Neomycin, Polymyxin B, and Hydrocortisone (Ophthalmic)

Neomycin, Polymyxin B and Hydrocortisone combination treatment is used to treat infection of the eye and to relieve the symptoms of the infection.


Neomycin, Polymyxin B and Hydrocortisone is a combination of medications that is administered as a Cortisporin eye drop to patients. It is used in the treatment of infections of the eye and contains both antibiotics for treatment and cortisone-like medication for the relief of the symptoms. In some cases it may be used to prevent permanent damage of the eye from occurring.

Neomycin, Polymyxin B and Hydrocortisone combination will relieve the symptoms of infection including redness, discomfort, affected vision and irritation. At the same time the medication will help to fight the infection.

Neomycin, Polymyxin B and Hydrocortisone is available only when it has been prescribed by a doctor and will be given to you as suspension for treatment as eye drops.

Condition treated

Infection of the eye

Type Of Medicine

  • Antibiotic
  • Cortisone-like medication

Side Effects

In addition to fighting the infection in the eye and relieving symptoms, Neomycin, Polymyxin B and Hydrocortisone can also cause other unwanted side effects to occur. If these side effects do occur then you may need to seek medical attention from the doctor in some cases:

You should immediately cease use of this treatment and seek emergency medical care if you experience any of the following side effects to use:

  • Fainting
  • Severe shortness of breath
  • Sudden and severe onset of lightheadedness
  • Swelling around the eyes and face
  • Trouble with breathing

You should seek immediate advice from your doctor if you experience any of the following side effects:

  • Blurring of vision
  • Change in color perception
  • Change in vision
  • Delayed healing
  • Irritation of the eye that was not present before you took the medication
  • Itching
  • Rash
  • Redness
  • Swelling

Neomycin, Polymyxin B and Hydrocortisone can also cause other unwanted side effects that are less serious and will abate over time. The following side effects will necessitate that you consult a doctor:

  • Stinging or burning of the eye during application.

Other side effects that have not been listed herein could also occur. If you experience any other side effects from the use of the Neomycin, Polymyxin B and Hydrocortisone combination then you should contact your doctor for advice. If you believe that you health is at immediate risk, however, then you should seek emergency care.


This medication will not be full when you receive it. This is deliberate to allow for proper control of the eye dropper and does not mean that medication has leaked out.

To use the eye drop you should follow these steps:

  • Wash your hands and face thoroughly with soap to ensure they are clean.
  • Put your head back and pull down on the lower eyelid. This will create a pouch under your eye.
  • Administer the correct dose of medication as prescribed into the pouch.
  • Do not blink.
  • Close your eye and hold shut with your head back for 1-2 minutes.
  • Replace the cap of the medication as soon as possible and avoid it coming into contact with any surface.

In order to completely clear the infection you should use this treatment for the full course. Do not stop using it when your symptoms abate and avoid missing any doses of the treatment.

The dose of this medication that is prescribed will vary depending on the condition being treated, the personal circumstances of the patient and other factors. You should use this medication only as you have been directed by your doctor and should never use more of it nor use it more frequently than you have been directed to. The following information is a guideline only and should not be used to amend your dosage:

When treating an infection of the eye:

  • Adults should be given 1-2 drops every 3-4 hours.
  • Children will have their dose determined by the prescribing doctor.

If a dose of this medication is missed then you should apply it as soon as it is possible to do so. If it is nearly time for your next dose, however, then you should skip the missed dose and return to the normal schedule of dosing. This medication relies on regular dosing being administered and patients should avoid missing any doses of the treatment.


Some medications may interact with one another in the body and this can cause serve complications in some cases. Drugs may interact violently, may stop one another from working and may increase the risk of certain side effects occurring. You must inform your doctor of all medications that you are taking before you begin use of this treatment. This is particularly important in the following cases:

Neomycin, Polymyxin B and Hydrocortisone should not be used in conjunction with the following medication. To do so risks serious interaction and your doctor may choose not to prescribe this treatment:

Neomycin, Polymyxin B and Hydrocortisone use is not usually recommended with the following medications. In some cases the use of both treatments may be required and your doctor may continue use of both with minor adjustments to dose or frequency of use:

  • Vecuronium
  • Valdecoxib
  • Tubocurarine
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sorafenib
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Rocuronium
  • Rapacuronium
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Pranoprofen
  • Pixantrone
  • Piroxicam
  • Pipecuronium
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Pancuronium
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Mivacurium
  • Metocurine
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Hexafluorenium
  • Gallamine
  • Furosemide
  • Foscarnet
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Fazadinium
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Droxicam
  • Doxacurium
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Decamethonium
  • Conivaptan
  • Colistimethate Sodium
  • Clonixin
  • Cisatracurium
  • Cidofovir
  • Choline Salicylate
  • Celecoxib
  • Bupropion
  • Bufexamac
  • Bromfenac
  • Bemiparin
  • Atracurium
  • Amtolmetin Guacil
  • Aldesleukin
  • Alcuronium
  • Acemetacin
  • Aceclofenac

Using Neomycin, Polymyxin B and Hydrocortisone can significantly increase the risk of certain side effects occurring in the patient. While such use would not normally be recommended in some cases this may still be the best treatment available for you. In such cases your doctor may prescribe both but may adjust the dose of one or other or may adjust the frequency of use to reduce this risk:

  • Vecuronium
  • Tubocurarine
  • Tosufloxacin
  • Sparfloxacin
  • Saiboku-To
  • Rufloxacin
  • Rocuronium
  • Rifapentine
  • Rapacuronium
  • Prulifloxacin
  • Primidone
  • Pipecuronium
  • Pefloxacin
  • Pazufloxacin
  • Pancuronium
  • Ofloxacin
  • Norfloxacin
  • Nadifloxacin
  • Moxifloxacin
  • Mivacurium
  • Metocurine
  • Lomefloxacin
  • Licorice
  • Levofloxacin
  • Hexafluorenium
  • Gemifloxacin
  • Gatifloxacin
  • Gallamine
  • Flumequine
  • Fleroxacin
  • Fazadinium
  • Enoxacin
  • Doxacurium
  • Colestipol
  • Cisatracurium
  • Ciprofloxacin
  • Bumetanide
  • Besifloxacin
  • Balofloxacin
  • Atracurium
  • Alcuronium

Interactions with other medications could also occur that have not been listed herein. It is vital that you inform your doctor of all conditions from which you suffer before you begin use.

Certain medical conditions could also impact on the use of this treatment. Some conditions may be worsened by use and others may cause a worsening of side effects from the treatment. You should inform your doctor of your full medical history before use and this is especially important in the following cases:

These conditions may be worsened by the use of Neomycin, Polymyxin B and Hydrocortisone:

Neomycin, Polymyxin B and Hydrocortisone use may delay healing in patients who have recently had the following surgery:

  • Cataract surgery

Other medical conditions can also impact on the use of Neomycin, Polymyxin B and Hydrocortisone. You should ensure your doctor is aware of all treatments you are using before you begin use of this medication.


Before beginning use of Neomycin, Polymyxin B and Hydrocortisone you should weigh the benefits of use against the potential risks of use. You should consider all of the factors herein with your doctor and should ensure that you have taken the following into account before use:

Allergies' You must inform your doctor if you have every reacted badly or unusually to any medications in the past. Allergies to medications, dyes, preservatives, animals, foods and other substances can all prohibit the use of certain medications. You should consult your doctor if you have any concerns about allergies.

Pediatric' The use of this medication has only been tested in adults. You should discuss use with your doctor and other medications may be found for the treatment of children.

Geriatric' There is no specific information relating to the use of Neomycin, Polymyxin B and Hydrocortisone in elderly patients. There are not expected to be any limitations to the use of this medication in the elderly, however. Elderly patients will be more likely to have other conditions of the eye that may require caution to be taken.

Pregnancy'You should inform your doctor before use if you are pregnant. The risk is rated as category C for use when pregnant. Use should only be carried out where treatment is clearly necessary.

Breastfeeding' There have been no adequate studies to determine the risk of use when breastfeeding. Discuss use with your doctor and weigh the benefits against the risk.

You will need to visit your doctor regularly if you are using this treatment for a period of longer than 10 days.

If the symptoms of infection do not improve in a couple of days or if they become worse then you should check in with your doctor. This may be a sign of complications occurring or another underlying condition.

Do not share this treatment with others as this can help the infection to spread to others. You should dispose of the medication after treatment. Using leftover medication in the future could cause the infection to recur. This medication may also be ineffectual against other types of infection.


This medication can be stored at room temperature.

You should keep this medication away from heat, direct light and moisture and should prevent it from freezing.

Always keep medications out of the reach of children.


Neomycin, Polymyxin B and Hydrocortisone is prescribed as eye drops for the treatment of infections of the eye.

This combination treatment contains both antibiotics and cortisone-like medicine that will serve to treat the infection and relieve the side effects of the condition.

To administer you should place the eye drops directly into the eye and keep the eye closed for 1-2 minutes. This allows the medication to interact with the infection before it is washed away by the eye. Some stinging and burning may occur at this stage, but this side effect will abate. Other side effects and increased irritation should be reported to your doctor.

Allergies to this medication can cause a worsening of condition so you must inform your doctor of any allergies from which you suffer. Other conditions of the eye including glaucoma can also prohibit the use of this medication.

You must complete the full course of this medication to ensure that the infection has been completely killed.