Oxycodone and Acetaminophen (Oral)

Oxycodone and Acetaminophen is a combination therapy drug that is widely sold throughout the world for mild to severe pain relief and fever reduction that can occur in many different health conditions.


The combination of Acetaminophen, a pain reliever and fever reducer, and Oxycodone, a narcotic form of pain relief, is prescribed world-wide to patients with different conditions. This medication can be habit forming due to the opioid ingredients.

Oxycodone/Acetaminophen is a controlled substance that is only available with a prescription from a medical doctor. Patients who are in severe to moderate pain from various conditions benefit from the actions of this medication, but are cautiously advised that it can be habit forming because it contains opiates. For this reason, supervision and monitoring by medical professionals is often part of the treatment therapy.

Patients can be prescribed several administrative forms of the drug including liquid solution, capsule and tablets that are taken orally. This medication is sold under different brand identifications, which include:

  • Magnacet
  • Percocet
  • Endocet
  • Narvox
  • Perloxx
  • Roxicet
  • Primalev
  • Roxilox
  • Xartemix XR
  • Tylox
  • Xolox

Acetaminophen, also sometimes referred to as Paracetamol, is an analgesic and antipyretic medication. By itself, it is effective on minor painful conditions, body aches and fever and is widely used world-wide and considered safe in most medical circles. It is even available in certain strengths of over-the-counter remedies for colds, flu and headaches. Unlike its aspirin counterpart, Acetaminophen does not affect the way blood clots nor does it provide any anti-inflammatory relief. It also doesn,t have the side effects of aspirin, which can include irritation to the lining of the stomach and effects on kidney function.

Oxycodone is synthetically derived from Codeine and is considered to be an addictive, potent narcotic drug that is carefully controlled. It is widely used, however, for the management of pain because of its powerful, long-lasting effects. Oxycodone and the combination drugs it is an ingredient in are typically prescribed for patients with chronic, severe or acute pain. A synthetic opiate, Oxycodone affects the central nervous system directly by dampening several nerve receptors at the site of pain.

Acetaminophen is associated with liver problems that can be life-threatening and therefore the amount of this substance that can be safely taken on a daily basis is limited to 4000 milligrams per 24 hour period in total. Oxycodone is a synthetic opioid such as morphine and comes with its own set of warnings on overdose and addiction risks. Patients who are prescribed Oxycodone and Acetaminophen drug therapy are urged to take this medication safely, with caution that it can become habit-forming and may cause issues with vital organs. It is imperative that patients take only what they are prescribed and do not increase their dosage frequency, amount or duration for any reason unless advised by their physician.

Conditions Treated

  • Severe to moderate chronic pain
  • Severe to moderate acute pain
  • Elevated body temperature

Type Of Medicine

Temporary pain and fever relief

Side Effects

This medication affects the central nervous system in order to relieve pain symptoms. In doing so, it may cause unwanted effects on health that are potentially dangerous if left untreated. Inform your physician if you experience any of the following symptoms:

  • Stools appear tar-like or black
  • Chills
  • Pain in abdomen or stomach
  • Urine is dark in color
  • Dizzy spells
  • Elevated body temperature
  • Headache
  • Stools appear light in color
  • Itching
  • Less appetite than normal
  • Nausea
  • Skin rash
  • Halitosis
  • Fatigue
  • Muscle weakness
  • Vomiting with signs of blood
  • Skin or eyes appear yellow
  • Hoarse voice
  • Coughing
  • Overall weak, tired feeling
  • Pain in side or lower back
  • Urination that is difficult or painful
  • Throat soreness
  • Ulcerated white spots on mouth or lips
  • Bruising or bleeding for no reason
  • Pains in stomach, leg or back
  • Gums bleeding
  • Bloated feeling
  • Stool or urine show signs of blood
  • Nails and lips appear blue
  • Vision changes or blurred
  • Pins and needles, numb, tingling sensation
  • Uncomfortable or painful chest area
  • Stools appear clay-colored
  • Urine is cloudy
  • Clumsy, uncoordinated muscles
  • Confused demeanor
  • Constipation
  • Coughing with frothy, pink saliva
  • Unresponsive or unaware demeanor
  • Urine amount or frequency has decreased
  • Breathing is labored or difficult
  • Wheezing
  • Difficulty breathing
  • Dribbling when urinating
  • Hard to swallow
  • Lightheaded, fainting spells or becoming dizzy when rising
  • Drowsy
  • Mouth dryness
  • Slow, shallow breathing
  • Passing out
  • Quick, labored breathing
  • Irregular heart rhythm, racing or slow
  • Warm sensation
  • Overall swelling of the body
  • Sweating increases
  • Thirsty
  • Upset stomach, indigestion
  • Swollen patches on sex organs, face, lips, eyes, tongue, hands, feet or legs
  • Lightheaded
  • Aches or tremors in muscles
  • Weak muscles
  • Nervous demeanor
  • Breathing is loud or labored
  • Nose bleeding
  • Numb, tingling feet, lips or hands
  • Pain in abdominal area moving to back
  • Skin appears pale
  • Tiny red spots on skin
  • Pounding noise in ears
  • Swollen, puffy face, eyes, tongue or lips
  • Flushed upper chest, face, arms or neck
  • Restless demeanor
  • Seizures or convulsions
  • Constipation, chronic or severe
  • Drowsy to the point of severity
  • Vomiting constantly
  • Blisters, hives, welts or rash on skin
  • Extreme fatigue
  • Throat soreness
  • Cramps in stomach
  • Eyes appear sunken
  • Swollen fingers, ankles or face
  • Chest tightness
  • Heavy sensation in the legs
  • Gaining weight

Overdose is at a high risk while taking Oxycodone and Acetaminophen, so be on the lookout for symptoms and seek emergency medical help if they occur:

  • Blue skin or lips
  • Passing out or losing consciousness
  • Skin is clammy or cold
  • Drowsy to the point of lethargy
  • Overall uncomfortable or ill feeling
  • Passing out
  • Blood pressure is low
  • Pulse cannot be detected
  • Breathing extremely slow
  • Becoming unconscious

Other symptoms, while not dangerous to your health, can also occur but will typically go away with the passage of time on the medication. Your health care provider may be able to advise you on ways to alleviate these symptoms until they pass:

  • Extreme calmness
  • Upset stomach
  • Acid reflux
  • Agitated mood
  • Unpleasant mouth taste
  • Belching
  • Taste changes
  • Dilated pupils
  • Cold sweats
  • Noises in ears like buzzing, pounding, ringing
  • Skin that is pale and cool to the touch
  • Depressed mood
  • Diarrhea
  • Difficulty moving
  • Perception of colors is abnormal
  • Vision changes, doubles or blurs
  • Excess gas
  • Euphoria
  • Dry skin that appears flushed or red
  • Stomach fullness
  • Overall ill or uncomfortable feeling
  • Halo appearance in light sources
  • Heartburn
  • Appetite increase
  • Urination amount or frequency increases
  • Indigestion
  • Painful joints
  • Weak muscles, spasms or cramps
  • Stiff, painful muscles
  • Blindness during dark hours
  • Nightmares
  • Lights appear unusually bright
  • Hallucinating
  • Seizures
  • Shaky, unsteady actions
  • Extreme drowsy or sleepy demeanor
  • Speech is slurred
  • Upset, uncomfortable or painful stomach
  • Sweating to the excess
  • Joints are swollen or painful
  • Thirsty
  • Insomnia
  • Tunnel vision
  • Weight loss for no reason
  • Tired, sluggish or dull feeling

You may also have other symptoms than those listed here which should be communicated to your doctor to protect your overall health while taking this medication.


Oxycodone and Acetaminophen combination drug therapy should be taken exactly as prescribed by your physician. Do not alter the amount you take, the frequency of your dosage or the length of your prescription without the permission of your medical doctor. Elderly patients especially should be careful to stay on their prescribed dose to avoid any health complications that can be life-threatening.

Taking this medication for a long period of time could cause physical or mental dependence that can be dangerous to your overall wellbeing. Exceeding the daily amount that is recommended for Acetaminophen dosage could cause damage to your liver over time.

You will receive a patient information leaflet with your prescription of Oxycodone and Acetaminophen that you should review thoroughly and share with your caregiver or family members. If you have any questions about taking this drug with regard to ill health effects, addiction or overdose, consult your physician or your pharmacist.

Use the measuring cup or spoon that is included with your liquid oral prescription of Oxycodone and Acetaminophen as it is accurate to use for your prescribed dosage. Household utensils and items should not be used as they can vary too widely and not deliver the prescribed dosage you should have.

Extended release tablet forms of Oxycodone and Acetaminophen should be swallowed with water and never broken, chewed, dissolved or crushed in any way. Do not get the tablets wet or lick them prior to putting them in your mouth and never administer this medication via a feeding tube.

If you are prescribed a capsule form, tablet form or extended release tablet form and are contemplating a switch to another format, discuss this change with your physician first as these administrations vary greatly from each other and could require a change in frequency or duration of your prescription.

Avoid using other medications while you are taking Oxycodone and Acetaminophen unless they are specifically approved by your physician. Many over-the-counter remedies contain acetaminophen ingredients, which can change your dosage amount and put you in danger for liver damage. You will have potentially exceeded the safety level of 4000 milligrams of acetaminophen in a one day period total without realizing it. Be sure to read labels and consult your physician before combining this drug with any other.

Oxycodone and Acetaminophen are prescribed for a wide range of conditions that occur in patients of all ages, body types and health conditions. Each prescription will be specific to the patient it is written for. Follow your doctor,s instructions and ask questions about anything that is unclear.

Adult patients with moderate pain to moderately severe pain will be prescribed a one capsule dose every six hours. Extended release tablets will typically be prescribed in a two tablet dose to be taken twice daily or every twelve hours. Liquid solution form, in general, is prescribed in a 5 milliliter amount to be taken every six hours, adjusted if required but never exceeding more than 60 milliliters per 24 hour period. Oral tablets are typically taken as a single tablet dose every six hours.

Pediatric patients who are prescribed Oxycodone and Acetaminophen for various health conditions will have their dosage, frequency and duration determined by their physician, who will take into account their health condition, pain relief requirements and body mass.

Missing a dose of Oxycodone and Acetaminophen should not cause you to double dose if you are close to taking your next dosage amount. Double dosing can cause dangerous overdose side effects including severe drowsiness or losing consciousness altogether with slowing pulse and breathing to dangerous levels. If in doubt about a missing dose, it is best to contact your physician for instructions.


Hypersensitivity to any substances such as other medications, dyes, perfumes, animals or preservatives should be reported to your doctor before you are prescribed Oxycodone and Acetaminophen. You should also let them know if you have had a bad reaction to this medication in the past. Read and comprehend all patient information that accompanies your prescription and ask any questions before you take your first dose.

Studies on pediatric patients have not provided any data that points to an effective use of Oxycodone and Acetaminophen on this age group, nor has this drug been proven safe for children. Doctors may or may not prescribe this drug for children, but most likely will opt for an alternate, safely proven form of treatment.

Elderly patients who have kidney or liver problems or other age-related conditions can still safely take Oxycodone and Acetaminophen if their dosage is adjusted accordingly. Healthy geriatric patients should experience the same effective, safe treatment with the normal precautions that adult patients experience.

Pregnant women and those that may become pregnant should not take Oxycodone and Acetaminophen. Your physician will want to know if you are pregnant before or during your treatment with this drug so that the safety of your child can be protected.

Women who are breastfeeding have not been studied with any level of data that provides a report on the safety of this medication with regard to their infants. Discuss use of this medication with your physician if you are breastfeeding.

This drug is a combination of Oxycodone and Acetaminophen, which are two medications that work together to control pain symptoms. Other drugs, however, may be dangerous when combined with this medication. Be sure to inform your physician of any other prescriptions you take or any non-prescription medications you rely on for other conditions. You should also let your doctor know if you regularly take any herbal supplements, holistic remedies or vitamin therapies.

The following medicines should be avoided if you are prescribed Oxycodone and Acetaminophen. Let your physician know if you are taking:

  • Naltrexone
  • Amifampridine

Some patients are already on a course of medications for other conditions that cannot safely be stopped in order to take Oxycodone and Acetaminophen. Fortunately your physician will be able to adjust the dose of one or more medications, if required, when informed of your entire drug therapy treatment. Let your doctor know that you take:

  • Abiraterone
  • Alfentanil
  • Acepromazine
  • Alprazolam
  • Almotriptan
  • Amineptine
  • Alvimopan
  • Amisulpride
  • Amiodarone
  • Amitriptylinoxide
  • Amitriptyline
  • Amoxapine
  • Amobarbital
  • Anileridine
  • Amprenavir
  • Aripiprazole
  • Aprepitant
  • Atazanavir
  • Asenapine
  • Benperidol
  • Baclofen
  • Bromazepam
  • Boceprevir
  • Brompheniramine
  • Bromopride
  • Buspirone
  • Buprenorphine
  • Butorphanol
  • Butabarbital
  • Carbinoxamine
  • Carbamazepine
  • Carisoprodol
  • Cariprazine
  • Ceritinib
  • Carphenazine
  • Chlordiazepoxide
  • Chloral Hydrate
  • Chlorpromazine
  • Chlorpheniramine
  • Citalopram
  • Chlorzoxazone
  • Clobazam
  • Clarithromycin
  • Clonazepam
  • Clomipramine
  • Clozapine
  • Clorazepate
  • Cocaine
  • Cobicistat
  • Conivaptan
  • Codeine
  • Dantrolene
  • Cyclobenzaprine
  • Desipramine
  • Darunavir
  • Dexmedetomidine
  • Desvenlafaxine
  • Dezocine
  • Dextromethorphan
  • Diazepam
  • Diacetylmorphine
  • Dichloralphenazone
  • Dibenzepin
  • Dihydrocodeine
  • Difenoxin
  • Diphenoxylate
  • Diphenhydramine
  • Donepezil
  • Dolasetron
  • Doxylamine
  • Doxepin
  • Duloxetine
  • Droperidol
  • Enflurane
  • Eletriptan
  • Erythromycin
  • Enzalutamide
  • Estazolam
  • Escitalopram
  • Ethchlorvynol
  • Ethylmorphine
  • Eszopiclone
  • Etomidate
  • Ethopropazine
  • Flibanserin
  • Fentanyl
  • Fluoxetine
  • Flunitrazepam
  • Flurazepam
  • Fluphenazine
  • Fluvoxamine
  • Fluspirilene
  • Fosphenytoin
  • Fosaprepitant
  • Frovatriptan
  • Fospropofol
  • Granisetron
  • Furazolidone
  • Haloperidol
  • Halazepam
  • Hexobarbital
  • Halothane
  • Hydromorphone
  • Hydrocodone
  • Hydroxyzine
  • Hydroxytryptophan
  • Iloperidone
  • Idelalisib
  • Imipramine
  • Imatinib
  • Iproniazid
  • Indinavir
  • Isoflurane
  • Isocarboxazid
  • Itraconazole
  • Isoniazid
  • Ketazolam
  • Ketamine
  • Ketoconazole
  • Ketobemidone
  • Levorphanol
  • Levomilnacipran
  • Lithium
  • Linezolid
  • Lopinavir
  • Lofepramine
  • Lorazepam
  • Loprazolam
  • Lormetazepam
  • Lorcaserin
  • Lurasidone
  • Lumacaftor
  • Melitracen
  • Meclizine
  • Meperidine
  • Medazepam
  • Meprobamate
  • Melperone
  • Mesoridazine
  • Mephobarbital
  • Methadone
  • Meptazinol
  • Methocarbamol
  • Metaxalone
  • Methotrimeprazine
  • Methdilazine
  • Methylnaltrexone
  • Methohexital
  • Milnacipran
  • Methylene Blue
  • Mitotane
  • Midazolam
  • Molindone
  • Mirtazapine
  • Morphine
  • Moclobemide
  • Nalbuphine
  • Moricizine
  • Nalorphine
  • Morphine Sulfate Liposome
  • Naratriptan
  • Nalmefene
  • Nelfinavir
  • Naloxone
  • Nicomorphine
  • Nefazodone
  • Nitrous Oxide
  • Nialamide
  • Olanzapine
  • Nitrazepam
  • Opipramol
  • Nortriptyline
  • Opium Alkaloids
  • Ondansetron
  • Oxazepam
  • Opium
  • Orphenadrine
  • Oxymorphone
  • Oxycodone
  • Palonosetron
  • Paliperidone
  • Paregoric
  • Papaveretum
  • Pentazocine
  • Paroxetine
  • Perampanel
  • Pentobarbital
  • Periciazine
  • Perazine
  • Phenelzine
  • Perphenazine
  • Phenytoin
  • Phenobarbital
  • Pimozide
  • Pimavanserin
  • Pipotiazine
  • Piperacetazine
  • Pixantrone
  • Piritramide
  • Posaconazole
  • Pneumococcal Vaccine
  • Primidone
  • Prazepam
  • Prochlorperazine
  • Procarbazine
  • Promethazine
  • Promazine
  • Propoxyphene
  • Propofol
  • Quazepam
  • Protriptyline
  • Ramelteon
  • Quetiapine
  • Remifentanil
  • Rasagiline
  • Risperidone
  • Remoxipride
  • Rizatriptan
  • Ritonavir
  • Samidorphan
  • Safinamide
  • Secobarbital
  • Saquinavir
  • Sertindole
  • Selegiline
  • Sibutramine
  • Sertraline
  • Sufentanil
  • Sodium Oxybate
  • Sumatriptan
  • Sulpiride
  • Tapentadol
  • Suvorexant
  • Telithromycin
  • Telaprevir
  • Thiethylperazine
  • Temazepam
  • Thiopropazate
  • Thiopental
  • Thiothixene
  • Thioridazine
  • Tilidine
  • Tianeptine
  • Tolonium Chloride
  • Tizanidine
  • Tramadol
  • Topiramate
  • Trazodone
  • Tranylcypromine
  • Trifluoperazine
  • Triazolam
  • Triflupromazine
  • Trifluperidol
  • Trimipramine
  • Trimeprazine
  • Venlafaxine
  • Tryptophan
  • Vortioxetine
  • Vilazodone
  • Ziprasidone
  • Zaleplon
  • Zolpidem
  • Zolmitriptan
  • Zotepine
  • Zopiclone

Medications listed below may increase certain unwanted health effects if used in combination with Oxycodone and Acetaminophen. If you take the following medications, alert your physician:

  • Acenocoumarol
  • Fosphenytoin
  • Carbamazepine
  • Miconazole
  • Lixisenatide
  • Rifampin
  • Phenytoin
  • Voriconazole
  • St John's Wort
  • Zidovudine
  • Warfarin

Certain foods should not be eaten when you are taking Oxycodone and Acetaminophen nor should you consume food at all when you are taking your tablet, solution or capsule of this medication. Your doctor will be able to advise you on if you should eat before or after your prescribed dosage. Eating cabbage while you are taking this medication is not advised, as the combination of this food and your prescription could cause adverse effects on your health.

It is best to avoid the consumption of alcoholic beverages and the use of tobacco products for your own safety if you are taking Oxycodone and Acetaminophen, as they could increase the risk for some adverse effects on your health. Discuss smoking cessation and alcohol counseling, if required, with your physician, who can advise you on the best path forward for your overall health.

Patients with certain medical conditions should avoid the use of Oxycodone and Acetaminophen as they could worsen due to the effects of this drug. Alert your physician if you suffer from any of the following conditions:

  • Alcoholism
  • Adrenal gland problems such as Addison disease
  • Tumors in the brain
  • Lung or breathing problems such as COPD
  • Heart problems
  • Abuse of narcotic drugs or dependency issues
  • Head injury
  • Underactive thyroid
  • Low volume of blood
  • Spine curvature accompanied by pulmonary issues
  • Mental health issues
  • Urination problems
  • Prostate issues
  • Physical weaknesses
  • Low blood pressure
  • Inflamed pancreas
  • Seizures or convulsion issues
  • Disease of the kidneys
  • Disease of the liver


Your continued prescription of Oxycodone and Acetaminophen will be dependent on what your physician finds during your regularly scheduled appointments. You will be monitored for signs that the medication is working to alleviate your pain and symptoms without causing any unwanted effects on your overall health or creating a dependency on the drug. Keep all appointments as closely as possible to the schedule and get in touch with your doctor should you have any changes to your overall mood, health or wellbeing in the meantime.

There are laws prohibiting you from sharing this medication, which is classified as a narcotic. Even if they have the same condition as you or have been prescribed the same medication therapy, do not share your prescribed Oxycodone and Acetaminophen medication with anyone. Secure your medication safely so that it cannot be stolen by those who are addicted to medications such as this or other drugs.

Substances that affect your central nervous system may have their effects amplified when combined with Oxycodone and Acetaminophen to the point of excessive drowsiness or lethargy. If you are taking any sleep aids, allergy or cold and flu medications, tranquilizers or sedatives, make sure your physician is aware of this before prescribing this medication to you. Do not combine this medication with other pain relief or seizure medications which may contain muscle relaxers, barbiturates or anesthetic ingredients.

Your potential for damaging your liver due to the acetaminophen ingredient in this drug will increase if you are also consuming alcoholic beverages. Limit your alcohol intake and consult with your doctor if you regularly consume alcohol as to the best course of treatment for you.

Dental anesthetics may also increase the unwanted health effects of this medication, so alert your dentist before any treatments begin that you are on this medication.

Oxycodone and Acetaminophen, due to the opioid ingredients, may become addictive or habit forming. If you notice a lessening in the effectiveness of this medication, do not increase your dose or frequency without checking with your doctor. Alert your family and care givers to the potential of addiction with this medication so that they can assist in keeping you safe.

If you are on a course of treatment for depression that includes a drug known as an MAO inhibitor type of medication, do not take Oxycodone and Acetaminophen as you could experience life-threatening effects on your health as a result of the combination. Let your doctor know if you are taking MAO inhibitors or are being treated for depression prior to being prescribed this medication.

The active ingredients in Oxycodone and Acetaminophen operate on your central nervous system and may cause you to experience lightheaded, dizzy or drowsy feelings as well as make you less alert and responsive physically. Before you drive, operate power tools or heavy equipment, make sure you are aware or have tested your reflexes and responsiveness in order to protect yourself and others from potentially dangerous situations.

Any painful, tender feelings in your stomach accompanied by stools that are light or pale in color, urine that changes to a dark color, appetite diminishment or loss, a nauseated stomach, a weak and tired feeling, and a yellow tinge to your skin or eyes could point to signs of liver damage as a result of taking this drug. Alert your physician to these symptoms right away for your own health and safety. Make your caregivers aware of these symptoms and the risk of liver damage while you are on this medication so that they can also be protective of your overall health.

Your skin may react to treatment with Oxycodone and Acetaminophen by blistering, loosening or peeling or even showing red spots, rashes, ulcers or sores. If you have any changes to your skin, especially those accompanied by an elevated body temperature and chills, make sure you let your doctor know immediately.

A severe hypersensitivity to this medication known as anaphylaxis occurs in some patients. This is a life-threatening condition that shows symptoms of breathing difficulty, swallowing difficulty, itchy skin rash, hoarse voice and swelling in the mouth, face or hands. If you have any of these symptoms, get in touch with your doctor right away.

Over an extended period of use, narcotic drugs like those found in Oxycodone and Acetaminophen can cause constipation that can be severe or prolonged. You may be prescribed laxative remedies while you are on this medication or be able to take an over-the-counter laxative as advised by your physician. Be sure to hydrate your system well with lots of water or other fluids and maintain a good diet that is high in fiber. Prolonged, severe instances of constipation can lead to serious problems that can be life-threatening. Seek medical assistance from your physician if you are constipated without allowing the condition to go on for too long.

Changing the amount you take or the frequency of your dose to be less than what you have been prescribed can cause adverse effects on your health. You should not slow down or discontinue using this medication without your physician advising you on a safe way to do so. Patients have been known to have symptoms of withdrawal with sudden stoppage of this medication, which include irritable mood swings, nausea with cramps in the stomach, anxious demeanor, elevated body temperature, restlessness, nasal congestion or running, and body tremors and insomnia. Do not alter your prescribed dosage amount in any way without first consulting your physician.

Women who are pregnant or those who may become pregnant should not be prescribed Oxycodone and Acetaminophen, as it poses a serious risk to fetal development and health. Inform your health care provider immediately if you believe you have become pregnant while taking this medication.

Other health care providers than the one prescribing you this medication should be made aware that you are taking this drug, as it can alter the way some medical tests or procedures are performed or the results that they have. Be sure to let all your health care providers know of your use of Oxycodone and Acetaminophen including your dentist.

Avoid taking other medications while you are taking Oxycodone and Acetaminophen, as many non-prescription and prescription medications alike interact with the active ingredients. You may even cause yourself to overdose or put your health at risk by combining other drugs with this medication. If you cannot avoid other medicines, vitamins or supplements, at least let your physician know what you require for treatment so that the combination can be discussed.


To properly and safely store your prescription of Oxycodone and Acetaminophen, keep it in the original packaging with the container closed at room temperature. Do not expose the liquid, tablets or capsules to excessive heat, light or moisture and never allow it to freeze.

By law, this medication is illegal to share or distribute to others in any way as it is a narcotic. Keep this medication where it cannot be easily stolen by persons who have substance abuse issues. This and all medications should be kept out of sight and reach of children. When it comes time to dispose of expired or unused Oxycodone and Acetaminophen, consult your doctor or pharmacist for the safest way to do so.


Oxycodone and Acetaminophen are combined in a medication that is prescribed for the relief of moderate to severe pain in patients suffering from a wide range of medical conditions. Considered safe and effective on a world-wide basis for use in people who are suffering from painful diseases, there are cautionary measures that are observed and well known with the use of this medication.

Oxycodone is a synthetic pain medication that is like codeine in that it has narcotic properties. Extremely effective and long-lasting against pain symptoms, it nonetheless may become habit-forming and patients are typically warned for this side effect and monitored accordingly. Patients are also urged to take care in only taking the prescribed amount of this medication to avoid overdose issues.

Acetaminophen is also a pain relief medication that complements the actions found in Oxycodone, which is why the two are combined. Additionally, Acetaminophen has fever reduction actions that are beneficial in some health conditions. Though it does not irritate the stomach or have an effect on how blood clots, Acetaminophen does come with other cautions. For instance, it can, with prolonged or heightened dosage, cause damage to the function of the liver. Patients are urged to take care in combining this drug with any other medication, even those found over the counter, which could put their level of consumed Acetaminophen in the danger zone of 4000 milligrams over a 24 hour period of time.

When used as prescribed, Oxycodone and Acetaminophen combined medication is effective on many types of temporary as well as short term pain symptoms. Use of this medication should be only as prescribed by a medical doctor.

Control of this medication is overseen by many local and national authorities with regard to the narcotic properties of the drug. Sharing or distributing this medication with anyone else is prohibited by law. Keep this medication safely stored where it cannot be borrowed or stolen or ingested accidentally.

Report any changes to your mood or health that may occur while you are taking this drug to your medical doctor in case of any drastic effects that could affect your wellbeing. Make your caregivers, friends and family aware that you are taking this medication and share the patient information leaflet information with them so that they can assist you with proactively making sure you are safe to continue this medication.

Avoid alcoholic beverages while you are taking Oxycodone and Acetaminophen, as they could amplify some of the adverse effects on your health and make you drowsy or lethargic in a severe or dangerous way. Also avoid taking any other medications that have an effect on your central nervous system such as sleeping medications or tranquilizers as they could form a dangerous drug combination. It is best to avoid any other medications when taking Oxycodone and Acetaminophen, and for overall safety to inform you health care provider of anything you take.

Oxycodone and Acetaminophen can alter your state of alertness to the point that it is dangerous for you to drive or operate any tools or machinery when you are taking this drug. Make sure you know your level of responsiveness before you put yourself or others in dangerous situations.

Last Reviewed:
March 26, 2018
Last Updated:
April 23, 2018
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