Neomycin, Polymyxin B, and Gramicidin (Ophthalmic)


Neomycin, Polymyxin B, and Gramicidin is given to patients suffering from a variety of eye infections. It is a combination of antibiotics and is best used under specific circumstances as opposed to other eye medications. Be aware that you can only access Neomycin, Polymyxin B, and Gramicidin combination via a prescription from your doctor. This is because they will first need to assess the extent of your condition to decide whether it is indeed the most suitable medicine for you. It is possible that it will interact with other drugs you are taking or cause unwanted side effects. If so, your doctor can advise on the best ways to avoid these.

Condition(s) treated

  • Eye infections

Type of medicine

  • Solution

Side Effects

As well as helping to treat your eye infection, it is possible that Neomycin, Polymyxin B, and Gramicidin combination will cause you to experience certain side effects. In some cases, these side effects are not very severe, but in other cases, they can cause greater concern. Below is a list of the more severe side effects you might experience. If so, you should contact your doctor immediately.

  • Redness, a rash, swelling, itching, or another sign of irritation in or around the eye that was not present before using this medicine

As well as this, it is possible you could experience some much less worrying side effects. Directly below is a list of these. You may find that they simply pass as your treatment progresses and your body becomes used to the medicine you are taking. However, if you do experience any of these effects and find them bothersome of lingering, you can still contact your doctor. They may be able to advise on a way to help alleviate your symptoms in some way, possibly by altering your doses.

Less common

  • A stinging or burning sensation in your eye

It is possible that you will experience other side effects that have not been listed here. If that is the case, you can still contact your doctor and discuss these with them.


Below you can find the typical dosages of Neomycin, Polymyxin B, and Gramicidin combination that are prescribed to patients suffering from eye infections. Do be aware that the exact doses you are prescribed may differ greatly from what is listed below. This is because each patient is different and your doses are based on your exact needs. It also takes into consideration other important factors such as other medical problems you have and other drugs you are currently taking. You should therefore not alter your dose unless told to do so by the prescribing doctor.

  • Adults and children. Place one drop in your eye 2 to 4 times per day for a period of seven to ten days. If the infection you have is more serious, the doctor may tell you to take one drop in your eye every 15 to 30 minutes to start. Afterwards, your doctor may then reduce the dosage as necessary.

In order to progress your treatment as effectively as possible, you should try to never miss a dose. However, if you were to miss one, then you should take the missed dose as soon as possible. However, if it is then almost time for you to take your next scheduled dose, you can simply skip the missed one.

Be aware that the bottle of medicine will only be partially full. This is to allow you to have better drip control and is not a mistake with packaging.

Here is some guidance on how to apply the medicine:

  • Before starting, wash your hands thoroughly.

In order to fully eradicate the infection, you should keep using this medicine for the full period of treatment. Keep doing so even if you believe your symptoms have disappeared early. Be careful not to miss any scheduled doses.


It was possible that Neomycin, Polymyxin B, and Gramicidin combination will interact with other drugs you are currently taking. These interactions can be serious in nature, and oftentimes your doctor will try and avoid them. To do so, you will need to advise your doctor on any other drugs you are currently taking. It may be the case that proceeding with two medicines that are known to interact is the best course of action. If so, then your doctor may reduce the doses on one or both medicines in order to limit the interactions.

As well as interacting with drugs, it is possible that Neomycin, Polymyxin B, and Gramicidin combination will interact with certain aspects of your dietary intake. This includes things that you eat, smoke, or drink. In order to provide you with the best course of treatment and maximum benefits from this drug combination, your doctor may advise you to make changes to your diet. This could mean smoking less or drinking less alcohol during the period you are using these eye drops.


Before prescribing you with these eye drops, your doctor will first want to ensure they are the best course of treatment for your exact condition. As a part of this process, they will need to understand any allergies you currently have. This includes any allergies to dyes, animals, preservatives, or foods. You should be open and honest during your consultation in order to find a drug that is best suited to you.

There are no apparent studies that have been conducted on the use of these eye drops on pediatric patients. Instead, any studies have only been conducted on adults. As such, it is unclear as to whether they are any less suitable from a testing standpoint. However, your doctor is best placed to advise whether they are indeed suitable for your child to take.

Similarly, the effects of this drug have not been properly studied in geriatric patients. However, you should know that this is the case with many drugs, not just this one. It just means that it is unclear as to whether it is potentially any less useful, or if it will likely cause any unwanted side effects. Your doctor will have access to any recent studies and can decide whether Neomycin, Polymyxin B, and Gramicidin combination is suitable for you if you are elderly.

It appears that some studies may have been conducted in pregnant women which demonstrate a harmful effect on the fetus if this drug is used. Your doctor can advise on the extent of this problem. However, it may be still suitable to use this medicine if the benefits it offers outweigh any risks.

As of writing, there are no adequate studies which have been performed into the effects of Neomycin, Polymyxin B, and Gramicidin combination in breastfeeding women. Your doctor is best placed to advise on any risks, and together you can weigh these risks against the benefits.

If you find that your symptoms get worse or do not improve after a few days of using this medicine, you should inform your doctor.


You should store your Neomycin, Polymyxin B, and Gramicidin combination in a sealed container at all times. Keep it at room temperature, and away from direct light, moisture, and heat. You should also never allow it to freeze, and should not allow children to access it as it may be harmful. Once you have finished with your treatment, you should dispose of any remaining medicine in a sensible and safe manner. The same should be done if you have any medicine that you find to be out of date. For more information on how to properly dispose of used medicine, contact your doctor.


If you are currently suffering from an eye infection, then the Neomycin, Polymyxin B, and Gramicidin combination may have been prescribed to you to help clear up the symptoms and relieve unwanted discomfort. However, you should take care in following all guidance your doctor offers you regarding the use of these eye drops. This includes, not just how much of the drops to use, but also other recommended dietary changes.

Above you can find details regarding some of the possible side effects that are associated with this drug combination. If you experience any of the more serious ones, then you should contact your doctor. Similarly, if you have any other questions regarding your treatment or the use of Neomycin, Polymyxin B, and Gramicidin, you should address these to your prescribing doctor.