Niacin and Lovastatin (Oral)

Niacin and lovastatin combination medication is a conjunction of two medications that work jointly to help lower cholesterol and lipid (known as fat) disorders.

Overview

Niacin is used on its own or in conjunction with other medications in the treatment of high cholesterol and triglyceride (fatty substances) levels in the blood. This can help prevent development of pancreatitis (inflammation in the pancreas) and other issues caused by heightened levels of cholesterol and triglycerides in the blood. Niacin is also used to help lower the risk of a heart attack in patients with a history of hyperlipidemia and heart attack.
Lovastatin is used alongside proper diet to help to lower the "bad" cholesterol and fats (like LDL, triglycerides) and to help raise the "good" cholesterol (HDL) in the blood. This medication belongs to a class of medications known as statins. This medication works by helping to reduce the amount of cholesterol created in the liver. Lowering the "bad" cholesterol and triglycerides and by raising the "good" cholesterol, helps to decrease the risk of any heart disease and helps to prevent stroke and heart attack.
In addition to consuming a better diet (such as one with reduced or lowered cholesterol or a low-fat diet), other lifestyle changes can help the effectiveness of this medication. These include exercising, losing weight if the patient is overweight and smoking cessation. You should speak to your health care provider for more details.
The combination of niacin and lovastatin is used together alongside a better diet to help to lower cholesterol and triglyceride (fat) levels in the blood. This medication can help prevent medical issues (such as heart attacks or strokes) that are caused by fat blockages and clogs the blood vessels.
Niacin is also known as vitamin B3, and it helps to reduce the amount of cholesterol found in the pateints blood. Lovastatin is part of a type of medication called HMG-CoA reductase inhibitors, also known as statins. It reduces the amount of cholesterol in the blood by obstructing the enzyme that is necessary to create cholesterol.

This medication is available only with your health care provider's prescription. This medication is available in the following form:

  • Tablet

Conditions Treated?

High cholesterol and triglyceride blood levels

Type Of Medication?

Niacin is also known as vitamin B3 and lovastatin is a from a group of medications called statins.

Side Effects

Along with the intended effects, a medication can sometimes cause unwanted side effects. And though you may not experience all or any of these side effects, if they are to occur they could warrant medical attention.
A small amount of patients taking lovastatin may experience mild memory issues or some confusion. If this rare side effect occurs, talk to your health care provider.
Rarely, statins can cause or in some cases worsen diabetes. Talk to your health care provider about the benefits and risks before use.
This medication can cause muscle issues (which can lead to some very serious conditions called autoimmune myopathy and rhabdomyolysis) although this is very rare. Tell your health care provider immediately if you develop any of the following symptoms during your treatment and if they persist once your health care provider stops the use this medication: muscle pains/ unusual tenderness or weakness (especially if seen with a fever or unusual/ unexplained tiredness), signs of kidney issues (such as a change in the amount of passed urine).
This medication can cause liver issues. If you experience any of the following rare but very serious side effects, tell your health care provider immediately: yellowing of the eyes or skin, darkened urine, severe stomach or abdominal pains, persistent nausea or vomiting.
A severe allergic reaction to this medication is rare. However, you should seek urgent medical attention if you experience any of the following symptoms of severe allergic reaction: rashes, itching or swelling to the face, tongue or the throat, trouble with breathing or severe dizziness.
This is not an exhaustive list of possible side effects. If you experience other side effects that are not listed you should contact your health care provider or pharmacist.
Lovastatin can cause some side effects. Tell your health care provider if the following symptoms are severe or are persistent:

    • Constipation
    • Confusion
    • Memory loss or feeling forgetful

Some side effects can be very serious. The following symptoms are usually quite uncommon, but if you experience any of the following, call your health care provider immediately or seekemergency medical help:

    • Fever
    • Extreme tiredness
    • Dark colored urine
    • Swelling of any of the following areas: face, tongue, lips, throat, eyes, hands, lower legs ankles or feet
    • Flu-like symptoms
    • Unusual bleeding or bruising
    • Weakness
    • Difficulty breathing or swallowing
    • Rash
    • Pain in the upper right part of the stomach
    • Itching
    • Hoarseness
    • Nausea
    • Hives
    • Lack of energy
    • Loss of appetite
    • Yellowing of the skin or eyes
    • Muscle pain, tenderness, or weakness

Lovastatin can cause other side effects. Contact your health care provider if you experience any abnormal or unusual issues while prescribed this medication.
Contact your health care provider immediately if any of the following side effects occur:

    • Darkened urine
    • Severe abdominal pains
    • Light or gray stools
    • Yellowing of the eyes or the skin
    • Loss or lack of appetite

Some additional side effects could occur that in most cases do not require medical attention. These side effects should disappear during your treatment when your body naturally begins to adjust to the medication. Your health care professional will be able to inform you of the ways in which you can prevent or help to reduce some of the side effects. You should contact your health care professional if any of these side effects continue for more than a few days or are particularly distressing or if you have further questions regarding them:
Less common

    • Nausea and/or vomiting
    • Cough
    • Headaches
    • Rashes or itching
    • Diarrhea
    • Runnynose
    • Experiencing redness or flushing on the skin, especially of the face or neck
    • Feeling of warmth
    • Stomach or abdominal pains
    • Stuffy nose
    • Sneezing

Incidence not known

    • Dryness of the skin
    • Swelling of the feet or lower leg
    • Fever
    • Dizziness or feeling faint
    • Joint pains
    • Sides, lower back or abdominal pain
    • Frequently urinating
    • Unusual thirstiness
    • Unusually faster, slowed, or irregular heartbeat
    • Unusual feeling of tiredness or weakness
    • Muscle aches or cramps

When used in combination, contact your health care provider immediately if any of the following side effects occur when taking both medications:
More common

    • Feeling of warmth
    • Coughing or feeling hoarse
    • Painful or difficultly urinating
    • Fevers or chills
    • Pains in the lower back or side
    • Redness, tingling or itching of the following areas: face, arms, neck and chest
    • Pain

Less common

    • Fruity breath odor
    • Abdominal or stomach pains
    • Unusual weight loss
    • Difficulty with moving
    • Increase in urination
    • Blurry vision
    • Dry skin
    • Muscle aches, weaknesses, tenderness, or pains
    • Increase in hunger
    • Dry mouth
    • Vomiting
    • Increase in thirst
    • Joint pains
    • Unusual tiredness or weaknesses
    • Swollen joints
    • Nausea
    • Cramping pain or unusual stiffness

Rare

    • Dark colored urine
    • Muscle cramps, pains, spasms, or unusual stiffness

Some additional side effects could occur that in most cases do not require medical attention. These side effects should disappear during your treatment when your body naturally begins to adjust to the medication. Your health care professional will be able to inform you of the ways in which you can prevent or help to reduce some of the side effects. You should contact your health care professional if any of these side effects continue for more than a few days or are particularly distressing or if you have further questions regarding them:
More common

    • Runny nose
    • Sore throat
    • Diarrhea
    • General feeling of discomfort or illness
    • Loss of appetite
    • Sweating
    • Trouble sleeping
    • Shortness of breath
    • Nausea
    • Itching skin
    • Headache
    • Rash
    • Shivering

Less common

  • Indigestion
  • Loss or lack of strength
  • Belching
  • Acidic or soured stomach
  • Heartburn
  • Stomach discomfort

Other side effects that are not listed may also occur in some patients. If you experience any other side effects, contact your health care provider.

Dosage

The dose of this medication will differ between patients. You should aim to follow your health care professional's advice or any directions on the label. The following advice is provided to include only average dosages of this medication. If your prescribed dosage is not the same, you should not alter it unless your health care professional specifically advises you to do this.
The exact dosage of medication that you will be prescribed will depend on the strength of the medication.
For oral dose form (tablet):
For high cholesterol:
Adults'Begin with 500 milligrams (mg) of niacin and 20 mg of lovastatin (combined tablet) once daily, preferably at night before going to bed. Your health care provider may adjust this dose as it is needed. However, the dose will not usually be more than 2000 mg of niacin and 40 mg of lovastatin daily.
Children'This medication is not recommended for children.

Missed Dose

It is important that if you miss a scheduled dosage of this medication, you should take it as soon as it is possible to. However, if it is close to the time you should be taking your next dose, the missed dose should be completely skipped and return to your regular dosing schedule. Never take a double dose of this medication.
If you have not used or taken this medication as directed for more than 7 days, contact your health care provider as you may need a reduced dose plan before continuing to use this medication again.

Interactions

Although certain medications should not be taken together at all, there are other cases in which two completely different medications may be used in conjunction, even if an interaction is likely to occur. In these cases, your healthcare provider may want to alter the dosages of one or both medications or follow other precautions which may be necessary. When you are taking this medication, it is very important that your healthcare provider knows if you are taking any of the medications that are listed below. The listed interactions below have been chosen based on their potential significance and other interactions could occur that are not listed below.
The use of this medication with any of the following medications is not recommended. Your healthcare provider may choose not to treat you with this medication or may also alter some of the other medications you take.

  • Lopinavir
  • Telaprevir
  • Amprenavir
  • Indinavir
  • Boceprevir
  • Nefazodone
  • Itraconazole
  • Tipranavir
  • Clarithromycin
  • Mibefradil
  • Atazanavir
  • Ketoconazole
  • Saquinavir
  • Cobicistat
  • Voriconazole
  • Nelfinavir
  • Fosamprenavir
  • Darunavir
  • Mifepristone
  • Erythromycin
  • Ritonavir
  • Telithromycin
  • Idelalisib
  • Posaconazole

The use of this medication with any of the following medications is usually not recommended, but in some case, it may be required in lowered or altered dosages. When both medications are prescribed jointly, your healthcare provider may alter the dosage amount or duration you use one or both medications.

    • Quinupristin
    • Daptomycin
    • Clofibrate
    • Atorvastatin
    • Lomitapide
    • Rosuvastatin
    • Fluconazole
    • Niacin
    • Conivaptan
    • Ceritinib
    • Amiodarone
    • Lovastatin
    • Diltiazem
    • Colchicine
    • Fenofibric Acid
    • Simvastatin
    • Cerivastatin
    • Danazol
    • Gemfibrozil
    • Delavirdine
    • Ciprofibrate
    • Fenofibrate
    • Cyclosporine
    • Lumacaftor
    • Dalfopristin
    • Verapamil
    • Ranolazine
    • Pitavastatin
    • Bezafibrate
    • Dronedarone

The use of this medication with any of the following medications is usually not recommended as there may be an increased risk of certain side effects, but in some cases, it may be required in lowered or altered dosages. When both medications are prescribed jointly, your healthcare provider may alter the dosage amount or duration you use one or both medications.

    • Pectin
    • St John's Wort
    • Azithromycin
    • Warfarin
    • Clopidogrel
    • Bosentan
    • Oat Bran

Other Interactions
There are certain medications which should not be used at or close to the time of eating food or certain kinds of food as interactions may occur. The use of alcohol or tobacco when taking certain medications may also cause interaction occurrence. It is important to discuss with your healthcare provider about the use of your medication with food, tobacco or alcohol.

  • Grapefruit Juice

Using this medication with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your health care provider may change the dose or how often you use this medication or give you special instructions about the use of food, alcohol, or tobacco.

    • Ethanol

Other Medical Issues
The presence of any other medical problems can affect the use of this medication. It is extremely important to tell your healthcare provider if you experience any other medical problems, especially the following:

  • Alcohol abuse or a history of
  • Liver disease or a history of 'Use this medication with caution. May worsen side effects
  • Angina (severe chest pains) if unstable
  • Diabetes
  • Gout
  • Heart attack, acute' Use this medication with caution. May worsen condition
  • Arterial bleeding
  • Liver disease, active
  • Liver enzymes, elevated
  • Peptic ulcer disease, active'Should not be used in patients with these conditions.
  • Electrolyte disorders, severe
  • Endocrine disorders, severe
  • Epilepsy (seizures), not well-controlled
  • Hypotension (low blood pressure)
  • Metabolic disorders, severe
  • Sepsis (severe infection in the blood)'Patients with this condition may be at risk of developing muscle and kidney issues.
  • Kidney disease'Use with caution. The effects this medication may be increased because of slower removal of the medication from the body.

Warnings

Allergies

Tell your health care provider if you have in your life experienced any abnormal, adverse or allergenic reactions to any other medications. Also tell your health care professional if you have any allergies; to foods, preservatives, dyes or any animals.

Pediatric

The use of niacin and lovastatin combination is not recommended for children.
Pregnancy
Studies in pregnant women have demonstrated positive evidence of fetal abnormalities in all trimesters. This medication should not be used for women who are or may become pregnant during use as the risk outweighs any possible benefits.
Breastfeeding
Studies in breastfeeding women have demonstrated harmful effects to infants. Alternative medication should be prescribed or breastfeeding should cease while taking this medication.
Using this medication while pregnant can harm the unborn baby. It is advised to use an effective birth control to prevent pregnancy. If you believe you have fallen pregnant during use of this medication, contact your health care provider immediately.
Blood tests may be requried to check for unwanted side effects.

Do not use lovastatin/niacin if you are using any of the following medications:

    • Boceprevir
    • Nefazodone
    • Telaprevir
    • Some antibiotics such as erythromycin, clarithromycin, ketoconazole, itraconazole, posaconazole and telithromycin
    • Some treatments for HIV/AIDS such as indinavir, atazanavir, ritonavir, nelfinavir or saquinavir

Using these medications together may cause serious side effects.

This medication can affect your blood sugar level which is important to note if you are diabetic or prediabetic. If you experience any changes in the results of your blood or urine sugar testing or you have further questions, contact your health care provider.
This medication should not be taken with any vitamins that contain nicotinamide or niacin.

Storage

Store the medication in a closed container, keep clear from all heat, direct light and moisture. Do not freeze. Must not be stored in your bathroom.

Keep out of children's reach and sight
Make sure to discard of any medication which is out of date or medication that is not needed.
It is important to ask your healthcare provider how you should dispose of any unwanted or unnecessary medications.

Summary 435 Words

Niacin is used on its own or in conjunction with other medications in the treatment of high cholesterol and triglyceride (fatty substances) levels in the blood. This can help prevent development of pancreatitis (inflammation in the pancreas) and other issues caused by heightened levels of cholesterol and triglycerides in the blood. Niacin is also used to help lower the risk of a heart attack in patients with a history of hyperlipidemia and heart attack.
Lovastatin is used alongside proper diet to help to lower the "bad" cholesterol and fats (like LDL, triglycerides) and to help raise the "good" cholesterol (HDL) in the blood. This medication belongs to a class of medications known as statins. This medication works by helping to reduce the amount of cholesterol created in the liver. Lowering the "bad" cholesterol and triglycerides and by raising the "good" cholesterol, helps to decrease the risk of any heart disease and helps to prevent stroke and heart attack.
In addition to consuming a better diet (such as one with reduced or lowered cholesterol or a low-fat diet), other lifestyle changes can help the effectiveness of this medication. These include exercising, losing weight if the patient is overweight and smoking cessation. You should speak to your health care provider for more details.
The combination of niacin and lovastatin is used together alongside a better diet to help to lower cholesterol and triglyceride (fat) levels in the blood. This medication can help prevent medical issues (such as heart attacks or strokes) that are caused by fat blockages and clogs the blood vessels.
Tell your health care provider if you have in your life experienced any abnormal, adverse or allergenic reaction to this medication or any other medications. Also tell your health care professional if you have any allergies; to foods, preservatives, dyes or any animals.
The use of niacin and lovastatin combination is not recommended for children.
Studies in pregnant women have demonstrated positive evidence of fetal abnormalities in all trimesters. This medication should not be used for women who are or may become pregnant during use as the risk outweighs any possible benefits.
Studies in breastfeeding women have demonstrated harmful effects to infants. Alternative medication should be prescribed or breastfeeding should cease while taking this medication.
Using this medication while pregnant can harm the unborn baby. It is advised to use an effective birth control to prevent pregnancy. If you believe you have fallen pregnant during use of this medication, contact your health care provider immediately.
Blood tests may be requried to check for unwanted side effects.