Ramucirumab is used either alone or in combination with paclitaxel to treat gastroesophageal junction cancer or advanced stomach cancer patients have received other medications to treat cancer. It's also used alongside docetaxel to treat metastatic non-small cell lung cancer (cancer that has already spread) in those who have received other medications that treat cancer. This drug is also used in combination with 5-fluorouracil, folinic acid, and irinotecan in the treatment of metastatic colorectal cancer (cancer that has already spread) in patients who have received other medications that treat cancer. This drug is only given under direct supervision from a trained health professional. It is available in the dosage form: solution.
Along with its intended effects, the use of ramucirumab can produce some unwanted side effects. Not all of these side effects may be present at one time, but if they are present, they may require medical attention.
Inform your doctor if you suffer from any of the following side effects whilst taking this drug.
Some side effects that occur with ramucirumab may not require medical attention. The side effects usually begin to disappear as your body begins to adjust to the medication. If they are giving you bother, you should contact your local pharmacist or a doctor for information and advice on ways to reduce these side effects.
Remember you can report all side effects to the FDA on 1-800-FDA-1088.
8 mg/kg IV every two weeks
10 mg/kg IV over sixty minutes on day one and twenty-one-day cycle prior to the docetaxel infusion.
8 mg/kg IV over sixty minutes every two weeks
Drug interactions can cause severe side effects or reduce the effectiveness of either drug. To limit the possibility of drug interactions, you should give your doctor a list of all the current medications you are currently taking and have taken in the past. This list should include prescription, non-prescription drugs, vitamins, and herbal remedies. You should also let them know if you currently suffer from any medical problems, or have a history of medical conditions. This includes any medical conditions that run in your family history.
There are over 191 drugs that are known to interact with ramucirumab. Let your doctor know if you are currently taking any of the following drugs. This list is not complete.
If you suffer from any other medical conditions, this may affect the use of this medication. You should inform y our doctor or a healthcare professional if you suffer from any other conditions including:
Studies have not been conducted on the relationship of age to the effects of ramucirumab injection on the pediatric population. Therefore efficacy and safety have not been established.
Appropriate studies on the relationship of age to the effects of ramucirumab injection have not been conducted in the older population. Therefore no geriatric-specific problems have been noted to date.
This medicine should be used when clearly needed as it may harm an unborn child. Discuss the risks and benefits associated with taking this drug with your doctor and obtain reliable forms of birth control for use during and for three months after you stop treatment. If you fall pregnant or think you may be pregnant, inform your doctor immediately.
This drug can be absorbed via the lungs and skin and therefore may harm an unborn baby.
With regards to breastfeeding, it's unknown if this medication passes into breast milk. Due to the possible risk to the infant, breastfeeding while using this drug is not recommended. Speak with your doctor or a healthcare professional before you start breastfeeding.
This drug can make you more prone to infections and may worsen any current infections. Therefore, make sure you wash your hands well to prevent spreading infections. Avoid contact with others who have infections that could spread to others and you such as chicken pox and flu. Speak with your doctor if you have been exposed to an infection.
This medication can also increase your risk of bleeding and cause delays in wounds healing. Stay away from rough sports or other areas where you could be cut, bruised or injured. Floss and brush your teeth gently. Be careful when using sharp objects, including fingernail clippers and razors. Inform your doctor immediately if you notice any unusual bruising or bleeding, black, tarry stools, blood in the stools or urine, or pinpoint red spots on your skin.
You may need to monitor your blood pressure at home while taking ramucirumab. If you notice any changes to your normal blood pressure, inform your doctor immediately.
This medication can increase your risk of gastrointestinal perforation. Let your doctor know immediately if you have severe stomach cramps or pain, bloody, black, or tarry stools, or vomiting of material that looks similar to coffee grounds.
This medication may increase your chance of having a brain condition known as reversible posterior leukoencephalopathy syndrome. Inform your doctor immediately if you suddenly develop severe headaches, seizures, fainting spells, unusual drowsiness, confusion, or problems with speech, vision or walking.
This drug should be stored intact vials at 36°F to 46°F (2°C to 8°C). Do not freeze this drug. Keep drug in its original carton to protect from direct light. Don't shake product.
When used correctly, ramucirumab is successful in the treatment of stomach or gastroesophageal junction cancer. To gain the most benefit from this medication, you should receive it regularly. To help you remember, mark a calendar to keep note of when to receive the next dose. Due to the high list of drugs that can interact with this medication, it's important to let your doctor know of all current medications you are taking. This drug should not be used during pregnancy or breastfeeding. If you are planning on becoming pregnant, you should let your doctor know, as in some cases, patients who have taken this medication have reported fertility problems. This drug will be given via injection in your arm by a trained professional in a clinical setting.