Orphenadrine (Oral)

Orphenadrine, when combined with physical therapy, diet, exercise and proper rest, is effective in the treatment of many conditions involving the musculoskeletal functions of the body such as sprains, strains and injuries.


Orphenadrine is prescribed to patients with Parkinson's disease, as it can lessen the tremors that they experience with their condition. It can also be effective on other conditions that cause painful spasms of the muscles.

Orphenadrine is sold under a few names to a world-wide market, where it may be recognized as Norflex. Available in an oral tablet form as well as an extended release tablet, there are different sizes and frequencies of dosage available depending on the patient's requirements. Orphenadrine should be taken exactly as prescribed, with the extended release tablet formulation swallowed whole and never crushed or chewed.

Orphenadrine connects to two receptors in the central nervous system known as NMDA receptors and H1 receptors. These nerve receptors control motor functions and musculoskeletal activities. Along with calming muscles that are painful or having spasms, Orphenadrine may also elevate the mood.

Patients who are not candidates for treatment with Orphenadrine include those who have had com/health/coma/">glaucoma, ulcers, urinary or intestinal blockage, and prostate enlargement, irregular rhythms of the heart or kidney, and heart or liver diseases. Those diagnosed with myasthenia gravis are also advised not to take this medication and women who are pregnant should avoid it as well.

Conditions Treated

  • Muscle spasms
  • Parkinson's disease tremors

Type Of Medicine

  • Muscle relaxant
  • Musculoskeletal agent

Side Effects

By affecting the central nervous system, Orphenadrine may also cause unexpected, unwelcome effects on other parts of the body and cause symptoms. Report these symptoms to your physician in case they are the sign of underlying health issues:

  • Chills
  • Fever
  • Coughing
  • Pain in chest
  • Hallucinating
  • Headache
  • Difficulty breathing
  • Chest tightness
  • Wheezing
  • Rash on skin or hives with itching or redness
  • Ulcerated white sores on skin
  • Painful, swollen glands
  • Bleeding or bruising that is unexpected
  • Weak muscles
  • Fatigue
  • Pain in stomach or abdomen
  • Fainting spells
  • Diarrhea
  • Heart rhythm that is irregular, pounding or rapid
  • Glaucoma symptoms
  • Muscle or joint pain
  • Nausea
  • Tingling, numb feet, hands or face
  • Sore, bloodshot eyes
  • Swollen lower legs or feet
  • Vomiting

As your system gets used to Orphenadrine, you may find that the following symptoms decrease over time. They should still be reported to your physician in case there is a way to diminish them sooner:

  • Dizzy, lightheaded feeling
  • Excited, nervous or restless demeanor
  • Irritable mood
  • Headache
  • Weak muscles
  • Dilated pupils of the eyes
  • Anxious demeanor
  • Dizziness accompanied by deep, quick breathing
  • Skin itching and irritation
  • Confused demeanor
  • Numb around the mouth or the hands
  • Shaking or trembling feet, legs, hands or arms

Do not take more Orphenadrine than prescribed by your doctor and do not increase the amount of times per day that you take it. Doing so may cause symptoms of overdose, which include:

  • Vision that is blurred
  • Delirious, confused demeanor
  • Hallucinations
  • Difficulty urinating
  • Constipation
  • Drowsy, sleepy
  • Difficulty breathing
  • Flushed face
  • Pain in eyes
  • Dry mouth, eyes, nose or throat

Report any symptoms that indicate you have been overdosed to emergency medical staff.


Increasing your dosage amount is not advised nor is it advised that you change the frequency of your dosage. You may experience dangerous health conditions by doing so as you could over dose yourself. Seek emergency medical assistance if you suspect that you have overdosed.

Extended release tablet forms of this medication should be swallowed whole without chewing, breaking or crushing the tablets in any way.

Your prescription has been written especially for your health condition by a physician who is familiar with you and your requirements. The information provided below is general and based on the manufacturer's recommendations for effectiveness and safety. Your directions may vary and should be followed.

Adult and teenage patients who have sore, stiff muscle symptoms will typically be prescribed 100 milligram extended release tablet forms of Orphenadrine to be taken two times per day, typically a morning and an evening dose.

Patients with Parkinson's disease are prescribed the tablet form in 50 milligram doses to be taken three times per day.

Use of this medication in children must be determine and prescribed by their physician to treat their specific condition.


Past experiences of hypersensitivity to this or other prescription medications or substances such as foods, perfumes, dyes or preservatives should be communicated to your doctor before you are approved for treatment with Orphenadrine. Include any allergies to animal dander or other substances as well.

Age related increases of adverse health effects have not been reported through any appropriate studies performed on the pediatric population. Use of Orphenadrine on children has not been proven safe or effective and is up to the physician to determine.

Elderly patients who have age-related liver, heart or kidney diseases may require caution when prescribing Orphenadrine as they could have a higher sensitivity to adverse health effects. Consult your physician if you are concerned about any symptoms you have in relation to these conditions.

Adequate data has not been provided through study of pregnant women patients with regard to the safety of this drug on the fetal development. Use of this medication in women who are pregnant is not advised. Discuss treatment options with your physician if you are pregnant and need this medication.

No studies have been performed on women who are breastfeeding to determine if they pass on Orphenadrine to their infants through breast milk. Women who require treatment with this medication may be advised to discontinue breastfeeding temporarily.

Certain medications, when used together, form effective, safe combination therapies that are required by many patients. Orphenadrine may be prescribed for other drugs, but is known to adversely react with the following medications and should be avoided. Alert your physician if you take:

  • Alfentanil
  • Bromazepam
  • Anileridine
  • Butorphanol
  • Buprenorphine
  • Dihydrocodeine
  • Codeine
  • Doxylamine
  • Donepezil
  • Flibanserin
  • Fentanyl
  • Hydromorphone
  • Hydrocodone
  • Meperidine
  • Levorphanol
  • Morphine
  • Methadone
  • Oxycodone
  • Morphine Sulfate Liposome
  • Pentazocine
  • Oxymorphone
  • Remifentanil
  • Propoxyphene
  • Sufentanil
  • Sodium Oxybate
  • Tiotropium
  • Tapentadol
  • Zolpidem
  • Tramadol

Certain adverse effects on your health may be at an amplified risk if you are taking Orphenadrine with:

  • Perphenazine

It is in the best interest of your health and safety to avoid other medications while taking Orphenadrine, if possible. If you take other prescription or non-prescription medications, let your physician know so that the best course of treatment can be determined. Use of vitamin supplements or herbal and holistic treatments are also topics that you should discuss with your doctor.

Consult your physician on whether you should take Orphenadrine with food or alone or if you should avoid certain foods altogether. Additionally, if you are a regular consumer of alcoholic beverages or use tobacco products, your physician may advise you to stop while you are on this medication.

Patients with the following medical problems may have problems with effectiveness when taking Orphenadrine and may also experience a worsening state of their condition or a higher risk of adverse health effects.

Communicate your full medical history to your doctor, especially if you have the following conditions:

  • Enlarged prostate
  • Glaucoma
  • Enlarged esophagus
  • Blockage in the intestine
  • Myasthenia gravis
  • Stomach ulcers
  • Blockage of the urinary tract
  • Heart rhythm problems


Your physician will want to schedule regular appointments to follow up on your drug treatment therapy with Orphenadrine. These visits will make sure the drug is working properly for you and isn't causing you any health issues.

Avoid double dosing; if you miss a dose of Orphenadrine, wait until your next scheduled dose if you remember too late. Signs of overdose include vision that is blurry, confusion, hallucinations, difficulty urinating, severe drowsiness, difficulty breathing and pain in the eyes. Seek emergency medical attention if you experience any of these symptoms.

Anaphylaxis, a serious hypersensitivity to Orphenadrine, is possible while taking this drug. Seek your doctor's advice immediately if you have any swelling of your tongue, throat or face, difficulty breathing or swallowing, skin rashes or itching and chest pains when you are taking your medication.

Some patients taking Orphenadrine have reported being less than alert, lightheaded, dizzy and having fainting spells while taking the drug. Until you know if you will experience the same issues, do not put yourself and others in danger by driving, operating tools or machinery.

It is best to avoid the consumption of alcoholic beverages during your drug therapy with Orphenadrine, as depressant substances interact poorly with Orphenadrine, causing adverse effects on health. It is also best to avoid any medications that contain narcotics or barbiturates such as seizure medication, tranquilizers, allergy medications or antihistamines and other drugs meant to act as muscle relaxers.

You may experience a chronic dry condition of your mouth while you are taking this medication. To relieve this symptom, it is recommended that sugarless gum or candy be used or melting ice chips as a substitute for saliva. If dry mouth symptoms become bothersome or last longer than 14 days, get in touch with your dental professional and tell them what medication you're taking and that you have dry mouth. Your dentist can assist you with ways to remedy this and prevent dental diseases, decaying of your teeth and fungal infections that can result from this condition.

Before you have surgery or any tests by other physicians, make sure they are aware that you are taking Orphenadrine, as it can cause odd results of some medical tests. This includes your dentist and other physicians treating you.

Elderly patients should be monitored for increased risks of confusion, constipation, difficulty urinating or drowsiness when taking Orphenadrine. Dizziness and drowsiness as well as confusion can lead to accidental falls in this age group. If you are concerned about these symptoms, check with your physician.

Unless your doctor has specifically reviewed and approved it or prescribed it themselves, do not take other medications with Orphenadrine. This includes any remedies from the health food store, vitamin supplements or holistic treatments.


Keep the original packaging and patient information leaflet that your Orphenadrine prescription arrives in for storage purposes. Store this medication at room temperature and avoid exposure to excessive moisture, light and heat. Keep Orphenadrine out of sight and reach of children and pets.

Dispose of any unused or expired medication safely under the instruction of your doctor or pharmacist, who will be aware of local ordinances on the disposal methods for this type of medication.


Prescribed along with physical therapy, Orphenadrine is used in some patients to relieve painful muscle spasms due to injury, sprains or severe strains. Classed as a muscle relaxant, Orphenadrine works on the central nervous system to lower the perception of muscle pain that the patient feels. Two nerve receptors are inhibited by Orphenadrine's active ingredients, known as NMDA and H1 receptors.

Orphenadrine also has an effect on the tremors experienced with Parkinson's disease, also providing a relaxing action to muscles in these patients that lessens their tremors and soothes the rigidity often experienced with this condition. As a majority of Parkinson's patients are elderly, it is cautioned that other health conditions be considered when prescribing and determining the dosage amount to patients in this age group.

Adverse health symptoms that occasionally accompany treatment with Orphenadrine include dry mouth, dizzy, lightheaded, drowsy feelings, stomach upset, constipation, vomiting, difficulty urinating, vision impairment and headaches. Until it is known how Orphenadrine affects your system and alertness, it is advised to avoid driving or operating machinery that could put you or others in danger.

Dry mouth symptoms should be reported to your dentist to be treated immediately, as they can lead to adverse dental health symptoms such as fungal infections, tooth and gum decay and other conditions. Your dental professional should be advised that you are being treated with this drug before performing any tests or surgical procedures.

Report any symptoms of anaphylaxis or any changes to your overall health or heart rhythm to your physician. Avoid taking this medication if you have any obstruction in your bowels or urinary tract, enlarged prostate or glaucoma. This medication has not been determined to be safe for children, women who are pregnant or those who are breastfeeding. Avoid alcoholic beverages and other drugs containing narcotics or barbiturates during your Orphenadrine treatment.