Nystatin (Vaginal)

Vaginal nystatin is a cream used to treat fungal infections of the vagina such as yeast infections.


Nystatin is an antifungal medication that is used to fight infections that are caused by the growth of fungus. Vaginal Nystatin is applied as a cream or inserted as a vaginal tablet to treat infections of the vagina such as yeast infections.

This antifungal medication is available only with a prescription from a doctor and is prescribed as mycostatin cream or vaginal tablet.

Condition treated

  • Vaginal infections

Type Of Medicine

  • Antifungal

Side Effects

In addition to the required effects from the use of vaginal Nystatin, this medication may also cause unwanted side effects to occur. While not all side effects may require you to seek medical attention, in some cases you may need to seek assistance from a doctor.

You should seek immediate medical attention if you experience any of the following side effects from use:

  • Burning or itching of the vagina that was not present before beginning treatment.

Other side effects can also occur that would not normally require you to seek medical attention. These side effects are usually mild and will abate over time. If they become bothersome or continue, however, you can contact your doctor for advice:

  • Unusual vaginal discharge
  • Unusual vaginal odor

Other side effects could also occur that have not been listed herein. If you experience any other side effects, you should contact your doctor for advice.


Vaginal Nystatin will be issued with a set of patient instructions that you should read through carefully. If there is anything that you do not understand, you should contact your doctor for advice.

This medication will be applied into the vagina using a provided applicator in most cases. If you are pregnant, however, then you should inform your doctor and seek advice before inserting the applicator.

To ensure that you are able to completely clear the fungal infection from your vagina you should use the full course of the treatment. You should not stop use even if you believe that your condition has cleared up. You should also continue use if you begin menstruation during treatment and should take steps not to miss any doses. If you stop use early or miss doses then the infection is likely to return.

The dose of this medication will differ for each patient depending on a range of factors including the extent of the infection. You should not make any changes to the dose given to you by your doctor unless instructed to. The following information is to be used as a guideline only and should not be used to amend your dose yourself.

Patients should ensure that the applicator is properly cleaned between uses as directed to in the medication guide.

When treating fungal yeast infections using the vaginal cream:

  • Adults and children - An applicator full of the treatment should be inserted into the vagina twice daily for two weeks. Alternatively, you may be instructed to insert one larger dose into the vagina once daily.

When treating fungal yeast infections using a vaginal tablet:

  • Adults and teenagers should insert one tablet into the vagina with an applicator once or twice daily for two weeks.

If a dose of this treatment is missed then you should take it as soon as you are able to. If you are nearly due to take your next dose, however, then you should skip the missed dose and return to the normal schedule of dosing. You should never take a double dose of this treatment. Patients should take every effort not to miss doses as this can make the treatment less effective and will increase the risk of the infection remaining.


Certain medications should not be used in conjunction with one another. This is because they can interact in the body with unwanted consequences. Certain medications may prevent one another from working effectively and others may increase the risk that severe side effects may occur. To avoid suffering complications from drug interactions you must inform your doctor of all medications and substances that you are taking before you begin treatment. This includes any treatments that were prescribed or any substances bought over the counter or otherwise.

Other medical conditions from which you suffer can also impact on the use of certain treatments. You should inform your doctor of all medical conditions from which you suffer and have suffered from in the past before you begin use.


In deciding to use this medication you must consider the risks in relation to the benefits. The risks of using this medication are limited, but you should ensure that you have considered all of the following with your doctor before use.

Allergies: You should inform your doctor of any allergies that you have suffered in the past. This is particularly important if you have ever reacted unusually to any antifungal medications in the past or if you have ever had any particular sensitivities of the vagina. Allergies to foods, dyes, preservatives and other substances are also important to share with your doctor.

Pediatric: There have been no studies carried out in the use of this treatment in children. This medication is only intended for the purposes of use in adults.

Geriatric: While there is no specific information relating to the use of vaginal Nystatin in elderly patients it is not expected that there will be any limitations to this use.

When treating this condition you will also need to carry out good health practices. Failure to do so will lead to a continuation of infection and only good health practices can prevent a return of the condition. These good health tips will help you to avoid reinfection:

  • You should wear cotton underwear in preference to synthetic underwear. Cotton underclothes will allow the vagina to breathe more freely and will help to make the vagina less habitable to the fungal growth.
  • You should wear freshly cleaned underwear at all times. Change your underwear at least once and day and consider changing your underwear whenever administering a new dose of this medication.
  • Carry out regular douching before carrying out the treatment to ensure the vagina is clean of all substances before application. There will be advice about this in the medication guide that you should follow. Ask your health care professional if you do not understand this.
  • Clean your bed sheets if you have a discharge on to them. This will help to get rid of the fungus.
  • Do not have sexual contact during the period of this treatment. Doing so may worsen your infection and will spread it to your sexual partner.
  • Once the condition has been treated you should exercise good sexual hygiene when you do have sexual intercourse. Ensure that you thoroughly clean your vagina after sex whether you are using condoms or having unprotected sex.

If you have any questions about vaginal health then you should discuss them with your healthcare professional or visit a sexual health clinic.

Vaginal discharge will occur during use of this treatment and you will need to wear a sanitary towel in order to protect your clothing from the leakage. Do not wear these for too long without changing and follow the instructions to maintain a high standard of vaginal health.


Patients may keep this medication at room temperature. It should be kept out of direct light and away from heat, cold and moisture.

Patients should ensure that this treatment is kept out of the reach of children at all times.

You should not keep this medication for any longer than required and should dispose of it safely and effectively once treatment is complete.


Vaginal Nystatin is used in the treatment of fungal infections affecting the vagina. These fungal yeast infections will need to be treated with a full course of treatment to ensure that the infection is completely gone.

Nystatin is administered as a tablet for vaginal insertion or as a cream for vaginal application. Both treatments will be administered with a provided applicator and treatment will usually be carried out twice daily for a period of two weeks.

Patients should not stop the use of this treatment due to menstruation and should not stop use because the symptoms have cleared up. Only by completing a full course of this treatment will patients be able to clear the infection completely.

You must exercise good vaginal hygiene when undergoing this treatment. Changing your underwear regularly and douching before application of the treatment will help to clear the infection. You should consult your doctor if you have any questions about this.

Vaginal drainage will occur when you are using this treatment and you will need to wear sanitary towels for the duration of the treatment to protect clothing.