Perflutren Lipid Microsphere (Intravenous)

Perflutren lipid microsphere is injected into the patient to allow a clearer picture to be collected through ultrasound of certain parts of the body including the heart.


Perflutren lipid microsphere is a contrast agent that is used to help provide a clearer picture during ultrasound scans.

Ultrasound is a diagnostic procedure that uses sound waves at a high frequency to create pictures of body parts. The sound waves bounce back' from different parts of the body and a clear picture can be seen by the ultrasound technician or doctor. Ultrasound dose not involve the use of any radiation as is found in X-rays.

Perflutren lipid microsphere contains certain lipid microspheres that contain a gas. This gas reflects the sound waves back to the imaging machine and enables a clearer picture to be developed. It is injected into the patient before the ultrasound begins and is used to assist in the diagnosis of conditions of the heart.

This medication should only be used under the direct supervision of a doctor who is trained in ultrasound procedures. This medication will not cure any conditions, rather it is used to help identify problems for treatment.

Perflutren lipid microsphere is administered as a suspension for injection.

Condition treated

  • Heart problems, diagnosis of

Type Of Medicine

  • Contrast agent

Side Effects

In addition to helping to create a clear picture for an ultrasound, Perflutren lipid microsphere can also have unwanted side effects in the body. While not all of these may occur, if you do experience them you should inform your doctor and medical attention may be required in some cases.

You should immediately inform your doctor if any of the following side effects are experienced following the use of Perflutren lipid microsphere:

  • Black stools with a tarry appearance
  • Blurring of the vision
  • Chest pains
  • Chills when warm
  • Coughing
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness
  • Fast or pounding heartbeat
  • Hives
  • Irregularity of heartbeat or pulse
  • Itching
  • Lightheadedness when rising suddenly from sitting or lying
  • Puffy or swollen around the eyes, face, lips or tongue
  • Severe or ongoing dizziness
  • Shortness of breath
  • Skin rash
  • Slowed heartbeat
  • Swelling of the glands
  • Tightness across the chest
  • Unusual bleeding
  • Unusual bruising
  • Unusual tiredness
  • Unusual weakness
  • Wheezing

Other side effects can also occur that would not normally require that you seek attention from the doctor. If these side effects are ongoing or are particularly bothersome, however, then you can inform your doctor and seek advice on how to alleviate them. These side effects will normally be mild and will alleviate over time:

  • Acid stomach
  • Back pain
  • Diarrhea
  • Difficulty moving
  • Dizziness
  • Dryness of the mouth
  • Feeling of warmth of the skin
  • Feeling that the self or one's surroundings are constantly moving
  • Feverishness
  • Headaches
  • Heartburn
  • Indigestion
  • Leg cramping
  • Muscle stiffness
  • Muscle tension
  • Nausea
  • Pain at the site of injection
  • Pain or swelling of the joints
  • Prickly or tingling sensation on skin
  • Reddening of the face, neck, arms or upper chest
  • Sneezing or running of nose
  • Sour stomach
  • Stomach pain
  • Stomach upset
  • Unexplained bruising

Other side effects could also occur that have not been listed herein. You should inform your doctor of any other side effects that occur.


This medication should only be administered by a trained healthcare professional. It will be administered by needle directly into one of your veins.

Before receiving this treatment and to ensure a good picture is given from the ultrasound you may be given specific instructions to follow in the days before the treatment. You should follow these instructions closely.

The usual dose given will be 10 microlitres per kg of weight. This is followed by a 10mL saline flush. A second dose may be administered after 30 minutes if it is required.


Perflutren lipid microsphere can interact with medications in the body and it is therefore vital that you inform your doctor of all medications that you are taking before you begin use of this treatment. You should not use certain medications together at all and others may require that the doses are adjusted when used together. The following list of medications has been compiled for severity and likelihood of occurrence but is not all inclusive. You must inform your doctor of all substances that you take before administration of Perflutren lipid microsphere.

The following medications are not recommended for use in patients receiving Perflutren lipid microsphere. Your doctor may choose not to administer this contrast agent if you are taking the following:

  • Ziprasidone
  • Thioridazine
  • Terfenadine
  • Sparfloxacin
  • Saquinavir
  • Piperaquine
  • Pimozide
  • Mesoridazine
  • Dronedarone
  • Cisapride
  • Bepridil
  • Amisulpride
  • Amifampridine

It is not normally recommended that you receive a diagnostic test with this medication if you are taking any of the following treatments. In some cases this may be necessary but your doctor may make changes to the dose that you take:

  • Zuclopenthixol
  • Voriconazole
  • Vinflunine
  • Vemurafenib
  • Vardenafil
  • Vandetanib
  • Triptorelin
  • Trimipramine
  • Trifluoperazine
  • Trazodone
  • Toremifene
  • Tetrabenazine
  • Telithromycin
  • Telavancin
  • Tacrolimus
  • Sunitinib
  • Sulpiride
  • Sotalol
  • Sorafenib
  • Solifenacin
  • Sodium Phosphate, Monobasic
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate
  • Sevoflurane
  • Salmeterol
  • Ranolazine
  • Quinine
  • Quinidine
  • Quetiapine
  • Protriptyline
  • Propafenone
  • Promethazine
  • Prochlorperazine
  • Procainamide
  • Posaconazole
  • Pitolisant
  • Pimavanserin
  • Pazopanib
  • Pasireotide
  • Panobinostat
  • Paliperidone
  • Ondansetron
  • Ofloxacin
  • Octreotide
  • Nortriptyline
  • Norfloxacin
  • Nilotinib
  • Nafarelin
  • Moxifloxacin
  • Mifepristone
  • Metronidazole
  • Methadone
  • Mefloquine
  • Lumefantrine
  • Lopinavir
  • Levofloxacin
  • Leuprolide
  • Lapatinib
  • Ivabradine
  • Imipramine
  • Iloperidone
  • Ibutilide
  • Hydroxyzine
  • Hydroxychloroquine
  • Histrelin
  • Haloperidol
  • Halofantrine
  • Granisetron
  • Goserelin
  • Gonadorelin
  • Gemifloxacin
  • Gatifloxacin
  • Fluoxetine
  • Fluconazole
  • Flecainide
  • Fingolimod
  • Escitalopram
  • Erythromycin
  • Efavirenz
  • Droperidol
  • Donepezil
  • Domperidone
  • Dolasetron
  • Dofetilide
  • Disopyramide
  • Deslorelin
  • Desipramine
  • Delamanid
  • Degarelix
  • Dasatinib
  • Dabrafenib
  • Crizotinib
  • Clozapine
  • Clomipramine
  • Clarithromycin
  • Citalopram
  • Ciprofloxacin
  • Chlorpromazine
  • Chloroquine
  • Buserelin
  • Azithromycin
  • Astemizole
  • Asenapine
  • Arsenic Trioxide
  • Aripiprazole
  • Apomorphine
  • Anagrelide
  • Amoxapine
  • Amitriptyline
  • Amiodarone
  • Alfuzosin

Interactions with other medications could also occur. Ensure you inform your doctor of all medications that you take.

Medical conditions not being examined can also be worsened by the use of Perflutren lipid microsphere. You must discuss your full medical history with your doctor before beginning use of this treatment. This is especially important in the following cases:

The risk of serious side effects will be increased in patients with:

  • Congestive heart failure
  • Heart attack
  • Heart disease
  • Heart rhythm problems
  • Respiratory distress syndrome

Do not use Perflutren lipid microsphere in patients who suffer from the following heart conditions:

  • Heart shunt
  • Right-to-left
  • Bi-directional
  • Transient right-to-left

Other medical problems can also impact the use of this treatment. You should ensure your doctor is aware of all conditions from which you suffer.


Before beginning use of this diagnostic treatment you should consider the risks of doing so in relation to the benefits of use. Before using this treatment you should ensure you have considered all of the following with your doctor:

Allergies If you have ever had an unusual reaction to any medications in the past then it is important that you inform your doctor. Bad reactions to medication may prohibit the use as can other allergies. Be particularly clear if you have ever had an allergy to dyes in the past.

Pediatric The safety and efficiency of use in children has not been established for this medication.

Geriatric No limitations are known for the use of this treatment in the elderly. Elderly patients are, however, more likely to be suffering from other conditions that may limit the use.

PregnancyThere is a low risk to the use of this treatment in pregnant women but this should not be ignored. Inform your doctor if you are pregnant before you receive this diagnostic injection.

Breastfeeding You should weigh the potential risks of use during breastfeeding with your doctor. There is no known risk but adequate studies have not been performed to determine the risks.

Your doctor will need to monitor you closely while you are taking this treatment. The prescribing doctor will be present for the scan and will ensure that you are responding to it properly. Your doctor may need to have a follow-up appointment with you after the diagnostics have been carried out.

A serious allergic reaction called anaphylaxis can occur from the use of this medication. This is a potentially life-threatening condition that needs to be treated with immediate effect. You should inform your doctor immediately if you are suffering from any of the following symptoms of anaphylaxis:

  • Rash
  • Itching skin
  • Hoarseness
  • Troubled breathing
  • Troubled swallowing
  • Swollen hands, face and mouth

You may also develop problems with your heart or your lungs during the use of this treatment. This can be potentially life-threatening and needs to be treated with immediate effect. You must report any symptoms to your doctor immediately. These symptoms include:

  • Chest pains
  • Changed heartbeat
  • Lightheadedness
  • Dizziness
  • Faintness
  • Fainting
  • Shortness of breath
  • Trouble with breathing

Patients should not take any other medications to treat any side effects that may occur or to treat any other conditions at the same time as this treatment. Discuss any medications that you might be using with your doctor before you receive the injection of this treatment.


Perflutren lipid microsphere should be stored refrigerated between 2 and 8 degrees C. Once activated the solution may be stored for up to 12 hours before it needs to be disposed of if unused.


Perflutren lipid microsphere is a diagnostic treatment that is used to get a clear picture of your heart from an ultrasound scan. It is injected directly into the vein of the patient before the scan is carried out.

Perflutren lipid microsphere contains microspheres of gas that cause the frequency waves of the ultrasound equipment to bounce back. They fill the heart and enable the doctor to get a much clearer picture of the heart than would normally be possible. This allows them to diagnose certain conditions of the heart.

Patients may be asked to follow some steps in the days preceding the treatment. This may include the cessation of other medications or changes to diet. You should follow these steps exactly to enable an accurate diagnosis to be made.

Patients with certain diagnosed conditions of the heart should not be treated with this medication. Ensure that your doctor is aware of all of your medical conditions before receiving treatment.

Before beginning treatment with Perflutren lipid microsphere it is important that the patient weighs the risks of the treatment against the benefits. Certain life-threatening conditions may occur during this test.