Oxymetazoline (Nasal)

Oxymetazoline is a hay fever and allergy relief that is used in patients with blockages of the nose.


Oxymetazoline is a solution or spray that is used to treat stuffiness or congestion of the nasal passage. It is used to treat hay fever, allergies, sinus troubles and colds.

Oxymetazoline is available without a prescription and comes in a wide range of forms. It is available in all of the following brands:

  • Vicks Sinex 12 Hour
  • Sinarest Nasal
  • NRS-Nasal Relief
  • Nostrilla
  • Neo-Synephrine 12 Hour
  • Nasin
  • Nasacon
  • Mucinex Moisture Smart
  • Mucinex Full Force
  • Genasal
  • Duration
  • Duramist Plus
  • Afrin
  • 4-Way Long Lasting

These medications are not cures for the conditions treated. Instead they are used to relieve the symptoms.

Patients should use caution when using this medication if they are taking any other treatments as they may interact. This is particularly important if you have, or are being treated for, any conditions of the heart.

Condition treated

  • Nasal congestion
  • Allergies

Type Of Medicine

  • Nasal decongestant

Side Effects

In addition to the desired side effects of Oxymetazoline, other side effects can also occur. The side effects of this treatment are usually mild and would not require that you seek a doctor. If side effects are ongoing or bothersome, you should stop using the treatment and should consult your doctor if they continue after you have stopped use:

  • Blurring of vision
  • Dizziness
  • Drowsiness
  • Fast heartbeat
  • Headache
  • High blood pressure
  • Increased runniness of nose
  • Increased stuffiness of nose
  • Irregularity of heartbeat
  • Lightheadedness
  • Nervousness
  • Pounding of heartbeat
  • Trembling
  • Trouble with sleeping
  • Weakness

Other side effects not listed here could also occur from the use of this treatment.


Follow these steps to use the nose drop solution for treatment:

  • Blow your nose lightly.
  • Tip your head backwards when sitting or standing and place the drops into each nostril.
  • Keep your head tipped backwards for 1-2 minutes to allow the spread of the medication.
  • Rinse the nose dropper and then clean it with tissue paper. Replace the lid after cleaning.
  • Only use one container of treatment per person to prevent the spread of infection.
  • Dispose of the container once your condition is improved.

Follow these steps to use the nose spray:

  • Blow your nose lightly.
  • Keep the head upright and spray the medication up into each nostril. Sniff hard while spraying the dose.
  • Rinse the top of the spray and clean with a tissue. Replace the cap straight away after cleaning.
  • Use only one container per person to avoid spreading the infection.
  • Dispose of the treatment once the condition is improved.

You should only ever use this medication as detailed on the label or as directed by a doctor. You should not use it for longer than three days. Overuse can make conditions worse and can increase the risk of side effects occurring.

The dose of this medication will differ for each individual, but you should never exceed the recommended doses. Follow the instructions carefully and follow the advice from your doctor if you have been ordered to use the treatment. The following information is a guideline only and should not be used to make adjustments to your dose:

When treating nasal congestion:

  • Children aged 6+ and adults should use 2/3 drops or 2/3 sprays of a 0.05% solution. This dose can be used in each nostril at 10 to 12 hour intervals. You should not use the treatment more than twice in each nostril within 24 hours.
  • Children below the age of six should not be given this medication unless it has been ordered by a doctor.

If a dose is missed then you should simply skip it and return to the normal dosing schedule. Never take more than advised on the packaging.


Oxymetazoline works by relaxing blood vessels in the nose and as such, it can interact with a wide range of other medications. If you are taking any other medications for any other conditions then you should not use this treatment without first checking that it is OK to do so with your doctor. Oxymetazoline can interact with all of the following medications, but this list may not be all-inclusive. You must discuss use with your doctor before taking Oxymetazoline.

The use of Oxymetazoline with any of the following treatments would not normally be recommended. In some cases, your doctor may prescribe both, but the dose used may need to be changed:

  • Trimipramine
  • Tranylcypromine
  • Timolol
  • Tianeptine
  • Sotalol
  • Selegiline
  • Safinamide
  • Rasagiline
  • Protriptyline
  • Propranolol
  • Procarbazine
  • Practolol
  • Pindolol
  • Phenelzine
  • Penbutolol
  • Oxprenolol
  • Opipramol
  • Nortriptyline
  • Nialamide
  • Nadolol
  • Moclobemide
  • Metipranolol
  • Methylene Blue
  • Melitracen
  • Lofepramine
  • Linezolid
  • Levobunolol
  • Labetalol
  • Isocarboxazid
  • Iproniazid
  • Imipramine
  • Furazolidone
  • Fentanyl Citrate
  • Doxepin
  • Dibenzepin
  • Desipramine
  • Clomipramine
  • Carvedilol
  • Carteolol
  • Amoxapine
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine

Other medical conditions from which you suffer could also impact the use of this medication. You should not use this medication if you have any of the following conditions as they may be made worse by use. In these cases you can consult your doctor to determine if there are any other medications that you could take instead:

  • Dryness inside the nose
  • High blood pressure or hypertension
  • Tachycardia or an unusually fast heart rate
  • Trouble with urinating caused by the enlargement of the prostate

Contact your doctor before use if you have any doubt or any questions about the safety of use with your medication or condition.


Before using any medication you must read the instructions and warnings carefully. Ensure that you understand the risks of use and weigh them in relation to the benefits. For the use of Oxymetazoline, you must consider your other medical conditions and the other medications that you are taking before using this product. Ensure that you have also taken the following into account:

Allergies' Read the allergy information on the label and packaging. Do not ever use any medication that you believe you may suffer an allergic reaction to. If you do suffer an allergic reaction then you should seek urgent medical care.

Pediatric' Children may have increased sensitivity to the use of this treatment. Use caution when treating children and be alert to any side effects that could occur.

Geriatric' This medication has not been tested specifically in elderly patients but not limitations are expected. Use caution if you suffer from any other medical conditions or if you are taking any other medications as these may interact with Oxymetazoline in the body.

Breastfeeding' The risks of use while breastfeeding is unknown. You should discuss the use of this treatment with a doctor before doing so if you are breastfeeding.

Pregnancy' Oxymetazoline is considered to be relatively safe for use during pregnancy. Pregnant women should be wary of the risks of overuse, however, and should discuss with a doctor if they have any concerns. Treatment should only be used where it is clearly necessary to do so.

Before having any surgery, tests or treatment you must inform your doctor that you are using it. This is because use could affect the test results and could prohibit the use of certain medication of the carrying out of certain medical procedures.

If you are undergoing any treatment for any condition relating to the heart then you should take extra caution and should check with your doctor before using this nasal decongestant or any other nasal decongestant. There is a high chance of interaction between these medications and use can put you at risk. The use of Oxymetazoline could also directly impact the condition of your heart and put you at immediate risk.


You should keep this medication sealed and at room temperature. You should not keep it in direct light or expose it to heat or moisture. Prevent this medication from freezing.

Always keep this and all medications out of the reach of children.

Dispose of outdated medication promptly and safely.


Oxymetazoline is a nasal decongestant that is used to treat patients who are suffering from an allergy such as hay fever, have a problem of the sinus or are suffering from a common cold. This medication is not a cure for these conditions but will serve to help to relieve the symptoms of the conditions.

Oxymetazoline is available as a spray or solution for nose drops and can be used in children aged 6+ and in adults. Caution should be used when treating children, however, as they can be more sensitive to the medication that you are giving to them. You do not need a prescription to use this medication.

You should never share a container of Oxymetazoline with anyone, even if you believe that they are suffering from the same cold or infection as you. To do so creates a risk of transfer of germs and infection. You should not keep the treatment once you have overcome a condition either as use in the future could infect you again with the same condition.

You should be very careful in the use of this treatment if you are receiving any medications or if you have certain medical conditions. Conditions of the heart and medications for blood pressure, in particular, are highly likely to interact with the nasal decongestant and this can cause serious and unwanted side effects to occur. If you are undergoing any other treatment then you must consult your doctor before making use of this treatment.

You should also inform any medical professionals including ophthalmologists, dentists and doctors that you are taking this medication before they carry out any tests or administer any treatments. This medication may change the results of tests and may prohibit the use of certain treatment too, so you should be cautious and share this information.