Ofloxacin (Ophthalmic)

Prescribed to treat bacterial eye infections, Ofloxacin ophthalmic solution may also be used to treat ulcers affecting the cornea of the eye.

Overview

Available as an ophthalmic solution, Ofloxacin is typically prescribed in the form of eye drops and is most commonly used to treat bacterial eye infections. Due to its antibiotic nature, Ofloxacin ophthalmic solution is not effective in treating viral or fungal eye infections.

Although Ofloxacin can be used to treat bacterial infections in other parts of the body, the medication is far stronger when administered orally or intravenously. Ofloxacin ophthalmic solution is typically prescribed at a strength of 0.3% w/v and this is strong enough to treat the vast majority of bacterial eye infections.

As Ofloxacin is a broad-spectrum antibiotic, it is effective against most types of bacterial infection. When administered, Ofloxacin inhibits an enzyme known as DNA gyrase. This enzyme is necessary for bacteria cells to replicate and, when it's inhibited, the cells are unable to replicate. As a result, Ofloxacin prevents the patient's infection from worsening and kills the bacteria which is already present.

By treating the infection, Ofloxacin effectively reduces the patient's symptoms. However, patients may be given another medication to reduce their symptoms whilst the Ofloxacin ophthalmic solution takes effect. Whether used as a monotherapy or in conjunction with other medicines, Ofloxacin is extremely effective in resolving the majority of bacterial eye infections.

Conditions Treated

  • Bacterial infection of the eye

Type Of Medicine

  • Antibiotic

Side Effects

Whenever patients take or use medication, there is a risk that they could experience side-effects. Whilst the presence of side-effects does not necessarily mean that the treatment isn't working, patients may need to obtain medical advice if certain side-effects develop during the course of their treatment.

The following side-effects are most likely to occur soon after Ofloxacin has been administered and medical attention may not be required if they are fairly mild:

  • Blurred vision
  • Increased sensitivity of the eye to light
  • Eye pain
  • Burning of the eye
  • Tearing, stinging or dryness of the eye
  • Irritation, itching or redness of the eyelid, eye or inner lining of eyelid

Although the above side-effects may not require medical attention, patients should obtain medical advice if the above side-effects are severe, on-going and/or bothersome to the patient.

However, if patients experience the following symptoms whilst using Ofloxacin ophthalmic solution, they will need to obtain immediate medical treatment:

  • Puffiness or swelling of eyes
  • Dizziness
  • Signs of an allergic reaction, such as itching, hives, swelling of lips or face, tightness in chest, rash, wheezing and/or troubled breathing

Patients should also seek medical help if they experience any other adverse effects whilst using Ofloxacin.

Dosage

When patients are prescribed Ofloxacin ophthalmic solution, their doctor will advise them how much medication to use and how often it should be administered. If patients are using Ofloxacin to treat bacterial infections of the eye, such as conjunctivitis, they will usually be instructed to administer one drop in the affected eye every two to four hours, while the patient is awake. This regime should continue for two days. Following this, patients are usually advised to use one drop of Ofloxacin ophthalmic solution in each eye four times a day, for a period of five days.

However, if patients are using Ofloxacin solution for the treatment of bacterial ulcers on the cornea, they may be advised to administer one drop in the eye every thirty minutes, during their waking hours, and one drop four to six hours after going to bed. This dosing regime should continue for two days, after which patients should administer one drop of Ofloxacin solution every hour whilst they are aware for a period of seven days. Following this, patients may be advised to administer one drop of Ofloxacin four times per day, until their doctor confirms the treatment is complete.

When administering Ofloxacin ophthalmic solution, patients should wash their hands and tilt their head back. By gently pressing on their lower eyelid, patients can create a gap between the eye and the eyelid and the medication should be administered here. After administering the Ofloxacin solution, patients should close their eye and keep the eye closed for approximately one to two minutes.

When applying Ofloxacin solution, patients should not touch the applicator or allow it to come into contact with any substances, including the eye itself. This ensures that the applicator is kept free of germs and prevents the spread of bacteria.

In order for Ofloxacin ophthalmic solution to be effective, patients should use the medication as their doctor has advised. Even if their symptoms are relieved, patients should continue to use Ofloxacin for the full course of treatment. Stopping the treatment too early can result in the infection returning and/or antibiotic resistance.

Ofloxacin solution should be used in accordance with the dosing schedule set out by the patient's doctor. However, if patients forget to administer a dose of Ofloxacin, they should do so as soon as they remember. If their next dose of medication is due soon, patients should skip the missed dose and continue with their treatment as normal. Patients should not attempt to administer a double dose of Ofloxacin, even if an earlier dose has been missed. If patients are unsure how to use Ofloxacin solution or when to apply it, they should contact their physician or pharmacist for advice.

Potential Drug Interactions

As some medicines can interact with one another, Ofloxacin may not be prescribed if patients are taking certain other medications. For example, Ofloxacin should not be used in conjunction with the following medicines:

  • Amifampridine
  • Saquinavir
  • Amisulpride
  • Sparfloxacin
  • Bepridil
  • Mesoridazine
  • Cisapride
  • Terfenadine
  • Dronedarone
  • Thioridazine
  • Pimozide
  • Ziprasidone
  • Piperaquine

In addition to this, the use of Ofloxacin solution alongside the following medicines is not typically recommended:

  • Acarbose
  • Erythromycin
  • Acecainide
  • Droperidol
  • Acetohexamide
  • Efavirenz
  • Alfuzosin
  • Domperidone
  • Alogliptin
  • Donepezil
  • Alosetron
  • Dolasetron
  • Amiodarone
  • Dofetilide
  • Amitriptyline
  • Glipizide
  • Amoxapine
  • Gonadorelin
  • Apomorphine
  • Insulin Bovine
  • Aripiprazole
  • Goserelin
  • Arsenic Trioxide
  • Haloperidol
  • Asenapine
  • Gliquidone
  • Astemizole
  • Glyburide
  • Azimilide
  • Granisetron
  • Azithromycin
  • Halofantrine
  • Bedaquiline
  • Insulin Aspart, Recombinant
  • Benfluorex
  • Insulin Glargine, Recombinant
  • Bretylium
  • Insulin Glulisine
  • Buserelin
  • Insulin Degludec
  • Canagliflozin
  • Insulin Detemir
  • Chloroquine
  • Linagliptin
  • Chlorpromazine
  • Methadone
  • Chlorpropamide
  • Metformin
  • Cholera Vaccine, Live
  • Lopinavir
  • Ciprofloxacin
  • Mefloquine
  • Citalopram
  • Metronidazole
  • Clarithromycin
  • Lumefantrine
  • Clomipramine
  • Liraglutide
  • Clozapine
  • Mifepristone
  • Crizotinib
  • Paliperidone
  • Cyclobenzaprine
  • Pitolisant
  • Dasatinib
  • Perflutren Lipid Microsphere
  • Dabrafenib
  • Pimavanserin
  • Dapagliflozin
  • Pioglitazone
  • Degarelix
  • Pazopanib
  • Delamanid
  • Pasireotide
  • Desipramine
  • Panobinostat
  • Deslorelin
  • Tedisamil
  • Disopyramide
  • Tolazamide
  • Escitalopram
  • Toremifene
  • Exenatide
  • Tizanidine
  • Fingolimod
  • Tolbutamide
  • Flecainide
  • Tetrabenazine
  • Fluconazole
  • Telithromycin
  • Gatifloxacin
  • Gemifloxacin
  • Octreotide
  • Gliclazide
  • Nortriptyline
  • Glimepiride
  • Ondansetron
  • Histrelin
  • Procainamide
  • Hydroxychloroquine
  • Pramlintide
  • Hydroxyzine
  • Posaconazole
  • Ibutilide
  • Norfloxacin
  • Solifenacin
  • Imipramine
  • Sulpiride
  • Insulin
  • Anagrelide
  • Insulin Lispro, Recombinant
  • Tacrolimus
  • Lapatinib
  • Sotalol
  • Leuprolide
  • Trifluoperazine
  • Levofloxacin
  • Trimipramine
  • Miglitol
  • Sorafenib
  • Moricizine
  • Sunitinib
  • Moxifloxacin
  • Iloperidone
  • Repaglinide
  • Nafarelin
  • Ranolazine
  • Nateglinide
  • Rasagiline
  • Nilotinib
  • Rosiglitazone
  • Prochlorperazine
  • Salmeterol
  • Promethazine
  • Saxagliptin
  • Protriptyline
  • Sitagliptin
  • Quetiapine
  • Voriconazole
  • Sevoflurane
  • Quinidine
  • Triptorelin
  • Sematilide
  • Quinine
  • Vemurafenib
  • Sodium Phosphate
  • Vardenafil
  • Sodium Phosphate, Dibasic
  • Vildagliptin
  • Sodium Phosphate, Monobasic
  • Warfarin
  • Vandetanib
  • Zuclopenthixol
  • Vinflunine

If doctors do prescribe Ofloxacin solution in addition to one of the medicines listed above, they may alter the patient's dose in order to try and prevent a drug interaction taking place.

Similarly, if patients use Ofloxacin solution whilst taking one of the following medicines, they may be more likely to experience side-effects:

  • Betamethasone
  • Hydrocortisone
  • Budesonide
  • Prednisolone
  • Fludrocortisone
  • Corticotropin
  • Methylprednisolone
  • Cortisone
  • Lanthanum Carbonate
  • Cosyntropin
  • Fluocortolone
  • Deflazacort
  • Triamcinolone
  • Dexamethasone
  • Prednisone
  • Didanosine

As well as interacting with other prescription medicines, Ofloxacin solution could interact with over-the-counter medicines, supplements and/or vitamins. Patients should, therefore, tell their physician if they are using any of these substances before they are prescribed Ofloxacin.

Patients should also obtain medical advice before taking any new medicines, supplements or vitamins once they have started using Ofloxacin solution.

Warnings

If patients have any existing health problems, it may affect the suitability of Ofloxacin as a treatment. Due to this, patients should discuss their existing health concerns and medical conditions with their physician before they are prescribed Ofloxacin.

Although Ofloxacin solution can be used to treat pediatric patients, it is not recommended for use in patients under the age of one year.

Usually, patients will notice an improvement in their symptoms within seven days of using Ofloxacin eye drops. However, if there is no improvement or if the patient's symptoms worsen, they should consult their physician.

Whilst patients are undergoing treatment with Ofloxacin solution, their eyes may be more sensitive to the light. Using sunglasses and avoiding exposure to bright lights and sunlight may help to reduce the patient's discomfort.

If patients are experiencing blurred vision as a result of the infection or increased sensitivity to light due to Ofloxacin, they should show extreme caution when driving. Patients should not drive if they feel their symptoms or side-effects are affecting their ability to do so safely.

As Ofloxacin has been classified as a category C drug in relation to pregnancy, it is not normally prescribed to patients who are pregnant. If Ofloxacin is used by pregnant patients, the risk of harm to the unborn fetus cannot be ruled out. Due to this, Ofloxacin should only be prescribed to pregnant patients if it is absolutely necessary and if the benefits clearly outweigh the risks.

It is not known whether Ofloxacin can be excreted in breast milk and, if so, whether it poses a risk to infants if transferred in this way. Due to this, patients are often advised not to breastfeed whilst using Ofloxacin. Patients should seek medical advice before breastfeeding if they are using Ofloxacin.

Before using Ofloxacin ophthalmic solution, patients should tell their doctor if they are allergic to any substances or if they have ever had an allergic reaction to anything before. This includes allergies to medicines, preservatives, foods, animals and/or dyes.

If patients exhibit a rash or an allergic reaction whilst using Ofloxacin eye drops, they should stop using the medication and obtain immediate medical help. A serious allergic reaction can be life-threatening and patients will require emergency medical treatment. An allergic reaction may include the following symptoms:

  • Rash on the skin
  • Itching
  • Hoarseness
  • Hives
  • Difficulty breathing
  • Swelling of the face, lips, tongue, mouth, throat and/or hands
  • Difficulty swallowing
  • Shortness of breath

Storage

In order to store Ofloxacin eye drops properly, patients should follow the manufacturer's instructions. When keeping medication at home, patients will need to find a secure location and ensure that children and/or pets cannot gain access to it. As Ofloxacin ophthalmic solution usually needs to be administered regularly, patients may need to take their medication out with them or to other locations, such as their workplace. If so, patients should take steps to ensure that the medicine is secure, stored appropriately and does not pose a risk to anyone else.

In most cases, Ofloxacin ophthalmic solution can be kept at room temperature but should not be frozen or exposed to heat, moisture and/or direct light. Due to this, patients should not leave Ofloxacin eye drops in the car or anywhere else they may be exposed to extremes of temperature.

If the medication reaches its expiry date or if patients are advised to stop using Ofloxacin ophthalmic solution, they will need to dispose of the medicine carefully. It is not safe to throw medication out with regular household waste. Instead, patients should contact their physician's office or pharmacist and use a specialist medicine disposal service.

Summary

When patients are suffering from a bacterial eye infection, they can experience a number of symptoms. As well as developing eye pain, patients may exhibit excessive tearing, itching and/or crusting around the eyes. In order for these symptoms to be fully reduced, the infection must be resolved.

Due to the medication's antibacterial properties, it is effective in treating bacterial eye infections and, therefore, reducing the patient's symptoms. Furthermore, Ofloxacin eye drops tend to take effect fairly quickly and patients may notice a reduction in their symptoms within a relatively short space of time.

As Ofloxacin ophthalmic solution can be used by both pediatric and adult patients, it is a commonly prescribed medication and extremely effective in resolving various types of bacterial eye infections.