Rauwolfia Alkaloid and Thiazide Diuretic Combination (Oral)

The combination of Rauwolfia Alkaloid and Thiazide Diuretic is to help lower the blood pressure in patients who suffer from high blood pressure or hypertension.

Overview

The combination of Rauwolfia Alkaloid and Thiazide Diuretic is used for the treatment of patients suffering from high blood pressure or hypertension.

Hypertension increases the pressure placed on both the heart and the arteries. If this condition is left without treatment, it can lead to the development of further problems due to the strain placed on the organs. After a period of time with high blood pressure, the patient's heart may cease to function normally. Common health problems that develop from high blood pressure in a patient include damage to the brain, heart and kidneys that result in stroke, heart failure or kidney failure. Patients with hypertension will also be at greater risk of having a heart attack unless blood pressure is brought down to a manageable level.

This combination treatment works in two disparate ways. Rauwolfia Alkaloid affects the nerve impulses that are transferred in the body. This can reduce certain signals that usually result in the constriction of blood vessels, thus allowing them to relax and lowering the blood pressure in the patient. Thiazide Diuretic will increase the excretion of urine from the body in order to lower blood pressure in the patient. This works by lowering the water content in the blood and therefore reducing the volume and pressure.

A doctor must prescribe this combination of medications.

It is important to note that this treatment is not a cure for high blood pressure. Instead, it acts upon the body to reduce the blood pressure in the patient. Any patient receiving this treatment should also be prescribed dietary and exercise advice that will enable them to lower their blood pressure naturally. Only by taking steps to live a healthier lifestyle will the patient ever be able to stop taking this combination treatment to control their blood pressure. Ceasing use without taking natural steps to lower your blood pressure will expose you to serious risks of stroke, heart failure, heart attack and kidney failure.

Condition treated

  • High blood pressure
  • Hypertension

Type Of Medicine

  • Rauwolfia Alkaloid: Antihypertensive inhibitor
  • Thiazide Diuretic: Diuretic

Side Effects

In addition to the required effects of treatment and the result of lowering the blood pressure in the patient, unwanted side effects may also occur from the use of these treatments. While not all side effects may occur, in some cases they may require the patient to seek medical attention if certain side effects do occur. Other side effects may not necessitate medical attention to be sought. The following side effects may occur.

You should consult your doctor immediately if you experience any of the following side effects:

  • Anxiousness
  • Drowsiness or undue tiredness
  • Faintness or fainting
  • Feeling of weakness
  • Impotence or decreased interest in sexual activity
  • Inability to focus or concentrate
  • Lack of energy
  • Mental depression
  • Nervousness
  • Nightmares
  • Undue tiredness in the early morning
  • Vivid dreams

If you experience any of the following side effects, you should contact your doctor as soon as reasonably possible:

Occurring less commonly:

  • Black stools with a tarry appearance
  • Blood in the vomit
  • Chest pains
  • Headaches
  • Irregularity of heartbeat
  • Joint pains or swelling
  • Shortness of breath without exertion

Occurring only rarely:

  • Feverishness
  • Itching
  • Nausea
  • Pain or difficulty during urination
  • Severe stomach pain
  • Skin rash
  • Soreness of the throat
  • Stiffness
  • Trembling and/or shaking in the hands and/or fingers
  • Unusual bleeding
  • Unusual bruising
  • Vomiting
  • Yellowing of the eyes
  • Yellowing of the skin

It is possible for an overdose to occur from the use of this treatment. You should be alert to the symptoms of overdose and should be sure to take only the correct dose of medication as prescribed. The symptoms of overdose can include:

Occurring in cases of excessive potassium loss and/or overdose:

  • Dryness of the mouth
  • Increased thirstiness
  • Muscle cramping
  • Muscle pain
  • Nausea
  • Vomiting

Other signs of overdose that may occur:

  • Flushing of skin
  • Severe dizziness
  • Severe drowsiness
  • Shrinking of the pupils of eyes
  • Slowed pulse rate

Side effects that would not normally necessitate the seeking of medical attention may also occur. These side effects are less serious and will often abate over time as the body adjusts to the new treatment that you are taking. If these side effects become bothersome or are ongoing then you can inform your doctor and seek advice on how to alleviate them, but they would not normally require that you contact a doctor:

  • Diarrhea
  • Dizziness experienced when rising quickly from lying or sitting positions
  • Loss of appetite
  • Blocked nose

This medication can continue to cause side effects in the body after you have ceased to use it. If side effects continue after use, you should consult your doctor for advice.

Other side effects that have not been listed herein may also occur. If you experience other side effects then you should consult your doctor for advice. If you believe your health to be at immediate risk, however, you should contact the emergency services.

Dosage

This medication will be prescribed alongside dietary control and exercise plans. This may include weight loss programmes. This treatment is not a cure for high blood pressure. Instead, it is a temporary treatment to lower the blood pressure artificially. This treatment will be required indefinitely unless you take appropriate steps to lower your blood pressure naturally. This will include controlling your intake of food, exercising regularly and controlling your weight. If you do not take steps to lower your blood pressure naturally and keep it down, you will have to take this medication for the rest of your lifetime.

In a lot of cases patients with high blood pressure or hypertension will not notice any symptoms of this and may feel normal. If you have high blood pressure, however, then your health will be at serious risk. You should not stop using this treatment if you feel normal as this will increase your blood pressure and expose you to risks once again.

When you first begin treatment with this medication you may feel unusually tired. In addition, you will likely notice an increase in the volume and frequency of your urination. These side effects should reduce over time but in the meantime, you can follow these steps to try and lessen the impact:

  • For those using a single dose “ take it in the morning.
  • For those using a double dose “ take the second dose at least three to four hours before bed unless otherwise directed by your doctor.
  • Plan dosing to reduce the impact on your sleep pattern and personal activities.

This medication should be taken on a strict schedule and you should take it at the same time every day to create a habit. Doing so will increase your chances of remembering the treatment and seeing better effects from use.

This medication can cause nausea. If it does, take it with either meals or with milk. If this does not alleviate the problem, you should contact your doctor.

The dose of this medication will be different for each patient and will differ depending on age, weight, blood pressure, other medical conditions and other factors. You should follow the advice of your doctor for dosing at all times. The following information serves the purpose of a guideline only:

For the treatment of high blood pressure with the combination deserpidine and hydrochlorothiazide:

  • Adults: 2 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination deserpidine and methyclothiazide:

  • Adults: ½-1 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination rauwolfia serpentina and bendroflumethiazide:

  • Adults: 1-4 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination reserpine and chlorothiazide:

  • Adults: 1-4 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination reserpine and chlorthalidone:

  • Adults: 1-2 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination reserpine and hydrochlorothiazide:

  • Adults: 1-4 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

For the treatment of high blood pressure with the combination reserpine and methyclothiazide:

  • Adults: 1-4 tablets daily.
  • Children: Use and dose should be determined by the prescribing doctor.

If you miss a dose of this treatment, you should take it as soon as it is possible to do so, unless you are then close to your next dose being due. In this case, you should skip the missed dose and return to your usual schedule of dosing. Do not ever take a double dose of this treatment.

Interactions

Certain medications can interact with one another when used together. In some cases, this can cause severe side effects while in others the medications can stop one another from working. Drug interactions can also increase the risk of certain side effects occurring in the patient. You should inform your doctor of all medications that you are taking before you begin this treatment. This includes over the counter treatments, prescribed medications, herbal remedies and vitamin supplements.

The use of alcohol, tobacco, caffeine and other substances can also have an effect on your blood pressure. You should discuss your habits with your doctor and you may be advised to cease certain practices in order to lower your blood pressure naturally so that you can reduce dependency on this medication.

Other medical problems from which you suffer can also affect the use of certain medications. This is because the effective use may be impacted by other conditions and these treatments may worsen other conditions. You should inform your doctor if you suffer from any medical conditions and this is particularly important with the following conditions

Rauwolfia Alkaloid may cause breathing problems in the patient. This is important to consider in patients with the following:

  • Allergies
  • Breathing problems
  • Asthma

Thiazide Diuretics can have an impact on the treatment required for the following condition:

  • Type II diabetes mellitus

Thiazide Diuretic can increase levels of uric acid in the blood, which may lead to worsening or return of the following condition:

  • Gout

Rauwolfia Alkaloid can cause changes to the heart rhythm causing problems in patients with the following conditions:

  • Heart disease

Patients with the following conditions may experience adverse effects from the use of this combination of treatments and conditions may be worsened:

  • Kidney disease
  • Liver disease
  • Lupus erythematosus

Rauwolfia Alkaloid can cause mental depression in patients making it potentially unsuitable for patients who suffer from, or have a history of:

  • Mental depression

Patients with the following should not use this treatment:

  • Pancreatitis
  • Pheochromocytoma

Rauwolfia Alkaloid treatments can cause effects similar to the following condition and may not be suitable for use in patients suffering from the following:

  • Parkinsons disease

Other medical conditions that have not been listed herein may also affect the use of this treatment in patients. You should inform your doctor of all medical problems from which you suffer or from which you have suffered in the past before treatment.

Warnings

Before beginning this treatment, you should consider the benefits of doing so in relation to the risks of doing so. If you do not take steps to improve your health naturally, you will be required to take this medication for the rest of your lifetime. You should discuss all of the potential risks from use with your doctor and you should ensure that you have considered the following before beginning treatment:

There is an unconfirmed risk that treatment with Rauwolfia Alkaloid may increase the risk of breast cancer. No specific tests in humans have been carried out on this, but tests on rats have seen an increased risk in tumor development when used in high doses. Discuss this with your doctor before use.

Allergies: You should inform your doctor of any allergies you have to medications, dyes, preservatives, animals, foods or other substances. Patients may be allergic to medications in this group and it is especially important that you inform your doctor if you have reacted badly to a similar medication previously.

Pediatric: There is no specific information on the use of this treatment in children. They are not, however, expected to cause different side effects or results. Discuss use with your doctor.

Geriatric: The use of these treatments in the elderly are not expected to garner different results from use in younger adults, although no specific tests have been carried out. There is, however, an increased likelihood in low levels of potassium effecting elderly patients and this should be monitored. Elderly patients are also more likely to suffer from age-related conditions that will expose them to risk from the use of this treatment.

Pregnancy: This medication has been shown to cause birth defects in a fetus and use in pregnant women should be avoided. If you are pregnant or may get pregnant when you begin this treatment then you should discuss this with your doctor. You should practice safe contraceptive use during use of this treatment to prevent pregnancy from occurring. If you decide that you want to become pregnant while using this treatment then you should speak to your doctor beforehand.

Breastfeeding: Rauwolfia Alkaloid and Thiazide Diuretic both pass into the milk of nursing mothers and these medications will be passed on to the infant in lower dosages. You should discuss breastfeeding with your doctor before you begin treatment and you may be advised not to or to use a different medication.

After you begin treatment with this medication your doctor will need to make checks on your progress regularly to ensure that your blood pressure is controlled. These checks will also include discussions about your diet and exercise to ensure that these plans are also being followed.

You should not use other medications, including those purchased over the counter, when you are taking this medication. You should discuss the use of all medications with your doctor before using them as some common medications for the treatment of colds and hayfever can increases your blood pressure and counteract the medication you are being treated with.

You should inform any medical professional with whom you interact that you are taking this medication. This treatment will affect test results and will impact treatments that you undergo too.

This medication will cause you to lose potassium from the body. In doing so this can put you at risk. To overcome this risk you should eat fruit and other foods that are high in potassium, take potassium supplements as directed by your doctor or take another treatment to prevent this loss if directed to by your doctor.

If you develop a sickness or diarrhea then you should inform your doctor. These conditions can cause you to lose a greater than usual volume of water and potassium from the body and my put you at risk.

This medication can make you dizzy or lightheaded, particularly when you are getting up from a sitting or lying position. To alleviate this you should get up slowly form these positions. Sitting on the side of the best for 1-2 minutes with your legs dangling can help. If this condition worsens over time then you should inform your doctor of this.

Lightheadedness and dizziness will occur more commonly if you consume alcohol, stand for prolonged periods, are exercising or are exposed to heat. You should limit alcohol consumption with this treatment and you should ensure that you are drinking enough water when sweating.

This medication can cause depression in some people. You should inform your doctor right away if you start having nightmares or notice unusual mood changes.

Patients taking this treatment may cause an increased sensitivity to light in patients. This can lead to an increased risk of skin cancer and an increased risk of severe burns developing. In order that you may be able to avoid these side effects you should keep out of direct sunlight, cover yourself in the sun, wear sun protection and avoid use of sunbeds or exposure to UV lights. If you have a reaction to the sun then you should contact your doctor. You may need to seek medical attention for severe burns.

This medication can cause a blocked nose in patients. Decongestants can, however, cause further problems in the patient and should not be used without first consulting your doctor.

This medication can cause the patient's mouth to feel dry. Chewing sugarless gum or melting bits of ice in your both can offer temporary relief as a saliva substitute. If it is a continuing problem then you should consult your doctor or dentist as this may lead to gum disease developing in the long run.

Storage

Medication should be kept out of reach of children at all times.

Ensure that the medication is stored in a sealed container at room temperature. Keep away from heat, direct light and moisture and prevent from freezing.

Dispose of outdated and unwanted medication safely and promptly as directed by your doctor.

Summary

The combination of Rauwolfia Alkaloid and Thiazide Diuretic is used in the treatment of high blood pressure and hypertension in patients. This treatment is not a cure for high blood pressure. Instead it is a temporary fix that should be accompanied by weight loss regimes, healthier eating and exercise plans. Your doctor will always prescribe this medication alongside advice on how to lower your blood pressure naturally. It is vital that you follow this advice in order that you may be able to stop the use of this treatment having naturally lowered your blood pressure.

Having a high blood pressure puts a great deal of strain on the organs. It can affect the blood vessels in the heart, arteries, kidneys and brain. If left untreated it will greatly increase your risk of suffering heart failure, heart attacks, strokes and kidney failure. It is very important that you take steps to lower your blood pressure naturally in addition to the use of this treatment.

This treatment needs to be taken regularly to have the desired effect and you should never cease use without being instructed to by your doctor. Stopping the use of this treatment suddenly can expose you to serious risks once again. The dose should only be reduced gradually as the blood pressure in the patient is reduced naturally.