Rosiglitazone and glimepiride (Oral)

Rosiglitazone and Glimepiride are commonly prescribed to those diagnosed with type 2 diabetes as a means to better regulate the pancreas.


Rosiglitazone and Glimepiride are a combination which is used alongside good exercise and a healthy diet to control the blood sugar levels of type 2 diabetics. The Glimepiride helps to stimulate the body's pancreas into releasing insulin, which can, in turn, be used to help turn food into energy. The Rosiglitazone helps the body to use the insulin in a more effective way. Rosiglitazone and Glimepiride come in tablet form and is only available via prescription from your doctor.

Before beginning upon a course of Rosiglitazone and Glimepiride, you should first properly consult with your doctor. One of the major factors surrounding type 2 diabetes is a lack of good exercise and a healthy diet, so this will also need to be discussed. Rosiglitazone and Glimepiride is not an alternative to this change in lifestyle but is there to help supplement the process and improve the recovery process.

Conditions Treated

Type of Medicine

  • Tablet

Side Effects

A number of side effects could occur whilst you take Rosiglitazone and Glimepiride, If any of the following side effects occur, then contact your doctor immediately.

More common:

  • Difficulty breathing
  • Ear congestion
  • Sneezing
  • Cough
  • Headache
  • Injury
  • Body pains or aches
  • Chills
  • Loss of voice
  • Sore throat
  • Unusual weakness or tiredness
  • Fever
  • Nasal congestion
  • Runny nose
  • Less common
  • Confusion
  • Blurred vision
  • Chest discomfort or pain
  • Cold sweats
  • Pale, cool skin
  • Coma
  • Dilated neck veins
  • Dizziness
  • Extreme fatigue
  • Irregular breathing
  • Depression
  • Anxiety
  • Increased hunger
  • Nausea
  • Nightmares
  • Seizures
  • Shakiness
  • Slurred speech
  • Decreased output or urine
  • Tightness in your chest
  • Swelling of the lower legs, feet, fingers or face
  • Unusual bruising or bleeding
  • Weight gain
  • Irregular heartbeat
  • Fast heartbeat
  • Troubled breathing with exertion

Incidence not known:

  • Coughing that is sometimes producing a frothy pink sputum
  • Dark urine
  • Stomach or abdominal tenderness or pain
  • Black, bloody or tarry stools
  • Blue fingernails and lips
  • Decreased appetite
  • Agitation
  • Stomach, leg, or back pains
  • Bleeding gums
  • General body swelling
  • Hostility
  • Increased sweating
  • Seizures
  • Sensitivity to the sun
  • Skin thinness
  • Increased thirst
  • Fast, difficult, or noisy breathing
  • Skin blisters filled with fluid
  • Irritability
  • Large, hive-like swelling of the face, lips, throat, tongue, eyelids, hands, feet, sex organs, or - - - Legs
  • Light-colored stools
  • Loss of appetite
  • Sores, white spots, or ulcers on the lips or in the mouth
  • Redness of the skin
  • Yellow skin or eyes
  • Stupor
  • Itching or skin rash
  • Sweating
  • Swollen glands
  • Vomiting
  • Muscle cramps or pain
  • Muscle twitching
  • Nosebleeds
  • Pain or discomfort in the neck, back, arms, or jaw

You may also incur one or more of the following side effects. They are not necessarily harmful, but if they are worrying you then you can contact your doctor. They may need to reduce your dosage or alter your intake in some way to mitigate the effects.

Less common:

  • Loss or lack of strength


  • Burning, itching, stinging, or redness of the skin that was not present before treatment

Incidence not known:

You may also occur other side effects as a result of taking Rosiglitazone and Glimepiride. If they do worry you at all, then again, contact your doctor for advice.


Below you can find average dosage requirements for children and adults. Do be aware that these are averages and your exact dosage will depend on a number of different circumstances. If what you see below is different to what has been prescribed by your doctor then do not attempt to change your dosage as it could lead to possible reactions that are uncomfortable. Your doctor will also advise you on other specifications regarding your dosage, such as how frequently you should take them and how long you should be taking them for.

Here is the dosage for those who are already taking either Glimepiride or Rosiglitazone on their own:

  • Adults. To start with, take 2mg of Rosiglitazone and 1mg or 2mg of Glimepiride once a day, or as directed by your doctor. This exact dosage will be adjusted based on your circumstances, though does not usually exceed 8 mg of Rosiglitazone and 4 mg of Glimepiride a day.
  • Children. This will be calculated by your doctor.

The following is for patients switching from taking a combination of Rosiglitazone and Glimepiride as separate tablets.

  • Adults. This dosage would normally remain as the same as you are taking. Your doctor will adjust as they see fit, though it will not normally exceed 8 mg of Rosiglitazone and 4 mg of Glimepiride a day.
  • Children. This will be calculated by your doctor.

If you have missed a dose for whatever reason, then take it as soon as you remember. However, if it is close to your next dosage time, then skip the missed one. It is important you don't double dose at any time.

You should take your medication with the first meal of the day.

If you take colesevelam, then be sure to take your Rosiglitazone and Glimepiride at least 4 hours before you take your colesevelam.

It is important that you do not increase the level of your dosage or the frequency with which you take it unless expressly told to do so by your doctor. Also, once your doctor says that your treatment is over, do not continue to take it.

If you have any other questions about your dosage you can speak to your doctor or refer to the medication guide that should have been supplied alongside your prescription.

The crucial part of helping to cure your type 2 diabetes is to eat a sensible, healthy diet and to exercise regularly.If you fail to do this alongside taking your regular doses of Rosiglitazone and Glimepiride, then any benefits you can expect to get will be greatly reduced. Keep an eye on your blood sugars by using the tools given to you to test your blood or urine.


There are a number of different drugs with which Rosiglitazone and Glimepiride are known to interact. In some cases, these interactions should be avoided, and so your doctor will advise you stop taking the old drug or simply avoid Rosiglitazone and Glimepiride altogether. In other cases, your doctor may adjust your dosage of one or the other to offset the chances of unpleasant interactions. Below you can find a list of drugs which it is recommended you do not take alongside Rosiglitazone and Glimepiride.In some cases, it may be necessary you take both, but your doctor can advise you on the best course of action. When you meet with your doctor to discuss your situation, make them fully aware of any drugs you do currently take, and inform them if you ever start taking any new drugs whilst receiving Rosiglitazone and Glimepiride. This includes prescription drugs, non-prescription, vitamins and herbal supplements.

  • Abiraterone
  • Aspirin
  • Balofloxacin
  • Besifloxacin
  • Ceritinib
  • Ciprofloxacin
  • Disopyramide
  • Dulaglutide
  • Enoxacin
  • Entacapone
  • Fleroxacin
  • Flumequine
  • Gatifloxacin
  • Gemifloxacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Isoniazid
  • Lanreotide
  • Levofloxacin
  • Lixisenatide
  • Lomefloxacin
  • Metreleptin
  • Miconazole
  • Moxifloxacin
  • Nadifloxacin
  • Carcinoloxía
  • Octreotide
  • Ofloxacin
  • Pasireotide
  • Pazufloxacin
  • Pefloxacin
  • Pixantrone
  • Prulifloxacin
  • Rufloxacin
  • Sparfloxacin
  • Thioctic Acid
  • Tosufloxacin
  • Voriconazole

Below is another list of medicines, this time which are known to lead to a variety of different side effects. Again, it may still be necessary for you to take this medicine and Rosiglitazone and Glimepiride alongside each other, but your doctor is best equipped to make that decision. They may alter your dosage or the frequency with which you take either medication.

  • Acebutolol
  • Atenolol
  • Betaxolol
  • Bisoprolol
  • Bitter Melon
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Colesevelam
  • Esmolol
  • Fenofibrate
  • Fenofibric Acid
  • Fenugreek
  • Furazolidone
  • Gemfibrozil
  • Glucomannan
  • Guar Gum
  • Iproniazid
  • Isocarboxazid
  • Labetalol
  • Levobunolol
  • Linezolid
  • Methylene Blue
  • Metipranolol
  • Metoprolol
  • Moclobemide
  • Nadolol
  • Nebivolol
  • Nialamide
  • Opicapone
  • Oxprenolol
  • Penbutolol
  • Phenelzine
  • Pindolol
  • Practolol
  • Procarbazine
  • Propranolol
  • Psyllium
  • Rasagiline
  • Rifampin
  • Safinamide
  • Selegiline
  • Sotalol
  • Timolol
  • Tranylcypromine
  • Trimethoprim

Beyond drugs, various aspects of your dietary intake could be known to interact with Rosiglitazone and Glimepiride. Therefore, you should fully disclose all elements of your diet, including what you eat, drink and smoke. It may be that you need to adjust a large part of your diet, as you naturally would with type 2 diabetes. It may also be you need to avoid certain foodstuffs all together to maximise the benefits to your health. Specifically, it is recommended that you do not consume ethanol whilst taking Rosiglitazone and Glimepiride tablets.

Finally, other medical conditions you have may mean it is not suitable for you to receive Rosiglitazone and Glimepiride, or at least a full dose. You can discuss your other medical problems with you and advise you whether or not you could expect any sorts of interactions from taking Rosiglitazone and Glimepiride. Below is a list of known medical problems which may affect you suing Rosiglitazone and Glimepiride.

  • Type 1 diabetes - Cannot be used in patients with this
  • Diabetic ketoacidosis (ketones in the blood)
  • Problems with the pituitary gland (underactive)
  • Diabetic macular edema (swelling of the back of the eye)
  • Edema (fluid retention or swelling)
  • Weakened physical condition - Use with caution. May cause side effects to become worse.
  • A history of allergy to sulfa drugs
  • Liver disease, active
  • Angina, acute and severe
  • Poorly nourished condition
  • Heart attack, acute
  • Problems with adrenal gland (underactive)
  • A history of Glucose 6-phosphate dehydrogenase (G6PD) deficiency (an enzyme problem)
  • Kidney problems
  • Heart failure, severe or with symptoms
  • A history of heart attacks
  • A history of heart disease
  • Liver disease - Use with caution. May make this worse
  • Fever
  • Infection
  • Surgery
  • Trauma - Use with caution. These may make it harder to control blood sugars
  • Fragile bones (especially in women) - Use with caution. This medicine may increase the risk of fractures


Before taking Rosiglitazone and Glimepiride, you will first need to sit down with your doctor and consult with them to make sure it is the right course of treatment for you. As a part of this discussion, you should make them aware of any allergies you have to animals, foods, preservatives, and dyes. As Rosiglitazone and Glimepiride are known to react to a number of such items. Also, make them aware if you have ever had an allergic reaction to Rosiglitazone and Glimepiride or any other drugs before.

As of writing, there has not yet been suitable studies performed on the relationship between the Rosiglitazone and Glimepiride and pediatric patients. No safety or efficacy standards have been established. Instead, your child will need to be properly assessed by a trained doctor who can then advise whether Rosiglitazone and Glimepiride are safe to take.

There have been some appropriate studies conducted which do not highlight any geriatric-related problems which limit the usefulness of taking Rosiglitazone and Glimepiride. However, it should be noted that elderly patients are often more likely of developing kidney problems. Such problems are aggravated by Rosiglitazone and Glimepiride, so an altered dose may be required.

As of writing, there are not adequate studies which have been conducted into the use of Rosiglitazone and Glimepiride on pregnant women. Your doctor is best informed with any evolving studies or developments and can advise whether the benefits of taking Rosiglitazone and Glimepiride outweigh any risks. If you become pregnant at all whilst taking Rosiglitazone and Glimepiride, be sure to notify your doctor as they may need to make some sorts of adjustments to offset any risk.

The same goes for breastfeeding women. No adequate studies have been performed, and your doctor can advise you on the best course of action.

Curing type 2 diabetes has much more to do with exercising regularly and eating a healthy and controlled diet. Though you should stick to taking your regular doses of Rosiglitazone and Glimepiride, you should also be sure to maintain whatever diet and exercise plan your doctor has prescribed to you. Failure to do so will lead to a lack of any real improvement in your condition.

You will need to agree to regular appointments with your doctor to track the progress of your type 2 diabetes and to ensure the medication isn't having any unwanted side effects. You may also need to take regular urine and blood tests to monitor your condition.

If at any time you experience shortness of breath, vomiting, sweating, chest pain or discomfort, nausea or pain or discomfort in your back, neck, arms or jaw, then contact your doctor immediately. These could be signs of a heart attack.

Other signs of a heart problem or edema include the following. If you experience any, then contact your doctor immediately.

  • Shortness of breath
  • Rapid weight gain
  • Chest discomfort or pain
  • Extreme weakness or tiredness
  • Irregular heartbeat
  • Irregular breathing
  • Excessive swelling of your feet, wrists, ankles or hands

Signs to look out for of a serious liver problem include the following.

  • Yellow skin or eyes
  • Loss of appetite
  • Stomach or abdominal pain
  • Darkened urine
  • Vomiting or nausea

There is also the chance that you may incur problems with your eyesight, in which your doctor should be notified as they may wish to schedule you in to see an ophthalmologist. Such signs to look out for include difficulty reading, blurred vision, or general changes in vision whilst taking Rosiglitazone and Glimepiride.

You will also want to contact your doctor for ways to ensure your bones are kept strong. Whilst taking Rosiglitazone and Glimepiride, it can increase the risk of bone fractures in women.

If you are a woman of childbearing potential, then you will need to discuss suitable birth control to take whilst using Rosiglitazone and Glimepiride. This is because it can cause you to ovulate out of routine, and women who have had problems ovulating or have had irregular periods in the past are more at risk. Therefore whilst taking Rosiglitazone and Glimepiride, you are potentially at a greater risk of becoming pregnant.

When outdoors in the sun, be sure to apply regular amounts of sunscreen. You should also avoid any tanning beds or sunlamps. This is because Rosiglitazone and Glimepiride can make your skin more sensitive to light.

Taking Rosiglitazone and Glimepiride may also affect the results of any medical tests you have, Be sure to make any testing doctor, nurses, or dentists aware of the fact you are taking Rosiglitazone and Glimepiride before any appointments get underway.

Your doctor will need to give you some strict advice and guidance regarding how you manage your lifestyle whilst taking Rosiglitazone and Glimepiride.Here are some common words of advice you should try your best to follow.

  • Regarding alcohol. Drinking alcohol has the effect of possibly causing your blood sugars to drop severely low, so be aware of this and be careful with monitoring your blood sugar levels when even drinking small quantities of alcohol.
  • Regarding other medicines. Unless you have been cleared to do so by your doctor, do not take other medicines whilst taking Rosiglitazone and Glimepiride. More importantly, this includes medicines for appetite control, asthma, hay fever, sinus problems or coughing.As well as non-prescription medicines including aspirin.
  • Regarding counseling. Counselling may be needed for newly diagnosed type 2 diabetics in a number of forms. This includes training family members on how to spot unwanted side effects and how to deal with them if they occur. As well as counseling on other type 2 diabetic-related medicines and changes in dosages that may occur due to changes in diet and exercise. Finally, you may need counseling regarding the increased risks of pregnancy and how to manage pregnancy whilst taking Rosiglitazone and Glimepiride.
  • Regarding travel. You should take steps to more prepared when you travel, such as by having your medical history and recent prescriptions with you. You should try and keep your meal times as close to they would be back home and so be more aware of time zones. Plan ahead for any potential emergencies to mitigate any risks you may face.
  • Regarding emergencies. Type 2 diabetic-related emergencies could occur, and you can put some steps in place to prepare. This includes purchasing and wearing one or more forms of type 2 diabetic ID at all times; this includes necklaces, bracelets or phone charms for example. You should also have an ID card which lists all of your medications and notifies people of your type 2 diabetes in the local language.
  • Regarding fluid retention. There is the possibility of developing fluid retention which can lead to heart problems. You should discuss with your doctor ways to spot fluid retention and handle it appropriately

Taking Rosiglitazone and Glimepiride may cause you to go into hypoglycemia, which is where your blood sugars are too low. This can also occur for a variety of other reasons, including missing meals, drinking too much alcohol, doing too much exercise or not being able to eat due to vomiting or nausea. You must treat hypoglycemia immediately as it can lead to you passing out and entering a coma. Depending on the individual, the symptoms of low blood sugars can differ, however, there are common symptoms to try to look out for.

  • Cold sweats
  • Difficulty thinking
  • Slurred speech
  • Unusual weakness or tiredness
  • Nervousness
  • Confusion
  • Cool, pale skin
  • Drowsiness
  • Excessive hunger
  • Anxiety
  • Restless sleep
  • Shakiness
  • Behavior change similar to being drunk
  • Blurred vision
  • Fast heartbeat
  • A continuing headache
  • Nausea
  • Nightmares

To help combat the effects of low blood sugars, you should take a suitable amount of the following;

  • Honey
  • Glucose tablets or gel
  • Sugar dissolved in water
  • Corn syrup
  • Non-diet soft drinks
  • Sugar cubes
  • Fruit juice
  • Glucagon (in emergencies)

If you experience seizures, convulsions or unconsciousness, then Glycogen is needed as a rapid treatment and your family should be trained in how to administer it. It comes in syringe and needle format.

On the flip side, hyperglycemia may occur when your blood sugars go too high. This can occur if you overeat during a meal, don't exercise enough, skip your medicine, or have an infection or fever. Symptoms of hyperglycemia to look out for include;

  • Nausea or vomiting
  • Tiredness
  • Blurred vision
  • Drowsiness
  • Fruit-like breath odor
  • Increased urination (frequency and amount)
  • Troubled breathing (rapid and deep)
  • Dry mouth
  • Flushed, dry skin
  • Unconsciousness
  • Sleepiness
  • Stomachache
  • Unusual thirst
  • Ketones in the urine
  • Loss of appetite

If hyperglycemia is occurring then monitor your blood sugar levels closely and contact your doctor and follow his instructions.


You should store your Rosiglitazone and Glimepiride is a sealed container and at room temperature. It should be kept away from heat, away from direct light and away from moisture. Keep it in a place where children cannot access it, as it could be potentially harmful. Once you have finished on your course of treatment, notify your doctor of any leftover medication and dispose of in a safe and sensible manner as directed by your doctor. If your medication goes out of date during your treatment then dispose of it and obtain a fresh prescription.


Rosiglitazone and Glimepiride is a common drug prescribed for those who have been diagnosed with type 2 diabetes. Rosiglitazone and Glimepiride combination acts a means to better encourage your pancreas to produce insulin, and for that insulin to be more effective in combatting blood sugars. Type 2 diabetes is reversible and is caused by lifestyle choices, therefore you should accompany Rosiglitazone and Glimepiride with a healthy diet and regular exercise plan.

There is a lot of information to take in when being diagnosed with type 2 diabetes and your doctor will be able to fully equip you with the necessary information and advice beyond what is supplied here. Taking Rosiglitazone and Glimepiride can lead to a number of possible side effects and interactions, so you need to make your doctor fully aware of your dietary intake, any allergies you have and any other drugs you take. They can then best advise you on the appropriate dosage of Rosiglitazone and Glimepiride.

If at any time you experience the worrying side effects as listed above, or need any other advice regarding your diabetes and the intake of Rosiglitazone and Glimepiride, then contact your doctor immediately. Finally, be sure to maintain regular appointments as scheduled so your condition can be properly monitored and any necessary adjustments in your lifestyle or Rosiglitazone and Glimepiride can be made.


Last Reviewed:
January 31, 2018
Last Updated:
April 26, 2018