Ombitasvir, Paritaprevir, and Ritonavir (Oral)

Ombitasvir, Paritaprevir and Ritonavir are used in conjunction with Ribavirin for the treatment of the hepatitis C infection where there is no cirrhosis of the liver.

Overview

Ombitasvir, Paritaprevir and Ritonavir are used in combination and taken together with ribavirin in the treatment of chronic hepatitis C infection. This treatment is used in patients who are not also suffering from cirrhosis of the liver.

Ombitasvir is used to bind and block activity of the NS5a protein. Paritaprevir is an acylsulfonamide inhibitor of the NS3-4A serine protease. Ritonavir is an HIV protease inhibitor that prevents reproduction of the HIV virus.

Ombitasvir, Paritaprevir and Ritonavir are prescribed in combination as Technicie tablets to be taken orally.

Condition treated

  • Hepatitis C, chronic

Type Of Medicine

  • Ombitasvir¬† Viral inhibitor
  • Paritaprevir - Acylsulfonamide inhibitor
  • Ritonavir¬† HIV protease inhibitor

Side Effects

Ombitasvir, Paritaprevir and Ritonavir can cause a range of unwanted side effects in addition to the needed effects of the treatment. While not all of these side effects may occur, when they do occur you may need to seek medical attention.

You should consult your doctor immediately if you experience any of the following side effects:

  • Abdominal pains
  • Chills when warm
  • Darkened urine
  • Dizziness
  • Feverishness
  • Headaches
  • Itching
  • Large swellings with a hive-like appearance developing on the:
  • Tongue
  • Throat
  • Sex organs
  • Lips
  • Legs
  • Hands
  • Feet
  • Face
  • Eyelids
  • Loss of appetite
  • Nausea
  • New breath odor
  • Rash
  • Stomach pains
  • Stools with a clay-like coloration
  • Unusual tiredness
  • Unusual weakness
  • Vomiting of blood
  • Yellow of the eyes
  • Yellowing of the skin

Other side effects can also occur that do not normally require that the patient seek medical attention. These side effects may abate over time as the body gets used to the treatment, may be mild and do not normally indicate the development of wider medical problems. If these side effects do become bothersome or do not abate then you can contact your doctor for advice, but you should not normally need medical attention with the following:

  • Blistering of the skin
  • Cracked of the skin
  • Crusting of the skin
  • Discoloration of the skin
  • Dry skin
  • Encrusted skin
  • Increased sensitivity of the skin to sunlight
  • Itching
  • Lack of strength
  • Loss of strength
  • Oozing of the skin
  • Reddening of the skin
  • Redness of the skin
  • Scaling of the skin
  • Scaly skin
  • Severe sunburn
  • Skin irritation
  • Skin rash
  • Swelling
  • Troubled sleep

Other side effects that have not been listed herein may also occur from the use of this combination of medications. If you experience any other side effects then you should contact your doctor for advice on how to react.

Dosage

In order to clear the infection of hepatitis C completely, the patient must take the full course of Ombitasvir, Paritaprevir and Ritonavir and ensure that they take the full course of ribavirin too. Even if you are feeling better this does not mean that the infection is gone. If you stop treatment too early then there is a high likelihood that the infection will return.

You must use the prescribed Technivie in regular doses in order for it to be effective for use in the treatment of hepatitis C. A consistent amount of the treatment will need to be present in the body in order for it to work properly.

Ombitasvir, Paritaprevir and Ritonavir should be prescribed with a medication guide that you should read through thoroughly before you begin treatment. If there is any part of this that you do not understand then you should discuss it with your doctor.

This medication should always be taken with food to reduce stomach upset.

The dose of this medication that you are prescribed will depend on a range of factors. You should only ever take it as prescribed by your doctor. Using more of it or missing doses can expose you to greater risks and stop the medication from working properly. The following dosing information is a guideline only and should not be used to adjust the dose as prescribed by your doctor.

When taking Ombitasvir, Paritaprevir and Ritonavir in conjunction with Ribavirin for the treatment of chronic hepatitis C where cirrhosis of the liver is not present.

  • Adults should take 2 tablets once per day. The treatment should be taken with a morning meal and should be taken for 12 full weeks.
  • The use of this medication in children should be determined by the doctor in each case.

If a dose of this treatment is missed then you should take it as soon as possible unless you are close to your next dose being due. After 12 hours you should skip the missed dose completely and return to your normal dosing schedule. Never take more treatment nor take it more frequently to catch up on the missed dose. If you miss more than one dose in a week then you should inform your doctor.

Interactions

Ombitasvir, Paritaprevir and Ritonavir can interact with a wide range of other medications. Drug interactions can be dangerous when they are not intended. In the most severe cases, the results of drug interactions can be fatal. In other cases, medications may stop one another from working. Ombitasvir, Paritaprevir and Ritonavir have a wide range of medication interactions so it is vital that you inform your doctor of all other treatments that you are taking. This is especially important in the following cases:

The use of Ombitasvir, Paritaprevir and Ritonavir with any of the following treatments is not recommended. Your doctor may stop another treatment or may choose not to prescribe this medication:

  • Ziprasidone
  • Voriconazole
  • Venetoclax
  • Triazolam
  • Tolvaptan
  • Thioridazine
  • Terfenadine
  • St John's Wort
  • Sparfloxacin
  • Simvastatin
  • Silodosin
  • Sildenafil
  • Romidepsin
  • Riociguat
  • Rifampin
  • Ranolazine
  • Quinidine
  • Propafenone
  • Primidone
  • Piperaquine
  • Pimozide
  • Phenytoin
  • Phenobarbital
  • Nimodipine
  • Nelfinavir
  • Naloxegol
  • Midazolam
  • Methysergide
  • Methylergonovine
  • Mesoridazine
  • Maraviroc
  • Lurasidone
  • Lovastatin
  • Lomitapide
  • Ivabradine
  • Isavuconazonium Sulfate
  • Grazoprevir
  • Fosphenytoin
  • Fluconazole
  • Flibanserin
  • Flecainide
  • Ethinyl Estradiol
  • Ergotamine
  • Ergonovine
  • Ergoloid Mesylates
  • Eplerenone
  • Encainide
  • Eletriptan
  • Elbasvir
  • Efavirenz
  • Dronedarone
  • Dihydroergotamine
  • Crizotinib
  • Conivaptan
  • Colchicine
  • Cisapride
  • Carbamazepine
  • Bepridil
  • Astemizole
  • Amisulpride
  • Amiodarone
  • Amifampridine
  • Alfuzosin

Use of the following treatments with Ombitasvir, Paritaprevir and Ritonavir would not normally be recommended. In some cases, however, these medications may be prescribed together. In these cases the doctor may adjust the dose or frequency of use of one or other of the treatments:

  • Zuclopenthixol
  • Zolpidem
  • Voriconazole
  • Vorapaxar
  • Vinflunine
  • Vincristine Sulfate Liposome
  • Vincristine
  • Vinblastine
  • Vilazodone
  • Vilanterol
  • Venlafaxine
  • Vemurafenib
  • Vandetanib
  • Triptorelin
  • Triamcinolone
  • Trabectedin
  • Toremifene
  • Topotecan
  • Ticagrelor
  • Temsirolimus
  • Tamsulosin
  • Tamoxifen
  • Tadalafil
  • Tacrolimus
  • Suvorexant
  • Sunitinib
  • Sulpiride
  • Sotalol
  • Sonidegib
  • Simeprevir
  • Sevoflurane
  • Sertraline
  • Salmeterol
  • Ruxolitinib
  • Rosuvastatin
  • Rivaroxaban
  • Rilpivirine
  • Rifapentine
  • Rifabutin
  • Retapamulin
  • Regorafenib
  • Reboxetine
  • Quinine
  • Quinidine
  • Quetiapine
  • Propafenone
  • Prednisone
  • Prednisolone
  • Pravastatin
  • Ponatinib
  • Pixantrone
  • Pitolisant
  • Pimavanserin
  • Pazopanib
  • Pasireotide
  • Panobinostat
  • Palbociclib
  • Oxycodone
  • Orlistat
  • Ondansetron
  • Omeprazole
  • Olaparib
  • Nilotinib
  • Nifedipine
  • Nafarelin
  • Moxifloxacin
  • Morphine Sulfate Liposome
  • Morphine
  • Mifepristone
  • Mexiletine
  • Metronidazole
  • Methylenedioxymethamphetamine
  • Metformin
  • Manidipine
  • Macitentan
  • Lopinavir
  • Lidocaine
  • Levomilnacipran
  • Levofloxacin
  • Leuprolide
  • Lapatinib
  • Lacosamide
  • Ketoconazole
  • Ixabepilone
  • Ivacaftor
  • Irinotecan Liposome
  • Irinotecan
  • Iloperidone
  • Ifosfamide
  • Idelalisib
  • Ibrutinib
  • Hydroxyzine
  • Hydroxychloroquine
  • Hydrocodone
  • Histrelin
  • Goserelin
  • Gonadorelin
  • Garlic
  • Fusidic Acid
  • Fosaprepitant
  • Fosamprenavir
  • Fluticasone
  • Fluoxetine
  • Flecainide
  • Fentanyl
  • Everolimus
  • Etravirine
  • Eszopiclone
  • Escitalopram
  • Erlotinib
  • Enzalutamide
  • Eluxadoline
  • Doxorubicin Hydrochloride Liposome
  • Doxorubicin
  • Donepezil
  • Domperidone
  • Docetaxel
  • Disopyramide
  • Digoxin
  • Dexamethasone
  • Deslorelin
  • Delamanid
  • Degarelix
  • Deferasirox
  • Dasatinib
  • Darunavir
  • Daclatasvir
  • Dabrafenib
  • Dabigatran Etexilate
  • Cyclosporine
  • Cyclophosphamide
  • Conivaptan
  • Cobimetinib
  • Cobicistat
  • Clarithromycin
  • Cilostazol
  • Ceritinib
  • Cariprazine
  • Calcifediol
  • Cabozantinib
  • Cabazitaxel
  • Buserelin
  • Bupropion
  • Budesonide
  • Bromocriptine
  • Brexpiprazole
  • Bosutinib
  • Bosentan
  • Boceprevir
  • Bepridil
  • Bedaquiline
  • Axitinib
  • Avanafil
  • Atazanavir
  • Artemether
  • Arsenic Trioxide
  • Aripiprazole
  • Aprepitant
  • Apixaban
  • Anagrelide
  • Amprenavir
  • Amiodarone
  • Afatinib
  • Ado-Trastuzumab Emtansine

Using the following medications in conjunction with Ombitasvir, Paritaprevir and Ritonavir can cause an increased risk of side effects occurring. Patients may be treated with both medications but the dose or frequency of use of one or other may be adjusted:

  • Warfarin
  • Valproic Acid
  • Trazodone
  • Theophylline
  • Tenofovir Disoproxil Fumarate
  • Risperidone
  • Quinupristin
  • Prasugrel
  • Paroxetine
  • Olanzapine
  • Norgestrel
  • Norgestimate
  • Norethindrone
  • Norelgestromin
  • Nefazodone
  • Mexiletine
  • Methamphetamine
  • Methadone
  • Mestranol
  • Meperidine
  • Medroxyprogesterone Acetate
  • Levothyroxine
  • Levonorgestrel
  • Lamotrigine
  • Itraconazole
  • Indinavir
  • Imipramine
  • Fosamprenavir
  • Etonogestrel
  • Ethynodiol Diacetate
  • Estradiol Valerate
  • Estradiol Cypionate
  • Dutasteride
  • Drospirenone
  • Disopyramide
  • Dienogest
  • Didanosine
  • Desogestrel
  • Desipramine
  • Delavirdine
  • Dalfopristin
  • Clonazepam
  • Cerivastatin
  • Amprenavir
  • Amitriptyline
  • Acenocoumarol

Interactions with other medications can also occur that have not been listed herein.

Warnings

Patients with any liver disease that is moderate to severe should not use this medication for treatment.

Patients should avoid consumption of grapefruit juice during treatment with Ombitasvir, Paritaprevir and Ritonavir.

This medication has not been tested for use in children and safety and efficiency have not been established.

There is a small risk to the use of Ombitasvir, Paritaprevir and Ritonavir in pregnant women. You must inform your doctor before use if you are pregnant. This medication is, however, usually given alongside Ribavirin, which can be harmful when taken during pregnancy. The use may also cause birth defects if the father is using these treatments at the time of conception. You should use birth control during treatment and should inform your doctor straight away if you believe that you have become pregnant during use.

Your doctor will need to check on your condition regularly during and after treatment with Ombitasvir, Paritaprevir and Ritonavir. Regular blood samples will be needed to check for unwanted side effects that may be occurring.

Serious liver problems can develop during the use of this treatment. If you experience any symptoms of a liver problem then you must see your doctor immediately.

Storage

This medication can be stored at room temperature but must be kept out of the reach of children at all times. Keep it out of direct light and away from moisture and heat. Prevent it from freezing.

Dispose of any unused or outdated medication safely ensuring that it is always out of the reach of children.

Summary

Ombitasvir, Paritaprevir and Ritonavir are used in conjunction with ribavirin for the treatment of chronic hepatitis C.

This treatment should not be used in cases where there are moderate to severe diseases of the liver, including cirrhosis, present in the patient.

Ombitasvir, Paritaprevir and Ritonavir is prescribed as a tablet to be taken once daily with breakfast.

Ombitasvir, Paritaprevir and Ritonavir interact with a wide range of medications. Do not take any other medications in conjunction with Ombitasvir, Paritaprevir and Ritonavir unless they have been approved by the doctor.