Proparacaine (Ophthalmic)

Proparacaine numbs the eye to prevent the patient experiencing pain during tests, procedures, and surgeries on the eyeball.

Overview

Proparacaine is a local anesthetic that is administered as an eye drop to patients. It is used to numb the eye from pain so that certain tests, surgeries and procedures can be carried out without the patient experiencing pain.

Proparacaine works by preventing the transmission of pain signals from the nerve endings at the point of application into the central nervous system.

This medication should only ever be administered under the supervision of an ophthalmologist in clinic or hospital conditions.

This medication comes in a number of forms including the following brands and is administered as an eye drop:

  • Parcaine
  • Ophthetic
  • Ocu-Caine
  • Alcaine

Condition treated

  • Eye pain, prevention of

Type of medicine

  • Local anesthetic

Side Effects

In addition to numbing the pain felt through the eyeball during treatment, the use of this medication may also cause unwanted side effects to be experienced. While not all of the side effects listed herein may occur, in some cases the patient may need to seek medical attention if they do.

The following side effects need to be checked by a doctor or nurse immediately and you should inform of their occurrence straight away:

Occurring only rarely in patients:

  • Blurring of vision
  • Excessive tearing of the eye
  • Increased sensitivity to the light
  • Reddening of the white part of the eye
  • Severe stinging of the eyeball
  • Throbbing pains in the eye

Frequency of occurrence unknown:

  • Bloody eye
  • Burning of the eye
  • Changed vision
  • Itching of the eye
  • Redness of the eye
  • Stinging of the eye

Other side effects can occur that would not require you to seek medical attention. These side effects will usually abate over time and are usually mild. If they are ongoing, however, or are bothersome then you should contact your doctor for advice on how to alleviate the irritation:

  • Dry skin around the eye
  • Cracked skin around the eye
  • Lines appearing on the skin of the fingertips
  • Skin rash
  • Itching
  • Hives
  • Redness

Other side effects may also occur that are not listed herein. If you experience other side effects then you should contact your doctor for advice on how to alleviate these side effects. If you are concerned about your immediate health, however, then you should contact the emergency services.

Dosage

These eye drops should only ever be administered by a nurse or trained healthcare professional under the supervision of a doctor. These eye drops will be placed directly into the eye before tests or treatment take place.

Your doctor will determine the dose that you need to be given and administer it directly. The following is a guideline only:

1-2 drops placed into each eye before treatment begins.

Dose will last for between 10-20 minutes. For prolonged surgeries, one drop should be given every five to 10 minutes for up to a maximum of 7 doses.

Interactions

Certain medications should not be used in conjunction with one another. In some cases, medications can react severely with one another or may prevent the effects of one treatment occurring. In other cases, they can increase the risk and severity of the side effects caused by the other medication. Before you are administered with Proparacaine you should inform your doctor of all treatments or medications that you are currently taking. This includes medications that are purchased over the counter, other prescribed medications and also herbal remedies or vitamin supplements that you might be taking. For the use of this eye drop treatment you should be especially certain to inform your doctor if you are taking any of the following medications:

  • Zuclopenthixol
  • Zotepine
  • Zopiclone
  • Zonisamide
  • Zolpidem
  • Zolazepam
  • Ziprasidone
  • Zimelidine
  • Ziconotide
  • Zaleplon
  • Xylazine
  • Xenon
  • Vortioxetine
  • Vinyl ether
  • Vigabatrin
  • Veralipride
  • Venlafaxine
  • Valproic Acid
  • Triprolidine
  • Trimipramine
  • Triflupromazine
  • Trifluperidol
  • Trifluoperazine
  • Trichloroethylene
  • Tricaine methanesulfonate
  • Triazolam
  • Trazodone
  • Tranylcypromine
  • Trans-2-Phenylcyclopropylamine
  • Tramadol
  • Topiramate
  • Tolcapone
  • Tizanidine
  • Tilidine
  • Tiletamine
  • Tiapride
  • Tiagabine
  • Thiothixene
  • Thioridazine
  • Thiopental
  • Thiamylal
  • Thalidomide
  • Tetrodotoxin
  • Tetrahydropalmatine
  • Tetracaine
  • Tetrabenazine
  • Temazepam
  • Technetium Tc-99m tilmanocept
  • Tasimelteon
  • Tapentadol
  • Tandospirone
  • Suvorexant
  • Sultopride
  • Sulpiride
  • Sufentanil
  • Stiripentol
  • Sodium oxybate
  • Sevoflurane
  • Sertraline
  • Sertindole
  • Sepranolone
  • Secobarbital
  • Scopolamine
  • Rufinamide
  • Rotigotine
  • Ropivacaine
  • Ropinirole
  • Romifidine
  • Ritanserin
  • Risperidone
  • Reserpine
  • Remoxipride
  • Remifentanil
  • Ramelteon
  • Raclopride
  • Quinisocaine
  • Quetiapine
  • Quazepam
  • PSD502
  • Proxibarbal
  • Protriptyline
  • Propoxycaine
  • Propofol
  • Propanidid
  • Promethazine
  • Promazine
  • Prochlorperazine
  • Procaine
  • Primidone
  • Prilocaine
  • Pregabalin
  • Prazepam
  • Pramocaine
  • Pramipexole
  • Pomalidomide
  • Pizotifen
  • Piritramide
  • Pipotiazine
  • Pipamperone
  • Pimozide
  • Phenytoin
  • Phenoxyethanol
  • Phenoperidine
  • Phenobarbital
  • Phenibut
  • Phenazocine
  • Pethidine
  • Perphenazine
  • Perospirone
  • Perazine
  • Perampanel
  • Pentobarbital
  • Pentazocine
  • Penfluridol
  • Paroxetine
  • Paraldehyde
  • Paliperidone
  • Oxymorphone
  • Oxycodone
  • Oxybuprocaine
  • Oxprenolol
  • Oxethazaine
  • Oxazepam
  • Osanetant
  • Orphenadrine
  • Opium
  • Ondansetron
  • Olopatadine
  • Olanzapine
  • Nortriptyline
  • Normethadone
  • Norflurane
  • Nitrous oxide
  • Nitrazepam
  • Nefazodone
  • Nalbuphine
  • Nabilone
  • Morphine
  • Molindone
  • Mirtazapine
  • Minocycline
  • Milnacipran
  • Midazolam
  • Metyrosine
  • Methylphenobarbital
  • Methylecgonine
  • Methsuximide
  • Methoxyflurane
  • Methotrimeprazine
  • Methohexital
  • Methocarbamol
  • Methaqualone
  • Methapyrilene
  • Methadyl Acetate
  • Methadone
  • Metaxalone
  • Mesoridazine
  • Meptazinol
  • Meprobamate
  • Mepivacaine
  • Melperone
  • Melatonin
  • Medetomidine
  • Medazepam
  • Meclizine
  • Mebicar
  • Maprotiline
  • Magnesium Sulfate
  • Lurasidone
  • Loxapine
  • Lormetazepam
  • Lorazepam
  • Loratadine
  • Loprazolam
  • Lofentanil
  • Lithium
  • Lidocaine
  • Levorphanol
  • Levomilnacipran
  • Levomethadyl Acetate
  • Levodopa
  • Levocetirizine
  • Levocabastine
  • Levobupivacaine
  • Levetiracetam
  • Lamotrigine
  • Ketobemidone
  • Ketazolam
  • Ketamine
  • Isoflurane
  • Indiplon
  • Indalpine
  • Imipramine
  • Iloperidone
  • Hydroxyzine
  • Hydromorphone
  • Hydrocodone
  • Hyaluronidase
  • Hexobarbital
  • Heroin
  • Halothane
  • Haloperidol
  • Halazepam
  • Guanfacine
  • Glutethimide
  • Gepirone
  • Gamma Hydroxybutyric Acid
  • Gabapentin Enacarbil
  • Gabapentin
  • Fospropofol
  • Fosphenytoin
  • Fluvoxamine
  • Fluticasone propionate
  • Fluspirilene
  • Flurazepam
  • Fluphenazine
  • Flupentixol
  • Fluoxetine
  • Flunitrazepam
  • Flunarizine
  • Fludiazepam
  • Fluanisone
  • Flibanserin
  • Fexofenadine
  • Fentanyl
  • Fencamfamine
  • Felbamate
  • Ezogabine
  • Etorphine
  • Etoperidone
  • Etomidate
  • Etizolam
  • Etifoxine
  • Etidocaine
  • Ethylmorphine
  • Ethyl loflazepate
  • Ethyl chloride
  • Ethyl carbamate
  • Ethotoin
  • Ethosuximide
  • Ethchlorvynol
  • Ethanol
  • Eszopiclone
  • Estazolam
  • Escitalopram
  • Entacapone
  • Enflurane
  • Eltanolone
  • Efavirenz
  • Ecopipam
  • Ecgonine
  • Dyclonine
  • Duloxetine
  • Drotebanol
  • Droperidol
  • Dronabinol
  • DPDPE
  • Doxylamine
  • Doxepin
  • Doramectin
  • Dixyrazine
  • Diphenoxylate
  • Diphenhydramine
  • Dimenhydrinate
  • Dihydromorphine
  • Dihydroetorphine
  • Dihydrocodeine
  • Difenoxin
  • Diethyl ether
  • Diazepam
  • Dezocine
  • Dextropropoxyphene
  • Dextromoramide
  • Dexmedetomidine
  • Dexbrompheniramine
  • Detomidine
  • Desvenlafaxine
  • Desloratadine
  • Desipramine
  • Desflurane
  • Deramciclane
  • Dapoxetine
  • Dapiprazole
  • Dantrolene
  • Cyproheptadine
  • Cyclobenzaprine
  • Cyclizine
  • Codeine
  • Cocaine
  • Clozapine
  • Clothiapine
  • Clorazepate
  • Clopenthixol
  • Clonidine
  • Clonazepam
  • Clomipramine
  • clomethiazole
  • Clobazam
  • Clidinium
  • Clemastine
  • Citalopram
  • Cinchocaine
  • Chlorzoxazone
  • Chlorprothixene
  • Chlorpromazine
  • Chlorphenamine
  • Chloroprocaine
  • Chlormezanone
  • Chlordiazepoxide
  • Chloral hydrate
  • Cetirizine
  • Carisoprodol
  • Carfentanil
  • Carbinoxamine
  • Carbamazepine
  • Canertinib
  • Butorphanol
  • Butethal
  • Butamben
  • Butalbital
  • Butacaine
  • Butabarbital
  • Buspirone
  • Buprenorphine
  • Bupivacaine
  • Brotizolam
  • Brompheniramine
  • Bromperidol
  • Bromisoval
  • Bromazepam
  • Brimonidine
  • Brexpiprazole
  • Benzyl alcohol
  • Benzocaine
  • Benperidol
  • Barbital
  • Baclofen
  • Azelastine
  • Azaperone
  • Asenapine
  • Articaine
  • Aripiprazole
  • Amperozide
  • Amoxapine
  • Amobarbital
  • Amitriptyline
  • Amisulpride
  • Alprazolam
  • Alphaprodine
  • Alphacetylmethadol
  • Allopregnanolone
  • Alfentanil
  • Alfaxalone
  • Alaproclate
  • Agomelatine
  • Adipiplon
  • Aceprometazine
  • Acepromazine
  • 7-Nitroindazole

Other medical conditions can also impact the use of treatments. Patients suffering from the following should be sure to inform their doctor before treatment:

  • Heart disease
  • Hyperthyroidism

Warnings

Before beginning treatment with this medication you should ensure that you weigh the benefits of use against the potential risks of using the treatment. You should consider everything herein with your doctor before beginning treatment. Ensure that you have considered the following:

Allergies: If you have previously had allergic reactions to anesthetic medications then this treatment may not be suitable for you. Inform your doctor of all allergies that you have.

Pregnancy: These is a risk to the use of this treatment in pregnant women. You should discuss this with your doctor and you may be advised to wait for treatment until after pregnancy where it is possible to do so.

You will need to be monitored during use of this treatment and there should always be a supervising doctor available during use.

When your eye is numb you will need to take extra steps to protect it from injury. You should not use any other eye drops until you are told to by your doctor. You should take care to keep the eye clear of sand, dust and other irritants in this period. Do not rub your eye or touch it excessively while it is numb either.

Storage

This treatment is supplied in dispensers holding 15ml of solution.

The bottle needs to be stored in the provided packaging to prevent it from being exposed to the light.

The medication should be stored between 2° and 8°C at all times.

Summary

Proparacaine is a local anesthetic that works by preventing pain signals being transmitted from the nerve endings in your eye into the central nervous system. This prevents you from experiencing pain while your eye is being tested or surgery is carried out.

This local anesthetic will numb the eyeball for between 10-15 minutes. For prolonged surgeries, the patient may require repeated use every 5-10 minutes to keep the eye numb throughout the surgery.

This eye drop must only ever be administered under the supervision of an ophthalmologist in a clinic or hospital environment.

While the eye is numbed the patient will need to take extra care to take care of the eye and prevent any further irritation. Foreign objects that get into the eye may cause irritation without the patient realizing it while the eyeball is numb.

No other treatments should be used in conjunction with this medication without first discussing this use with your doctor. This treatment interacts with a wide range of other medications so it is important that you inform your doctor of all treatments you are receiving before use of this treatment.

Resources
Last Reviewed:
January 28, 2018
Last Updated:
April 23, 2018