaxis may occur.
  • Patients should not wear contact lenses with symptoms of bacterial conjunctivitis.
  • Prolonged use may develop anti-resistant bacteria.

Studies and clinical observations for specific population segments suggest precautions when using this medication.

Pregnancy

Higher than normal ophthalmic doses were administered to animals – the results included decreased fetal body weight and delayed skeletal development. If you are pregnant or trying to conceive – let your doctor know.

  • Because there are insufficient studies in pregnant women – recommendations include not using this medicine during pregnancy.

Breastfeeding

Precautions are necessary even though moxifloxacin ophthalmic has not been measured in human breast milk.

Pediatric

Safety and effectiveness of this medicine for infants under 4 months of age has not been established.

Geriatrics

No differences in safety and effectiveness have been reported when treating this population segment with a moxifloxacin ophthalmic solution.

Storage

Store this medicine in a closed container at room temperature (between 36 to 77 Fahrenheit), away from heat, moisture and direct light.

  • DO NOT freeze.
  • Keep this medicine out of the reach of children and pets.
  • Do not keep expired or unused medicine. Talk with the doctor or your pharmacist for disposal.

Summary

Moxifloxacin ophthalmic solution has been effective in treating eye infections for adults and adolescents. There are warnings linked to existing health conditions affecting the outcomes. Individuals using this medicine need to talk with their doctor to understand the risks and the benefits associated with this medication. Personal hygiene includes washing your hands before and after when handling this medicine.