Nedocromil (Inhalation)

Overview

As well as a form of treatment to prevent asthma attacks, Nedocromil is additionally used before exposure to specific substances or conditions. This could include airborne allergens, cold air, pollutants or even chemicals. Nedocromil acts to prevent or reduce a bronchospasm reaction, such as difficulty breathing and wheezing.

Despite Nedocromil being a preventative medication for use with asthma, it will not prevent or help a patient who is already undergoing a bronchospasm or asthma attack. This drug only works to prevent this condition from happening before symptoms beginning.

This medication can be taken as a sole treatment for asthma or may also be used as part of a series of treatment for this condition. This medicine may be used alongside medications such as steroids, which are cortisone-like drugs or bronchodilators, which can be used to help open up breathing passages that are narrowed.

Nedocromil functions by working on specific inflammatory cells within the lungs, which prevents them from releasing substances related to the cause of bronchospasm and other asthmatic symptoms. This medicine is solely available through a doctor's subscription.

Nedocromil-based inhalation medicines were removed from the US market by King Pharmaceuticals on the 30th of April, 2008.

Conditions Treated

  • Asthma

Type Of Medicine

  • Aerosol powder

Side Effects

Nedocromil has several necessary effects that allow the medication to prevent asthma attacks and bronchospasm. In addition to these effects, this medication may result in additional, unwanted side effects as a result of the effect of this medication on the system. These side effects range from minor inconveniences to more serious conditions. Whenever taking a new form of medication, it's important to monitor your health and condition to see if the drugs you are taking are having any negative effect on yourself or your child.

It's important that you speak to your doctor as soon as possible should you experience any of the following side effects:

  •  Voice changes
  • Unusual tiredness or weakness
  • Trouble in swallowing
  • Tightness in chest
  • Tender, swollen glands in neck
  • Stuffy nose
  • Sneezing
  • Shortness of breath
  • Runny nose
  • Pain, swelling or stiffness of joints
  • Noisy breathing
  • Nasal congestion
  • Loss of voice
  • Increased wheezing
  • Hoarseness
  •  Fever
  • Ear congestion
  • Dryness or soreness of throat
  • Difficulty in breathing
  •  Cough
  • Congestion
  • Chills
  • Body aches or pain
  • Abdominal pain

As well as the above-listed effects that can result from taking Nedocromil, you may also experience other side effects or conditions that are a result of your medication. Typically, these types of side effect will reduce as your body become used to your medication, and over time will likely lessen or disappear. However, if these symptoms become a problem or if they continue for longer than they should, your doctor should be able to provide you with methods to reduce these effects, or ways to prevent them.

Should you experience any of the listed symptoms, contact your doctor if you feel it is necessary:

  • Unpleasant taste
  • Tremor
  • Throat irritation
  • Sensation of warmth
  • Nausea or vomiting
  • Headache

The side effects of Nedocromil that are listed above have been chosen for the relevance and likelihood of their occurrence. However, this does not mean that additional side effects will not occur to your during the time you take this medication.

Should you notice any unusual or unexpected effects, first and foremost you should contact your medical doctor. Following this, you can report any side effects directly to the FDA at 1-800-FDA-1088.

Dosage

The dosage of Nedocromil that is prescribed to you is based on certain parameters and measures and should be followed according to what is on the label of your personal medication. Each dose of this medicine is different for each patient, and your doctors' orders should be followed. The listed dosages below are based on an average, and you should never change or alter your personal dosage unless told to do so by your doctor.

The amount of Nedocromil that you take in each dose can depend on the strength of the medication, as well as other factors such as the number of doses you take each day, the time between each dose and how long you take your medication for. These factors are all considered when your doctor prescribes the dosage that is customized to your requirements.

Average dosage for aerosol inhalation:

Adults or children older than six years: two 'puffs' taken four times per day at equally spaced intervals, as prescribed by a medical professional

Children younger than six years:

dosage to be determined and prescribed by a trained medical professional.

Should you miss a dose of your medication, it's important that you take it as soon as you remember or are able to. However, should the time to your next dose be short, you should skip the dose that you have missed and return to your normal medication schedule. Never double up on doses of Nedocromil.

Interaction:

Certain medications are not designed or developed to be used together. In certain cases, your doctor may decide that specific medications should be used at the same time, even if this may cause an interaction to occur. This is at the discretion and advice of your doctor, and all factors will be considered prior to the prescription of two conflicting medications.

Nedocromil does not have any known specific interactions with other medications. However, it's important that your doctor is aware of all medications that you are taking, which should include everything from over-the-counter medication to vitamins and herbal supplements. This ensures that all medications you take for asthma or other conditions that are commonly prescribed alongside this drug will no result in side effects or negative interactions.

In addition to interaction with types of medication or drugs, many medications can have both direct and indirect with foods, alcohol and tobacco. This could be in regard to eating certain types of foods or even taking medication around the time of eating food. Nedocromil has no known interactions with alcohol, tobacco or food, but it is important your doctor knows any and all interactions you have experienced with food. It's also critical your doctor knows any allergies or conditions you have in regard to these substances.

The existence of other medical conditions may directly affect the functionality of Nedocromil. This may result in the medication being less effective, or even result in increased side effects. Ensure your doctor is informed if you are suffering from any of the following conditions:

- Active asthma attack - medication will not be effective when this condition has already manifested.

Warnings

When you are prescribed Nedocromil, it's important that you check in with your doctor regularly to confirm if this medication is working for you. If your medical issues related to asthma do not reduce within a month, speak to your doctor. If your symptoms of asthma become worse when you begin taking this drug, speak to a medical professional as soon as possible.

When you are prescribed Nedocromil, you could also be given a bronchodilator or steroid medication in order to ease the symptoms and related problems associated with asthma. If you are prescribed this additional medication and you find your asthma has reduced, it's important that you do not stop taking your medication unless this decision has been made by a medical professional.

Taking Nedocromil may result in an unpleasant taste or irritation in the throat. Should these side effects occur when taking this medication, rinsing the mouth and gargling after every dose can help to reduce or prevent this from actually happening.

It's key that your doctor is kept up to date with all of your medical records, including allergic or unusual reactions you have experienced in regard to any medication you have taken. Your doctor should also be informed of any allergies you have, including dyes, animals, foods or preservatives. If you are aware of a specific allergy you have, ensure you carefully read package ingredients and medicine labels carefully to prevent reactions.

There have been few pediatric studies performed that suggest that the use of Nedocromil in infants below the age of six would be limited. However, the safety of this medication on children below this age has also not been established and should be discussed in full with your child's doctor prior to prescription.

Nedocromil is listed as FDA Category B. This suggests that studies carried out on this medication have demonstrated no risk to the fetus, and as such doctors may choose to prescribe this medication both to expecting mothers and to women who are breastfeeding. Your doctor will be able to discuss with you the risks and benefits of taking this medication.

Nedocromil as an aerosol inhalation medicine will be prescribed with full patient information and directions. It's important that prior to you or your child taking the medication you read all directions carefully and fully. If you are unsure of how to use the inhaler correctly, your doctor will be able to help you with the exact technique to use your medication most effectively. Ensure that you visit your doctor regularly to ensure that you are still using your medication correctly.

An average container or canister of Nedocromil contains around 104 inhalations. It's important that you keep a full record of the number of inhalations you have taken so you know when you are likely to run out of Nedocromil. This ensures that you never run out of this medication and have time to collect refills prior to emptying the canister. Nedocromil canisters do not float in water to test its fullness, therefore this method is not accurate to determine when your medication is empty.

When you or your child use Nedocromil for the first time, or after not using a canister for longer than a week, it is likely that the inhaler will not deliver the correct amount of medication with the first 'puff'. Priming the inhaler before use can ensure you receive the right dose each time, as per the instructions below:

- Insert the Nedocromil canister properly into a clean mouthpiece. Ensure that the canister is placed correctly into the mouthpiece before beginning step 2.
- Remove the cover from the mouthpiece and make sure you shake the inhaler well.
- Face the canister away from you against an easily visible backdrop, and depress the canister, spraying the Nedocromil into the air. Repeat this action two more times. If your inhaler is functioning correctly, a fine mist should be sprayed from the mouthpiece. At this point, your inhaler is primed for use.

When using your inhaler, it's important to follow the instructions provided with your Nedocromil prescription, as well as the advice and guidance of your doctor. There are two methods for inhalation, which can be discussed with your doctor to decide on the best technique for you:

Open-mouth method:

Instead of placing the mouthpiece in the mouth, instead place it between one to two inches from your mouth, which is open. Ensure that the inhaler is aimed into the mouth, and keep your mouth open as wide as possible so it doesn't hit your tongue, teeth or roof of your mouth. Spray into your mouth, closing your eyes to ensure no spray gets into them.

Closed-mouth method:

Begin by placing the mouthpiece of the inhaler into the mouth between your teeth and tongue. Your lips should be closed tightly over the inhaler mouthpiece, and your tongue kept away from the opening. Spray directly into the mouth, tilting your head back.

When spraying your Nedocromil into your mouth, make sure that your breathing is slow and measured, and that you spray the canister as you breathe in. This ensures that the medication is working effectively. If you are using the closed-mouth method, then you must ensure that your medication is not coming out of your mouth or nose, as this indicates the inhaler is not being used effectively. Count backward from 10, holding your breath, following application to ensure that your Nedocromil inhaler is as effective as possible. This allows the drug time to reach your airways and your lungs.

If you have been prescribed more than one 'puff' of Nedocromil per dose, wait at least a minute between sprays to ensure that both doses are effective. Ensure you shake the inhaler between each dose. Should you be prescribed a bronchodilator in addition to Nedocromil, take each medication as prescribed, with a small gap between of two-three minutes.

A medical professional may choose to prescribe you Nedocromil alongside a spacer device, which makes this medication easier to use and inhale. The functionality of this device allows more of the medication to reach your airways and lungs, reducing the amount that is left in the mouth and throat. If you are asked to use a spacer with your medication, follow the manufacturers' directions that are included with the device.

In comparison to a traditional spacer-free inhalation, taking Nedocromil with a spacer is easier and more efficient. You will still be required to hold your breath for 10 seconds to allow the medication to be the most effective, but the act of taking the medication in the first place will be simpler and with less room for error.

It's important to keep all equipment related to your medication, including your inhaler, spacer or any other equipment, is kept clean and sanitary. This ensures that your medication is effective, and also that you do not cause any harm to yourself or your child when taking Nedocromil due to illness from unclean equipment.

To clean your Nedocromil inhaler and spacer, follow the steps given by your doctor on prescription. For basic cleaning, follow the below steps:

- Wash the mouthpiece of your inhaler and your spacer daily to ensure no blockage
- Remove the metal canister from your inhaler and set aside in a clean, dry place. Do not allow the canister to become wet or submerged.
- Wash the mouthpiece of both the inhaler and spacer in hot water
- Shake off any excess water and allow to completely dry before returning the canister to the inhaler. Air drying is preferable, though drying with paper towels also works.

Storage

Nedocromil should be stored in a closed, locking container at room temperature. This medication should always be kept away from moisture, direct light, and heat. Never freeze this medication. Should this medicine be stored in unsuitable conditions, do not use this medication. Speak to your doctor as soon as possible for advice.

It is important that you don't store Nedocromil medication in a location where it will be exposed to both extreme heat and cold; such as in a vehicle or outside. Never poke holes in the canister or dispose of this medication via a fire, even if the canister appears to be empty. Always dispose of your medication responsibly.

Keep Nedocromil out of the reach of any children and pets in your household at all times. Never keep outdated medicines or medication that is no longer needed, instead dispose of this medicine appropriately. Speak to a healthcare professional to find out how you can dispose of any medicine you no longer need or do not use.

Summary

Nedocromil is a medication used for the management of asthma and in order to prevent bronchospasm in adults or children's suffering from asthma attacks due to anything from allergens to air pollutants. This medication is a preventative form of medication and is only used to stop bronchospasm and other signs of an asthma attack from occurring. This medicine does not prevent asthma attacks that have already started.

This medication is prescribed as an inhaler type drug and can be prescribed both alone and with a spacer to improve ease of use. Nedocromil may also be prescribed with a variety of different medications to help prevent issues related to asthma, including cortisone-like steroids and bronchodilators that help to open up breathing passages that have been narrowed.

Nedocromil acts on the patient by working on inflammatory cells within the lungs. This medication prevents these cells from producing certain reacting substances, that can result in asthma attacks and bronchospasm. This medicine is prescribed to patients of all ages and shows no negative symptoms when used with pregnant women, those that are breastfeeding or even infants and the elderly.

Nedocromil is offered by prescription only from a trained medical professional and was withdrawn from the U.S. market by King Pharmaceuticals on April 30 2008.