Nadolol and Bendroflumethiazide (Oral)

High blood pressure, often called hypertension, can lead to more serious problems when it is not managed effectively; nadolol and bendroflumethiazide, when taken in combination, is an effective treatment for this ailment.

Overview

When left untreated, hypertension or high blood pressure can lead to more serious health conditions such as stroke and heart attack. There is also the risk of damage to blood vessels in the brain, serious kidney issues or failure and numerous other heart ailments. Patients who treat their high blood pressure and manage it effectively can prevent the occurrence of such medical conditions.

The prescription drug called nadolol and bendroflumethiazide, when taken in combination, is an effective treatment for this ailment. Nadolol, a beta-blocker, is effective in disrupting the nerve impulses that affect the heart which helps to lower blood pressure via slowing the beating of the heart.

This sequence of actions also helps to increase the amount of both blood and oxygen that are transported to the heart. This action, when combined with the diuretic bendroflumethiazide, also reduces water retention and increases urine flow, two factors that also aid the lowering of the patient's blood pressure.

The combination of nadolol and bendroflumethiazide has been reported to cause overdoses in some situations. Patients and their caregivers should review the signs of overdose with the prescribing physician and familiarize themselves with the proper course of action should they occur.

Nadolol and bendroflumethiazide combination comes in one dosage delivery method:

  • Tablet

Conditions Treated Hypertension

Type Of Medicine

  • Thiazide
  • Diuretic
  • Beta-Adrenergic Blocker, Nonselective

Side Effects

This medication can cause unwanted side effects in addition to delivering the desired results. There are certain side effects that may be a sign of a more serious issue and others that will typically dissipate on their own. Anytime a symptom lingers for a period of time greater than a few days or becomes worse, the prescribing physician should be informed. Patients are encouraged to understand the different types of signs and symptoms and to recognize those that require additional medical attention.

Patients who experience any of the following symptoms and side effects should notify their doctors right away as they may be a sign of a more serious problem:

Less likely:

  • Blurred vision
  • Unusual tiredness or weakness
  • Chest pain or discomfort
  • Tightness in the chest
  • Coughing
  • Sweating
  • Dilated neck veins
  • Slow or irregular heartbeat
  • Extreme fatigue
  • Paleness or cold feeling in fingertips and toes
  • Lightheadedness, dizziness, or fainting
  • Noisy breathing
  • Wheezing
  • Shortness of breath
  • Irregular breathing
  • Slurred speech
  • Dizziness, faintness, or lightheadedness
  • Swelling of face or extremities
  • Difficulty breathing
  • Tingling or pain in fingers or toes
  • Confusion
  • Weight gain
  • Burning, crawling, or tingling feelings

An unknown incidence of occurrence:

  • Back or leg pains
  • Upper right abdominal pain
  • Bleeding gums
  • Unexplained bleeding or bruising
  • Blood in urine or stools
  • Troubled breathing
  • Clay-colored stools
  • Tenderness of salivary glands
  • Cold sweats
  • Sugar in the urine
  • Coughing up blood
  • Sores, welting or blisters
  • Difficulty swallowing
  • Sore throats
  • Dry mouth
  • Restlessness
  • Fever
  • Rash
  • Fruit-like breath odor
  • Puffiness or swelling of the eyelids
  • A general feeling of discomfort or illness
  • Pale skin
  • Headaches
  • Painful or difficult urination
  • Hoarseness
  • Nosebleeds
  • Increased thirst
  • Muscle tremors
  • Indigestion
  • Loss of appetite
  • Light-colored stools
  • Yellow eyes or skin
  • Lower back or side pain
  • Joint pain, stiffness, or swelling
  • Nausea and vomiting
  • Increased urination
  • Pain in muscles
  • Increased hunger
  • Pains in stomach, side, or abdomen
  • Hives
  • Pinpoint red spots on the skin
  • General tiredness and weakness
  • Rapid, deep breathing
  • General body swelling
  • Redness, soreness, or itching skin
  • Flushed, dry skin
  • Skin rash
  • Fast heartbeat
  • Sores, ulcers, or white spots on the lips
  • Drowsiness
  • Stomach cramps
  • Dark urine
  • Swollen or painful glands
  • Constipation
  • Thickening of bronchial secretions
  • Cloudy urine
  • Unpleasant breath odor
  • Chills
  • Unexplained weight loss
  • Bloating
  • Vomiting of blood
  • Black, tarry stools

Symptoms of overdose that require immediate emergency medical attention:

  • Change in consciousness
  • Low blood pressure
  • Unusual paleness
  • Diarrhea
  • Trembling
  • Gas
  • Seizures
  • Increase in heart rate
  • Numbness, tingling, pain, or weakness in the extremities
  • Indigestion
  • Wrinkled skin
  • Muscle cramps
  • Loss of consciousness
  • Pale or blue lips, fingernails, or skin
  • Increased sweating
  • Sunken eyes
  • Heartburn
  • Unusual drowsiness, dullness, or feeling of sluggishness
  • Fast, slow, or shallow breathing
  • Weakness and heaviness of legs
  • Decreased urination

As your body adjusts to the new medication it may take a day or two for it to regulate. During this time you may experience some side effects that will dissipate on their own and do not require additional medical attention. Patients should notify their doctors if they experience any side effects that last for more than a few days or become worse with time:

Less likely:

  • Change in behavior
  • Stomach soreness or discomfort
  • Decreased interest in sexual intercourse
  • Inability to feel relaxed and calm
  • Excess air or gas in stomach or intestines
  • Inability to have or keep an erection
  • Hearing loss
  • Unexplained weight loss
  • The loss of sexual ability, desire, drive, or performance
  • Hair loss, thinning of hair
  • Excessive sleepiness
  • Dry eyes or skin
  • A stuffy nose
  • Continuing ringing or buzzing in the ears

An unknown incidence of occurrence:

  • Cracks in the skin
  • Scaly skin
  • Feeling of constant movement of self
  • Loss of heat from the body
  • Large, flat, blue or purplish patches in the skin
  • Severe sunburn
  • Muscle spasm, weakness, or restlessness
  • Increased sensitivity of skin to sunlight
  • A sensation of spinning
  • Discoloration of the skin

While this list aims to be all-encompassing, it is possible that a patient may experience side effects that are not listed here. Patients are encouraged to confer with the prescribing physician should they experience any significant reactions or side effects.

Dosage

Patients who suffer from high blood pressure will also be counselled on effective lifestyle habits that can help to keep their hypertension under control. Your doctor will likely recommend changes to your diet and encourage any overweight patient to lower their caloric intake. A low-sodium diet may also be encouraged. It is important that your family and caregivers understand the importance of these changes and are supportive. Regular exercise and increased activity levels are also a part of the changes necessary for effective hypertension management.

Hypertension can often be an unknown issue as it is a medical condition that can take some time to show symptoms. Even if you feel well and do not think that you have any health concerns, it is important to take hypertension medicine as directed and to continue taking it until your doctor advises differently.

While taking this medication your doctor will likely want to perform certain diagnostic tests such as blood and urine screenings. It is important for patients to keep all follow-up appointments and undergo all testing as scheduled.

There is no cure for hypertension, but the proactive management of the condition can keep it from worsening. Do not change the way that you take this medication without first discussing your prescription with your doctor. If hypertension is left untreated the condition can worsen and even cause other ailments such as blood vessel issues, heart failure, kidney disease, and stroke.

The dosage guidelines that are outlined below reflect the typical way in which this medication combination is prescribed, however, if your doctor has given you different instructions, those must be followed. Do not alter, in any way, the process that you take this medication without first discussing any changes with your doctor.

Patients should not try to stop taking this drug on their own as that can lead to complications. Your doctor will work with you to decrease the dosage over time in order to prevent any negative reactions when you conclude your course of treatment.

Typical dosage amount:

One tablet is taken one time per day. As your body adjusts to this medication, your doctor may alter the dosage amount for greater effectiveness.

This is not a medication that is typically prescribed for use in children; in such cases, the doctor will determine the dosage level on a case by case basis.

Patients who inadvertently miss a dose of their medication should take it as soon as possible. If it is close in time to the next scheduled dosage, it is best to skip it entirely. For further guidance on what to do when a dosage is missed, contact your pharmacist for advice. Do not ever take a double dosage of this medication to make up for one that is skipped.

Major Drug Interactions

Many drugs cannot be taken together due to the reaction that can occur. Patients are advised to inform their doctors of all prescription and non-prescription drugs that they are taking as well as any herbal remedies and vitamin and mineral supplements. If a medication that you are currently contraindicated for use with nadolol and bendroflumethiazide your doctor may alter the medication. Certain combinations of drugs may increase the risk of experiencing unwanted side effects and in such cases, your doctor may alter the way that you take one or both of the medications.

The use of the drugs included in this list are not usually taken concurrently with nadolol and bendroflumethiazide. Your doctor may change one of the drugs that you are taking or find an alternative option to nadolol and bendroflumethiazide. Patients who are taking one or more of this drugs are advised to inform their doctors:

  • Aceclofenac
  • Tolmetin
  • Acetyldigoxin
  • Tiaprofenic Acid
  • Arsenic Trioxide
  • Sulindac
  • Bepridil
  • Sodium Salicylate
  • Bufexamac
  • Salicylic Acid
  • Choline Salicylate
  • Rivastigmine
  • Clonixin
  • Propyphenazone
  • Deslanoside
  • Piroxicam
  • Dexketoprofen
  • Phenylbutazone
  • Diflunisal
  • Oxyphenbutazone
  • Digitoxin
  • Oxaprozin
  • Diltiazem
  • Nimesulide
  • Dofetilide
  • Nepafenac
  • Droperidol
  • Nabumetone
  • Epinephrine
  • Metildigoxin
  • Etofenamate
  • Mefenamic Acid
  • Felbinac
  • Lumiracoxib
  • Fenoprofen
  • Indomethacin
  • Lornoxicam
  • Feprazone
  • Lidocaine
  • Flecainide
  • Lacosamide
  • Flufenamic Acid
  • Ketoprofen
  • Ibuprofen
  • Morniflumate
  • Ketorolac
  • Flurbiprofen
  • Levomethadyl
  • Floctafenine
  • Lithium
  • Fingolimod
  • Loxoprofen
  • Fepradinol
  • Meclofenamate
  • Fenoldopam
  • Meloxicam
  • Etoricoxib
  • Ketanserin
  • Etodolac
  • Naproxen
  • Droxicam
  • Niflumic Acid
  • Dronedarone
  • Nimesulide Beta-Cyclodextrin
  • Dipyrone
  • Oxymetazoline
  • Digoxin
  • Parecoxib
  • Digitalis
  • Piketoprofen
  • Diclofenac
  • Proglumetacin
  • Dexibuprofen
  • Proquazone
  • Crizotinib
  • Rofecoxib
  • Clonidine
  • Salsalate
  • Celecoxib
  • Sotalol
  • Bromfenac
  • Tenoxicam
  • Aspirin
  • Tolfenamic Acid
  • Amtolmetin Guacil
  • Valdecoxib
  • Acemetacin
  • Verapamil

This next list of medications may increase the risk of the occurrence of unwanted side effects when taken with nadolol and bendroflumethiazide. In such instances, your doctor may alter the way in which one or both of the medications are taken:

  • Acarbose
  • Urapidil
  • Acemetacin
  • Tolmetin
  • Albiglutide
  • Tolbutamide
  • Alogliptin
  • Tviaprofenic Acid
  • Amtolmetin Guacil
  • Tenoxicam
  • Aspirin
  • Sulindac
  • Bufexamac
  • Sodium Salicylate
  • Canagliflozin
  • Saxagliptin
  • Chlorpropamide
  • Salicylic Acid
  • Clonixin
  • Rofecoxib
  • Deslanoside
  • Proquazone
  • Dexketoprofen
  • Proglumetacin
  • Diflunisal
  • Pranoprofen
  • Digoxin
  • Piroxicam
  • Doxazosin
  • Piketoprofen
  • Dulaglutide
  • Phentolamine
  • Etodolac
  • Phenelzine
  • Etoricoxib
  • Oxyphenbutazone
  • Felbinac
  • Nimesulide Beta-Cyclodextrin
  • Fepradinol
  • Niflumic Acid
  • Floctafenine
  • Nateglinide
  • Flurbiprofen
  • Nabumetone
  • Glimepiride
  • Morniflumate
  • Glyburide
  • Miglitol
  • Mibefradil
  • Ibuprofen
  • Metformin
  • Insulin Aspart, Recombinant
  • Mefenamic Acid
  • Insulin Detemir
  • Lumiracoxib
  • Insulin Glulisine
  • Lornoxicam
  • Insulin Human Isophane (NPH)
  • Liraglutide
  • Insulin Lispro, Recombinant
  • Licorice
  • Ketorolac
  • Metildigoxin
  • Linagliptin
  • Ketoprofen
  • Lixisenatide
  • Insulin Human Regular
  • Loxoprofen
  • Insulin Human Inhaled
  • Meclofenamate
  • Insulin Glargine, Recombinant
  • Meloxicam
  • Insulin Degludec
  • Mefenamic Acid
  • Indomethacin
  • Gossypol
  • Moxisylyte
  • Glipizide
  • Naproxen
  • Ginkgo
  • Nepafenac
  • Flufenamic Acid
  • Nimesulide
  • Feprazone
  • Oxaprozin
  • Fenoprofen
  • Parecoxib
  • Exenatide
  • Phenoxybenzamine
  • Etofenamate
  • Phenylbutazone
  • Empagliflozin
  • Pioglitazone
  • Droxicam
  • Pramlintide
  • Dipyrone
  • Prazosin
  • Digitoxin
  • Propyphenazone
  • Diclofenac
  • Repaglinide
  • Dexibuprofen
  • Rosiglitazone
  • Dapagliflozin
  • Salsalate
  • Choline Salicylate
  • Sitagliptin
  • Celecoxib
  • St John's Wort
  • Bunazosin
  • Tamsulosin
  • Bromfenac
  • Terazosin
  • Arbutamine
  • Tolazamide
  • Amiodarone
  • Tolfenamic Acid
  • Alfuzosin
  • Trimazosin
  • Acetyldigoxin
  • Valdecoxib
  • Aceclofenac
  • Vildagliptin

Patients may find that taking this medication with food is beneficial to how their body reacts; they may also find that taking the medication on an empty stomach works better for them. It is up to the preference of the patient as either approach is acceptable and neither will interfere with the effectiveness of the medication.

Inform your doctor of any lifestyle habits that you have that may affect the way that this medication interacts with your system. If you use any tobacco products or regularly drink alcohol be sure to inform your doctor prior to starting your course of treatment. Your doctor may address some changes that they would like you to make to better manage your high blood pressure.

Patients are reminded to enlist the help and support of their families and caregivers in order to make the necessary changes to their diets and lifestyles to successfully manage their high blood pressure.

Avoid taking the following as it can cause a negative interaction when taking this medication:

  • Green Tea

Patients who also suffer from any of the following medical conditions may experience negative reactions due to this drug and their doctor may find an alternative option for them:

  • Angina
  • Hyponatremia
  • Liver disease
  • Asthma
  • Hypoglycemia
  • Heart block
  • Diabetes
  • Blood vessel disease
  • Parathyroid disease
  • Hyperuricemia
  • Sympathectomy
  • Hypokalemia
  • Anuria
  • Hypomagnesemia
  • Lung disease
  • Hypochloremia
  • Systemic lupus erythematosus
  • Gout
  • Hyperthyroidism
  • Heart failure
  • Kidney disease
  • Bradycardia

Warnings

Your doctor will likely order regular diagnostic tests, such as blood and urine screenings, in order to monitor how effective the medication is as well as to monitor any side effects or other medical conditions. It is important that patients keep all follow-up appointments and undergo all testing as scheduled.

Patients and their caregivers must familiarize themselves with the symptoms and what action to take should they occur. If you experience any of the side effects or symptoms listed below seek immediate emergency medical care:

  • Chest pain or discomfort
  • An irregular heartbeat
  • Swelling of the face or extremities
  • Extreme fatigue
  • Wheezing
  • Shortness of breath
  • Irregular breathing
  • Weight gain
  • Dilated neck veins

Taking this medication can have an effect on the blood sugar level of the patient. The medication may also mask certain signs and symptoms of low blood sugar. Once such symptom, a rapid rate of the pulse, can be a sign that further medical attention is needed. Due to the possibility of symptoms going undetected, it is very important that patients undergo all diagnostic tests that are ordered by their doctor.

Inform all of your doctors, dentists, and eye doctors that you are taking this medication. In certain instances, you may be required to cease your course of treatment temporarily, for example, if you are to undergo surgery or have certain medical tests.

This medication has been reported to cause overdoses in certain circumstances and patients and their caregivers must familiarize themselves with the signs and symptoms of overdose and seek emergency medical treatment immediately.

Symptoms of overdose that require immediate emergency medical attention:

  • Change in consciousness
  • Low blood pressure
  • Unusual paleness
  • Diarrhea
  • Trembling
  • Gas
  • Seizures
  • Increase in heart rate
  • Numbness, tingling, pain, or weakness in the extremities
  • Indigestion
  • Wrinkled skin
  • Muscle cramps
  • Loss of consciousness
  • Pale or blue lips, fingernails, or skin
  • Increased sweating
  • Sunken eyes
  • Heartburn
  • Unusual drowsiness, dullness, or feeling of sluggishness
  • Fast, slow, or shallow breathing
  • Weakness and heaviness of legs
  • Decreased urination

Patients should inform their doctors of all of their allergies as these may affect the way that their system reacts to the medication. Include allergies to other medications, foods, animals, cleaning solutions, and other substances. Your doctor must also be aware of all medications that you are currently taking, including both prescription and non-prescriptions drugs, herbal remedies, and vitamin and mineral supplements.

Storage

It is always best practice to store all medications in the original packaging. Keep the container in a low-moisture environment and away from direct light; avoid extreme heat or cold. Do not let the nadolol and bendroflumethiazide freeze.

Store this medication and all others in a place that is inaccessible to small children and pets.

Dispose of any unused, excess or expired medication at the conclusion of your course of treatment. Confer with your pharmacist or the prescribing physician if you are unsure of the safe and appropriate manner of disposal for this particular medication.

Summary

When left untreated, hypertension or high blood pressure can lead to more serious health conditions such as stroke and heart attack. There is also the risk of damage to blood vessels in the brain, serious kidney issues or failure, and numerous heart ailments.

Patients who treat their high blood pressure and manage it effectively can prevent the occurrence of such medical conditions. The prescription drug called nadolol and bendroflumethiazide, when taken in combination, is an effective treatment for this ailment. Nadolol, a beta-blocker is effective in disrupting the nerve impulses that affect the heart which helps to lower blood pressure via slowing the beating of the heart.

This sequence of events also helps to increase the amount of both blood and oxygen that are transported to the heart. This action, when combined with the diuretic bendroflumethiazide, also reduces water retention and increases urine flow, two factors that also aid the lowering of the patient's blood pressure.

There is no cure for hypertension, but the proactive management of the condition can keep it from worsening. Do not change the way that you take this medication without first discussing your prescription with your doctor. If hypertension is left untreated the condition can worsen and even cause other ailments such as blood vessel issues, heart failure, kidney disease, and stroke.

This medication can cause heart failure and patients and their caregivers must familiarize themselves with the signs and symptoms of heart failure and know what action to take should they occur.