Oxtriphylline and Guaifenesin (Oral)

Oxtriphylline and guaifenesin is a combined medicine that is used to combat some of the symptoms of asthma, emphysema, and chronic bronchitis.


In Canada, oxtriphylline and guaifenesin combination is better known under the brand name, Choledyl Expectorant Elixir. The drug is a prescription-only medication and comes in the form of tablets or as an elixir.

Oxtriphylline and guaifenesin is a combination medication that is used to prevent or treat the symptoms of certain respiratory diseases, including emphysema, the chronic form of bronchitis, and asthma.

The medication works by loosening and thinning any mucus that is clogging the patient's airways, improving the flow of air, and making breathing easier.

Oxtriphylline and guaifenesin cannot cure these conditions, but it can help to relieve the troublesome effects that they cause.

This medicine is not suitable for treating the common cold.

Conditions treated

  • Asthma
  • Emphysema
  • Chronic bronchitis

Type of medicine

  • Tablets
  • Elixir
  • Expectorant

Side effects

In addition to the effects it is designed to have, oxtriphylline and guaifenesin can also cause a few side effects. Not everyone experiences side effects, but if they do occur, you may need to seek further medical assistance.

If you notice any of the following effects, you should check with your GP:

  • Continual trembling
  • Persistent nervousness or restlessness
  • Heartburn and/or vomiting
  • Rapid and/or irregular heartbeat
  • Feeling dizzy or lightheaded
  • Diarrhea
  • Bloody or dark vomit
  • Convulsions
  • Confusion or changes in behavior
  • Severe or continual abdominal pain

Some of the side effects that are caused by this medicine do not generally need any further medical assistance. The effects usually disappear once your body gets used to the new medicine. Your GP may also be able to give you some advice on how to manage or prevent these effects.

If any of the following effects prove to be especially persistent or troublesome, check with your GP:

  • Trouble sleeping
  • Trembling
  • Rapid heartbeat
  • Nervousness
  • Nausea
  • Increased urination
  • Headaches

There may be a few other side effects that are noted by some patients who are taking oxtriphylline and guaifenesin. If you notice any other effects, you should check with your doctor.


Oxtriphylline and guaifenesin is most effective when taken on an empty stomach and with water, either an hour or so before you eat or a couple of hours afterwards. This allows the drug to enter the bloodstream more quickly. However, your GP may ask you to take oxtriphylline and guaifenesin with or immediately after a meal in order to reduce the likelihood of a stomach upset. If you have any concerns or questions about how to take oxtriphylline and guaifenesin, you should check with your GP.

You must only use oxtriphylline and guaifenesin as instructed by your GP. Do not use more or less of the medicine, do not increase the frequency of use, and do not prolong its use. Misusing this drug may increase the likelihood of severe side effects.

For oxtriphylline and guaifenesin to be fully effective, you must use it every day at the frequency prescribed. This ensures that a constant amount of the medication remains in your blood.

Before you begin using oxtriphylline and guaifenesin, tell your GP if you are on a special diet, for example low-carbohydrate, high-protein, or high-carbohydrate.

The dose of oxtriphylline and guaifenesin that you are told to use will vary between patients, depending on the condition being treated. You must keep to the directions your doctor has given you or those on the product label.

The dose you are prescribed will depend on the potency of the preparation. In addition, the number of daily doses you use, the time you leave between each dose, and the total duration of your course of treatment with the medication will be dependent on the particular health condition for which you are using oxtriphylline and guaifenesin.

While you are using this medicine, it is very important that you see your GP regularly in order to have your blood levels of theophylline checked. This will determine whether your dose of oxtriphylline and guaifenesin needs to be adjusted. You must not change the dose of the drug unless you are told to do so by your GP.

If you leave out or forget to take any of your doses of oxtriphylline and guaifenesin, try to take it immediately. However, if your next dose is almost due, leave out the one you forget to take and return to your usual dosing regimen. Do not take double the dose.


Drug interactions

There are certain drugs that must never be taken at the same time, as to do so could cause an interaction to occur between the two products. In some cases, it may be appropriate to your treatment for you to use two drugs at the same time. Your GP will offer advice on how to prevent or mitigate any interaction that does take place.

While you are using oxtriphylline and guaifenesin, you must tell your treating physician if you are also using any other medicines. This should include prescription and over the counter products, herbal remedies, diet pills, and vitamin supplements.

It is not recommended that you use oxtriphylline and guaifenesin with any of the drugs listed below. Your GP may decide to use an alternative product or may alter some of the other drugs that you are using:

  • Riociguat
  • Amifampridine

It is not generally recommended to use oxtriphylline and guaifenesin with any of the products listed below. However, this may be necessary in some cases. If both drugs are prescribed for use at the same time, your GP may decide to adjust the dose or frequency of use of one or both of the medications:

  • Zileuton
  • Vemurafenib
  • Troleandomycin
  • Thiabendazole
  • Siltuximab
  • Secukinumab
  • Rofecoxib
  • Regadenoson
  • Pixantrone
  • Phenytoin
  • Peginterferon Alfa-2b
  • Peginterferon Alfa-2a
  • Pefloxacin
  • Norgestrel
  • Norgestimate
  • Norethindrone
  • Norelgestromin
  • Mexiletine
  • Mestranol
  • Medroxyprogesterone Acetate
  • Levonorgestrel
  • Levofloxacin
  • Imipenem
  • Idrocilamide
  • Idelalisib
  • Halothane
  • Golimumab
  • Fosphenytoin
  • Fluvoxamine
  • Fluconazole
  • Etonogestrel
  • Etintidine
  • Ethynodiol Diacetate
  • Ethinyl Estradiol
  • Estradiol Valerate
  • Estradiol Cypionate
  • Erythromycin
  • Enoxacin
  • Drospirenone
  • Donepezil
  • Dihydroartemisinin
  • Dienogest
  • Desogestrel
  • Deferasirox
  • Ciprofloxacin
  • Cimetidine
  • Ceritinib
  • Bupropion
  • Blinatumomab
  • Adenosine

Using oxtriphylline and guaifenesin with any of the drugs listed below can present an increased risk of you suffering some side effects, but using both products might be the most appropriate course of treatment in your case. If you are prescribed both drugs together, your doctor might adjust the dose or frequency with which you use the medication:

  • Zafirlukast
  • Viloxazine
  • Triazolam
  • Ticlopidine
  • Temazepam
  • Telithromycin
  • Tacrine
  • St John's Wort
  • Secobarbital
  • Ritonavir
  • Riluzole
  • Rifapentine
  • Rifampin
  • Quazepam
  • Propafenone
  • Prazepam
  • Piperine
  • Phenobarbital
  • Pentoxifylline
  • Pancuronium
  • Oxazepam
  • Nitrazepam
  • Nilutamide
  • Midazolam
  • Methotrexate
  • Medazepam
  • Lormetazepam
  • Lorazepam
  • Ketazolam
  • Isoproterenol
  • Ipriflavone
  • Interferon Alfa-2a
  • Halazepam
  • Flurazepam
  • Flunitrazepam
  • Febuxostat
  • Estazolam
  • Disulfiram
  • Diazepam
  • Clorazepate
  • Clonazepam
  • Clobazam
  • Chlordiazepoxide
  • Carbamazepine
  • Cannabis
  • Brotizolam
  • Azithromycin
  • Amiodarone
  • Aminoglutethimide
  • Alprazolam
  • Adinazolam

Other interactions

There are some drugs that must not be taken when you are eating a meal or with particular types of foods, as this can cause interactions to take place. The use of tobacco or alcohol with certain medications can also cause interactions to happen. The potential interactions mentioned in this guide are not the only ones that could happen, but they are the most important.

It is not recommended that you use oxtriphylline and guaifenesin with any of the items listed below as to do so could cause an interaction which will make the side effects of the drug worse. However, this may be unavoidable in some instances. In this case, your GP may change the dose or frequency of use of oxtriphylline and guaifenesin, or provide you with directions on how to use tobacco, food, or alcohol while you are using the medicine:

  • Tobacco
  • Caffeine
  • Food

Medical interactions

Some pre-existing or historical medical conditions can cause problems with the way in which oxtriphylline and guaifenesin works. Be sure to discuss your medical history fully with your GP before you begin using this drug, paying particular attention to the following health conditions:

If you have a history convulsions (seizures) you should be aware that oxtriphylline can worsen this condition.

In patients with liver disease, heart disease, or underactive thyroid, it can cause the effects of oxtriphylline to become increased.


When considering whether or not to use a particular medicine, you must take into account the risks as well as the benefits of doing so. This decision is best arrived at following discussions with your GP. In the case of oxtriphylline and guaifenesin, patients should consider the following information:

You must mention to your GP any odd or unexpected reactions to oxtriphylline and guaifenesin or to any other prescription or over the counter medicines. You must also tell your GP if you have ever had an allergic reaction to food colors, animal derivatives, food preservatives, or particular food groups. If in doubt, check the list of ingredients on the product packaging before you start using the medicine.

Although there is no definitive research that would preclude the use of oxtriphylline and guaifenesin in children, it is not generally recommended that this medication is used, because the medicine has a high alcohol content.

When treating patients who are aged over 60 years, a lower dose of oxtriphylline and guaifenesin should be used. This is to reduce the risk of side effects that could be caused by high doses of oxtriphylline. Your GP may ask you to have blood tests in order to establish whether a change of dose is required. When the correct dose levels have been established, there is no specific evidence to suggest that using this drug in geriatric patients would cause any age-specific problems.

There is no evidence to suggest that using oxtriphylline and guaifenesin to treat pregnant women presents any risk to the unborn baby. However, if you are expecting a baby, you may wish to discuss the risks versus the benefits of using this medicine before you begin taking it.

Although it is generally thought to be safe to breastfeed while using guaifenesin, studies have shown that oxtriphylline can present a minimal risk to a nursing infant. Before deciding whether to continue breastfeeding, you may wish to discuss the potential risks of doing so with your midwife or GP. To err on the side of caution, you may wish to consider using an alternative feeding solution for your infant.

While you are taking oxtriphylline and guaifenesin, you must attend your treating physician regularly for check-ups, especially for the first month or so after you start taking the medication. Blood tests may also be taken to enable your GP to decide whether or not to adjust the dose of the medicine that you are taking. These visits will also give you the chance to mention any side effects that you have noticed.

Patients should be aware that the oxtriphylline component of this drug can increase the stimulant effects of certain foods or drinks that contain caffeine such as a coffee, tea, chocolate, cocoa, and cola drinks. Try to avoid consuming these kinds of foods and drinks in high quantities while you are using oxtriphylline and guaifenesin. If you are unsure about this, check with your GP.

Certain physical or behavioral changes can affect how oxtriphylline and guaifenesin works. You should check with your GP if you experience any of the following:

  • Begin or stop using another drug
  • Begin or quit smoking
  • Develop a fever of 102 °f or greater, for a minimum of 24 hours or over 100 °f for more than 24 hours
  • Make a long-term change to your diet

If you are due to undergo myocardial perfusion tests, you must inform the treating physician in charge that you are using oxtriphylline and guaifenesin. This medication can sometimes alter certain test results.


You must keep your prescription of oxtriphylline and guaifenesin in a sealed container and at room temperature. Keep the drug away from direct sunlight and away from sources of heat. Do not freeze the medicine.

Oxtriphylline and guaifenesin can be harmful to children. Make sure that you put the medication somewhere children and pets cannot gain access to it.

You should not keep any medication that has become out-of-date or that you no longer need. Ask your GP or pharmacist for guidance on how to dispose of any unwanted medications.


Oxtriphylline and guaifenesin is a combination drug that is used to treat and prevent the symptoms of some respiratory diseases, including emphysema, chronic bronchitis, and asthma.

Patients should note that this medication cannot cure these conditions, but it does provide relief from the symptoms. In addition, you should be aware that oxtriphylline and guaifenesin should not be used to treat a cough that is caused by a common cold or flu.

The drug is an expectorant. It works by opening up the patient's airways to that they can breathe more easily.

Throughout the course of your treatment with this drug, you will need to attend your GP for regular check-ups and blood tests. These visits are important to check for side effects or adjust the dose of the drug if necessary.