This medication functions by delivering an enzyme known as adenosine deaminase or ADA into the body. In children who do not have a fully developed or underdeveloped immune system, Pegademase can be used to improve immunity if this underdevelopment is due to a lack of ADA in the child's system.
This form of treatment is called enzyme replacement therapy, and can be used from birth or for children of any age who suffer from a severe combined immunodeficiency disease (SCID). This medicine is often used if the child is not a suitable candidate for a bone marrow transplantation, or if they have already failed this form of treatment.
Often, taking Pegademase is a permanent solution of treatment, which means children and infants with conditions that require the reintroduction of ADA into their bodies will likely be on this type of medicine for their whole lives.
Pegademase is solely given by a trained medical professional or doctor, in a clinical and suitable setting.
Along with the effects that are required and designed for the use of Pegademase, during treatment with this particular medication, certain additional side effects may become present or occur. This medication is known to cause certain unwanted effects or conditions. If any of the listed side effects do occur to you or your child during your time of treatment with Pegademase, then it's critical that you get in contact with a medical professional as soon as possible to ensure there is nothing more serious resulting from these effects.
You should speak to a medical professional as soon as you can if any of the listed effects occur to you or your child during treatment with Pegademase:
In addition to the above-listed side effects that may be indicators of a more serious condition or can cause harm to you or your child, treatment with Pegademase may also cause other side effects that are of a less serious nature. These effects may occur at the beginning of, during or following treatment.
Should any of the listed effects become worse over time for you or your child, continue for longer than anticipated or become increasingly bothersome or difficult to deal with, a medical professional may be able to advise you on the best way to prevent certain effects, as well as help you to reduce these conditions. Often, side effects caused by medication reduce or go away over time as the body becomes used to the drug.
If any of the following occur during your treatment with Pegademase, you can consult your doctor regarding any concerns but often this is not required:
When taking any form of medication, including Pegademase, it is important that you follow all directions on your prescription label. This medication may be given in a controlled and clinical setting, but even if this is the case it is still important to be aware of any requirements prior to or following your injection. Your doctor may occasionally choose to change your dose, so it is also important to be aware of any alterations in your medication.
Pegademase Bovine is injected directly into the muscle of the patient. Depending on the condition of the patient and the circumstances of this medication, you may be taught the correct and proper way to inject this medication yourself at home. If you are unsure about the right way to give an intramuscular injection, never self-inject without this knowledge, as it may cause problems or complications. A doctor or nurse will be able to talk you through every step of the injecting process to ensure that your technique is correct.
Pegademase bovine is generally given as an injection once every seven days. It is important that the dosage information provided by your doctor is acknowledged and adhered to when taking this form of treatment.
When using a disposable syringe and needle, it's important that you do so only once. Never reuse needles or syringes. Each state or local area has its own laws and regulations about throwing away or disposing of used medical items such as syringes and needles, so it is important you are aware of the correct disposal methods.
When you start treatment with Pegademase from home, you should be provided with a sharps bin, a puncture-proof way to dispose of needles. If you are not given one of these bins, speak to your doctor or a pharmacist about the best place to get one.
It is important to keep both your disposal container and your prescribed medication itself safely out of the reach of both pets and children at all times.
Each dose of Pegademase should be decided and calculated based on the monitoring of both the plasma adenosine deaminase (ADA) activity levels in the body and the red blood cell deoxyadenosine triphosphate (dATP) content. From this, your doctor will calculate the exact dose for you and your child.
The usual pediatric dosage of this medication is as follows:
Generally, there are certain types of medications that should not be used at the same time. This may be due to direct side effects caused by taking this medication at the same time, or these medicines may even cause the other to be less effective. Despite this, in some cases taking two incompatible medications together may be required in order to provide the best possible treatment to a patient. If this is the case, your doctor may decide to alter your dosage or change the times you take your medications to reduce your risks.
The interactions listed were chosen based on the possible significance of their interaction with Pegademase and this list is not necessarily all-inclusive. Taking the following medicine alongside this drug may cause interactions, so it is important that your doctor is fully formed of both your current usage and history of medications at all times:
In addition to interaction with drugs, certain medicines are not designed to be taken at or around the same time as eating food or taking alcohol or tobacco. Also, different types of food may cause specific interactions to occur during treatment. In the case of Pegademase, there are no direct interactions with food, alcohol and tobacco. However, it is important to consult with your doctor on this, as other medications you are prescribed may have these interactions.
The pre-existence of other medical conditions or problems may directly affect the use of Pegademase as a form of treatment. Try to inform your doctor as soon as possible and before starting treatment with this medication if you have any other medical issues, especially:
Should you suffer from any form of allergic reaction to dyes, animals or foods, as well as direct allergies to forms of medication, it's important that your doctor is fully informed of this. It is key that your doctor always has an up to date medical record of you or your child to ensure the best possible treatment.
Due to the nature of Pegademase, it's important that you or your child continue to receive treatment with this medication. In the majority of cases, this treatment continues for life and stopping this medication without the prior approval of a medical professional can result in life-threatening side effects, including the break down of the immune system and even a serious infection risk.
You or your child should make an effort to avoid people who are either sick or suffering from an infection. If you feel that you or your child have contracted an infection, inform your doctor at once for prompt treatment. Your blood will also need to be tested regularly while under treatment, ensuring that there are no signs of infection internally.
When taking Pegademase, it can take upwards of six months for the immune system to improve, and for your risk of infection and illness to decrease. Keep on taking this medication as prescribed and inform your doctor if this time passes, and there is no difference.
To ensure that Pegademase Bovine as a course of treatment is safe and a correct choice for you, tell your doctor if you have:
This medication is listed as FDA pregnancy category C. This means that it is not known if Pegademase will harm an unborn infant. Inform your doctor as soon as possible if you are pregnant or planning to become pregnant while taking this medicine.
Pegademase comes in a single-use vial (bottle) form, which is for one use only. Even if medication is left in the vial following your injection, never use this solution, and dispose of it appropriately.
Never use medication like Pegademase if it has changed color or has particles in it that were not there before. Speak to a pharmacist for new medication, and dispose of the old properly.
Store this medication in the refrigerator, never freeze it. Should any of this medicine become frozen, you must throw it away and not use it.
Pegademase Bovine is a form of medication this is delivered intramuscularly and contains an enzyme called adenosine deaminase (ADA). This medication is used for the treatment of children with an immune system that has not developed properly due to a lack of ADA produced by the body.
This medication replaces a crucial part of the immune system and can be used from birth. This medication is very often used as Enzyme replacement therapy for ADA deficiency for life, and therefore this medicine is a long-term solution or treatment. This medication is often used should a bone marrow transplant not be an option, or if it has been unsuccessful.