Podofilox (Topical)

Podofilox is a gel that is used to treat genital warts and warts of the rectum in patients.

Overview

Podofilox is used for the treatment of genital warts. It is a gel or solutions that is applied to warts for their removal from the skin on the outside of the genitals. The gel may also be used for the treatment of warts occurring on the skin between genitals and rectum, but the solution cannot be used for this purpose. Neither treatment should be used for warts that are occurring within the rectal cavity, vagina or in any urinary passages inside the penis or vulva.

Podofilox works to destroy the skin covering the wart but can be used in more sensitive areas than other wart removing creams, which should typically not be applied in these areas.

This medication is only available when prescribed by a doctor and is available as a gel or solution for topical application.

This treatment can be used for a maximum of four weeks and should not be used for more than three days in seven. The gel or solution is applied twice daily for three days and then a four-day break is taken with no treatment. If the wart is still present after this period of time then a new cycle of treatment can be carried out. After four weeks you should consult a doctor if the wart is still there.

Condition treated

  • Genital warts

Type Of Medicine

  • Antimitotic

Side Effects

In addition to the desired effects of Podofilox, other unwanted effects may also occur. While not all side effects may occur, in cases where they do you may need to seek medical attention.

You should seek advice from a doctor as soon as possible if you experience any of the following side effects from use of this topical medication:

  • Bad odor
  • Bleeding in the area of treated skin
  • Blistering or scabbing of treated skin
  • Blood in the urine
  • Burning feeling at the point of application
  • Crusting of the skin
  • Dizziness
  • Headaches
  • Itching of area of application
  • Pain at area of application
  • Pain felt during sexual intercourse
  • Problems with foreskin of the penis
  • Red or swollen area of treated skin
  • Scarring of area of application
  • Skin ulceration in area of application
  • Vomiting

Other side effects can occur that are not normally a cause for concern and will usually abate over time may occur. If they become bothersome or are ongoing, however, then you should report them to your doctor and seek advice:

  • Dryness of treated area of the skin
  • Peeling of treated area of the skin
  • Soreness or tenderness of the treated skin
  • Stinging, soreness or tingling of the treated skin
  • Trouble with sleeping
  • Discoloration of the treated skin
  • Skin rash

It is also possible to overdose on this medication. Patients should be alert to symptoms of overdose and should contact emergency care if they believe they are experiencing them. These symptoms include:

  • Nausea and vomiting
  • Diarrhea
  • Chills
  • Feverishness
  • Soreness of the throat
  • Unusual bleeding
  • Unusual bruising
  • Oral ulceration

Other side effects could also occur that are not listed herein. If you experience other side effects that are not listed then you should contact your doctor for advice on what to do.

Dosage

This medication will be provided with a patient information guide. This guide will contain all you need to know about the safe and effective use of this treatment. You should read it carefully and consult your doctor if there is anything that you do not understand or if you require further information.

You should keep this medication away from all mucous membranes including the eyes, inside of the penis, inside of the rectum and inside of the vagina. If you get it into these areas you will suffer extreme irritation. If you do get it into one of these areas then you will need to flush the area thoroughly and repeatedly with water for 15 minutes.

Podofilox is not for long-term use and use needs to be limited. You should use it for no more than 3 days in a week and for no more than 4 cycles of treatment. You should not use it more than this, in higher doses than prescribed, nor for longer than instructed. Doing so will increase the risk of side effects occurring.

You should not use this medication in any other area or wart other than that which it was prescribed for. If you get more warts then you should return to your doctor for advice.

The total amount of treatment used at any one time on all warts should not exceed an area larger than the surface of a dollar coin.

To use the treatment follow these steps:

  • Use a cotton ended applicator to apply the solution to the affected area.
  • Use your finger to apply the gel to the affected area.
  • Never reuse a finger or applicator to get more gel or solution.
  • Only apply this treatment to specific warts that have been discussed with your doctor.
  • Podofilox may irritate the normal skin around the warts. If you get this treatment into areas where it is not needed you should wash it off.
  • You should clean and dry the affected area after treatment. Do so before it comes into contact with untreated skin.
  • You should wash your hands thoroughly immediately after you have finished applying the treatment.

This medication will be used in different doses for each different patient. You should follow your doctor's orders for use and application only. The following information is for guidance only and you should use this treatment only as you have been instructed to:

When using the gel for treatment of genital warts or warts occurring in between rectum and genitals:

  • Adults “ Apply the gel twice daily for 3 days. Wait for 4 days without using the treatment and then repeat this process if the wart is still present. You may repeat the process 4 times at most until the wart is gone. If the wart does not go in this time then you should consult your doctor.

When using the solution for treatment of genital warts:

  • Adults “ Apply the treatment to the wart twice daily with an applicator for 3 days. Wait for 4 days and then repeat the process if the wart is still present. You can repeat this process for up to 4 weeks until the wart is gone. Do not exceed a dose of 0.5ml taken daily.

If you miss a dose you should take it as soon as possible. Do not take double doses, however, and do not take doses too close together.

Interactions

Medications can interact with one another and you should not use them together unless told to do so by a doctor. You should not use any other topical applications in the affected area at the same time as using this treatment. Before beginning treatment with Podofilox you should inform your doctor of all other medications that you are taking to ensure that no interactions may occur.

Other interactions may also occur with other medical conditions that you have. Certain skin conditions or irritations may affect the use of this treatment so you should inform your doctor of all other conditions from which you suffer.

Warnings

Before beginning use of any medication it is important to weigh the potential risks of use against the benefits of use. You should make this decision with your doctor ensuring that you have taken all of the following into consideration:

Allergies “ You must inform your doctor of any allergies from which you suffer. If you have ever reacted unusually to any medication that you have received in the past then you should inform your doctor of this before use as this may prohibit this treatment.

Pediatric “ The studies of this medication have only been carried out on adult patients. This treatment should not be used on children.

Geriatric “ There is no expected limitation to the use of this treatment in the elderly population. Podofilox has not, however, been tested specifically for the elderly population.

Pregnancy “ There is a risk to the use of this treatment when pregnant. If you are pregnant then you should inform your doctor of this before beginning use of this treatment.

Breastfeeding “ There are no adequate studies into the use of this treatment while breastfeeding. Patients should consider the risks in relation to the benefits of doing so with their doctor before use.

Podofilox is not able to stop warts from returning, prevent new warts from developing nor prevent the contraction of genital warts.

This medication is flammable and could ignite. You should not use it near a naked flame nor apply it while you are smoking.

You should avoid having sexual intercourse while having this treatment to prevent the spread of genital warts to others. If you do have sexual intercourse then you should inform your partner that you are getting treatment and should use protection with condoms.

Storage

Store the medication in the original packaging and keep it at room temperature. Keep the treatment out of direct light and keep it away from heat, moisture and direct light.

  • Prevent this treatment from freezing.
  • Keep this medication out of the reach of children at all times.
  • Dispose of any unwanted medication.

Summary

Podofilox is used in the treatment of genital warts. It is an antimitotic treatment that kills the skin of the wart and causes it to die. This treatment is less potent than other wart removal creams that are often unsafe for use in the genital area.

The treatment is available as a solution or as a gel. The gel can be used externally on all genital warts and on warts between the rectum and the genitals. The solution can only be used on the warts of the genitals.

Neither treatment should be used inside the vagina, rectum or penis and if it gets into these areas or into the eyes then you will need to rinse them thoroughly for 15 minutes with water.

Both treatments will irritate any skin that they come into contact with so it is vital that the treatment is applied only to the affected area in need of treatment.

Podofilox should be used for no more than 3 days in a week. After this period there needs to be a break for the application to take effect and for the body to recover. Using more of this treatment than advised can expose you to severe risk of side effects and should be avoided at all times. The treatment may be used for a maximum of 4 weeks. If the treatment has not gotten rid of the warts in this time then you should consult your doctor for further advice.

Patients should avoid sexual intercourse during use to prevent the further spread of genital warts. If sexual intercourse is carried out then latex condoms should be worn for protection and the partner should be informed of your condition. Pain may occur during intercourse when undergoing this treatment.