Ocriplasmin (Intraocular)

Ocriplasmin injection is a drug that is used in the treatment of an age-related eye condition called vitreomacular adhesion, which can cause severe deterioration of vision or blindness.


In the US, ocriplasmin is known under its brand name, Jetrea. This injectable solution is administered by a medical professional in a clinic or hospital setting as a one-off treatment.

Ocriplasmin injection is used to treat a condition that affects the eyes, called symptomatic vitreomacular adhesion, which largely affects older people. As part of the ageing process, the vitreous substance inside the eye begins to shrink. Vitreomacular traction occurs when the vitreous adheres to an area in the rear portion of the eye called the macula. This damage to the light-sensitive area can cause a tear in the macula, leaving a hole. The patient's vision is seriously affected, especially the ability to see clearly ahead, and blindness can sometimes occur.

Ocriplasmin is used to separate the vitreous from the damaged macula and close off any tears or holes. The drug works by dissolving the proteins linking the macula to the vitreous membrane, effectively detaching the vitreous from the retina.

Conditions treated

  • Vitreomacular traction

Type of medicine

  • Solution
  • Injectable

Side effects

In addition to the desired effects and benefits ocriplasmin brings, it can cause a few unwanted side effects. Not every patient suffers from these effects, but if you do notice anything odd, you may need to seek medical advice and attention.

If you experience any of the effects that are noted in the list below, you must check with your treating physician right away:

  • Throbbing pains
  • Tearing of the eye
  • Increased sensitivity of the eye to light
  • Seeing floating spots in front of your eyes, or a curtain or veil appearing across part of your vision
  • Seeing sparks,'shooting stars', or flashes of light
  • Redness of the eye
  • Loss of vision
  • Eye pains
  • Eye discomfort
  • Unusually poor night vision
  • Decreased vision
  • Change in color vision
  • Blurred vision or other change in vision
  • Bloody eyes

There are some effects that are caused by ocriplasmin that go away on their own without requiring further medical treatment as your body adjusts to the drug. Your treating physician may be able to give you advice on how to prevent or manage some of the effects that you notice.

You may find that your eyes feel particularly dry after this treatment. This effect should disappear after a day or so. However, if it persists or becomes particularly bothersome, check with your treating physician.

There may be other effects noted by some patients who have received treatment with ocriplasmin that are not necessarily including in this guide. If you notice any other effects, you should speak with your treating physician.


Ocriplasmin is always given by a specialist medical professional in a clinic or hospital setting.

This drug is administered via an injection directly into your eye. Your treating physician will give you a local anesthetic shot before you have your ocriplasmin injection so that you cannot feel any pain.

Ocriplasmin is recommended as a treatment for certain adults who have no scar tissue across their retina (the area at the back of the eye that is sensitive to light). In addition, the hole in the retina must measure up to 400 micrometers in diameter and must be causing severe sight problems.

You must tell your treating physician right away if you do not notice any improvement in your vision after your treatment or if you think that your vision is actually getting worse.


Drug interactions

Some medicines must never be used at the same time as this could cause an interaction to occur. However, in some instances, two or more drugs may be used together if the patient's condition dictates that to do so would be the most effective course of treatment. In such circumstances, your treating physician will give you advice on how to prevent or manage any interactions that could take place.

Before you have your treatment with ocriplasmin, you must tell your treating physician if you are currently taking any other prescription or over the counter medicines.

Other interactions

Some medicines should not be taken when you are eating or if you are eating particular foodstuffs, as an interaction could occur. Similarly, the use of tobacco or alcohol can also cause adverse reactions with some drugs. Be sure to discuss this aspect of your therapy with your treating physician before you have your ocriplasmin injection.

Medical interactions

Some existing or historical medical conditions can preclude the use of ocriplasmin as a suitable treatment option. You must discuss your medical history fully with your treating physician before you have treatment with this medication.

Ocriplasmin must be used with caution in patients who have a history of any of the following conditions, as doing so could make these problems worse:

  • Lens subluxation (partial dislocation of the eye lens)
  • com/health/coma/">Glaucoma (increased pressure in the eye)
  • Eye infection
  • Dyschromatopsia (color vision disorder)
  • Detached retina (eye disorder)


Before you agree to have treatment with a particular medication, you should always take into account the risks as well as the benefits of doing so. This decision can be arrived at following detailed discussions with your treating physician. In the case of ocriplasmin, there are a number of things to take into consideration as outlined below.

Be sure to tell your treating physician if you are already taking any other medication, including non-prescription products, herbal remedies, vitamin supplements, and diet pills.


It is very important that you inform your treating physician if you have ever had an allergic reaction to ocriplasmin or to any other prescription drugs. You must also mention any known allergies that you have or bad reactions that you have experienced to over the counter medicines, food colors, food preservatives, particular food groups, or animal derivatives.


There have been not studies to show that ocriplasmin cannot be used safely in children. However, if your child is scheduled to receive this medication, you should raise any concerns that you have with your child's treating physician.


Although there have been no studies to show that ocriplasmin causes any geriatric-specific complications or issues, you may wish to discuss your treatment with this drug with your treating physician if you have any concerns.

Pregnancy and breastfeeding

As far as can be determined by medical research studies, ocriplasmin is safe for use in pregnant women. However, if this applies to your condition, you may wish to discuss the use of the medicine with your treating physician.

It is not known if ocriplasmin could pass into breast milk where it could present a risk of side effects to a nursing infant. However, if you are breastfeeding your child, you may prefer to err on the side of caution and use an alternative feeding solution while you are being treated with this medicine. Discuss any concerns that you have with your treating physician or midwife.

Medical complications

You will need to attend your treating physician for regular check-ups, especially in the first week or so following your treatment with ocriplasmin.

This medication can sometimes cause serious eye problems.

You must check with your treating physician immediately if you notice any of the signs listed in the bullets below:

  • Reddening of the eyes
  • Increased sensitivity to light
  • Pain in the eye
  • Visual changes
  • A sensation of increased pressure within the eye several days following your treatment

Ocriplasmin can sometimes cause blurred vision in a few patients. This effect usually only lasts for a few days and will resolve itself. However, during this time you should not drive, operate machinery, or take part in any other form of activity that could potentially be dangerous if you cannot see clearly. If this problem persists for more than a week or so, you should arrange to have your eyes checked by your treating physician.


This medication is not designed for home use. The solution will be stored in hospital under the correct conditions as recommended by the manufacturer.


Ocriplasmin injection is used in the treatment of a primarily age-related eye condition called symptomatic vitreomacular adhesion. It is usually a one-off treatment that is administered in a specialist clinic or in hospital by via injection directly into the back of the eye.

Although there are no noted drugs that could cause an interaction when used with ocriplasmin, this drug can cause a number of unwanted side effects. For this reason, you must discuss your current drug regimen and full medical history before undertaking treatment with this medicine. You will be required to attend your eye specialist for regular check-ups following your treatment to make sure that the drug is working correctly and to discuss any side effects that are bothering you.