Orphenadrine, aspirin, and caffeine (Oral)

Orphenadrine displays anticholinergic and antihistaminic properties because it’s a progeny of diphenhydramine; the combination of aspirin and caffeine is used to relieve musculoskeletal pain.


The combination of orphenadrine, aspirin, and caffeine is used for treating muscle pain caused by various injuries such as sprains and strains. However, the drug is not a replacement for other forms of treatment prescribed such as exercise or rest; this combination is available only as a prescription. The medication combination alters the functioning of the central nervous system to relax the muscles. The reactions that take place in the nervous system are also the cause of a few of the side effects.

The medicine is for adults but not recommended for children. The dosage can be taken before or after meals; take after meals if you experience stomach upsets. Drink plenty of water as well.

Before you decide to use any medication, it's advisable to weigh up the risks and benefits first. The same applies to the orphenadrine mixture. Discuss with a healthcare provider so that your medical history can be reviewed. Keep a list of everything that gives you an allergic reaction such as animals, preservatives, dyes, foods, and non-prescription products.

Apart from the fact orphenadrine delivers fast relief; it can also cause negative effects. This is why you should not use the drugs if you're exhibiting symptoms of other diseases such as chickenpox and flu. Avoid using the drug after you have lost huge amounts of body fluids through sweating, vomiting, diarrhea etc.

As a musculoskeletal relaxant, this drug combination works by reducing inflammation, which as a result alleviates muscle pain. However, it may lead to several severe side effects if it's expired, check the expiry date to ensure that you are not taking harmful tablets. If the medication has a strong odor resembling vinegar, do not use it; contact your doctor for another prescription. In case you forget to take the medication, it's advisable to take the missed dose immediately you remember. Nevertheless, if it's already time to take your other dose, take it and continue as normal. Do not take double doses.

Conditions Treated

  • Musculoskeletal pain/ injury

Type Of Medicine

  • Painkiller

Side Effects

Although this is an active drug used in treating muscle pain, some side effects have been reported. Patients usually experience a mix of different symptoms, but it's rare for a single patient to experience all of them. Seek medical help urgently in case these side effects are persistent.

Numerous severe and less severe side effects can occur. The severe side effects often include:

  • Bloody urine
  • Seizures
  • Severe lightheadedness or dizziness
  • Difficulty in hearing
  • Diarrhea
  • Confusion
  • Severe drowsiness
  • Increased sweating
  • Chronic migraine
  • Fever
  • Hallucinations
  • Nervousness
  • Fast-paced breathing
  • Vomiting
  • Dehydration
  • Behavior change
  • Fatigue
  • Vision problems

On the other hand, several side effects are rare and less harmful to overall health. You can wait for a few days for these symptoms to disappear. Seek medical assistance if they are persistent. The less severe effects that are common in many patients include the following:

  • Abdominal pain
  • Black stained stools
  • Difficulty in urinating
  • Fainting
  • Mild eye pain
  • Mouth ulcers
  • Sores on lips
  • Unusual bruising and bleeding
  • Swollen glands
  • Skin rash
  • Wheezing, trouble breathing

Some side effects of the orphenadrine mixture are not serious and may not require medical attention. These are often the reactions that are brought about as a result of the patient's body adjusting to the therapy. A healthcare provider will be able to provide you with detailed information on how to prevent and manage these effects. Ask all relevant questions particularly on how soon to seek treatment if the symptoms become chronic.
The following are some more common side effects that are less severe:

Rare symptoms that are also less severe include the following:

  • Blurred vision
  • Constipation
  • Dizziness
  • Restlessness
  • Trembling
  • Muscle weakness

The orphenadrine, aspirin, and caffeine combination can lead to numerous other side effects not discussed in this guide. It's important to check with your doctor in case you develop other unusual or persistent symptoms.


The dosage for the combination of orphenadrine, aspirin, and caffeine depends on several factors, but most adults will be prescribed 1 or 2 tabs to be taken 3 to 4 times a day. The medication is not recommended for children.

Since it's a healthcare provider's job to write the prescription, the dosage will differ according to the requirements of the patient. If you do not get specific instructions from your doctor, follow the directions on the medicine's label, which is the average dose of the medication set by the manufacturer. Dosage should not be altered unless it's under the directions of a healthcare provider.

For each dose prescribed, the doctor will take into consideration the strength of the drugs. Other influencing factors include the number of doses a patient is required to ingest each day, the time difference between the doses, and the overall period the medicine will be taken.

The medicine should be taken orally with plenty of water, as directed by healthcare professionals. Also, ensure that you take the medication with food to avoid stomach upsets. When taking medicine, do not chew or crush the pills because this can cause the drug to release all its effects at once leading to an overdose, which consequently intensifies the side effects. The tablets should be swallowed whole without chewing or crushing.

Dosage for each patient depends on medical history, other medical conditions, age, and responsiveness. It's not recommended to alter dosage or take the drugs more often than prescribed by the doctor. Drug abuse is the improper use of the medicine, and this may result in detrimental effects like seizures, hallucinations or even death.

If you have been directed by your healthcare provider to take medicine daily, ensure that you swallow it regularly to get the best effects. This can best be achieved by taking the dosage at exact times of the day.

Major drug interactions

The orphenadrine combination interacts with other prescription drugs, herbal products, supplements, and street drugs. Discuss with your doctor for a way forward if you're using any of these. Some medication may be changed, but at times a lesser dose amount may suffice. According to FDA records, the total number of over-the-counter medication that interacts with orphenadrine is 1,171. For both brand and generic drugs, the number is 6,765.

This is how orphenadrine interacts with the major drugs:

  • Diphenhydramine

Reports indicate that an orphenadrine and diphenhydramine interaction can lead to severe side effects such as confusion, blurred vision, memory problems, constipation, flushing, dry mouth, and difficulty in urinating. This interaction mostly occurs in people with serious conditions and the elderly.

  • Olmesartan

The interaction with this medicine plays a large role in a low blood pressure condition. Also, the combination may cause other unpleasant effects such as fainting, dizziness, and migraine. Statistics reveal that these effects occur at the beginning of therapy. Even though these effects are mild, seek medical attention if they persist for a few days after treatment has started.

  • Duloxetine

The combination of orphenadrine and duloxetine increases your risk of bleeding, especially if you're elderly or suffering from a chronic liver or kidney condition. Visit your doctor if you see any signs of bruising or bleeding. Other symptoms that may also occur as a result of this interaction include severe headache, red stools, dizziness, and dried blood that resembles coffee grounds.

  • Phenytoin

Using orphenadrine with this drug can increase the severity of the commonly experienced side effects of both drugs. These include, but are not limited to, confusion, drowsiness, and lack of concentration. It has also been reported that some people (particularly the elderly) also suffer from poor judgment, thinking, and impaired motor skills.

  • Fentanyl

Medication for a cough and narcotic pain interact with orphenadrine causing depression of the central nervous system. The combination can lead to harmful effects such as coma, distress, and death. Speak to a healthcare provider for alternatives that may not interact with this drug. In other cases, however, a dose alteration may suffice but only under frequent monitoring to ensure safety.

  • Ginkgo

Even though they have numerous health benefits, Ginkgo Biloba products may also cause bleeding when used together with orphenadrine. To use both types of medication safely, a dose adjustment prescribed by a healthcare professional is mandatory. Do not stop taking the medication without consulting your doctor first.

  • Escitalopram

The interaction with this drug also causes excessive bleeding. Elderly people and patients who suffer from other types of liver diseases are at a higher risk. Other symptoms include vomiting or coughing up blood.

  • Pentobarbital

These medications interact to cause symptoms such as drowsiness, dizziness, and impaired mental ability. In case your doctor has given you the go-ahead to use both types of drugs, avoid activities that require mental alertness such as operating heavy machinery or driving.

  • Oxycodone

Interaction with oxycodone can be fatal, especially in case of large dose amounts. The combination of these two drugs and alcohol should be avoided. Patients should only use oxycodone together with the orphenadrine mixture with a doctor's approval. Self-medication can lead to detrimental effects.

  • Quetiapine

Using these drugs together increases the side effects of orphenadrine such as abdominal cramping, dry mouth, blurred vision, difficulty urinating, confusion, and irregular heartbeat. These side effects are often more severe in elderly patients and those suffering from another medical condition.

  • Bupropion

The combination may increase the patient's blood levels while increasing the side effects of bupropion. Seek medical assistance immediately if you experience any of the following symptoms: Insomnia, anxiety, confusion, and seizures.

  • Nicotine

It causes minor side effects although it can cause harmful ones too, especially if the interaction frequently occurs and for a prolonged period. Stop smoking during the therapy period for the medication to deliver desired results, and to prevent any side effects from occurring. Patients who fail to stop smoking may require a therapy change to minimize the effects.

  • Alcohol

Limit or avoid alcohol consumption; it causes pharmacologic effects to the central nervous system. This can be dangerous as it may result in a depression of the nervous system, which is characterized by impaired thinking, judgment, and inability to drive. These effects may be severe among patients who receive higher doses and are heavy drinkers.

Some of the diseases that interact with orphenadrine include:

  • Coagulation

Patients suffering from this condition should not use orphenadrine as it can cause hemorrhagic disorders like hemophilia. If you have a Vitamin K deficiency, do not take this medication because aspirin intake may lead to hepatic impairment.

  • Cardiac disease

Orphenadrine interacts with medication used to treat heart disease, hypertension, peripheral arterial, and hyperthyroidism. Interaction leads to symptoms like chest pain, stroke, syncope, and severe arrhythmias. Sudden death can occur in patients with these conditions as the drugs interact. Before this medication is prescribed, a detailed assessment of the patient is conducted to ensure that they pass the cardiac evaluation.

  • Liver disease

Interaction with this medical condition can be severe. Orphenadrine should be administered moderately and under strict guidance from a healthcare professional to patients with liver disease (moderate to severe). Some symptoms to be on the lookout for include dark urine and jaundice. Patients with a moderate liver disease can still use the medication; however, treatment should be stopped immediately when there is evidence of liver injury.

  • Seizures disorders

Because orphenadrine causes stimulation to the central nervous system; it may increase the likelihood of seizures occurring. This is especially common in patients with a history of EEG abnormalities. Therapy may still be conducted with caution, but it should be discontinued in case seizures start to appear.

Patients with an active peptic ulcer should not use orphenadrine because the medication may cause severe side effects. Treatment for peptic ulcers must be administered cautiously for patients using the orphenadrine, aspirin, and caffeine mixture.

Statistics reveal that 10% of asthma patients are also sensitive to aspirin. The interaction is often characterized by asthma attacks. Treatment with anti-inflammatory drugs should also be avoided, especially if you have a history of bronchitis that is triggered by these drugs. Manufacturers recommend healthcare providers to start therapy using low dosage and increasing it steadily.


Seek medical assistance if the symptoms continue for more than a week. Patients who are treating themselves should read the instructions on the medicine's package to be sure that you're using the correct product. Inquire from your pharmacists for any other generic drugs available.

Use this drug properly as prescribed by your doctor; do not share your pills with other people or use the medication to treat a different condition other than the one prescribed.
The orphenadrine, aspirin, and caffeine mixture is not recommended for children, especially those younger than six years.

Patients who take this medication for a prolonged period should be checked regularly by their doctors to ascertain progress. Before you start using the orphenadrine, aspirin, and caffeine mixture, create a list of all over-the-counter medication that you take. Take note if any of them contains any of these drug's elements to prevent a case of overdose.

Taking this medication with other types of prescription pills or supplements may lead to unpleasant side effects. The risk and severity of the unwanted effects is dependent on the amount of dosage taken. Medicines that interact with the orphenadrine mixture can still be taken (but under the strict direction of a healthcare professional); however, they should not be used together for a long period.

For patients who are suffering from diabetes, combining this medicine with their regular medication may lead to false sugar test results. This mostly occurs in patients who are taking higher doses of the medicine; reports reveal that smaller dose amounts may not affect the urine sugar tests. Consult your doctor if you have diabetes before you start using the pills.

Do not take the orphenadrine mixture five days before you undergo any type of surgery such as dental. The drug may cause excessive bleeding.

The orphenadrine mixture intensifies the effects of depressants, which are other drugs that affect the central nervous system for example alcohol. Such a mixture often slows down the nervous system, which consequently causes drowsiness. Numerous types of medication fall under the depressants such as drugs for allergies, colds, tranquilizers, and anesthetics.

For temporary relief from the dry mouth when taking this medicine, you can use sugarless gum or candy. Consult your dentist if the dry mouth persists for more than two weeks because it can be an indicator of another dental disease such as fungal infections, gum disease, or tooth decay.

In case of an overdose, contact the local poison control unit or take the victim to a hospital immediately. Overdosing on this combination may lead to unconsciousness or even death. Symptoms of an overdose include the following: Seizures, ringing in the ears, fatigue, nervousness, and confusion.

Sick and elderly patients exhibit severe side effects when they use this medication. Pregnant and breastfeeding women should also exercise take precaution to avoid harming the fetus or infant.


It's important to store your orphenadrine, aspirin, and caffeine medication appropriately to prevent damages. To properly store the drugs, you must observe the following:

  • Store the pills away from light, air, moisture, and heat.
  • Keep the medication in a dry and cool place. A kitchen cabinet that is away from cooking appliances, sinks, and stoves is the best place.
  • Do not keep the medicine in a bathroom cabinet. Although most people do this, it's ill-advised because the moisture and heat from your sink, shower, and bath may spoil the drugs. The drugs may expire before the date set by the manufacturer or even become less effective.
  • Always store the medication in their original containers.
  • Remove the cotton ball that usually comes with the bottle once you open it. The cotton ball absorbs moisture into the container.
  • Always store the medicine out of sight and reach of children and pets.
  • Do not take medicine that has already been damaged as it can cause you to fall sick.
  • Do not take medicine that has a different smell, color, or texture. This should be observed even for medication that has not yet expired.
  • Unused or expired medication should be appropriately discarded. Do not flush the medicine or throw it away with your regular trash.
  • You can also take unused medication to the pharmacist or give them to community programs that collect medication for the less needy.
  • When traveling, do not store the medicine in the car's glove compartment because it can get too cold or hot.


The orphenadrine, aspirin, and caffeine combination is used to relax muscles and alleviate the pain caused by sprains, strains, and other muscle injuries. The mixture alters the functioning of the central nervous system thereby producing the required muscle relaxant results. The action of the medication on the nervous system also leads to specific side effects. The medicine combination is available over-the-counter but only under a doctor's prescription.

The proper way to take this medication is with a full glass of water to reduce the likely occurrence of stomach irritation. If this medicine has a strong odor that resembles vinegar, it's an indication that the aspirin in the mixture is decomposing. Do not take the pills but rather go to a healthcare professional for a prescription replacement. Do not alter dosages to avoid overdosing on the drugs.

For doses, follow your doctor's prescription, which will largely depend on your medical history, medicine strength, and therapy period. Before you start using the orphenadrine mixture, discuss with your doctor all potential risks and benefits. Alert your healthcare provider if you are suffering from other medical conditions, or you're using other prescription pills, supplements, herbal products, and street drugs. Read the packages of other prescription medication you take to ascertain whether or not they contain ingredients that may interact with the orphenadrine mixture.