Rubella and Mumps Virus Vaccine Live (intramuscular)

This is a joint vaccine given to children older than 12 months to prevent contracting rubella and mumps virus, given via live vaccine, typically injected into the arm.


The rubella and mumps live vaccine is an active immunizing agent that is used to prevent infection by the mumps and rubella viruses. They work by pushing your body to produce its own protection called antibodies to protect against the virus.

Rubella, which is also known as German measles, is a serious infection that can cause stillbirths, com/health/miscarriage/">miscarriage, or birth defects in unborn babies when women contract the disease whilst pregnant.

Mumps is an infection that can cause serious problems, such as meningitis and encephalitis. These conditions can affect the brain. In addition, men and adolescent boys are very susceptible to a condition called orchitis. This condition causes swelling and pain in the scrotum and testicles and in some rare, extreme cases, it can cause sterility. Mumps can also cause random abortion in women during the first three months of pregnancy.

Immunization against rubella and mumps is recommended for all people aged 12 months or older, but it's especially important for those women of childbearing age and anyone who is traveling outside the United States.

If a child is to be given the rubella and mumps live vaccine, they need to be at least twelve months of age. This is to ensure that the vaccine is effective in protecting them. If a child is less than twelve months old, the antibodies from the mother could prevent the vaccine from being effective and working correctly. This vaccine can only be given by or under the supervision of a healthcare professional or your doctor. It is available via the dosage form: Powder for solution via injection.

Conditions Treated

  • For the prevention of rubella
  • For the prevention of mumps

Type of Medicine

  • Powder for solution
  • Intramuscular route

Side Effects

Along with its intended effects, this vaccine may cause some unwanted effects. There is no guarantee that all of these side effects may occur, but if they do, some may require medical attention. You should inform your doctor or a healthcare professional immediately if any of the following side effects occur after you have been given this vaccine.

Symptoms of allergic reaction:

  • Itching, especially of hands or feet
  • Difficulty in swallowing or breathing
  • Hives
  • Swelling of face, eyes or inside of nose
  • Reddening of skin, especially around ears
  • Unusual weakness or tiredness (sudden and severe)

Inform your doctor asap if you experience any of the following side effects after this vaccine.

Less common side effects:

  • Tenderness or pain in the eyes

Rare side effects:

  • Fever over 103 °F (39.4 °C)
  • Purple spots or bruising on the skin
  • Confusion
  • A severe or a continuing headache
  • Numbness, pain, or tingling in the arms, hands, legs, or feet
  • Irritability
  • Swelling or tenderness of testicles and scrotum
  • Vomiting
  • Stiff neck

Some side effects that occur may not require medical attention. You usually find that these side effects begin to disappear as your body begins to adjust to the medicine. If, however, these side effects are bothering your day to day life, you should contact your local pharmacist, a healthcare professional or your doctor for advice on ways to minimize or prevent these side effects. The following side effects are ranked in terms of more common and less common.

More common side effects:

  • Stinging or burning around place of injection
  • Swelling of glands in neck
  • Skin rash

Less common side effects:

  • Mild headache
  • Nausea
  • Swelling, itching, redness, tenderness, or hard lump in place of injection
  • Runny nose
  • Aches or pain in joints
  • A vague feeling of bodily discomfort
  • Sore throat

The side effects listed above are more likely to affect adults and women. This is particularly true of aches and pains in the joints.

Remember you can report all side effects to the FDA on 1-800-FDA-1088.


The dose of this vaccine will differ depending on the patient. Follow your doctor's orders. The following information includes only the average doses of rubella and mumps vaccination. Don't worry if your dose is different, it doesn't mean it is wrong.

For prevention of rubella and mumps via injection:

  • Adults and children older than twelve months of age - one dose injected under the skin.
  • Children up to twelve months of age - the use of this vaccine isn't recommended.


Interactions can happen between different drugs producing serious side effects or reducing the effectiveness of the drug given. It's therefore important that you give your doctor or healthcare professional a full list of all the medications you are currently taking, and have taken in the past. This list should include prescription and nonprescription drugs, herbal remedies and vitamins. You should also give a history of any other medical problems you currently suffer from as well as past medical problems. If there are medical problems that run in your family, they should be mentioned too. There are over 200 drugs that interact with this vaccine. Some of the most known are listed below, but this list is not complete. That is why it's important to mention all drugs you are currently taking.

Although some medications should not be used together at all, sometimes it may be the best option for you. In this case, your doctor may want to change the dose of one of the medications you are taking or take other precautions. Before you receive this vaccine, you should let your doctor know if you are taking any of the following drugs listed below.

Taking this vaccine with any of the following medications isn't recommended. Your doctor may decide against giving you this vaccine or alter other medications you take.

  • Alemtuzumab
  • Bortezomib
  • Bendamustine
  • Bosutinib
  • Cabazitaxel
  • Carfilzomib
  • Capecitabine
  • Carboplatin
  • Carmustine
  • Cladribine
  • Chlorambucil
  • Cisplatin
  • Clofarabine
  • Cytarabine
  • Cyclophosphamide
  • Cytarabine Liposome
  • Dasatinib
  • Dacarbazine
  • Daunorubicin
  • Deflazacort
  • Daunorubicin Citrate Liposome
  • Docetaxel
  • Etoposide
  • Doxorubicin
  • Epirubicin
  • Fludarabine
  • Gemcitabine
  • Fluorouracil
  • Hydroxyurea
  • Gemtuzumab Ozogamicin
  • Idarubicin
  • Imatinib
  • Ifosfamide
  • Interferon Alfa
  • Irinotecan Liposome
  • Irinotecan
  • Lomustine
  • Melphalan
  • Mechlorethamine
  • Mercaptopurine
  • Mitomycin
  • Methotrexate
  • Mitoxantrone
  • Nilotinib
  • Nelarabine
  • Ofatumumab
  • Paclitaxel
  • Oxaliplatin
  • Paclitaxel Protein-Bound
  • Pentostatin
  • Pemetrexed
  • Ponatinib
  • Rituximab
  • Procarbazine
  • Temozolomide
  • Thiotepa
  • Teniposide
  • Topotecan
  • Vinorelbine
  • Tositumomab
  • Vinblastine

Taking this vaccine with any of the following medications is not usually recommended, but in some rare cases, it may be required. If you prescribed both medications together, your doctor may alter the doses or how the frequency you use one or both of the medications.

  • Antithymocyte Globulin Rabbit
  • Azathioprine
  • Adalimumab
  • Brodalumab
  • Certolizumab Pegol
  • Etanercept
  • Dupilumab
  • Everolimus
  • Guselkumab
  • Fingolimod
  • Golimumab
  • Immune Globulin
  • Leflunomide
  • Infliximab
  • Mycophenolic Acid
  • Sarilumab
  • Rilonacept
  • Secukinumab
  • Teriflunomide
  • Sirolimus
  • Tocilizumab
  • Ustekinumab
  • Trabectedin

Taking this vaccine with any of the following medications may increase your risk of certain side effects, but in some cases, the use of both drugs may be the best choice of treatment for you. If both medications are prescribed together, your doctor may alter the dose or change the frequency of when you use the medications.

  • Abatacept

Other Interactions

Some medications should not be used at or around the time of eating certain types of food, or eating food in general, due to interactions. The use of tobacco or alcohol may also interact with some medications causing interactions. You should discuss with your doctor or a healthcare professional about the use of this vaccination with alcohol, food or tobacco.

Other Medical Problems

Some medical conditions can affect the use of this vaccine. Ensure you inform your doctor if you suffer from any other medical problems, especially:

  • Immune deficiency condition, including a family history.

Having this condition can increase the chance of certain side effects and increase their severity. It may also decrease the useful effects of the vaccination.

  • Severe illness with fever'the symptoms of this condition may be confused with the possible side effects of the vaccination.


Use in pediatric patients

The use of this vaccination isn't recommended for infants younger than twelve months of age. If a child has received this vaccine when they were under twelve months of age, they should be given another dose when they become in the age bracket of twelve to fifteen months of age.


It's important you let your doctor or a healthcare professional know if you have ever had an allergic or unusual reaction to this medication or any other medications. This includes informing them of any other allergies, such as allergies to foods, preservatives, dyes, animals etc.

Advice for pregnant women and those breastfeeding

This vaccine is under pregnancy category C. You should not become pregnant for at least three months after receiving this vaccine without first consulting with your doctor. This is due to an increased risk of birth defects this vaccine could cause.

Consult with your doctor if you are already pregnant.

Studies conducted in women have suggested that this medication poses minimal risk to an infant when used during breastfeeding.

Tell your doctor that you have received this vaccine:

  • If you are to receive immune globulins or blood products or within a 14 day period of receiving this vaccine
  • If you are to receive this vaccine within three months of receiving immune globulin or blood products
  • If you're to receive a tuberculin skin test within four to six weeks after receiving this vaccination. The is because the results of the test could be affected by this vaccine.

If disinfectant or alcohol is used to clean the skin before the vaccine is given, it should be allowed to evaporate before vaccination to prevent any possible inactivation of live vaccines.


Consideration must be exercised to store all vaccines under the necessary conditions required, otherwise, the preparation could prove ineffective. Refrigerated storage is necessary with most vaccines requiring storage of 2'8°C and they should not freeze. Vaccines need to be protected from light. Opened multidose vials and reconstituted vaccines must be used within the period recommended in the product guide. Any unused vaccines need to be disposed of by incineration at a disposal contractor.


When given correctly, at the correct age, the rubella and mumps live vaccine is extremely successful in preventing the development of rubella and mumps. It is important that this vaccine is given to a child under the age of 12 months and it's important that anyone receiving this vaccine informs their doctor or healthcare professional of all the various medications they are currently taking. This is due to the high number of drugs that can react with this vaccine, so precautions may need to be put in place. It isn't recommended you fall pregnant for at least three months after receiving this vaccine. You should use an effective birth control to prevent this from happening.


Last Reviewed:
February 02, 2018
Last Updated:
April 09, 2018
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