Orphenadrine (Injection)

As a muscle relaxant that works within the central nervous system, Orphenadrine is prescribed to patients suffering from muscle stiffness and pain.


Orphenadrine is a drug given to patients who need help relaxing certain muscles in the body. It is often used to relieve the pain, stiffness, and discomfort caused by sprains, strains, or other muscle injuries. It works inside the central nervous system to produce muscle relaxant effects.

It should be noted that this is not a one-stop cure for stiff muscles but should be accompanied by physical therapy, exercise, and any other appropriate treatment for your medical problem. You shouldn't try to access orphenadrine by yourself, as it is only available via a prescription from your doctor. It is known to interact with a variety of drugs and can cause a variety of side effects that your doctor will likely wish to make you aware of before proceeding with this treatment.

Condition(s) treated

  • Stiffness and pain in muscles

Type of medicine

  • Solution

Side Effects

As well as having its intended effect, it is possible that Orphenadrine could cause a variety of other side effects as well. In some cases, these side effects are not very severe, but in other cases, they can be more worrying. Directly below is a list of side effects which, if experienced while using Orphenadrine, should be reported to your doctor immediately.


  • Fast heartbeat

Incidence not known

  • Sores in mouth

Below are the symptoms of overdose. If you experience these, seek emergency medical assistance.

  • Drowsiness

As well as these more serious side effects, it is possible that you will experience less serious ones which don't require immediate assistance. In fact, you may find that many of the side effects listed below will simply pass over time as your body adjusts to the medicine. However, if any of the following side effects are bothersome, or if they continue for an extended period of time, you may still contact your doctor. It is possible they will be able to alter your dosages or offer another means to help reduce the effects you are experiencing.

Incidence not known

  • Mental confusion

Though the above lists are extensive, they are not necessarily all-inclusive. You may experience other side effects which have not been listed here. If this is the case and you would like to ask questions regarding the side effects you are experiencing, you should contact your doctor.


You will not need to worry about dosages regarding Orphenadrine. It is injected into one of your veins or into a muscle by a trained nurse, doctor, or another medical professional. They will calculate the amount that is most suitable for your condition.


It is possible that Orphenadrine will interact with other drugs you are currently taking. This is why your doctor will need to know about any and all drugs you are currently taking. This includes any prescription and nonprescription drugs, as well as any herbal or vitamin supplements. In most cases, your doctor will likely try and avoid any interactions occurring, but in other cases, it may be necessary. Directly below is a list of drugs which it is usually not recommended you take at the same time as Orphenadrine. However, as mentioned, it may well be necessary that you take both. If this is the case, your doctor may well adjust the doses you receive of one or both of the medicines in order to limit any unwanted interactions.

  • Hydromorphone

Beyond this, the following drugs could cause an increased chance of certain side effects if they are taken at the same time as Orphenadrine. Again, if it is necessary for you to take both, your doctor may wish to alter the doses of one or both medicines.

  • Perphenazine

As well as interacting with drugs, it is possible that Orphenadrine will interact with certain elements of your typical dietary intake. Your doctor may, therefore, make recommended changes to certain things that you eat, drink, or smoke in order to limit the chance of such interactions and to provide the best treatment possible. For example, they may need to limit the amount of alcohol you drink or tobacco you smoke.

Finally, other medical problems you currently suffer from could potentially interact with Orphenadrine. You should advise your doctor of all other medical problems you currently have. In particular, note any of the following.


Before being prescribed this drug, your doctor will first need to give you a full medical examination to ensure this is the most suitable course of treatment for you. As part of this examination, they will need to be made aware of any allergies you suffer from. This includes any allergies to preservatives, foods, dyes, and animals.

At the time of writing, no safety and efficacy have been established for pediatric patients taking this medicine. This is because no adequate studies have been performed into the effect it has on younger patients. Instead, your doctor is best placed to advise of any increased risks and to decide if this drug is indeed well suited to your child.

Similarly, no information is available regarding the effects this drug may have on older patients. This may be because no suitable geriatric-specific studies have been conducted. However, you should be aware that older patients are more likely to suffer from age-related liver, kidney, or heart problems. If so, greater levels of caution will need to be exercised when using Orphenadrine.

As of writing, it is unclear as to whether there is an increased risk to pregnant women using Orphenadrine. This could be because insufficient studies have yet been performed. Either way, your doctor is best placed to advise you of any increased risk to either you or your child. Together you can weigh the benefits and risks of taking Orphenadrine. If, while taking this drug, you become pregnant, you should inform your doctor.

Similarly, there are no adequate studies that have been performed on breastfeeding women using this medicine. Your doctor can advise on the increased risks and then weigh them against the benefits.

After receiving a few injections of Orphenadrine, your doctor may decide to switch you to a different medicine that you can take orally, but which works in a similar way. If you are concerned about this process, then you can address these worries to the prescribing doctor.


You will not be required to store this drug. Instead, it will be given by a trained nurse or doctor in a medical setting. They will be responsible for its safe storage and transportation.


If you are suffering from muscle stiffness or pain as a result of sprains, strains, or other incidents, then Orphenadrine can be a useful drug in helping to relieve your symptoms. You should be aware however that it is only available following a doctor's prescription and a full medical examination. This is because it is only suitable for certain patients, and has the potential to interact with a wide range of other drugs or certain dietary components.

If you are prescribed this drug, you should be careful in following any other guidance your doctor gives you alongside it. This will likely include an exercise regime and possibly some physical therapy sessions. Following all guidance is the best way to gain maximum benefits from using this drug. If you receive Orphenadrine and experience any of the serious side effects listed above, you should contact your doctor immediately. Similarly, if you have any other questions regarding this drug, you should address them to your doctor.