Prednicarbate (Topical)

Inflammation due to psoriasis, eczema, and other medical conditions can be relieved by prednicarbate, which has some of the properties of steroids.


One of the most commonly prescribed medications for inflammation and severe itching attributable to eczema or psoriasis is prednicarbate. It can be applied directly to the skin to target the precise area which is inflamed or causing the itching sensation. It is sometimes also used to alleviate the symptoms which are associated with allergies and allergic reactions.

It should be noted that this medication is akin to steroid medicines, and can therefore be absorbed through the skin and trigger reactions in the body similar to steroidal reactions. This is one reason why prednicarbate must be carefully considered as a treatment option for children, because young people have a tendency to absorb much more of the medication through their skin. This would naturally cause even more pronounced side effects throughout the body, for which additional treatment might be needed.

Prednicarbate will generally be effective in managing whatever medical condition is being treated, within the first two weeks of usage, and in cases where this is not true, a doctor should be consulted and informed of the lack of progress. It is also possible for viral, fungal, or bacterial infections to develop with use of this medication, and at the first signs of any such infection, treatment with prednicarbate should be discontinued, and a medical professional should be consulted.

When prednicarbate is applied to the skin, that area should be left open to the free air, rather than covered up, for instance with a bandage or other covering. When the medication is covered up in this fashion, there will be a strong tendency for a greater amount of the medication to be absorbed into the skin and trigger steroidal reactions in the body.

Your doctor will advise you on proper usage, but in general it should only be used on skin surfaces, and not around the eyes, groin, face, or underarms. It should also not be applied anywhere around the vagina, and it should not be used to combat diaper rash on an infant, especially when tight-fitting diapers are normally used.

Conditions Treated

Type Of Medicine

  • Corticosteroid

Side Effects

Like virtually all medications, there are sometimes some undesirable side effects which accompany the intended beneficial effects of using drugs and medications to treat a medical condition. One of the most important side effects to be concerned about with prednicarbate or any other medication is an allergic reaction. If you suspect that you're having an allergic reaction to prednicarbate, you should seek medical attention immediately, because there is a potential for side effects to worsen and even become life-threatening. Some of the symptoms to look out for during an allergic reaction are the following:

  • Extreme and persistent itching at various sites around the body
  • Difficulty with breathing, often accompanied by a sensation of tightness in the chest
  • Pronounced disorientation or dizziness
  • Hives and/or rashes which appear on the skin
  • Noticeable swelling in the facial area, especially around the nose, eyes, lips, and mouth.

It is normal when applying prednicarbate on the skin to experience certain sensations like tingling, burning, itching, dryness, redness, or stinging. This generally only happens with the first few applications, and after several days of usage, the body will normally have adjusted to the medication, and most patients no longer feel any of the above side effects.

If these sensations do not fade away after several days, or if they become even worse, you should immediately contact your doctor for consultation. While the majority of patients do not feel any adverse side effects from using prednicarbate, the potential is always there. Some of the more serious side effects which can occur include:

  • Excessive hair growth
  • The development of hair bumps
  • Initiation of, or worsening of acne
  • Stretch marks
  • Thinning of the skin
  • Discoloration of the skin

Although it is extremely unlikely, it is possible that prednicarbate will be absorbed through the skin into the bloodstream rather than into muscle or other tissue. When this happens, there is a greater likelihood of absorbing an excess of corticosteroid in the body, and this can trigger symptoms such as:

  • Extreme fatigue or tiredness
  • Sudden unexplained weight loss
  • Persistent headaches
  • Blurry vision or other vision problems
  • Increased thirst
  • More frequent urge to urinate
  • Swelling in the area of the feet and ankles
  • Increased urgency to urinate

It is more likely for children to absorb excess prednicarbate into the body and the bloodstream than it is for adults, but it is also possible for adult users to absorb excess corticosteroid when using prednicarbate over a long period of time, or when very large areas of skin are being treated.


Proper application procedures for prednicarbate should be observed by any user, so as to avoid an unpleasant reaction somewhere around the body. To begin treatment, make sure that the target area on the skin has been washed clean with warm water and soap, then thoroughly dried off. Your hands should also be washed clean and dried before touching the medication.

Be very careful about getting any of this medicine near the eyes, because it has the potential to cause com/health/coma/">glaucoma, or to significantly hasten any effects of glaucoma you may already have. It is likewise strongly recommended that prednicarbate be kept well away from the nose or mouth, and if some is inadvertently applied near either of these, you should thoroughly rinse the affected area with plenty of water.

A thin layer of prednicarbate should be applied to the target area and gently rubbed in, usually twice each day, unless your doctor has recommended more or fewer treatments. After application, your hands should again be thoroughly washed and dried so that there is no danger of you spreading the medication to other areas of the body. The affected area should be left open to the air and not covered or bandaged in any way, because that will promote greater absorption through the skin, and the real treatment area is actually on the surface of the skin.

If the condition being treated does not improve after about two weeks of regular treatment, or if the condition worsens during that time frame, you should tell your doctor as soon as possible. It may be that an alternative medication will be needed to treat your medical condition, or that some other approach entirely will be necessary.


Anytime you are using strong medication for the treatment of a medical condition, there is a chance that it might interact with other drugs you are currently taking, and trigger some adverse side effects which must be dealt with. The likelihood of such drug interactions is far less when using a topical medication such as prednicarbate, because the majority of the medication should remain on the skin surface, rather than being absorbed into the body where it would have the potential to interact. Still, such interactions are possible, and should therefore be taken seriously by any patient using prednicarbate for treatment.

Part of this due diligence should include the preparation of a full list of all other medications you are currently taking, as well as the dosages of each of these. When preparing this list, make sure to include all herbal supplements, vitamins, over-the-counter drugs, and all other prescription medications which you are currently using, so that your doctor can review the list and make an appropriate determination.

It will also be worthwhile to have this list handy for those times when you need to make a trip to an emergency room or healthcare clinic where your primary care doctor is not in residence. By showing this list to the emergency room doctor, he/she will be able to treat whatever condition you came in for safely, because it will be possible to avoid any kind of drug interactions with those on your list.

You should not stop, start, or change your usage of any of the medications on your comprehensive list unless you are instructed to do so by your primary care doctor. The main drug interactions which you should be alert to when using prednicarbate are the following:

  • Any kind of oral corticosteroids, such as prednisone
  • Any other topical corticosteroids, such as hydrocortisone
  • Drugs which are known to have a suppressing effect on the immune system, such as cyclosporine.


There are a few precautions which should be carefully observed by patients using prednicarbate. The first of these is to avoid using the medication if you are allergic to it or to any other corticosteroids, such as prednisone or hydrocortisone. If you have any other allergies that you know of, for instance those which might be triggered by pets, fabrics, preservatives, or certain foods, you should alert your doctor to these other allergies.

When consulting with your doctor about using prednicarbate, you should fully inform him/her about any medical history you have regarding:

  • Immune system problems
  • Any history of reduced blood circulation
  • Either type I or type II diabetes
  • Any skin conditions such as rosacea or perioral dermatitis.

Prednicarbate should not be used on skin areas where there is an infection, or where there are open sores. There is a potential for prednicarbate to reduce the effectiveness of certain products containing latex, e.g. condoms, so it is advisable to use some other method of birth control during a period of treatment with prednicarbate.

When prednicarbate or any other corticosteroid medication is used on very large patches of skin, or over a prolonged period of time, it can lower your body's ability to cope with physical stress. For that reason, if you know that you are about to undergo surgery of any type, you should alert your doctor or dentist to the fact that you are taking prednicarbate.

By the same token, if a child is being treated with prednicarbate for a very long period of time, there is a possibility that it can hinder the normal growth and development of that child, for instance in both height and weight.

It is not known whether prednicarbate has any adverse effects on fetuses carried by a mother who is being treated with this medication, so to be on the safe side, it is recommended that you discontinue usage of prednicarbate if you are pregnant or thinking of becoming pregnant.

While it is also not known whether prednicarbate is passed on to an infant through breast milk, it is known that corticosteroids taken orally are passed on through breast milk. Therefore, mothers who intend to breast feed should avoid treatment with prednicarbate throughout the period of breastfeeding, or avoid breastfeeding during treatment.


Prednicarbate should be stored at room temperature and in a location which is not subject to any extremes of temperature or humidity. It should be kept well out of the reach of pets and children, ideally in a spot so high up that it cannot be reached, even when standing on furniture. If you suspect that your child has accessed prednicarbate topical, and may perhaps have swallowed the medicine, you should contact the Poison Control Center and follow any instructions you are given.


Prednicarbate is a topical ointment which has proven to be very effective in the treatment of skin conditions such as eczema and psoriasis, which are generally characterized by extreme itchiness and pronounced inflammation of the skin. Generally within two weeks of the initial treatment, the symptoms being treated should start to fade away and may have cleared up entirely.

It is important to keep prednicarbate away from sensitive areas like the groin, vagina, underarms, mouth, nose, and eyes. Special care should be taken to keep this medication away from the eyes, as it can cause or worsen glaucoma in the patient. Care should be taken when applying the topical medication, making sure that the treatment area on the skin is washed and dried, and the hands are washed before and after treatment, so that no medicine can reach the eyes.