Perphenazine and Amitriptyline (Oral)

In the form of a tablet, this combination drug is used to treat various mental or emotional conditions.


Perphenazine and Amitriptyline is a drug combination prescribed to patients suffering from various emotional and mental conditions.

You can only access this drug with a doctor's prescription. This is because it is known to interact with a wide variety of other drugs, and can cause a number of side effects to occur. Your doctor is best placed to inform you of any interactions that may occur. They can also advise you on teh necessary means to avoid unwanted side effects.

Condition(s) treated

  • Emotional and mental conditions

Type of medicine

  • Tablet

Side Effects

As well as having its intended effect of helping to treat different mental and emotional conditions, this drug combination can cause other side effects to occur. These side effects can range in their severity and their need for assistance. Some patients may experience a number of side effects, whereas others may experience none at all. If you experience any of the side effects listed directly below, then you should seek emergency medical assistance.


  • Unusually pale skin

If you experience any of the side effects listed below, you should contact your doctor immediately.

More common

  • Twitching or tic-like movements

Less common

  • Irregular heartbeat or slow pulse


  • Dry, hot skin or lack of sweating

Below are the symptoms of overdose. You should familiarise both yourself and close family members with these. If you show signs of these at any times, then you should seek emergency medical assistance.

  • Hallucinations (feeling, seeing, or hearing things that are not there)

As well as these more serious side effects, it is possible that you will experience less serious ones. Below is a list of such effects. They do not necessarily require immediate attention. In fact, you will likely find that they pass over time as your body adjusts to the medicine. However, if they are lingering or bothersome than you can still contact your doctor for advice.

More common

  • Drowsiness

Less common

  • Decreased sexual ability

Once you stop taking PA, you may find that you experience some side effects that require attention.

It is possible that you will experience some side effects not listed here. If so, then you can discuss these with your doctor.


Below you can find the typical doses of Perphenazine and Amitriptyline prescribed to patients suffering from certain emotional and mental conditions. Be aware that your exact prescription may differ greatly from what is listed below. This is because each patient is unique in their condition and requirements. Your doses will take into account many factors, such as the extent of your condition as well as other drugs you are currently taking. If you have any questions about your dose you should address these to your doctor. You should never alter your doses without the strict permission from your doctor.

  • Adults. To start, take 1 tablet three or four times per day. Your doctor may then increase your dose if necessary.

It is important that you do not miss any doses as this will impact upon the overall effectiveness of your treatment. However, if you do miss a dose, you should take it as soon as you remember. This is as long as it is not almost time for your next scheduled dose. If it is, then you should skip the missed one and carry on with your dosing schedule as regular. It is important you never double dose.

In order to limit upset of your stomach, it is recommended you take Perphenazine and Amitriptyline wither with food or immediately afterward. This is as long as your doctor hasn't advised you otherwise.

You should never take this drug for longer than instructed by your doctor. Similarly, never take any more of it. This condition is very important for older patients as they are generally more sensitive to the effects this medicine has.

In order to reach the full effect of this drug, it may be necessary to take Perphenazine and Amitriptyline for several weeks.


It is possible that this drug will interact with other drugs you are currently taking. You should, therefore, inform your doctor of all drugs you are currently taking, both prescription and nonprescription. It is often the prerogative of the prescribing doctor to avoid any interactions where possible, so this could mean changing certain drugs you take. However, in other cases, it is unavoidable that certain interactions will occur as they are best for your overall treatment, Under such cases, your doctor may alter the dosages of one or both medicines, or how frequently you take them. Directly below is a list of drugs which it is recommended you don't take at the same time as Perphenazine and Amitriptyline. If you do take any of the following, then your doctor may need to alter one or both drugs in order to avoid an interaction.

  • Tranylcypromine

It is usually not recommended that you take any of the following at the same time as Perphenazine and Amitriptyline.However, if it's required that you take both then your doctor may adjust one or both doses you receive.

  • Tapentadol

If you take any of the following drugs at the same time as P, then you could face an increased chance of certain side effects. Again, however, if it is necessary for you to take both, then your doctor may alter your doses of one or both medicines.

  • Belladonna

As well as interacting with other drugs, Perphenazine and Amitriptyline may interact with other aspects of your dietary intake.This includes what you eat, drink, or smoke. Your doctor may, therefore, recommend changes to your daily diet to avoid such interactions. Below is a list of things which it is usually recommended you do not consume whilst taking this drug.

  • Tobacco

If you consume any of the following at the same time as Perphenazine and Amitriptyline, then you may be at increased risk of some side effects. If it is important that you consume both, then your doctor may reduce your intake or doses somehow.

  • Ethanol

Finally, it is also possible that this drug will interact with other medical problems you suffer from. You should inform your doctor of your complete medical history and be careful in highlighting any of the following.


Before your doctor prescribes you this medicine, they will first want to ensure it is indeed suitable and safe for you to take. A part of this will mean understanding any allergies you suffer from now or have in the past. You should inform your doctor of any such allergies relating to preservatives, animals, dyes, or to food.

Children are more sensitive to some of the effects of Perphenazine and Amitriptyline. As such, they may be more likely to experience the following side effects.

  • Twitching or tic-like movements

With children who suffer from depression, the Perphenazine and Amitriptyline combination must be used with caution.Some clinical trials amongst children have shown that, whilst taking this drug, they have thought about or attempted suicide. As of writing, more studies in children are needed in order to decide whether this drug is safe or not for their use.

Elderly patients are more likely to experience the following side effects. This is because geriatric patients are usually more sensitive to the effects of Perphenazine and Amitriptyline than younger adults.

  • Dryness of mouth

As of writing, there are no suitable studies that have been conducted to decide whether this drug combination is safe for women breastfeeding.Your doctor will need to weigh any increased risks with you against the benefits.

In order to check your progress, your doctor will schedule regular appointments whilst you take this drug. It is important you attend these so they can make any necessary adjustments to your prescription and check for unwanted effects.

You should not stop taking Perphenazine and Amitriptyline without first checking with your doctor. Instead, of stopping suddenly, they may want to slow down your prescription gradually. This will help stop your condition getting worse and prevent some side effects.

You should not take Perphenazine and Amitriptyline within two hours of having medicine for diarrhea or antacids.Taking these close together may reduce the effectiveness of Perphenazine and Amitriptyline.

Taking Perphenazine and Amitriptyline will increase the effects of CNS depressants and alcohol. Some examples of CNS include sedatives, tranquilizers, or sleeping medicine; medicine for seizures; anesthetics, including some dental anesthetics; prescription pain medicine or narcotics; barbiturates; or medicine for hay fever, other allergies, or colds. If you currently take any of these, then you should discuss them with your doctor before you start taking Perphenazine and Amitriptyline.

Whilst taking this medicine, and after stopping, you may experience a condition known as tardive dyskinesia.This is a movement disorder. Signs that you have this include uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs, fine, worm-like movements of the tongue, or severe muscle stiffness. You may also experience other rare, but serious side effects such as loss of bladder control, seizures (neuroleptic malignant syndrome), unusual tiredness or weakness, fever, fast heartbeat, increased sweating, or difficulty breathing. Your doctor and you can discuss the risks of taking this drugs as well as any benefits it holds.

You should tell any doctor in charge that you take Perphenazine and Amitriptyline if you are about to have an emergency treatment, surgery, or dental treatment. Taking this drug alongside other common drugs used in clinical settings may increase the CNS depressant effects you experience.

Perphenazine and Amitriptyline combination may cause you to display abnormal behaviors or become irritable or agitated. In some cases, it can lead to greater levels of depression or cause you to have suicidal thoughts. If you, or any caregiver you have, notice any of these effects, you should notify your doctor immediately.

During the first few weeks of treatment, and beyond this, Perphenazine and Amitriptyline may cause you to become less alert or more drowsy. Even if taken before bedtime, you may feel drowsy or less alert the following morning. You should therefore not drive, or perform any other dangerous tasks until you fully understand how this drug affects you.

When getting up from a sitting or lying position, you may experience fainting, dizziness, or lightheadedness. You can get up slowly to help avoid this. However, if this problem is persistent, or if it becomes worse, you should inform your doctor.

Taking Perphenazine and Amitriptyline combination can cause your body to produce less sweat. In turn, this can make your body temperature go up. You should, therefore, be careful not to overheat in hot weather or during exercise. Overheating has the potential to lead to com/health/heat-stroke/">heat stroke. Similarly, being inside of saunas or hot baths may make you feel faint or dizzy.

This drug may cause you to experience some extent of mouth dryness. To help relieve this temporarily, you can melt ice in your mouth, use sugarless candy or gum, or take a substitute saliva. If this problem continues for longer than 2 weeks, then you should consult your dentist or doctor. This continued dryness could potentially lead to tooth decay, fungus infections, gum disease, or dental disease.

Taking Perphenazine may cause your skin to become more sensitive to direct sunlight. Being exposed to the sun, even for short periods may lead to itching, discoloration of the skin, a rash, or severe sunburn. Here is some advice to follow when you start taking this drug.

  • Avoid direct sunlight between the hours of 10 am and 3 pm.

If you do experience a severe reaction to the sun, then discuss how to proceed with your doctor.


You should store you Perphenazine and Amitriptyline in a sealed container that comes with the medicine. It should be kept at room temperature, away from heat, direct light, and moisture. It should also never be allowed to freeze. It can be harmful to children, so should be stored somewhere safe and out of reach. Once you have finished on your treatment with Perphenazine and Amitriptyline, you should dispose of any remaining medicine. Similarly, if you have any medicine that is out of date, you should dispose of this. For advice on how to dispose of medicine in a safe and sensible manner, you can ask your doctor.


If you are suffering from certain emotional or mental conditions, then the drug combination of Perphenazine and Amitriptyline may be a very useful way to help treat the condition.However, you should be aware that it can cause a number of side effects (as listed above) and can interact with other drugs. Therefore, you should be open and honest with your doctor about disclosing all drugs you take and should follow any guidance they offer you with regards to avoiding side effects.This may mean they will ask you to make other lifestyle or dietary changes at the same time as taking Perphenazine and Amitriptyline. This drug does have the potential to make you more sensitive to sunlight, so you should be careful in avoiding sunburn. To help you do this, there is some guidance above.

Also, when you initially start taking this drug, you may become faint or drowsy. You may want to have someone drive you around for the first few days of taking this medication.This gives your body time to adjust and for you to see how it affects you exactly. If you are experiencing any of the more serious side effects, or have any other questions regarding this drug, then you should discuss them with your doctor. The best way to ensure a healthy treatment is to maintain the regular appointments set with your doctor. They can monitor you closely and then make any necessary adjustments to your treatment.