Nebivolol and Valsartan (Oral)

 

Nebivolol and valsartan are two medications taken together to lower blood pressure in patients with high blood pressure.

Overview

Nebivolol and valsartan are two medications used in combination to lower blood pressure in patients who suffer from high blood pressure, or hypertension.

High blood pressure can cause physical damage to the blood vessels throughout the body, including those in the brain, heart, or kidneys. For people who have high blood pressure for a long time, the blood vessels and heart stop functioning correctly and result in this damage. The damage caused by long-term high blood pressure can increase a patient's risk of kidney failure, heart failure, and stroke.

High blood pressure is a medical condition that is common in the United States. High blood pressure increases the likelihood of heart attacks and other cardiovascular issues. Properly treating hypertension by reducing blood pressure will reduce the risks of heart failure, stroke, and kidney failure, by stopping the damage to the blood vessels.

Nebivolol is a beta-blocker. It alters the response of some areas of the body to nerve impulses. This causes the patient's heart to beat slower, which lowers blood pressure and improves the heart's supply of oxygen and blood.

Valsartan is an angiotensin II receptor antagonist. It works by preventing blood vessels from narrowing, or tightening. This improves blood flow, lowers blood pressure, and improves the flow of blood and oxygen to the heart.

Nebivolol and valsartan therefore work together to lower the body's blood pressure and improve the heart health of the patient.

Nebivolol and valsartan are only available with a prescription from your doctor.

Nebivolol should not be used by pregnant women. If you suspect you might be pregnant, stop taking nebivolol immediately and talk to your doctor. Valsartan can be fatal to the fetus if it is taken during your second or third trimesters.

Many medications can have negative interactions with nebivolol and valsartan. Tell your doctor about all the medications that you are taking, including over the counter medications, vitamins, and supplements. Do not begin taking new medications without talking to your doctor or pharmacist about it first.

Some medical conditions may make it dangerous for you to take nebivolol and valsartan, or can make it more likely that you will experience side effects. Talk to your doctor about your medical history before you begin taking nebivolol and valsartan.

It can cause dangerous imbalances in your body's electrolytes if you become seriously dehydrated while taking nebivolol and valsartan. Make sure you take steps to stay hydrated while you are taking nebivolol and valsartan, especially if you are sweating a lot. If you become sick with diarrhea and/or vomiting while you are taking nebivolol and valsartan, talk to your doctor right away. This can cause you to become dehydrated.

Do not stop taking nebivolol and valsartan without talking to your doctor first. It can be dangerous to abruptly stop your normal dosage of nebivolol and valsartan, as your blood pressure may suddenly rise. Your doctor will help you to gradually decrease your dosage so your body adjusts safely to the changes.

Condition Treated

  • Hypertension (High blood pressure)

Type Of Medicine

  • Beta-blocker
  • Angiotensin II Receptor Blocker

Side Effects

All medications come with the risk of causing negative side effects as well as the effects that they are intended to produce. Talk to your doctor or medical professional if any of the side effects that you experience are causing problems for you, or if you have any questions about them. Your physician may be able to help you prevent or lessen some of the side effects that you are experiencing.

If you experience any of the following side effects, tell your doctor about them immediately:

  • Blurring of your sight
  • Chest tightness
  • Difficulty breathing
  • Dilation of your neck veins
  • Feeling confused
  • Feeling nervous
  • Irregular heartbeat
  • Irregularity of your breathing
  • Gaining weight
  • Heavy or weak feeling in your legs
  • Lightheadedness, faintness, or dizziness when rising from being seated or lying down
  • Nausea
  • Pain in your chest
  • Pain in your stomach or abdomen
  • Powerful fatigue
  • Swollen lower legs, fingers, feet, or face
  • Tingling or numb sensation in your feet, hands, or lips
  • Unusual sweating
  • Urinating less
  • Vomiting

Most people will not experience all of these side effects. After you have been taking nebivolol and valsartan regularly, your side effects should ease. If your side effects continue after taking nebivolol and valsartan consistently, or if they get worse, talk to your doctor.

It is also possible that you may experience other side effects that have not been listed here. Check in with your doctor if you experience any other side effects. Your doctor will determine if the effects are normal or are possibly an indication that the medication is not functioning properly. You can also talk to your doctor if any of the side effects that you are experiencing are causing problems for you.

You may also report any side effects that you experience to the FDA at 800-FDA-1080.

Dosage

Your doctor will prescribe you an individual dosage based upon factors like your weight and the severity of your high blood pressure. Do not change your dosage for any reason unless your doctor has instructed you to do so. Increasing your dose will not increase the positive effects of the medication.

A typical dose of nebivolol and valsartan is one tablet taken by mouth each day. Nebivolol and valsartan tablets may be taken either with or without food.

After two to four weeks, you should reach the maximum benefit of nebivolol and valsartan on your high blood pressure. Continue taking nebivolol and valsartan until your doctor instructs you to stop taking it.

Do not stop taking nebivolol and valsartan suddenly. Talk to your doctor before you stop taking it. Suddenly stopping your normal dosage may cause a dangerous increase in your blood pressure. Your doctor will tell you how you can safely wean off of nebivolol and valsartan to prevent this from happening.

Interactions

In some instances, taking more than one medication at the same time can make one or both of them less effective or increase your risk of side effects. Make sure you talk to your doctor or pharmacist about any medications you are taking before you start taking nebivolol and valsartan to make sure there will not be any interactions. Do not begin taking any new supplements, vitamins, over the counter medicines, or prescription medicines unless you discuss it with your doctor first.

Taking nebivolol and valsartan with any of the following medications is not recommended. Your doctor may have you stop taking one of these medicines, or find a different medication for you to take instead.

  • Aliskiren

Taking nebivolol and valsartan with any of the medications listed below is generally not recommended. Your physician may decide that you need to take both medicines. They may have you take one or both of the medications in a different way to stop interactions from occurring.

  • Moexipril
  • Fluoxetine
  • Quinapril
  • Simeprevir
  • Enalapril
  • Rivastigmine
  • Bupropion
  • Ramipril
  • Cinacalcet
  • Doxepin
  • Sertraline
  • Quinidine
  • Terbinafine
  • Fenoldopam
  • Duloxetine
  • Moclobemide
  • Lithium
  • Dronedarone
  • Lisinopril
  • Panobinostat
  • Crizotinib
  • Lacosamide
  • Quinine
  • Captopril
  • Benazepril
  • Trimethoprim
  • Verapamil
  • Diltiazem
  • Enalaprilat
  • Trandolapril
  • Paroxetine
  • Fosinopril
  • Fingolimod
  • Perindopril
  • Clonidine
  • Rolapitant

Taking nebivolol and valsartan with any of the following medications may increase the risk or severity of some side effects. Despite this, your doctor might still decide that you should take both medications. Your doctor may have you take one or both medications in a different way, or have you take a different dosage.

  • Deslanoside
  • Acetyldigoxin
  • Arbutamine
  • Sitagliptin
  • Tolfenamic Acid
  • Acarbose
  • Acemetacin
  • Aceclofenac
  • Mefenamic Acid
  • Meloxicam
  • Alfuzosin
  • Dapagliflozin
  • Bunazosin
  • Empagliflozin
  • Miglitol
  • Pramlintide
  • Bromfenac
  • Clonixin
  • Cimetidine
  • Pranoprofen
  • Indomethacin
  • Amiodarone
  • Choline Salicylate
  • Linagliptin
  • Diflunisal
  • Chlorpropamide
  • Alogliptin
  • Loxoprofen
  • Dexibuprofen
  • Oxyphenbutazone
  • Bufexamac
  • Albiglutide
  • Valdecoxib
  • Amtolmetin Guacil
  • Metildigoxin
  • Nimesulide
  • Urapidil
  • Celecoxib
  • Aspirin
  • Niflumic Acid
  • Canagliflozin
  • Saxagliptin
  • Tenoxicam
  • Ketorolac
  • Tolazamide
  • Insulin Human Regular
  • Nabumetone
  • Insulin Human Inhaled
  • St John's Wort
  • Insulin Detemir
  • Prazosin
  • Flurbiprofen
  • Repaglinide
  • Etofenamate
  • Tamsulosin
  • Dulaglutide
  • Lixisenatide
  • Liraglutide
  • Glyburide
  • Proglumetacin
  • Insulin Aspart, Recombinant
  • Piroxicam
  • Piketoprofen
  • Dipyrone
  • Salsalate
  • Dexketoprofen
  • Sulindac
  • Nepafenac
  • Metformin
  • Mibefradil
  • Moxisylyte
  • Nimesulide Beta Cyclodextrin
  • Naproxen
  • Droxicam
  • Terazosin
  • Vildagliptin
  • Tolbutamide
  • Salicylic Acid
  • Propyphenazone
  • Fenoprofen
  • Exenatide
  • Rofecoxib
  • Felbinac
  • Insulin Degludec
  • Insulin Glulisine
  • Tiaprofenic Acid
  • Rosiglitazone
  • Sodium Salicylate
  • Parecoxib
  • Digitoxin
  • Morniflumate
  • Glipizide
  • Doxazosin
  • Glimepiride
  • Propionic Acid
  • Flufenamic Acid
  • Tolmetin
  • Fepradinol
  • Phenoxybenzamine
  • Trimazosin
  • Insulin Glargine, Recombinant
  • Lumiracoxib
  • Feprazone
  • Meclofenamate
  • Digoxin
  • Ibuprofen
  • Phentolamine
  • Insulin Lispro, Recombinant
  • Etodolac
  • Lornoxicam
  • Diclofenac
  • Oxaprozin
  • Pioglitazone
  • Etoricoxib
  • Sildenafil
  • Nateglinide
  • Insulin Human Isophane (NPH)
  • Proquazone
  • Ketoprofen
  • Floctafenine
  • Phenylbutazone

It is possible that nebivolol and valsartan may interact with other drugs that are not listed here. Because of this risk, you must tell your doctor about all medications that you are taking.

Some foods may interact with certain medications. Your doctor or pharmacist will tell you if there are certain foods that you should avoid, or if you need to maintain a special diet of any kind while taking nebivolol and valsartan.

Some medications my interact with alcohol or tobacco. If you use alcohol or tobacco, talk to your doctor about your usage. Your doctor or pharmacist will tell you if you need to alter your use of tobacco or alcohol in order to ensure the optimal functioning of nebivolol and valsartan.

Warnings

Do not take nebivolol and valsartan in any way except the way your doctor or pharmacist has instructed you to take them. If you do not understand how you are supposed to be taking nebivolol and valsartan, talk to your doctor or medical professional before taking them. Do not share your prescription with others.

Before you take nebivolol and valsartan, make sure you have told your doctor about all of your allergies. It is possible that nebivolol and valsartan may contain inactive ingredients that you are allergic to.

Make sure that your doctor knows about your medical history. Tell your doctor about all the medical conditions that you know you have. Other medical conditions may affect the way your body reacts to nebivolol and valsartan. Make sure your doctor knows if you have any of the following conditions.

  • Adrenal gland tumor
  • Coronary artery disease
  • Dehydration
  • Hyperthyroidism
  • Kidney disease
  • Liver disease
  • Low blood levels of potassium
  • Low blood pressure
  • Low blood sugar
  • Lung diseases
  • Other heart conditions like a slow heartbeat or cardiogenic shock
  • Peripheral vascular disease
  • You are on a low-salt diet

If you have diabetes, you should not take nebivolol and valsartan together with certain medications that treat diabetes. Talk to your doctor or pharmacist to make sure your medications are safe to take with nebivolol and valsartan.

Certain medical conditions may prevent you from taking nebivolol and valsartan. If you have any of the following conditions, do not take nebivolol and valsartan.

  • A history of heartbeats slow enough to have caused you to faint
  • Heart block or AV block—second or third degree
  • Heart failure serious enough that you needed to be hospitalized
  • Sever liver disease
  • Sick sinus syndrome (without a pacemaker)

Nebivolol and valsartan have not established to be safe for use by children. Children should not use nebivolol and valsartan without serious consideration of the possible risks they may pose.

It is not known whether nebivolol and valsartan are safe for use by breastfeeding women. Nebivolol and valsartan may pass into the breastmilk of breastfeeding mothers. If you are breastfeeding, talk to your doctor about the potential risks. He or she may instruct you to stop breastfeeding when you begin taking nebivolol and valsartan, to prevent the possibility of harm to your baby through your breastmilk.

Do not use nebivolol and valsartan if you are pregnant. Take effective steps to prevent pregnancy while you are taking nebivolol and valsartan. If you think you may have become pregnant, stop taking nebivolol and valsartan immediately and talk to your doctor right away. Taking nebivolol and valsartan while you are pregnant can cause serious injury or death to the fetus.

Your doctor should perform regular checkups while you are taking nebivolol and valsartan to make sure that they are working the way they should. These checkups may require blood tests.

Nebivolol and valsartan can cause you to become dizzy or lightheaded. Do not drive or operate machinery until you know how nebivolol and valsartan will affect you and you know that you will be able to do so safely.

Make sure you drink plenty of water while you are taking nebivolol and valsartan in order to prevent dehydration. If you are exercising, especially in hot weather, take extra steps to ensure that you stay hydrated. If you are sick and are vomiting or have diarrhea, call your doctor right away. Dehydration can be dangerous.

Do not stop taking nebivolol and valsartan unless your doctor tells you to do so. Stopping this medication suddenly may cause a dangerous increase of your blood pressure. Your doctor will help you to safely wean off nebivolol and valsartan when you decide to stop taking them.

Do not take any supplements containing potassium while you are taking nebivolol and valsartan. Nebivolol and valsartan can cause a condition called hyperkalemia, which is a high level of potassium in your blood. Talk to your doctor immediately if you experience any of the following signs of hyperkalemia: confusion, difficulty breathing, tingling sensation or numbness in the lips, feet, or hands, nausea, vomiting, shortness of breath, stomach or abdominal pain, feeling nervous, heavy or weak feeling in your legs.

Storage

Nebivolol and valsartan should be kept at room temperature (between 20C and 25C or 68 and 77F). Keep in a tightly sealed container. Keep all medications out of the reach of children and animals.

Do not used expired medications. Do not dispose of medications by flushing them down the toilet, pouring them in the sink, or putting them in the garbage. Ask your pharmacist how you should safely and appropriately dispose of unused medications.

Summary

Nebivolol and valsartan are two medications that are used in combination to treat high blood pressure. High blood pressure (hypertension) can cause dangerous damage to the body's blood vessels, resulting in an increased risk of heart failure, kidney failure, and stroke. By properly treating hypertension, you can reduce your blood pressure and your risk of the serious health implications it carries.

Nebivolol is a beta-blocker, which has the effect of slowing your heartbeat. By slowing the rate at which your heart beats, nebivolol lowers your blood pressure and increases the amount of blood and oxygen in the heart.

Valsartan is an angiotensin II receptor antagonist, which helps to keep the blood vessels from narrowing. This lowers blood pressure as well as increasing the amount of blood and oxygen in the heart.

Together, these medications can significantly lower blood pressure in patients with hypertension and reduce the risk of dangerous cardiovascular events.

Make sure you understand all the instructions you received about how to store and take nebivolol and valsartan. If you did not understand any of the instructions, ask your doctor or pharmacist for clarification before you begin taking nebivolol and valsartan.