Norfloxacin (Oral)

Norfloxacin belongs to a class of drugs known as fluoroquinolone antibiotics used to treat urinary, gynecological, inflammation and prostate bacterial infections.

Overview

Norfloxacin treats certain drug resistant bacterial infections by eradicating the abnormal cells and preventing any new growth. As a fluoroquinolone antibiotic, it treats bacterial infections of the urinary tract, prostate and gonorrhea.

The U.S. Food and Drug Administration (FDA) has posted a black box warning on this medicine, due to serious and irreversible adverse reactions during and after treatment. Introduction of this medicine to can cause side effects lasting for weeks during treatment and in some cases several months after treatment. It also has the potential of causing permanent damage. Fluoroquinolones including norfloxacin have caused disabling disorders in some patients. Medical reports suggest this medicine should not be administered to individuals diagnosed with these health conditions.

  • Central Nervous Systems (CNS)
  • Hypersensitivity reactions
  • Myasthenia gravis
  • Peripheral neuropathy
  • Tendinitis and tendon rupture

The FDA has recorded severe risks to individual health conditions, particularly when patients are 60 years of age or older. Health risks for this age group increase if they are taking corticosteroid drugs. Health care professionals recommend weighing the benefits before considering this medication for treatment of the elderly. Other population groups with these existing health conditions may find this medicine unacceptable.

  • Abnormal urinary tract formation or function
  • Acute bacterial sinusitis
  • Chronic bronchitis
  • Heart or lung transplants
  • Kidney

For some individuals with serious bacterial infections, including anthrax or bacterial pneumonia the benefits of fluoroquinolones may outweigh the risks. The doctor will need to complete the first testing and reviews the lab results before deciding if this medicine may be the right therapeutic choice for the patient.

FDA Safety AnnouncementIn 2016 July, the FDA revised the 'œBoxed Warning' on the safety of this drug. The organization addressed health concerns of norfloxacin; one medicine belonging to the class of drugs known as fluoroquinolone antibiotics. The purpose of the revision was to updated segments of the drug label along with the patient's medication guide for this medicine and other fluoroquinolone antibiotics.

Included in its determinations were cited references about the use of this medication for patients with no other alternative options for treating acute bacterial sinusitis, bacterial exacerbation of chronic bronchitis and uncomplicated urinary tract infections. Further remarks identified the serious side effects outweighing the benefits of taking this medicine for many patients. Additional observations made by the FDA acknowledged some benefits did outweigh the risks for certain patients, making the choice of using fluoroquinolone antibiotics suitable for therapy.

Conditions Treated

  • Bacterial infections
  • Prostatitis
  • Sexually transmitted diseases
  • Urinary tract infections

Type Of Medicine

  • Antibiotic

Side Effects

Medicines influence the results of treatments, they also cause some unwanted consequences. As individuals, we are unique in how we respond to some medications, causing the side effects to vary from person to person. It takes time for our body to process the new medication. When it finally reaches a balance with just the right concentration in the bloodstream the effects start to fade.

If you have existing disorders treated with other medicines, the effects or the condition itself could worsen. Before you start treatments with norfloxacin, talk to your doctor. Share as much information about your family's medical history, current health ailments and daily routines. Each of these life phases has valuable information to help your doctor decide what works best for you.

Here's a list of the most common, least common, and rare side effects known to occur. If you experience effects and they worsen or persist beyond a week, tell your doctor at once. Other effects not listed may occur.

More Common effects

  • Cramps
  • Diarrhea
  • Dizziness
  • Fatigue
  • Headache
  • Heartburn
  • Increased tendon and soft tissues injuries
  • Muscle and joint aches
  • Nausea
  • Pain
  • Sweating

If you suffer from diarrhea, talk with the doctor. DO NOT self-treat the side effect. Existing health conditions or your own intolerance to the certain chemical substances could be linked to the effects and may worsen the condition.

Sometimes a combination of medications will cause minor to serious side effects for some individuals. Medical precautions are taken into account for individuals with several existing health conditions before starting treatment. The reason, these health conditions may contribute to live-threatening side effects.

Least Common

  • Change in taste
  • Genital itching
  • Hearing loss
  • Loss of strength
  • Ringing in the ears
  • Vision problems

Talk with your doctor about the effects, the more the doctor knows about how you are responding to the medicine will make a difference to your health recovery. If you experience effects that interferer with normal functions, talk to the doctor. DO NOT stop taking any of your medicines or change the doses without your doctor's approval.

These effects are rare, but they can happen. If you experience any of these, or ones not listed' tell your doctor. Your doctor will help to prevent or ease an uncomfortable effect.

Rare

  • Acid or sour stomach
  • Anxiety
  • Bleeding gums
  • Chest pain or discomfort
  • Chills
  • Dry mouth
  • Dry skin
  • Excess gas
  • Fever
  • Heartburn
  • Increased sensitivity of the skin to sunlight
  • Irritability
  • Nosebleeds

Adverse Effects

Adverse effects are more serious and sometimes fatal due to a person's hypersensitivity when taking quinolones such as norfloxacin. The severity of the reaction increases in some individuals when taking multiple doses of this medicine. Contact your doctor before making any changes. The doctor may discontinue treatment due to these reactions.

This medicine may trigger any of these conditions or cause the serious effects:

  • Allergic pneumonitis' allergic reaction causing inflammation of the lungs
  • Anemia hematologic abnormalities
  • Epidermal necrolysis' life-threatening dermatologic disorder
  • Fever
  • Hepatitis' liver disease
  • Renal failure' kidney fail to remove waste and balance fluids

Health Precautions

Some individuals experience sensitivity to natural and artificial light. You should avoid exposure to tanning beds or natural ultraviolet rays when taking this medicine. If you are outdoors, be sure to wear loose fitting clothes and cover your body to protect your skin against sun exposure.

Talk with your doctor about alternative methods of protecting your skin to avoid serious side effects to your health. Your doctor may suggest using a sun block product with a sun protection factor (SFP) of 15 or higher. If you are sensitive to the sun and susceptible to sunburn, this medicine will increase the sensitivity. You may need to increase your SFP to a higher level.

If you are sunburned, contact your doctor' serious skin conditions can occur in the outer layer causing a sub-layer infection. Symptoms could blister, peeling of the skin accompanied by a fever.

Allergic reactions occur with this medicine with some effects causing problems with breathing or swallowing. If you experience swelling of your hands, face or mouth contact your doctor.

For most of us, life continues even with medical treatments. Because this medicine causes dizziness, you should not operate a vehicle, machinery or take part in activities requiring full mental concentration, alertness and coordination skills.

Serious Health Conditions

This medication should not be used for patients with other treatment options. Professional health care recommendations include stopping treatment if life-threatening effects occur. Harmful secondary infections can be instigated when taking this medicine. If you have either of these disorders, talk to your doctor. The doctor may decide not to prescribe this form of therapy for you. You need to understand the risks to your health before starting any form of treatment with this medicine.

  • Clostridium Difficile Associated Diarrhea (CDAD) CDAC appears with antibacterial medicines with side effects ranging from mild to severe to fatal colitis.
  • Syphilis Treatment This medication is known to hide the symptoms of incubating syphilis.

Medical reports and observations show some side effects lasting for an average of 14 months to 9 years after treatments were completed. Other cases, the side effects stopped after treatment and the condition improved significantly; validating the benefits for different individuals treated with this medicine.

Dosage

Norfloxacin is available in the form of a tablet and should be taken orally with a full glass of water. The following information includes the average doses of the medicine. Your doctor will prescribe the strength and scheduled doses taken each day for each condition. To help stop the infection from recurring, keep taking your medicine even if you are feeling better.

Be sure to read the medication guide and talk with your pharmacist if you have questions. Avoid consuming food products or drinks containing large amounts of caffeine. Norfloxacin may increase the effects of caffeine or extend the duration of the side effects. It's best to take this medicine at the same time each day. This routine keeps the right amount of medicine in your body to treat the condition.

For infections

Take norfloxacin with a full glass of water. DO NOT consume food or dairy products for 2 hours before or after taking this medicine. Drink plenty of fluids to keep your body hydrated and cleansed.

Adult

  • 400 milligrams (mg) every 12 hours for 3 to 21 days, as directed by your doctor.

For Prostatitis

  • 400 milligrams (mg) every 12 hours for 28 days

For Gonorrhea

  • 800 milligrams (mg) in a single dose

Children the doctor will decide the dosage and frequency

Geriatrics

  • Elderly patients treated for urinary tract infections should have a creatinine clearance greater than 30mL/min/1.73m2. The doctor will decide the dose recommendations as directed under normal renal function.
  • Elderly patients treated for urinary tract infections should have a creatinine clearance less than 30mL/min/1.73m2. Dose recommendations are 400 mg as directed under normal renal function.

Medical Precautions

DO NOT share this medicine with others even if they appear to have similar symptoms. Your doctor has prescribed the exact dose for your condition and health history. Sharing this medicine may have serious or fatal consequences.

DO NOT keep unused medication for later unless the doctor has approved it. Your health condition may change requiring an adjustment to the dosage or a change of medications for continuing treatment.

This medicine is no longer available in the United States (U.S.) based on the FDA findings. For health situations outside of the U.S., patients need to have a discussion with the doctor about the FDA precautions noted on this medicine.

Missed Dose

If you miss a dose, take it as soon as possible the only exception if it is almost time to take the next dose, skip the missed dose and continue with your normal schedule. Contact your doctor about the missed dose. DO NOT double the dose; you could trigger a serious side effect.

Overdose

Accidental or unintended overdose can occur when taking this incorrectly. If an adult or child has symptoms of facial swelling or trouble breathing contact the emergency center at once. If a child is involved in this overdose, contact the pediatric poison information center in your neighborhood for instructions.

Interactions

Medicines help to improve our health and most work well together. Yet, certain medications when used together have serious or unpleasant interactions. Different medicines will interact with each other and they can happen at any time. If you start or stop taking the medicine suddenly or change doses, it can trigger a response. The doctor may adjust the doses of the drugs to support your health during treatment.

Some health conditions require multiple medications; you need to learn about the potential interactions to all of the medicines you are taking now. The doctor has determined this medicine is the best solution for you based on your health and medical history.

Because all medicines go through a development process, they may share the same chemical compounds. If you are taking multiple prescriptions, there's an increase change the combinations will change the outcome of treatment due to the chemical quantities.

If you are taking, any of these medicines listed or you believe you are taking medicines that may share similar ingredients, tell your doctor. There are medications not listed that interact with norfloxacin.

  • Acarbose
  • Acecainide
  • Acetohexamide
  • Alfuzosin
  • Alogliptin
  • Alosetron
  • Aluminum Carbonate
  • Amifampridine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Benfluorex
  • Bepridil
  • Betamethasone
  • Bretylium
  • Budesonide
  • Buserelin
  • Calcium
  • Canagliflozin
  • Chloroquine
  • Chlorpromazine
  • Chlorpropamide
  • Cholera Vaccine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Dabrafenib
  • Dapagliflozin
  • Dasatinib
  • Deflazacort
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dexamethasone
  • Didanosine
  • Dihydroxyaluminum
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Dronedarone
  • Droperidol
  • Efavirenz
  • Erythromycin
  • Escitalopram
  • Exenatide
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fludrocortisone
  • Fluocortolone
  • Fluoxetine
  • Gatifloxacin
  • Gemifloxacin
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydrocortisone
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Insulin
  • Iron
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Linagliptin
  • Liraglutide
  • Lopinavir
  • Lumefantrine
  • Magaldrate
  • Magnesium
  • Mefloquine
  • Mesoridazine
  • Metformin
  • Methadone
  • Methylprednisolone
  • Metronidazole
  • Mifepristone
  • Miglitol
  • Moricizine
  • Moxifloxacin
  • Mycophenolate
  • Mycophenolic
  • Nafarelin
  • Nateglinide
  • Nilotinib
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pimavanserin
  • Pimozide
  • Pioglitazone
  • Piperaquine
  • Pitolisant
  • Posaconazole
  • Pramlintide
  • Prednisolone
  • Prednisone
  • Probenecid
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Rosiglitazone
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Sematilide
  • Sevoflurane
  • Sitagliptin
  • Sodium Phosphate
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Sucralfate
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Thioridazine
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Toremifene
  • Trazodone
  • Triamcinolone
  • Trifluoperazine
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vildagliptin
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Ziprasidone
  • Zuclopenthixol

Other Interactions

If you suffer from multiple disorders and take two or the prescription medicines for treatment, let your doctor know. Sometimes, taking several different medicines together requires some adjustment to treat the conditions and avoid side effects. Understanding the side effects or changes associated with these conditions when introducing a new medicine can prevent serious consequences to your health.

Prescription medicines or over-the-counter (OTC) treatments, health supplements, herbal remedies can cause side effects. Lifestyle choices about alcohol, tobacco, exercise routines and specific foods can also cause interactions to new medications. You doctor monitors your response to this medicine - so should you.

If you have been taking several drugs for a long time, let your doctor know. It could change how you respond to this medication. If you detect changes, tell the doctor. These changes could be symptoms of serious side effects.

Health Interactions

If you are starting treatment with norfloxacin, it may increase certain health risks if you suffer from any of the disorders. Medications taken for these disorders will interact with norfloxacin, the condition could worsen or the side effects could be more severe. Talk with your doctor and make sure you understand the health risks associated with your health.

If you have a family history associated with these disorders, tell your doctor. This treatment could trigger an underlying or hidden health condition.

  • Bradycardia slow heartbeat
  • Brain disease
  • Diabetes
  • G6PD deficiency
  • Heart disease
  • Heart rhythm problems
  • Hypokalemia low potassium in the blood
  • Kidney disease
  • Myocardial ischemia reduced blood supply in the heart
  • Organ transplants
  • Rheumatoid arthritis
  • Seizures

It is important that your doctor check your progress while taking this medicine. These intermediate checkups help to verify your response to treatment. Your doctor may ask for routine lab tests to check your blood and urine levels for unwanted effects. If you detect problems or unusual changes in your body, tell your doctor.

Warnings

The U.S. Food and Drug Administration (FDA) posted black box warnings on norfloxacin. FDA regulations and notices are intended to protect the public health and offer information for consumers and industry professionals when making health decisions involving drugs or medications.

Warnings are known risk factors associated with a medicine and the effects on an individual's health. The information collected about medication responses affecting medical conditions is gathered through observations and clinical assessments over the course of an illness and the recovery of a doctor's patient.

Health warnings are based on the drug's benefits, outweighing the risks for the condition the drug will treat for the majority population. When deciding to use this medicine, you need to understand the risks and the benefits associated with this drug and the potential effects. Before starting treatment, be aware, your own health may contribute to side effects.

The FDA information is available to individuals for helping to recognize the early signs for preventing unwanted or emerging health disorders before they develop into serious conditions.

FDA NORFLOXACIN WARNINGS

Serious adverse reactions include tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects (CNS) and exacerbation of myasthenia gravis. Fluoroquinolones like norfloxacin have been associated with disabling and irreversible adverse reactions that occur together during treatment with this medicine.

  • Your doctor may stop prescribing norfloxacin if you experience serious reactions.
  • If you have a history of myasthenia gravis, you should not take this medication.
  • Norfloxacin is reserved for patients with no alternative treatment options for uncomplicated urinary tract infections.

To reduce the development of drug resistance bacteria and retain the effectiveness of the norfloxacin or other antibacterial drugs this medicine should only treat or prevent infections suspected to be caused by bacteria.

  • Norfloxacin is no longer available in the United States of America. If you are treated with this medicine, your doctor may change to an alternative treatment.

Medication Guide

The patient's medication guide is available to public. This information has important data on each fluoroquinolones including norfloxacin, describing the safety and health concerns associated with all of these medicines. A directive for the medical industry continues to evaluate and review the safety issues reported by consumers and medical professionals. The FDA maintains ongoing assessments and updates the public on changes affecting these drugs and treatment conditions.

If you are considering this medication for therapy, be sure to tell the doctor about the side effects experienced throughout treatment.

Health Warnings

This medicine will increase the risk of you developing tendinitis, a swelling of a fibrous tissue that connects the bone to a muscle. The effect may persist for several months after treatment in completed. Because norfloxacin weakens the muscles in some individuals, it may cause serious or fatal breathing problems. If you experience shortness of breath, contact the emergency medical center for assistance at once.

Although these conditions or ruptured tendons can happen at any age, elderly patients over the age of 60 are more susceptible to serious side effects and permanent injury. Your doctor needs to know if you are taking oral or injectable steroids. If so, this medicine may not work for you.

Pregnancy

If you are pregnant or trying to conceive, talk with the doctor. The FDA has assigned a Category C to this medication. There are no actual studies or controlled observations of pregnant women. The known effects and risk to other health conditions and the potential of instigating serous disorders suggests precautions before starting treatment.

œFDA Category C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.'

Breastfeeding

There is insufficient data to show any risk to the fetus or whether harmful amounts of norfloxacin were excreted in human breastmilk. One study administering 200 mg of this medicine to nursing mothers did not detect norfloxacin in the breastmilk.

  • Once again, the serious health concerns surrounding this medication, recommends all nursing mothers to consider the risk and the potential harm to the infant.

Pediatric

The safety and effectiveness of this medicine for pediatric patients or adolescents under the age of 18 years old has not been established.

Geriatric

There is an increased risk for this age group developing tendon disorders when taking fluoroquinolones. The risks increase in patients receiving concomitant corticosteroid therapy.

  • Caution is critical when prescribing this medicine for elderly patients.
  • All patients should be aware of the side effects and symptoms related to their own health conditions before starting treatment.

Storage

Store at room temperature in the prescribed container and keep it away from light, heat and moisture. DO NOT freeze.
Keep this medicine out of the reach of children and pets.

DO NOT flush or dispose of this medicine in the household trash. Discard any unused medicine as instructed. If you have questions or need assistance, ask your doctor or pharmacist.

Summary

Norfloxacin treats a specific type of bacteria that invades the body and can cause serious illness or fatal diseases. For this reason, the benefits of taking this medicine need to outweigh the risks.

The FDA has posted a serious warning for this medicine and advisement to its public health partners about the precautions when prescribing or administering this drug. The chances of increased risks or unexpected side effects to your health are high when taking this medication. Before you begin treatment, have a discussion with your doctor and take the time to read the medical guide on this form of therapy.