Peramivir (Intravenous)

Peramivir is an antiviral medicine (neuraminidase inhibitor) used to treat flu symptoms caused by influenza viruses occurring during late fall and early winter.


Peramivir is a neuraminidase inhibitor, administered intravenously (IV) to block the spread of influenza infection. The infection is contagious and transmitted through respiratory droplets when an infected person coughs or sneezes. If you are within proximity, you are susceptible. Coming in contact with contaminated surfaces is another source of transmission.

U.S. Food and Drug Administration (FDA) approved this medicine for adults and pediatric patients 2 years and older with symptomatic effects for less than three days. Peramivir IV offers immediate delivery of a single dose for patients requiring urgent treatment. This medicine is also the selected choice when patients do not respond to other antiviral oral or inhalant therapies.

  • Patients with hypersensitivity or life-threatening allergic reaction (anaphylaxis) to this medicine or its chemical components should not use this medicine.

Conditions Treated

  • Influenza Infection

Type Of Medicine

  • Antiviral Inhibitors

Side Effects

Varying levels of side effects will occur with treatment of peramivir. The severity of each effect depends on the individual's health, age and the severity of the treated condition. The side effects associated with this medicine range from mild to serious. If you have existing disorders treated with other medicines, the effects or the condition itself could worsen.

It's important to share all of your health, medical and family history with your doctor. The information will help in predicting how you may react to this medicine. Your doctor will have solutions for prevention or relief for you. If you have allergies, be sure to tell your doctor, this medicine worsens the reaction.

Here's a list of the most common, least common, and rare side effects that have occurred with this medicine. In most cases, once your body adjusts to the medicine, they will fade away. If you experience any of these effects beyond your own comfort level, talk to your doctor. If the effect worsens or persists beyond a week, contact your doctor immediately.

There are side effects not listed that may occur. If you recognize other effects, check with your doctor.

Most common

During clinical trials, eight percent of the patients receiving treatment of peramivir at doses of 600 milligrams (mg) experienced the side effect of diarrhea. Although all the side effects are possible, you may avoid them by keeping your doctor updated on your how you are feeling.

In some situations, medical attention is not needed, but your doctor needs to know how you are responding to the medicine. DO NOT stop taking any of your prescribed medicines without your doctor's approval.

Less common

Some effects are rare, but introducing new medications can prompt them. Sometimes, adjustments made to existing medicines or an underlying health condition can instigate the side effect. If you have known allergies before starting this treatment - tell your doctor.


  • Allergic reaction
  • Constipation
  • Fever
  • Hallucination
  • High blood pressure
  • High blood sugar
  • Itching
  • Muscle pain
  • Red eyes

Adverse Side Effects

If you suffer from any disorders and take prescription medicines for treatment let your doctor know. You need to recognize the side effects or changes with these conditions before they trigger serious consequences to your health. Sometimes, when two different medicines are taken together, the doses and the scheduled times for taking them need to be adjusted to treat both conditions and avoid side effects.

Prescription medicines or over-the-counter (OTC) treatments, health supplements, herbal remedies can cause side effects. Lifestyle choices about alcohol, tobacco, exercise routines and specific foods affect your body's response to medications. Your doctor will watch how these medicines work for you.

If you have been taking a single drug for a long time, whether it's a prescription or non-prescription, let your doctor know. It could change how you respond to this medication.


A nurse or trained health professional in a hospital will administer peramivir. The medicine needs to be administered as soon as you recognize the flu symptoms or within the first 2 days of illness indications.

Your doctor needs to know if you have received the live flu vaccine before starting this treatment. It may affect your response to this medicine and your doctor may suggest delaying this therapy.

The doses listed are averages for healthy individuals. The doses will vary depending on the severity of your condition and other health circumstances or your own tolerance to this medication.

For Influenza

Adults and Adolescents - 13 years of age and older - Single dose

  • 600 mg administered through an IV for 15 to 30 minutes.

Pediatrics 2 to 12 years of age - Single dose

  • 12 mg administered through an IV for 15 to 30 minutes.
  • Maximums of 600 mg

Adults with Renal Impairment - Single dose Altered Creatinine Clearance (CrCl)

  • CrCl 50 or higher milliliters per minute (mL/min) is 600 mg
  • CrCl 30-49 mL/min is 200 mg
  • CrCl 10 -29 mL/min is 100 mg


Certain medicines should not be used together. There are situations where two different medicines are effective even though they interact. You may experience a mild interaction. When major or life-threatening reactions are expected, your doctor will consider changing the dose or the medication to prevent harmful responses.

It's important for your doctor to know about the medicines you are taking now. The following lists include known interactions with peramivir or its chemical compounds. If you are taking any of these medicines, tell your doctor before starting treatment.

Drug Interactions

  • Acyclovir
  • Adefovir
  • Aldesleukin
  • Amikacin
  • Carboplatin
  • Cidofovir
  • Cisplatin
  • Clofarabine
  • Cyclosporine
  • Flucytosine
  • Foscarnet
  • Ganciclovir
  • Gentamicin
  • Ifosfamide
  • Kanamycin
  • Oxaliplatin
  • Pemetrexed
  • Penicillamine
  • Pentamidine
  • Streptomycin
  • Tacrolimus
  • Tenofovir df
  • Tobramycin
  • Vancomycin
  • Zoledronic acid

Adverse Reactions

Unintended responses do not occur in everyone, but when individuals have existing ailments or carry hidden genetics susceptible to specific medicine they happen. The outcome may be an allergic reaction, interference with a biological function or intensified side effects. Your doctor will watch your reactions to this medicine and make the adjustments as needed to support your health.

  • If you suffer from kidney disease, tell your doctor. You need to take precaution when using this medicine. The doses may need adjustments because this medicine may amplify the side effects.
  • Abnormal behavioral (neuropsychiatric) events occur in some patients during the early treatment phases.
  • Skin reactions (hypersensitivity) associated with Stevens-Johnson syndrome can happen.


Health warnings are based on the drug's benefits, outweighing the risks for the condition the drug will treat for the majority population. When deciding to use this medicine, you need to understand the risks and the benefits associated with a drug and the potential effects, your own health may contribute before starting treatment.


There are risks to mothers and unborn infants associated with influenza. Data available for this medicine is limited. During clinical studies with animals, no adverse effects were detected when using human single doses. It's in your best interest to talk to your doctor to make sure you and your unborn child are safe.

  • Precautions need to be taken if you are pregnant or become pregnant while being treated with this medicine.
  • Pregnant women are at a higher risk for complications from the infection and treatment.


If you are treated with peramivir and consider breastfeeding, talk to your doctor. Test data on nursing animals show small traces of this medicine in the milk. The data is inconclusive for human maternal conditions with unknown effects and precautions of passing traces of peramivir to the infant.


The safety and effectiveness of this medicine for pediatric patients 2 to 17 years have been established.

  • In most cases, patients of 13 to 17 years of age are treated with single doses of 600 mg.
  • 2 to 12 years of age are treated with lower starting doses to a maximum of 600 mg.
  • Safety and effectiveness of this medicine for pediatric patients less than 2 years has not been established.


Elderly adults share the same risk factors as younger individuals. Due to age and the natural digression with health, this group is more susceptible to the side effects caused by the medication during treatment. Second, older adults suffer from renal malfunctions, immune disorders or other health ailments that can increase the complications of treatment.

  • In clinical studies, 65 year old adults and older showed no signs in responding differently compared to younger adult aged individuals.


Health care staff or professional care providers store this medicine at temperatures 68 to 77 Fahrenheit.

  • DO NOT freeze this vaccine' if freezing occurs, dispose of it.
  • Used medical supplies and unused portions are disposed according to healthcare guidelines.


Peramivir has been effective in treating influenza for persons of normal health and individuals with other health disorders. The medicine has not shown the same benefits for individuals suffering from serious influenza symptoms in need of hospitalization.