Muromonab-cd3 (Intravenous)

As part of a treatment plan for transplant patients, muromonab-cd3 works by suppressing the body's immune system so it does not reject the new organ.


Organ transplants are difficult and complicated procedures, and there are many things that can go wrong before, during, and afterward. One of the many possible complications that can occur is when the immune system attacks the new organ (also referred to as rejecting the organ). For certain types of organ transplants, muromonab-cd3 is medication given to patients around the time of the transplant to stop the immune system from going after it. It suppresses white blood cells in the bloodstream and prevents them from responding with an attack on the new organ.

Conditions Treated

  • Possible rejection of transplanted organs

Type Of Medication

  • Monoclonal antibody

Brand Name or Other Names:

  • Orthoclone OKT3

Side Effects

Like other medications, muromonab-cd3 can have effects other than the ones intended by its manufacturers. Some side effects are more serious and will need medical treatment right away if they occur. If any of these side effects occur, contact your doctor immediately:

  • Blood in stools or urine

Additionally, there may be effects that are delayed for months or years after use of this drug is complete. Some of these effects include skin cancers, lymphoma, and certain other types of cancer. You should talk to your doctor about the potential for these side effects to occur.

There also may be other side effects than the ones listed above. Talk to your doctor about any other effects you notice while you are using this medication.

Dosage Information

The amount of this medicine you actually take will depend on the medication's strength, how many doses you take in a day, the amount of time between doses, and how long you are on the medication. All of these factors will be determined by your doctor. Their determination will also be based on the medical condition you are taking this for, other medical issues you may have, and other medications you are currently taking.

This medication is only to be administered by your doctor or by someone underneath their direct supervision within the confines of a doctor's office, health care clinic, or hospital. It should only be prescribed by a doctor who is familiar with immunosuppressive therapies and how they are supposed to work.

For children twelve or older and adults using this drug to prevent rejection of an organ transplant, you will be given 5 mg intravenously once a day for ten to fourteen days following the transplant procedure.

For children younger than the age of 12, your doctor will determine the exact dose amount based on how much your child weighs and that amount will be given once daily for ten to fourteen days following their transplant procedure.

Types of Interactions:

Although muromonab-cd3 was created to stop the body from rejecting an organ that has been transplanted into it, there are certain drugs, products, and medical conditions that may cause it to work in other ways that may do more harm than good. Sharing information about all of the medications and products you are using, your dietary habits, and your medical history will help your doctor determine whether or not this medication will be beneficial for you, as well as what amount would be best.

Drug Interactions:

The list of drugs and health products that may change or negate the effects of muromonab-cd3 is long. Some of the more common interactions with this medication include:

  • Acne agents like tretinoin topical

This is not a complete list of possible interactions. Discuss your use of these drugs and products with your doctor, along with anything else you are using. There are other interactions which could interfere with the effects this medicine is intended to have.

Food and Drink Interactions:

There are no known food or drink interactions with the use of this medication. You should still discuss your dietary habits with your doctor, however, as these habits do have an effect on your overall health.

Disease Interactions:

Use of muromonab-cd3 to prevent the rejection of a transplanted organ can affect other medical conditions a patient already has, or cause other medical conditions to occur. A list of these conditions includes:

  • Chicken pox

Be sure to discuss your previous medical history with your doctor prior to use of this medication. Knowledge of your history with these conditions (or some of the medications used to treat them) will help them to decide on the best course of treatment for your current medical condition.


Do not use muromonab-cd3 if you are allergic to any of the ingredients in the medication or if you are allergic to products produced with mouse protein, if you have certain levels of antimouse antibody titers, if you have a history of certain heart conditions, fluid overload, are at risk for or have a history of seizures, have a fever of over 100 degrees Fahrenheit, or if you have chicken pox or shingles.

Tell your doctor about any allergies (to medications or otherwise) or unusual reactions you have had to this or other medications. There may be inactive ingredients in this medication that can cause a serious allergic or unusual reaction.

As long as you are being treated with muromonab-cd3, and for a time after you stop receiving this treatment, you should not get any immunizations without approval from your doctor. This medication weakens your body's resistance to illness and infections, and in some cases, there is a chance you may become sick with the illness the vaccine was created to stop. In other cases, your doctor may feel it is especially important to receive the vaccine.

Also while you are being treated with this medication, anyone else living with you in your home should avoid taking the oral polio vaccine because they might pass the virus on to you. Try to avoid anyone you know who has recently received this vaccine. If complete avoidance is not possible, try to not stay in the same room as them for any length of time, and stay as far away from them as possible. If it is not possible to take any of these precautions, wear a protective face mask that covers your mouth and nose.

Because this medication affects your body's ability to fight off illness and infection, avoid anyone who has a cold or infection of some kind. If you feel like you might be coming down with one of these, see your doctor.

Common effects of using this medication include chest pain, dizziness, shortness of breath, a fever or chills, upset stomach and trembling in the first few hours after taking the first dose. The effects should lessen after the second dose, as your body adjusts to the medication. Still, let your doctor or nurse known right away if you start having chest pains, an irregular or rapid heartbeat, wheezing or shortness of breath or if your face or throat start swelling after receiving any dose.

Children being given this medication may be more sensitive to some of the potential side effects that may occur with its use, such as dehydration from the vomiting and diarrhea.

This medication should not be used if you are pregnant, as there is a risk of this medication crossing the placenta and affecting the developing fetus. It also should not be used if you are nursing, due to the risk of excretion into breast milk.

Storage And Disposal Instructions

This medication is only administered by healthcare professionals in a medical office, health clinic, or hospital. Unopened vials of this drug are to be stored in refrigerators there at temperatures between 36 degrees and 46 degrees Fahrenheit. The healthcare professional administering this medication will dispose of unused or expired doses in accordance with the guidelines set forth by the facility they work in.


Organ transplants are often the final treatment option for severe medical conditions. There are many things that can go wrong before, during, and after a transplant procedure, but proper use of muromonab-cd3 (or other immunosuppressant medications) prevents organ rejection from being one of those complications once the procedure is complete.

Proper use of this medication during the organ transplant process depends on a number of factors. One of the most important of these is how much a patient has communicated with their doctor about their medical history, their family's medical history, their daily habits, and the medications they are taking. There are many serious risks involved with the use of this medication, and it is difficult for doctors to accurately assess the risk without this important information. If some of the information they need is deliberately left undisclosed, they may inadvertently put their patient at greater risk by using this medication.

When muromonab-cd3 is administered in the correct manner, with all of the risk factors taken into account, its suppression of the immune system gives a transplanted organ the opportunity it needs to become part of its new body and function the way it was intended to. A successful organ transplant gives patients years longer than they could have expected and the chance at a much greater quality of life then they could have imagined.

Muromonab-cd3 is an immunosuppressant drug given to transplant patients to stop the immune system from attacking the new organ once it has been transplanted.

  • Immunosuppressant
  • Chest tightness
  • Chills and/or fever
  • Confusion
  • Diarrhea
  • Difficult or painful urination
  • Eyes become unusually sensitive to light
  • Face or throat swelling
  • Faintness or dizziness
  • Feeling unusually tired
  • Feeling weak
  • General feelings of illness or discomfort
  • Hallucinations (i.e. hearing, feeling, or seeing things that are not really there)
  • Headache
  • Hoarseness or coughing
  • Irregular/rapid heartbeat
  • Joint or muscle pain
  • Labored or troubled breathing
  • Loss of vision or hearing
  • Nausea and vomiting
  • Neck stiffness
  • Painful or swollen glands
  • Pain in the chest
  • Red pinpoint spots on your skin
  • Shaking or trembling hands
  • Side or lower back pain
  • Signs of unusual bruising or bleeding
  • Skin rash
  • Tarry, black stools
  • Tingling or itching
  • Ulcers, sores, or white spots in your mouth or on your lips
  • Wheezing or shortness of breath
  • Antiviral combinations like elbasvir/grazoprevir and ledipasvir/sofosbuvir
  • Debriding agents like collagenase topical
  • Diuretics like furosemide or hydrochlorothiazide
  • Natural penicillins
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen
  • Nutraceutical products like inositol and ubiquinone
  • Ophthalmic com/health/coma/">glaucoma agents like brinzolamide ophthalmic
  • Topical agents like eflornithine topical, minoxidil topical and zinc oxide topical
  • Topical antibiotics like silver sulfadiazine topical
  • Topical anti-infectives like imiquimod topical
  • Topical steroids like hydrocortisone topical
  • Vaccines for influenza virus, measles virus, mumps and rubella viruses, polio virus, smallpox virus and other viruses
  • Vitamins and supplements like cod liver oil, Super B Complex, and vitamins B12 and D3-50
  • Chest pain (angina)
  • Infections
  • Kidney issues
  • Lung issues
  • Nervous system issues
  • Prior issues with blood clotting
  • Problems with circulation
  • Recent heart attack or other heart issues
  • Seizures (convulsions)
  • Shingles