Pentosan Polysulfate Sodium (Oral)

This drug is a weak blood thinner that should only be taken by those prescribed the medication.


In the event of cysts or other bladder issues, Pentosan Polysulfate Sodium can be used to the thin the blood and reduce pain. This drug can be beneficial to anyone suffering from interstitial cystitis, and can also be used in other situations to treat various issues.

This drug should only be used with the approval of a doctor. It is a prescription drug, and should only be used as long as it is needed. As a blood thinner, this drug can change the blood and cause side effects. If you experience easy bleeding or other dangerous symptoms, stop using this drug and notify your doctor.

Conditions Treated

Type Of Medication

  • Blood thinner

Side Effects

This drug may cause side effects in addition to the wanted effects of the medication. These side effects may lessen or disappear the longer you take this drug. Side effects can range from mild to severe, so be sure to keep an eye on your body after starting this drug.

If you experience anything troubling, contact your doctor and notify them as soon as possible. If you believe your life is in danger at any point, call an ambulance or get yourself to the hospital.

Some side effects may be mild and do not require medical attention. These side effects should go away over time, but if they persist and become a problem, talk to your doctor. Mild side effects can include:

  • Depressed mood
  • Nausea
  • Vomiting
  • Other forms of stomach upset

These side effects are mild and should go away over time. If you have an issue with them, ask your doctor about solutions or other non-interactive medications to treat these issues. If these side effects persist and begin to affect your daily life, make sure to tell your doctor. This may be solved by a change in dose, other medications, or a different medication entirely.

Some side effects may be a sign that this medication is not right for you. If you experience any of these side effects, stop taking Pentosan Polysulfate Sodium and contact your doctor. They may take you off the drug and find a more suitable medication for you. If these side effects seem life threatening at any point, seek help.

  • Unusual fatigue or weakness
  • Unusual bleeding/bruising
  • Blood in urine
  • Blood in stool
  • Changes in vision
  • Passing out

This drug may also cause allergies. If you have an allergy to this drug, or drugs of this nature, do not take Pentosan Polysulfate Sodium. Allergy symptoms include unexplained fever, rash, trouble breathing, swelling of the face/mouth/lips. Stop taking this drug if you experience any of those side effects or any other allergy-based symptoms.


Your dosage of this drug can change depending on your condition, weight, age, and other factors. Be sure to talk about your dose with your doctor to decide a safe and manageable dose for you. Your dose may change over time, or remain the same for the entire duration of your treatment.

If you have a conflicting condition or are currently taking interactive medications, your dose of this drug may be lowered. This is normal, and you should only take the dose your doctor recommended for you.

The most common dose of this drug is 100mg, three times per day. This is the adult dose, and any child's dose should be determined on a case-by-case basis. This dose is also meant for those suffering from interstitial cystitis, so if you are taking Pentosan Polysulfate Sodium for another reason, your dose may change.

This drug should be taken one hour before any food/milk is consumed. Take this drug with a glass of water, and go about your day. Be sure to take this drug as directed, and take any missed doses as soon as you remember. If too much time has passed, just skip the dose and continue taking the medication as usual. Do not double dose.

This drug may take some time to begin working at full capacity. Do not feel discouraged if there is no immediate effect. Talk to your doctor about your condition and treatment, and make sure to show up for all your necessary tests and check-ups while taking this drug. If your doctor gives you special instructions on how to take this drug, be sure to follow them closely.


This drug may interact with other medications you are taking. These interactions can vary between mild to severe, so be sure to discuss all possible interactions with your doctor before taking this drug. Keep a detailed list of all your medications, including over the counter drugs and herbal remedies. Interactions are not limited to prescription medications, so you should always mark down any drugs you have taken in the past month.

In the event of an interaction, your doctor may ask that you stop or lower the dose of an existing medication. While unpleasant, this is the best option for your health. If this is an issue, be sure to mention it to your doctor. You may be able to switch to a less interactive medication, lower your Pentosan Polysulfate Sodium interaction, or find another treatment option.

Known interactions of Pentosan Polysulfate Sodium include:

  • Heparin or Warfarin (Coumadin)
  • Fondaparinux (Arixtra)
  • Tirofiban (Aggrastat)
  • Urokinase (Abbokinase)
  • Lepirudin (Refludan)
  • Bivalirudin (Angiomax)
  • Abciximab (ReoPro)
  • Alteplase (Activase)
  • Clopidogrel (Plavix)
  • Tenecteplase (TNKase)
  • Anagrelide (Agrylin)
  • Dipyridamole (Persantine or Aggrenox)
  • Eptifibatide (Integrelin)
  • Ticlopidine (Ticlid)
  • Enoxaparin (Lovenox)
  • Cilostazol (Pletal)
  • Dalteparin (Fragmin)
  • Prasugrel (Effient)
  • Argatroban (Acova)
  • Other NSAIDs such as ibuprofen and naproxen

Please note that this list is not exhaustive. There may be additional interactions or interactions that haven't been recorded. It is also important to note that food interactions can occur with this drug, including:

  • Interaction with avocado

Be sure to avoid any interactions during your treatment, and change your prescription list and diet accordingly. Talk to your doctor if you are taking any of these drugs, and make sure to discuss your treatment plan thoroughly before your first dose.


This drug may come with risks for anyone taking it. These risks may be aggravated by existing conditions or other factors involving your health, but everyone taking this drug should be aware of the warnings.

Do not take this drug if you have an allergy to it, have had an allergic reaction taking this drug, or have an allergic history with similar drugs. If you experience allergies caused by this drug, do not take it and throw away the extra medication. Your doctor will prescribe another treatment. Allergies can be fatal if left unchecked, so be sure to monitor yourself for any allergy symptoms. If trouble breathing or swelling of the airways occurs, contact medical help.

If you suffer from blood problems, polyps, or blockage in the intestine, talk to your doctor before taking this drug. These conditions may prevent you from taking this drug, and you may require another form of treatment. Those with stomach ulcers may experience an increased risk of bleeding. Be sure to mention any ulcers or bleeding issues to your doctor.

If you have liver disease, your ability to filter this drug may be hindered. This can cause increased side effects. Tell your doctor if you experience intensified or aggravated side effects while taking this drug, and consider a lowered dose for the best effect.

Because this drug is a blood thinner, it can cause the blood to thin and induce bleeding. If you experience easy bleeding from the gums, nose, or other parts of the body, tell your doctor. If you begin coughing up blood, find blood in your urine or stool, or begin bleeding uncontrollably after cutting/harming yourself, stop taking this drug and contact your doctor immediately.

Try to avoid sharp objects like razors and knives, and be sure to stem any bleeding with clean rags. If the bleeding becomes an issue, or you believe your life is in danger, contact medical help.

Be sure to show up for your blood tests, and speak to your doctor if any troubling side effects occur. Only take this drug as long as directed, and only use it as directed. In the event of overdose, contact medical help immediately.


Keep this drug away from water, as they will dissolve and lose their form. Do not take ruined pills, since there is almost no way to know how much of the drug you are getting. Store this drug at room temperature to avoid heat damage, and do not freeze it. Heating or freezing this drug may make it less effective during treatment. If you need a refill, talk to your doctor or pharmacist.

If this drug has expired, throw it out. Old medication is less effective, so you may be getting the wrong dose entirely. Do not keep extra medication after your prescription has ended. This drug needs to be taken every day over the period of three months to work effectively, so taking one solitary pill won't do anything.

Do not give this drug to anyone else, even if they have similar symptoms. Every person is different, and where you might benefit from a Pentosan Polysulfate Sodium prescription, another person may react adversely. If a friend or loved one is suffering from bladder problems or cysts, advise them to speak to their doctor as soon as possible.

Keep this drug out of reach of children and pets. If accidental consumption has occurred, contact poison control. Have the prescription bottle on hand, and be ready to tell them how much was taken, when it was taken, and any other pressing medical information.

If you need to throw this medication away, put it in its prescription bottle or seal the pills in a ziplock bag. Do not give this drug to anyone else, and do not throw loose pills into the garbage. If you can, look for a medication take-back program in your area. These programs should be sponsored by a pharmacy or hospital.


Pentosan Polysulfate Sodium can be a valuable treatment for anyone suffering from interstitial cystitis. Cysts can be painful and hard to treat with normal painkillers, so this drug can be a valuable prescription for those issues. However, this drug should only be used with a prescription. If you believe you may need this drug, talk to your doctor personally and mention this drug.

If this drug is right for you, your doctor will write you a prescription. Talk to your doctor about this medication, its risks, potential side effects, and any existing conditions you have. Upon receiving this drug, make sure to go over all the dosage and storage information. If you do not understand something, ask your doctor to explain it to you. Be sure to take home any and all information pamphlets and guides, and do not throw them away.

This drug should only be taken as directed. Try to take this drug on an empty stomach. If you have been instructed to take this drug on a schedule, avoid missing doses. Keep this drug out of reach of children and pets, as accidental consumption can cause overdose. If you believe you or a loved one is suffering from an overdose of this drug, contact emergency services immediately.

You may require blood tests while taking this drug. Be sure to attend all of your regularly scheduled check-ups and tests, and talk to your doctor about how this drug is working for you. If it is having no effect or an adverse effect, stop taking it. If this drug isn't working correctly for you, your doctor may recommend another option or a stronger dose.

Avoid taking this drug with any other medications that can cause easy bleeding. This includes other blood thinners and NSAIDs such as ibuprofen. Talk to your doctor about what is safe to take on this drug, and only take approved medications to avoid interactions.