Rosiglitazone (Oral)

Rosiglitazone is used in conjunction with proper diet and exercise, and sometimes other medications, for the control of blood sugar levels in patients with type II diabetes.


Rosiglitazone is used in the treatment of type II diabetes. It is not effective in the treatment of type I diabetes conditions.

Rosiglitazone can be used in isolation or in conjunction with other medications such as sulfonylurea or metformin.

This treatment will always be prescribed along with advice on how to control blood sugar levels through the use of a healthy diet and exercise. This treatment will not work effectively without the patient following this regimen as set out by the doctor.

Rosiglitazone works by helping the body to utilize insulin more effectively.

This medication will only be available with a doctor's prescription and is administered in the form of a tablet called Avandia.

Conditions Treated

  • High blood sugar levels
  • Type II diabetes
  • Type of medicine
  • Thiazolidinedione

Side Effects

In addition to having the desired effect of lowering the content of sugar in the blood of the patient, this treatment may also have some other unwanted effects. While these side effects may not all occur, the patient may need to seek medical attention in some cases where they do.

You should check with your doctor immediately if you experience any of the following side effects during treatment:

Occurring less commonly:

  • Abdominal pains
  • Blurring of the vision
  • Changed breath odor with a fruit-like scent
  • Chest pains or discomfort across the chest
  • Decrease in volume of urine produced
  • Dry mouth or feelings of dehydration
  • Flushed and dry skin
  • Increased appetite
  • Increased thirstiness
  • Increased volume of urination
  • Irregularity of heartbeat
  • Nausea
  • Noisy and rattling breathing
  • Pain across the shoulders, arms, jaw, and/or neck
  • Pale skin
  • Rapid weight gain
  • Stomach pain
  • Sweating
  • Swelling of the fingers, hands, feet, and/or lower legs
  • Troubled breathing
  • Unexplained weight loss
  • Unusual bleeding
  • Unusual bruising
  • Unusual tiredness
  • Unusual weakness
  • Unusual weight gain
  • Vomiting

Occurring only rarely:

  • Anxiousness
  • Chills
  • Cold sweats
  • Coma
  • Confusion or disorientation
  • Darkened urine
  • Depression or extreme sadness
  • Dizziness
  • Fast heartbeat
  • Headache
  • Loss of appetite
  • Nightmares
  • Seizures or convulsions
  • Shakiness or uncontrollable trembling
  • Slurring of the speech

Frequency of incidence unknown:

  • Bluish tinge to lips and fingernails
  • Changed vision
  • Cough producing a pink frothy sputum
  • Itchiness or skin rash
  • Lightened coloration of stools
  • Redness of the skin
  • Swelling with the appearance of hives on the:
    • Eyelids
    • Face
    • Feet
    • Hands
    • Legs
    • Lips
    • Sex organs
    • Throat
    • Tongue
  • Yellow eyes
  • Yellow skin

Other side effects may also occur that would not normally necessitate the seeking of medical attention. The following side effects will usually abate over time as the body gets used to the treatment. If, however, the side effects are ongoing and bothersome then you should consult your doctor to determine how the side effects may be alleviated:

Occurring more commonly:

  • Ear congestion
  • Feverishness
  • General feeling of discomfort
  • General feeling of illness
  • Hoarseness or other voice changes
  • Injury
  • Joint pains
  • Muscle aching and pains
  • Runny or blocked nose
  • Shivering
  • Sneezing
  • Soreness of the throat
  • Troubled sleep

Occurring less commonly:

  • Back pain
  • Coughing
  • Lightheadedness
  • Mild diarrhea
  • Tenderness around eyes and cheekbones

Other side effects that have not been listed herein may also occur. If you experience any other side effects then you should consult your doctor. If you feel that your immediate well being is at risk then you should always contact the emergency services.


You should use this medication only as directed by your doctor. Never take more than prescribed and never take it more frequently than prescribed. This medication should only be stopped or changed on the order of your doctor.

This medication will be provided with a medication guidance booklet that will help you to understand the drug, what it will do to you and how it can effectively help you to control your blood sugar levels.

This medication can be taken with or without food as required.

Your doctor will also provide you with a diet and exercise plan that you should follow closely if you can hope to control your blood sugar level. Eating the wrong foods and consuming too much sugar will prevent this treatment from working. Changing your exercise plan or stopping exercise can also cause your blood sugar levels to rise again.

The dose used for each patient will differ depending on the level of development of condition and how much sugar is present in the blood. You should follow the dosing as prescribed by your doctor. The following information is a guideline only and you should not make changes to your treatment unless ordered to do so.

For oral dosing by tablet for the treatment of high blood sugar levels in patients with type II diabetes:

  • Adults - 4mg daily across a single or double dose. This can be adjusted up to a maximum of 8mg daily across a single or double dose.
  • Children - Use and dose must be determined by the prescribing doctor.

This medication works to help you control blood sugar levels and you need to avoid spikes in blood sugar that will occur if you eat too much sugar or miss a dose of this medication. If you miss a dose then you should take it as soon as possible. If, however, it is close to your next dose being due when you realize then you should skip that dose and return to your normal schedule. You should make a note of when any missed doses took place and make note of any effects this has on your blood sugar levels too. Report these missed does to your doctor as they may impact tests that your doctor takes to determine effective use of the treatment.

Never take a double dose of this medication.


Certain medications can interact with one another in the body and cause unwanted side effects. In the worst cases, the use of two medications that should not be mixed can cause serious life-threatening results. In other cases, they may stop each other from working or increase the risk of certain side effects being experienced. Before beginning treatment with this medication, it is vital that you inform your doctor of all medications that you are taking. Your doctor may need to make changes before prescribing you with Rosiglitazone. This is especially important if you are taking any of the following:

The use of Rosiglitazone in conjunction with any of the following would not normally be recommended. Your doctor may still prescribe both, but may wish to make changes to the dose or frequency of use:

  • Tosufloxacin
  • Thioctic Acid
  • Sparfloxacin
  • Rufloxacin
  • Prulifloxacin
  • Pixantrone
  • Pefloxacin
  • Pazufloxacin
  • Pasireotide
  • Ofloxacin
  • Octreotide
  • Norfloxacin
  • Nadifloxacin
  • Moxifloxacin
  • Lomefloxacin
  • Levofloxacin
  • Lanreotide
  • Insulin Lispro, Recombinant
  • Insulin Glulisine
  • Insulin Glargine, Recombinant
  • Insulin Detemir
  • Insulin Degludec
  • Insulin Bovine
  • Insulin Aspart, Recombinant
  • Insulin
  • Gemifloxacin
  • Gatifloxacin
  • Flumequine
  • Fleroxacin
  • Entacapone
  • Enoxacin
  • Ciprofloxacin
  • Ceritinib
  • Besifloxacin
  • Balofloxacin
  • Abiraterone

Use of the following treatments alongside or in conjunction with Rosiglitazone could increase your risk of exposure to certain side effects. Your doctor may still prescribe both, but may wish to make changes to the dose or frequency of use of one or other treatment:

  • Trimethoprim
  • Timolol
  • Sotalol
  • Rifampin
  • Psyllium
  • Propranolol
  • Practolol
  • Pindolol
  • Penbutolol
  • Oxprenolol
  • Opicapone
  • Nebivolol
  • Nadolol
  • Metoprolol
  • Metipranolol
  • Levobunolol
  • Labetalol
  • Guar Gum
  • Glucomannan
  • Gemfibrozil
  • Fenugreek
  • Fenofibric Acid
  • Fenofibrate
  • Esmolol
  • Celiprolol
  • Carvedilol
  • Carteolol
  • Bitter Melon
  • Bisoprolol
  • Betaxolol
  • Atenolol
  • Acebutolol

Other medications that have not been listed herein may also interact with Rosiglitazone. This list has been compiled for severity and is not all-inclusive. Tell your doctor about all medications you are taking before beginning this treatment. You should then inform all doctors and dentists that you are taking this treatment in the future before tests or treatment.

Other medical conditions from which you suffer can also be impacted by the use of this treatment and this treatment can also be made less effective by other conditions that you have. You should inform your doctor of all medical conditions from which you suffer or have suffered in the past before you begin use of this treatment. This is especially important if you suffer from or have suffered from any of the following in the past:

Do not use this medication in patients suffering from the following:

  • Severe and acute angina
  • Diabetic ketoacidosis
  • Acute heart attack
  • Severe heart failure
  • Type I diabetes

Do not use this medication in combination with metformin in patients who suffer from the following:

  • Kidney disease

The following conditions may be worsened by the use of this medication:

  • Diabetic macular edema
  • Edema
  • History of heart attack
  • History of heart disease
  • Liver disease

The following conditions can affect sugar control in the patient:

  • Fever
  • Infection
  • Surgery
  • Trauma

This medication can increase the risk of fractures in patients with the following condition. This is intensified further in female patients:

  • Fragile bones

Other medical conditions may also affect the use of this treatment. Ensure that you inform your doctor of all conditions from which you suffer as these conditions have been listed only for reasons of severity.


Before deciding to use any medical treatment you should consider the benefits of doing so in relation to the risks. You should weigh all of the factors listed herein with your doctor to make this decision and ensure that you have also considered the following factors that may impact use:


You should tell your doctor if you have ever experienced an unusual reaction to any medications in the past. Ensure your doctor is also aware of any other allergies that you may have including to dyes, preservatives, animals, foods and other substances.


Safety and efficiency of use have not been determined in children. Alternative treatments should be sought if possible. Discuss use with your doctor if prescribed.


No age-related limitations have been reported with the use of this treatment. Be cautious of age-related medical conditions that may impact the use of this treatment, however. Kidney, liver, and heart conditions may limit safe use.


Strict normoglycemia is vitally important to achieve during pregnancy. This medication should not be used in pregnant women where possible unless the benefits of use clearly outweigh the risks of use. You should discuss use and pregnancy with your doctor and inform them if you think you are pregnant or may be pregnant before you begin treatment. You should practice the use of effective contraception while you are taking this treatment too and should inform your doctor if you plan to become pregnant or believe you have become pregnant during use.


This medication is excreted into the milk of the mother and will be passed into the body of the nursing infant. A decision should be made to cease use of the medication or to cease use of nursing. Discuss the use of this treatment in relation to breastfeeding with your doctor if you are a nursing mother.

When using this medication you will need to have regular check-ups with your doctor to check on your progress and ensure the medication and diet are working properly in conjunction with one another. You will also be checked for signs of unwanted side effects that may be occurring.

This medication can contribute to the occurrence of a heart attack. You should contact the emergency services straight away if you experience the symptoms of a heart attack. These symptoms can include:

  • Chest pain
  • Nausea
  • Pain in the back
  • Pain in the jaw
  • Pain in the neck
  • Shortness of breath
  • Sweating
  • Vomiting

This medication can also contribute to the occurrence of heart problems and edema. If you experience any of the following symptoms you should contact your doctor straight away:

  • Chest pains
  • Excessive swelling of the hands, wrists, ankles or feet
  • Extreme tiredness
  • Extreme weakness
  • Irregular breathing
  • Irregular heartbeat
  • Weight gain

This medication can expose you to risk of developing liver problems. You should contact your doctor if you experience these symptoms of liver problems:

  • Irregular breathing
  • Irregular heartbeat
  • Nausea
  • Unusual tiredness
  • Unusual weakness
  • Vomiting
  • Yellowing of the eyes or skin

You may need to get your eyes checked by an ophthalmologist if while you are taking this medication. Do so straight away if you experience changes in vision or a blurring of vision.

This medication can increase the risk of bone fractures, particularly in women. Your doctor can advise you on how to maintain bone strength to reduce risk.

This medication can in some cases make women more likely to conceive a child. If you are of childbearing age then you should discuss contraceptive methods with your doctor.

Ensure that any doctor or dentist treating you is aware that you are taking this medication. This medication can affect the results of tests that they may need to take.

Your doctor will give you specific advice to follow during the use of this treatment. It is very important that you follow your doctor's instructions in all matters as failure to do so can put your health at serious risk. You will be advised in the following areas:

  • Alcohol - You will be advised not to drink or to significantly limit your drinking. Doing so is very important as alcohol consumption will have a significant impact on the level of sugar in the blood.
  • Other medications - Under no circumstances should you take any other medications without first discussing this with your doctor.
  • Counseling - Counseling may be provided to you and to other family members to help you to cope with changes that you may experience when using this treatment. You may also get special counseling to help you with diet and exercise plans. Counseling on contraception may also be required because of the risks of pregnancy in diabetic individuals.
  • Travel - You should always have your prescription details with you when traveling. You should also take time-zone changes into account so that you can maintain correct dosing.
  • In emergencies - You need to be prepared for emergencies as there is a likelihood that you may need emergency medical attention in the future. Consider wearing an ID tag at all times and keeping an ID card in your wallet with details of your condition.
  • Symptom recognition - You will need to learn how to recognize the symptoms of various conditions that may develop so that you can react appropriately.

This medication will not induce hypoglycemia in the patient, but this may occur if you miss a meal, change your exercise pattern, drink alcohol, exercise more than you normally would or make other changes to your usual practice. You need to learn the signs that occur before you lose consciousness from this condition so that you can treat yourself immediately. You should discuss this in detail with your doctor before you begin this treatment. You will learn to recognize these signs and react appropriately in time.

Hyperglycemia can occur if you miss doses or do not take enough medication. It can also occur if you overeat, get a fever or stop exercising to appropriate levels. You should discuss this with your doctor and take steps to prevent this from happening.


You should store this medication in its original packaging at room temperature.

Keep out of direct light, away from moisture and most importantly you should keep it away from children.

You should not keep outdated medication and you should dispose of any unused medication properly and as soon as it is possible to do so. Discuss appropriate disposal methods with your doctor.


Rosiglitazone is a treatment for type II diabetes. It will not be effective in the treatment of type I diabetes.

This medication is prescribed to help with the effective management of sugar levels in the blood in patients with type II diabetes. It is not a cure for diabetes. Rather it is an element of a larger plan that will help you to keep your blood sugar levels at a reasonable level. This treatment works by improving the body's ability to utilize insulin effectively.

This treatment will always be given alongside a diet plan and an exercise plan. It is essential that you follow this treatment plan to the letter to control your blood sugar levels. Any changes to diet, dose or exercise will cause a dip or rise in blood sugar levels that can expose you to serious health risks. Discuss all of this with your doctor before use.

There is a risk that this treatment can make women more likely to conceive a child. As there are serious risks to becoming pregnant when diabetic you should exercise extreme caution and practice safe contraception at all times. Discuss this with your doctor before beginning treatment.


Last Reviewed:
February 01, 2018
Last Updated:
April 05, 2018
Content Source: