Ofloxacin (Otic)

Ofloxacin treats ear infections brought on by bacteria and won’t work for other kinds of ear infections.


Ofloxacin is in a class of drugs known as quinolone antibiotics and helps treat bacterial infections. It's available under the brand name Floxin.

Ofloxacin otic helps treat ear canal infections in adults and children aged six months or older. It is used by adults and children aged one year or older to treat otitis media (an infection of the inner ear).

Ofloxacin otic can be used in the long-term to treat the infection that causes a ruptured ear drum (a hole inside the ear drum) in anyone aged 12 years or older.

Ofloxacin can also be taken for other reasons not discussed in this drug guide.

Conditions Treated

  • Outer ear bacterial infection
  • Middle ear bacterial infection
  • Outer ear inflammation
  • Chronic middle ear inflammation

Type Of Medicine

  • Quinolone antibiotic

Side Effects

Mild discomfort or irritation in the ear, earache, headache, changes in taste and dizziness may occur while you're using Ofloxacin otic. If any of the effects mentioned below worsen or persist, notify your pharmacist and doctor promptly.

Keep in mind that your physician has prescribed Ofloxacin otic because they have considered its benefit to be greater than the possibility of side effects. The majority of people using Ofloxacin don' suffer serious side effects.

Notify your doctor promptly if you develop any of these serious but unlikely side effects: tingling or numbness.

Notify your doctor at once if you develop any of these very serious but rare side effects: hearing changes.

Using Ofloxacin otic for repeated or prolonged periods may lead to a new fungal infection of the ear. Don't use Ofloxacin beyond the prescribed period. Give your doctor a call if you notice worsening or new symptoms.

Ofloxacin otic is unlikely to cause a very serious allergy. However, be sure to seek medical intervention as soon as it occurs. The following symptoms may indicate a serious allergy: trouble breathing, severe dizziness, rash and itching or swelling of the throat, tongue or face.

This isn't a full list of possible Ofloxacin otic side effects. If you develop other effects not mentioned in this section, call your pharmacist and doctor.


Follow all instructions on the prescription label. Don't use Ofloxacin in smaller or larger quantities than stated or use it beyond the prescribed period.

Ofloxacin otic solution comes with a patient information leaflet. Make sure you read it and, if you've got any queries, consult your pharmacist and doctor.

To avoid contamination and to be accurate, have someone else administer the ear drops if necessary.

Warm the container by holding it for a few minutes. This will reduce dizziness. Shake Ofloxacin otic properly before each use.

To apply Ofloxacin ear drops, start by washing your hands. To avoid contamination, don't touch the tip of the dropper or allow it to touch the ear or other surface. Tilt the infected ear upward or lie on the side. Place the dropper over the ear and give yourself the number of drops prescribed. If you're using single-use containers, simply empty the substance in the number of containers prescribed into your ear.

To treat infections of the outer ear, adults should hold their earlobe upwards and back to help the drops get into the ear. As for children, their earlobe should be held down and back. To treat infections of the middle ear, gently press down on the cartilage partially covering your ear opening several times to let the drops enter the middle ear.

Tilt your head for around five minutes or place a soft piece of cotton wool in your ear if so instructed. Repeat the steps above for the other ear if you are directed to do so.

Don't rinse the dropper. After each use, replace the cap of the dropper. If you're using single-use containers, throw away any unused drops after each use. Don't reuse the drops.

Use Ofloxacin otic on a regular basis to get the most out of it. Remember to apply Ofloxacin at the same daily intervals. Continue using this medication for the entire prescribed period, even if symptoms clear after a number of days. Don't stop taking this medication too soon, otherwise bacteria may continue to grow, potentially causing the infection to return.

Inform your physician if your condition doesn't get better in seven days. Report any discharge of the ear that happens after your treatment period is over.

Don't use Ofloxacin otic in the eye.

An overdose of Ofloxacin otic is not likely to be serious, but please call your local poison control agency at 1-800-222-1222 or seek emergency medical intervention if anyone has swallowed the medication accidentally. If the victim is not breathing or has collapsed, call 911.


When you're taking Ofloxacin otic, it's vitally important to notify your healthcare professional if you're using any of the drugs listed below. The following Ofloxacin drug interactions have been picked based on their potential impact and aren't necessarily comprehensive.

Using Ofloxacin with any of these drugs is not advisable. Your physician may decide to not treat you with Ofloxacin or change a few of the medications you take.

  • Mesoridazine
  • Saquinavir
  • Amisulpride
  • Piperaquine
  • Thioridazine
  • Sparfloxacin
  • Ziprasidone
  • Cisapride
  • Amifampridine
  • Pimozide
  • Dronedarone
  • Terfenadine
  • Bepridil

Using Ofloxacin otic with any of these drugs is normally not advisable, but may be necessary in certain situations. If your healthcare professional prescribes both medicines together, they may adjust your dose or how frequently you take both or one of the drugs.

  • Prochlorperazine
  • Insulin Lispro, Recombinant
  • Telithromycin
  • Tolbutamide
  • Deslorelin
  • Tolazamide
  • Desipramine
  • Moxifloxacin
  • Azimilide
  • Fluconazole
  • Saxagliptin
  • Lopinavir
  • Sunitinib
  • Insulin Glulisine
  • Trifluoperazine
  • Arsenic Trioxide
  • Pramlintide
  • Azithromycin
  • Quetiapine
  • Bretylium
  • Toremifene
  • Cyclobenzaprine
  • Hydroxychloroquine
  • Pioglitazone
  • Vandetanib
  • Nilotinib
  • Insulin Bovine
  • Apomorphine
  • Tedisamil
  • Exenatide
  • Tizanidine
  • Hydroxyzine
  • Sodium Phosphate, Dibasic
  • Clozapine
  • Bedaquiline
  • Octreotide
  • Norfloxacin
  • Rosiglitazone
  • Posaconazole
  • Chlorpropamide
  • Aripiprazole
  • Dapagliflozin
  • Crizotinib
  • Pimavanserin
  • Metronidazole
  • Rasagiline
  • Gliclazide
  • Perflutren Lipid Microsphere
  • Miglitol
  • Ciprofloxacin
  • Histrelin
  • Degarelix
  • Cholera Vaccine, Live
  • Salmeterol
  • Moricizine
  • Tacrolimus
  • Procainamide
  • Ranolazine
  • Nortriptyline
  • Amitriptyline
  • Sotalol
  • Glipizide
  • Pitolisant
  • Flecainide
  • Dasatinib
  • Disopyramide
  • Linagliptin
  • Chloroquine
  • Insulin Aspart, Recombinant
  • Ibutilide
  • Leuprolide
  • Vardenafil
  • Clarithromycin
  • Pazopanib
  • Glimepiride
  • Insulin Degludec
  • Protriptyline
  • Alosetron
  • Warfarin
  • Solifenacin
  • Levofloxacin
  • Dofetilide
  • Sorafenib
  • Canagliflozin
  • Benfluorex
  • Clomipramine
  • Haloperidol
  • Acarbose
  • Pasireotide
  • Sulpiride
  • Vildagliptin
  • Nateglinide
  • Insulin Detemir
  • Mefloquine
  • Triptorelin
  • Iloperidone
  • Tetrabenazine
  • Insulin
  • Amoxapine
  • Sevoflurane
  • Fingolimod
  • Lapatinib
  • Dabrafenib
  • Sodium Phosphate
  • Nafarelin
  • Vinflunine
  • Anagrelide
  • Lumefantrine
  • Citalopram
  • Sematilide
  • Droperidol
  • Amiodarone
  • Glyburide
  • Acetohexamide
  • Efavirenz
  • Promethazine
  • Ondansetron
  • Sitagliptin
  • Dolasetron
  • Sodium Phosphate, Monobasic
  • Escitalopram
  • Panobinostat
  • Chlorpromazine
  • Granisetron
  • Gatifloxacin
  • Astemizole
  • Methadone
  • Imipramine
  • Insulin Glargine, Recombinant
  • Erythromycin
  • Repaglinide
  • Buserelin
  • Quinidine
  • Gemifloxacin
  • Liraglutide
  • Gliquidone
  • Delamanid
  • Asenapine
  • Goserelin
  • Mifepristone
  • Quinine
  • Zuclopenthixol
  • Halofantrine
  • Voriconazole
  • Metformin
  • Paliperidone
  • Donepezil
  • Domperidone
  • Acecainide
  • Gonadorelin
  • Vemurafenib
  • Trimipramine
  • Alogliptin
  • Alfuzosin

Using Ofloxacin otic with any of the drugs listed below may increase the risk of some side effects, but taking both drugs could be your best option of treatment. If your healthcare professional prescribes both drugs together, they may adjust your dose or frequency of taking both or one of the medicines.

  • Budesonide
  • Deflazacort
  • Prednisolone
  • Didanosine
  • Fluocortolone
  • Methylprednisolone
  • Dexamethasone
  • Hydrocortisone
  • Fludrocortisone
  • Triamcinolone
  • Betamethasone
  • Cortisone
  • Lanthanum Carbonate
  • Corticotropin
  • Cosyntropin
  • Prednisone

Other interactions

Certain drugs shouldn't be used at mealtimes or when eating certain kinds of food because interactions can occur. Smoking cigarettes or taking alcohol with certain drugs may also lead to drug interactions. Please discuss the use of Ofloxacin with food, cigarettes or alcohol with your doctor.


Tell your pharmacist and doctor if you have allergies to Ofloxacin (Floxin) otic, Ciprofloxacin (Cipro), Cinoxacin (Cinobac), Enoxacin (Penetrex), Gatifloxacin (Tequin), Levofloxacin (Levaquin), Gemifloxacin (Factive), Lomefloxacin (Maxaquin), Nalidixic Acid (NegGram), Moxifloxacin (Avelox), Sparfloxacin (Zagam), Norfloxacin (Noroxin), Alatrofloxacin and Trovafloxacin combination (Trovan), or any other drugs. Please note that some of these drugs aren't available in North America, including Cinoxacin, Enoxacin, Gatifloxacin, Sparfloxacin, and the combination of Alatrofloxacin and Trovafloxacin.

Tell your pharmacist and doctor about every sort of medications you use, including non-prescription and prescription medications, nutritional supplements, herbal products and vitamins, as well as those that you're planning to use.

Tell your physician if you're pregnant or wish to get pregnant. Also, tell them if you're nursing an infant. If you get pregnant while taking Ofloxacin (Floxin) otic, let your doctor know. Don't give Ofloxacin otic to a child without medical advice.

You need to keep your affected ear(s) dry and clean while applying Ofloxacin otic. Don't get your affected ear(s) wet while taking a bath, and don't swim unless told otherwise by your doctor.

If your symptoms become worse or they don't improve in a few days, please check with your physician.

Systemic and oral Ofloxacin and other related antibiotics have, at times, caused a very serious allergy. It is unclear whether Ofloxacin otic can cause this kind of reaction. However, stop taking Ofloxacin otic and see your physician promptly if you notice shortness of breath, itching and skin rash or swelling of your face or neck.

Ear infections can sometimes cause loss of balance and dizziness. Take care when operating machinery, driving a vehicle or carrying out other hazardous tasks or activities if you lose your balance or experience dizziness.

During your treatment with Ofloxacin otic, don't allow water to get inside your affected ear(s). You should take care while having a bath and it may not be advisable to swim. For more information, consult your healthcare professional.

Ofloxacin otic ear drop solution should be used only in the ears. Don't take it orally, apply it to your eyes or nose, or to your skin.

Ofloxacin otic ear drops don't kill all the organisms that may bring on ear infections. Thus, if your ear infection seems to worsen or hasn't improved within seven days, or if you suffer persistent or severe itching or discomfort, consult your healthcare professional. You may require a different medicine.

It's vital to keep Ofloxacin otic clean and free from bacterial contamination. Thus, do not allow the applicator tip to touch any surface, including the ear and hands.

When taken by mouth, Ofloxacin (Ofloxacin otic's active ingredient) has been shown to cause very serious allergic reactions. While this sort of reaction is unlikely to occur with Ofloxacin otic (since so little of the medication gets into your bloodstream), seek medical attention at once if you develop any symptoms of a very serious allergic reaction, including a rash, itching, hives, wheezing, difficulty with breathing or swelling of throat and lips.


Keep Ofloxacin at room temperature and keep it away from moisture, heat and light. Dispose of any unused Ofloxacin medication after the completion of your treatment.


Please keep all of your doctor and lab appointments.

Do not allow anybody else to take your Ofloxacin medicine. Your prescription is most like not refillable. Give your doctor a call if you still experience symptoms of infection once your Ofloxacin treatment is over.

Before taking Ofloxacin otic, tell your pharmacist and doctor if you've got allergies to it, allergies to any other quinolone antibiotics (including Levofloxacin or Ciprofloxacin), or if you've got any other allergies. Ofloxacin otic can contain inactive ingredients (eg Benzalkonium Chloride) that may cause allergies or other issues. For more details, consult your pharmacist.

Before using Ofloxacin otic, tell your healthcare professionals about your medical past, especially if you've had two or more infections of the ear within six months, or other ear problems.

Ofloxacin only treats ear infections brought about by bacteria and won't help treat other kinds of ear infections.

Don't take Ofloxacin otic by mouth or use it in the eyes. This medication is to be used only in the ears.

Don't allow the opening of the dropper to touch any surface, such as your hands and ears. The opening is sterile, but if it gets contaminated, it may cause another ear infection.

Your symptoms should start to improve within a few days after starting Ofloxacin treatment. If your symptoms don't get better after seven days or become worse, call your doctor.

Take Ofloxacin otic until the prescription is finished, even if your symptoms improve. If you skip doses or stop taking Ofloxacin too soon, your ear infection may not be treated completely and the bacteria could develop resistance to antibiotics.

Ofloxacin may also be taken for other reasons not discussed in this medicine guide.

Last Reviewed:
March 26, 2018
Last Updated:
April 27, 2018
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