Quinapril

Quinapril is an angiotensin-converting enzyme (ACE) inhibitor medication used for the effective treatment of hypertension (high blood pressure), alongside other medicines.

Overview

Quinapril is used primarily for the treatment of patients with hypertension, or high blood pressure. This medication belongs to a type of drug called angiotensin-converting enzyme (ACE) inhibitors. It acts on the body by blocking specific substance that causes tightening in the blood vessels. This medication can also be prescribed for patients with congestive heart failure.

Hypertension is a condition that can cause risks to both the heart and the arteries, as it increases the workload of the body in order to continue functioning. Over time, the arteries and heart can fail to function correctly, resulting in heart conditions and medical complications. This lack of functionality can over time damage blood vessels within the heart, brain and kidneys, leading to increased risk of a stroke, kidney failure or heart failure.

Quinapril is an effective treatment to reduce blood pressure, therefore reducing chance or risk of conditions such as stroke and heart attack. This medication relaxes the blood vessels, increasing the supply of oxygen and blood in and around the heart.

This medication is available solely through a prescription from your doctor and should be used exactly as directed.

Conditions Treated

  • High blood pressure (hypertension)

Type of Medicine

  • Angiotensin-converting enzyme (ACE) inhibitor
  • Tablet

Side effects

Along with the required effects caused by Quinapril, including the relaxation of blood vessels, this medication can also be the cause of some unwanted or unneeded effects. It is unlikely that all of these side effects will occur, but some may become prevalent during the course of treatment with this drug. Some of the side effects that can occur may require medical support or attention.

If any of the listed conditions or symptoms occur during the course of treatment with Quinapril, it is vital that you contact your doctor immediately:

  • Bleeding gums
  • Blurred vision
  • Chest pain
  • Cold, clammy skin
  • Confusion
  • Diarrhea
  • Difficult or labored breathing
  • Dizziness
  • Enlarged pupils
  • Faintness
  • Fast or slow heartbeat
  • Increased sensitivity of the skin or eyes to sunlight
  • Lightheadedness
  • Nausea
  • Stiff or sore neck
  • Stomach pain
  • Sweating
  • Tightness in the chest
  • Unusual tiredness or weakness
  • Vomiting

Other side effects that may occur during the course of treatment with Quinapril may not require medical support or attention, and also may reduce or disappear during the time you are taking this medication. If you find any of the listed symptoms are prevalent beyond treatment, become worse or are uncomfortable, you can speak to a medical professional about methods to prevent or avoid certain side effects.

Speak to a medical professional if you have queries about any of the listed effects:

  • Back pain
  • Coughing
  • Difficulty with moving
  • Headache
  • Joint pain
  • Muscle aching or cramping
  • Muscle pains or stiffness
  • Rash
  • Swollen joints

Dosage

The dosages listed below are the generic doses that are prescribed for Quinapril. If you are prescribed this medication or any other medicine, it is important that you adhere to the correct dose that you have been prescribed by your doctor, as well as the exact instructions you are supplied with for taking this medication correctly.

Generic Adult Dose for Hypertension

  • First dose: 10-20 mg orally once per day in patients not on diuretics
  • Continued dose: 20-80 mg orally per day, taken as a single dose or in two divided doses

Generic Adult Dose for Congestive Heart Failure

  • First dose: 5 mg orally two times a day
  • Continued dose: 20-40 mg orally per day taken in two divided doses

Usual Geriatric Dose for Congestive Heart Failure

  • Continued dose: 10 mg orally once per day

Usual Geriatric Dose for Hypertension

  • Continued dose: 10 mg orally once per day

Interactions

When taking Quinapril, there are certain medications that should not be taken alongside this drug, as these medications may not be compatible. Taking two different incompatible drugs together can result in an increased risk of interactions, which in certain cases can prove to cause harm and varied effects in patients.

If you are prescribed Quinapril with an incompatible medication, a medical professional may choose to alter the dosage of medications you take or suggest other precautions that you can take. It is critical that everyone involved in your medical care is completely aware of every medication that you currently take, including over the counter drugs, vitamins and herbal supplements. This also applies to any medication you have taken recently, in order to provide a full and consistent medical history.

The listed interactions have been included due to their significance and chance of interaction, but are not all-inclusive. Always contact your doctor if you are concerned about taking two forms of medication together.

Taking Quinapril with the below medications is not recommended as a treatment plan. Your doctor may opt to remove you from treatment with this medication or alter other medications you take:

  • Sacubitril
  • Aliskiren

Taking Quinapril with any of the below-listed medications is generally not recommended practice, but may be unavoidable or required in specific individual cases. If both drugs are prescribed at the same time, your doctor may alter your dosage or the regularity with which you use these medicines:

  • Valsartan
  • Trimethoprim
  • Triamterene
  • Telmisartan
  • Spironolactone
  • Sirolimus
  • Potassium
  • Olmesartan Medoxomil
  • Mercaptopurine
  • Losartan
  • Lithium
  • Irbesartan
  • Everolimus
  • Eprosartan
  • Eplerenone
  • Canrenoate
  • Candesartan Cilexetil
  • Azilsartan Medoxomil
  • Azilsartan
  • Azathioprine
  • Amiloride
  • Alteplase, Recombinant

In addition, taking Quinapril with these medications can carry an increased risk of potential side effects. However, taking these medicines together might be the best option for you, and the best way to treat your condition. Speak to your doctor if you are concerned about taking any of the below alongside Quinapril:

  • Valdecoxib
  • Torsemide
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Propionic Acid
  • Proglumetacin
  • Piroxicam
  • Piretanide
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta-Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nesiritide
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Gold Sodium Thiomalate
  • Furosemide
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethacrynic Acid
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Capsaicin
  • Bupivacaine Liposome
  • Bupivacaine
  • Bumetanide
  • Bufexamac
  • Bromfenac
  • Azosemide
  • Amtolmetin Guacil
  • Acemetacin
  • Aceclofenac

As well as interactions with specific drugs and medications, many medicines can cause issues and interactions when taken with certain foods, taken on a certain food schedule or taken with alcohol or tobacco. Though there is little proof that Quinapril causes interactions with food, it’s important to speak to your doctor about the use of your medications with food, tobacco and alcohol.

Pre-existing or previously diagnosed medical conditions and problems can directly affect the usage of Quinapril as a treatment for hypertension or congenital heart failure. Ensure your doctor has a full copy of your medical history, notify them if you have suffered or currently suffer from any of the listed conditions:

  • Angioedema
  • Collagen vascular disease
  • Congestive heart failure with low blood pressure
  • Congestive heart failure with low blood pressure
  • Diabetes
  • Diabetic patients with end-organ damage
  • Electrolyte imbalances
  • Fluid imbalances
  • Hyperkalemia
  • Kidney disease
  • Kidney problems, moderate to severe
  • Liver disease

Warnings

Quinapril is registered as FDA category D for pregnancy, which suggests that studies in expecting women who have taken this medication have demonstrated a pronounced risk to the fetus. In situations in which the use of Quinapril is to treat a life-threatening situation, the risks and benefits should be weighed of continuing with this medication. Should you become pregnant during treatment with this medication, or if you’re planning to become pregnant, speak to a doctor as soon as possible.

Due to this risk, is it advised that a valid form of birth control is utilized while taking Quinapril. To avoid the dangers of this medication during pregnancy, your doctor will be able to inform you of the best, most effective forms of contraceptive to use during the course of this medication.

For breastfeeding women, there are few adequate studies to determine whether infant risk is a factor during treatment with this medication. It is advised that nursing mothers prescribed Quinapril should discuss this threat with their doctor prior to beginning medication.

It is critical that a medical professional is able to check your progress during regular visits to ensure this medicine is working correctly, helping to resolve your condition. Blood tests may be required to check for unwanted effects.

Quinapril can cause a particularly life-threatening form of allergic reaction that is called anaphylaxis. Anaphylaxis can be incredibly dangerous to the patient and will most likely require medical attention and support if the symptoms of this condition are apparent. A doctor or emergency medical care should be contacted immediately if any of the following symptoms are present:

  • Hoarseness
  • Itching
  • Rash
  • Swelling of hands, face, mouth, or throat
  • Trouble breathing
  • Trouble swallowing

If you experience any signs of severe stomach pain or illness when you are taking Quinapril, get in contact with your doctor or a relevant medical professional as soon as possible. This symptom, both with or without nausea or vomiting, can be a precursor or symptom of a medical condition called intestinal angioedema, which if untreated can be very dangerous.

Dizziness, fainting, or lightheadedness can also occur when taking Quinapril, especially when getting up from lying or sitting positions, the risk of which is increased if you are taking a diuretic in addition. Ensure you are aware of how you personally react to Quinapril before driving, using machines, or doing other things that could prove to be dangerous when you are dizzy or not completely alert. If you begin to feel dizzy as a result of your medication, lie down so that you do not faint.

If you experience tenderness or pain in the upper stomach, have pale stools, dark urine, notice a loss of appetite, extreme nausea, feel an unusual tiredness or weakness, or even yellow eyes or skin, you should contact a doctor as soon as possible. These may be the symptoms of a serious liver condition.

In addition, if you are experiencing pain in the lower back or side, a decreased frequency or amount of urine, bloody-looking urine, an increased thirst, swelling in and around the face or fingers, swelling of the lower legs, fast weight gain, or high blood pressure, these could indicate a serious kidney problem or disease. It is critical that you contact and notify a medical professional as soon as you can if you are experiencing any of these side effects.

As well as the above conditions, if you are experiencing chills, a fever or soreness in the throat, these may be symptomatic of an infection that has resulted from low white blood cells. This can be a very serious condition and will require treatment. Contact your doctor if you experience these symptoms.

Hyperkalemia (high potassium in the blood) can occur while you are prescribed this course of treatment. Notify your doctor immediately if you notice any of the following symptoms:

  • Weakness or heaviness of the legs
  • Shortness of breath
  • Numbness or tingling in the hands, lips or feet
  • Nervousness
  • Nausea or vomiting
  • Irregular heartbeat
  • Difficulty with breathing
  • Confusion
  • Abdominal or stomach pain

Consult with your doctor before using any medicine, supplement, or substitute that contains potassium.

Prior to any medical treatment or surgery, it is important to ensure your doctor or dentist is fully aware of your medical history, including that you are currently taking or have recently taken Quinapril. You may be required to pause the use this medicine a few days before having surgery or taking any medical tests.

Due to the way, this medication works in the body, it can be less effective in black patients. Black patients may also experience an increased risk of swelling – including the hands, arms, mouth, face, or throat. Talk to your doctor if you are experiencing these symptoms or you have concerns about them.

Other than prescribed medications, do not take other drugs unless they have been decided on and discussed with your doctor. This includes but is not limited to any over-the-counter (nonprescription) medications that are for appetite control, colds, cough, asthma, hay fever, or sinus issues, as they may increase your blood pressure, causing problems with your Quinapril treatment.

As well as the use of Quinapril, treatment for high blood pressure can include weight control and alteration to the types of foods you eat, especially foods that are higher in sodium (salt). Your doctor can discuss with you which of these forms of treatment will be most important for you. You should discuss any plans with your doctor before drastically changing your diet.

For many patients who suffer from high blood pressure, it is possible that they will not notice any signs of a problem. In fact, many can feel completely normal even when suffering from blood pressure that is high enough to cause additional medical problems and conditions. It is critical that, even if you feel completely well, you should take your medicine exactly as prescribed and that you keep every appointment with your doctor at all times.

It is worth noting that this medicine does not cure high blood pressure. However, Quinapril does help to control it. Therefore, it’s important to continue to take your medication as directed if you expect to reduce your blood pressure and keep it low. You need to take high blood pressure medications for the rest of your life. If high blood pressure is left untreated, it can cause many serious conditions including heart failure, stroke, blood vessel disease or kidney disease.

Storage

Quinapril should always be stored in a closed container that is provided on prescription and kept at a consistent room temperature. This medication should be kept away from any heat, moisture and direct light in order to maintain the quality of medication, and prevent any adverse effects or lack of function. Never freeze this medicine.

Keep Quinapril out of the reach of children and pets at all times, even when stored within a child-proof container. Never use outdated medicine or medicine that is no longer needed. Speak to your doctor about the right way to dispose of any medication you do not use or no longer require, never flush medication down the toilet if you no longer need it.

Summary

Quinapril is used both as a single treatment or as part of a multi-medication treatment plan for patients with hypertension, or high blood pressure. It functions to relax the blood vessels, but blocking a substance within the body that causes them to tighten.

As an angiotensin-converting enzyme (ACE) inhibitor, Quinapril can help to lower blood pressure and increase the supply of blood and oxygen to the heart. This provides a way to reduce hypertension and return the blood pressure to a healthier level.

Ongoing hypertension can add to the workload of the heart and arteries over time. This can result in the heart and arteries not functioning properly. Over time, this lack of functionality can cause harm to the blood vessels of the brain, heart, and kidneys - resulting in a stroke, heart failure or kidney failure.

Quinapril is also used as a treatment for heart failure or may be used for other conditions as determined by a medical professional.

 

Resources
Last Reviewed:
January 29, 2018
Last Updated:
January 27, 2018
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