Prothrombin Complex Human (Intravenous)

As it contains coagulation factors II, VII, IX, and X, Prothrombin Complex Human is a useful drug given to certain adult patients who are suffering from acute major bleeding.


Prothrombin Complex Human is given via an injection as a means to reverse the effects of blood thinners or anticoagulants. It is usually only given to adult patients at times when they are suffering from acute major bleeding.

Prothrombin Complex Human works by helping the blood to clot and thus stop the bleeding. It can do this as it contains coagulation factors II, VII, IX, and X, as well as proteins C and S. You will only be given Prothrombin Complex Human injection as a prescription following a full assessment by your doctor.

This is because it is only used on certain patients who are at low risk of major side effects, or other interactions occurring. It will then be injected by a trained nurse or doctor.

Condition(s) treated

  • Major bleeding caused by anticoagulants or blood thinners

Type of medicine

  • Powder for solution

Side Effects

Just like all drugs, Prothrombin Complex Human does have the potential to cause side effects among a number of patients. In some cases, these side effects are less serious, and may simply pass as time does. In other cases, however, such side effects are much more serious and require emergency medical assistance. Directly below is a list of such side effects. If you spot any, you should contact your doctor, or seek alternative medical assistance right away:

Less common

  • Decrease in amount of urine

Incidence not known

  • Sudden trouble breathing or shortness of breath

As well as these, and as already mentioned, there are a number of other side effects which could occur and which are far less serious. As your body adjusts to the medicine, it is possible that these effects will simply pass. However, in other cases, they can be persistent and a little worrying. If you do experience any of the side effects listed below and would like to find a way to relieve them, then you can contact your doctor. They may be able to offer you a way to help reduce the unwanted effects you are experiencing.

More common

  • Pain in the joints

Less common

  • Tearing of skin

Incidence not known

  • Blistering, ulceration, lumps, discoloration of the skin, warmth, inflammation, coldness, hives, infection, stinging, numbness, feeling of pressure, burning, bleeding, tenderness, soreness, redness, rash, scarring, tingling, itching, pain, swelling, at the injection site.

There may be other side effects not listed here which you could experience. Again, if you have any questions about those side effects and would like some relief, then you should contact your doctor.


You will not need to worry about dosage as this drug is administered by injection from a trained nurse or doctor. They will assess the extent of your bleeding and provide you with the amount as needed.


Prothrombin Complex Human does have the potential to interact with a wide variety of different things. These interactions can be dangerous, so it is imperative that your doctor is made fully aware of your medical condition before they give you this drug. One key area of these possible interactions is surrounding other drugs that you currently take. Your doctor should have access to a full list of drugs you take, both prescription and non-prescription. In some cases, you should strictly never take Prothrombin Complex Human alongside other drugs. In other cases, two drugs may be taken, but it may be that the dosages or frequency of having them needs to be reduced. Below is a list of the drugs which is usually not recommended that you take alongside the Prothrombin Complex Human injection. Your doctor may avoid giving you the injection and instead provide an alternate form of medication.

  • Coagulation Factor VIIa

As well as this, it is possible that the Prothrombin Complex Human injections may cause interactions to occur with other aspects of your daily dietary intake. This includes what you eat, drink and smoke. It may be that your doctor will need to limit your intake of certain things following or before an injection of Prothrombin Complex Human being given. Be open and honest when describing all aspects of your typical daily diet.

Finally, other existing medical problems that you suffer from could also cause interactions to occur. If you suffer from any of the following problems, then be sure to make your doctor aware of them.

  • A history of allergies to coagulation factors II, VII, IX, and X, heparin, proteins C and S, human albumin, or antithrombin III.


Before being administered with the Prothrombin Complex Human injection, your doctor will need to fully understand the extent of your medical condition, including any allergies you have. These allergies include any to the injection itself and to other drugs, as well as to foods, animals, dyes, and preservatives. In turn, your doctor can properly weigh any possible risks against the benefits of taking the injection.

As of writing, no safety and efficacy have been established in using the Prothrombin Complex Human injection in the pediatric population. This is because appropriate studies have not been performed. Your doctor is most informed to decide whether your child is at any sort of increased risk when being administered the injection.

As of writing, all appropriate studies that have been performed to date, have not yet demonstrated any problems that arise when giving this injection to geriatric patients. There are no apparent signs that the usefulness of this drug has been reduced. Instead, your doctor will still need to assess the full medical condition of any elderly patients before prescription.

As of writing, it is unclear as to whether the Prothrombin Complex Human injection cause any added and unwanted effects to pregnant women. Your doctor will be most up-to-date with any such studies performed and can advise as to whether you are at added risk.

As well as this, there are not adequate studies that have been performed on breastfeeding women. Before taking the injection, the administering doctor will weigh the benefits and risks with you to decide whether it could cause any added infant risk.

Whilst being administered the Prothrombin Complex Human injection, it is vital that your doctor is present to assess your condition and analyze the effect that the drug has on your blood clotting.

Prothrombin Complex Human injection does have the ability to cause a severe allergic reaction known as anaphylaxis. This condition is life-threatening and requires you to receive immediate medical assistance. If you experience any of the following symptoms having just received this injection, then you should inform your doctor straight away.

  • Difficulty with swallowing

It could mean that Prothrombin Complex Human leads to blood clotting problems. If you experience any of the following symptoms, then you should tell your doctor right away as this issue needs to be dealt with immediately.

  • Trouble swallowing or breathing

Making this medicine is performed by receiving donations of human blood. In order to keep the risks of virus transmissions to a minimum, all donors are screened extensively. However, there is a small chance that viruses can be transmitted to those receiving the Prothrombin Complex Human injection. If you are concerned about this risk and would like to find out more then speak to your doctor.


You will not be required to store Prothrombin Complex Human at any time. Instead, the administering nurse or doctor is responsible for its safe storage.


The Prothrombin Complex Human injection is a very useful drug to those suffering from thinning of the blood and has the potential to help prevent a number of further medical problems from arising. However, it should only be given to patients with whom the doctor has firm understanding of their medical history. For this reason, you should be upfront and honest in helping your doctor to understand any problems you suffer from, as well as your typical intake of other drugs and aspects of your diet.

Above you can find a full list of interactions and side effects that can possibly occur. If you experience any of the more serious side effects, then you should ask your doctor for immediate help. They can advise ways to help alleviate or reduce a number of side effects. If you have any other questions about this drug then you should address them to your doctor who is best informed to answer them.